Did You Know...
...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
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| Number | Title | Issue Date |
| 8426636 | Sterically bulky stabilizers A sterically bulky stabilizer that is associated non-covalently with a benzimidazolone pigment. The sterically bulky stabilizer compound includes an aromatic acid derivative, and the presence of the sterically bulky stabilizer limits an extent of particle growth and... | 04/23/2013 |
| 8426562 | Methods and compositions for modulating tumor cell activity Antibodies which target clusterin, a protein involved in the epithelial-to-mesenchymal transition of carcinoma cells, are identified and characterized. The antibodies may be used to modulate tumor cell activity through binding the clusterin. ... | 04/23/2013 |
| 8421019 | Identification of immunoglobulin (lg) disorders using fourier transform infrared spectroscopy A method and a corresponding system for obtaining a serum mid-infrared spectroscopic profile using Fourier-transform infrared spectroscopy (FTIR) are described. The method comprises acquiring FTIR spectra for dried sera and preprocessing the FTIR spectra of sera by ... | 04/16/2013 |
| 8410341 | Nucleic acid encoding N-methylputrescine oxidase and uses thereof The gene encoding N-methylputrescine oxidase (MPO) and constructs comprising such DNA are provided, including methods of regulating MPO expression independently or with other alkaloid biosynthesis genes to modulate alkaloid production in plants and host cells. MPO g... | 04/02/2013 |
| 8383107 | Single domain brain-targeting antibody fragments derived from llama antibodies A phage-displayed library of llama single heavy domain antibodies (sdAbs) was enriched for species that selectively bind to and are internalized by human cerebromicrovascular endothelial cells (HCEC). From the enriched library, two sdAbs were selected, sequenced, su... | 02/26/2013 |
| 8372954 | Phage display libraries of human Vfragments Phage display libraries are taught in which the recombinant phage population displays a plurality of potential binding fragments having preferred characteristics of solubility and/or intermolecular interaction. Also taught are methods of biasing display libraries to... | 02/12/2013 |
| 8361462 | Anti-apoptotic protein antibodies Single-domain anti-bodies that bind pro-apoptotic proteins Bax and caspase-3 are identified and isolated. These single-domain antibodies may be used to modulate the active of Bax and caspase-3, thereby modulating the symptoms and steps of oxidative stress and/or cel... | 01/29/2013 |
| 8278654 | Electrostatically regulated atomic scale electroconductivity device An atomic scale electroconductivity device with electrostatic regulation includes a perturbing species having a localized electronic charge. A sensing species having an electronic conductivity is placed in proximity to the perturbing species at a distance sufficient... | 10/02/2012 |
| 8257705 | Single-domain antigen-binding antibody fragments derived from llama antibodies A phage display library of variable heavy domain (VHH or VH) fragments (sdAb fragments) derived from the antibody repertoire of a non-immunized llama is disclosed. The sdAb fragments of the library are characterized by the absence of cysteine residues in ... | 09/04/2012 |
| 8163894 | DNA for eukaryotic expression of CymR The invention relates to a new “gene-switch” (cumate-inducible switch) for mammalian cells, having a mammalian promoter which has a TATA element and is linked to the coding sequence of CymR. This switch is as useful in the development of expression systems and c... | 04/24/2012 |
| 8063018 | Bivalent thrombin binding molecules comprising linkers There is provided herein a multivalent binding molecule and uses thereof. The molecule is useful in binding a target under certain conditions and releasing it under other conditions. The molecule has the general formula (1) of BM1-L-(BM2)n (1) wherein, BM... | 11/22/2011 |
| 8012254 | Nanosized particles of benzimidazolone pigments A nanoscale pigment particle composition includes an organic benzimidazolone pigment, and a sterically bulky stabilizer compound, wherein the benzimidazolone pigment associates non-covalently with the sterically bulky stabilizer compound that is a substituted pyridi... | 09/06/2011 |
| 7972860 | Methods and compositions for the detection and analysis of nucleic acids by signal amplification The present invention relates to a novel integrated PCR-free signal amplification polynucleotide detection system which combines a specific receptor, an optical transducer, and an amplification mechanism. This novel detection system is based on different electrostat... | 07/05/2011 |
| 7943129 | Single-domain brain-targeting antibody fragments derived from llama antibodies A phage-displayed library of llama single heavy domain antibodies (sdAbs) was enriched for species that selectively bind to and are internalized by human cerebromicrovascular endothelial cells (HCEC). From the enriched library, two sdAbs were selected, sequenced, su... | 05/17/2011 |
| 7938903 | Nanosized particles of benzimidazolone pigments A nanoscale pigment particle composition includes an organic benzimidazolone pigment, and a sterically bulky stabilizer compound, wherein the benzimidazolone pigment associates non-covalently with the sterically bulky stabilizer compound that is an alkylated-benzimi... | 05/10/2011 |
| 7910351 | Mutant strain and uses thereof A mutant strain of Francisella tularensis has attenuated virulence and has a mutation in the gene coding for a putative peroxynitrite resistance protein A (prpA) which prevents normal function of the protein. The mutant is useful as a vaccine against type A a... | 03/22/2011 |
| 7905954 | Nanosized particles of benzimidazolone pigments A nanoscale pigment particle composition includes an organic benzimidazolone pigment, and a sterically bulky stabilizer compound, wherein the benzimidazolone pigment associates non-covalently with the sterically bulky stabilizer compound that is an alkylated derivat... | 03/15/2011 |
| 7897417 | Hybrid nanocomposite semiconductor material, and method of producing inorganic semiconductor therefor Hybrid semiconductor materials have an inorganic semiconductor incorporated into a hole-conductive fluorene copolymer film. Nanometer-sized particles of the inorganic semiconductor may be prepared by mixing inorganic semiconductor precursors with a steric-hindering ... | 03/01/2011 |
| 7881777 | Method and apparatus for performing intra-operative angiography Method for assessing the patency of a patient's blood vessel, advantageously during or after treatment of that vessel by an invasive procedure, comprising administering a fluorescent dye to the patient; obtaining at least one angiographic image of the vessel portion... | 02/01/2011 |
| 7872105 | Anticarcinoma antibodies and uses thereof A novel single domain antibody AFAI and fragments thereof which has specific affinity for binding to carcinoma, and especially lung carcinoma. This antibody, and portions thereof, can be used, inter alia in the diagnosis and treatment of carcinoma. ... | 01/18/2011 |
| 7778499 | Silicon photonic wire waveguide biosensor Methods and devices relating to a sensor for use in detecting and monitoring molecular interactions. A silicon waveguide sensing element is provided along with a layer of silicon. A silicon oxide layer is also provided between the waveguide element and the layer of ... | 08/17/2010 |
| 7769062 | Quantum dot based semiconductor waveguide devices Methods and devices for providing a multiwavelength laser which may be used for multicasting and other optical communications uses. The present invention provides a quantum dot based multiwavelength laser with a monolithic gain block. The Fabry-Perot gain block has ... | 08/03/2010 |
| 7759490 | Phosphorescent Osmium (II) complexes and uses thereof There is disclosed herein phosphorescent compounds, uses thereof, and devices including organic light emitting diode (OLEDs) including such compounds. Compounds of interest include: wherein A... | 07/20/2010 |
| 7759060 | Molecular method for diagnosis of prostate cancer Methods for diagnosing or detecting cancerous prostate tissue. A panel of 8 specific marker genes are provided. The overexpression of some of these marker genes compared to their expression in normal prostate tissue and the underexpression of the rest of these marke... | 07/20/2010 |
| 7756588 | Method of fabricating a multichannel electrode The invention provides a multichannel electrode (“MC electrode”) which can perform multiple functions such as recording, stimulating and lesioning simultaneously or sequentially upon a single insertion into a target site. In one aspect, the MC electrode further ... | 07/13/2010 |
| 7737432 | Voltage controlled computing element for quantum computer A computing element for use in a quantum computer has at least three coupled quantum dots, and at least one gate for applying an electric field to manipulate the state of said qubit. ... | 06/15/2010 |
| 7670824 | Multicopy-integration of heterologous genes and expression in The integration of genes into methylobacterium, such as M. extorquens ATCC is disclosed, using a transposon system, preferably the mini-Tn7 transposon system, and under the control of a promoter, such as the strong methanol dehydrogenase promoter (PmxaF | 03/02/2010 |
| 7655412 | Self-assembly molecules There is provided a method of forming a multimeric complex having affinity for a target. The method comprises: obtaining a plurality of self-assembly molecules, said self-assembly molecules including complementary self-assembly units such as verotoxin subunit B, eac... | 02/02/2010 |
| 7608442 | β1,3-galactosyltransferase polypeptides from the LOS locus of This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an α2,3- and an α2,8-activity. A β1,4-GalNAc transferase and a β1,3-galactosyltransferase are also provided by the invention, as are other glycosyl... | 10/27/2009 |
| 7507535 | Strong PCR primers and primer cocktails The invention disclosed relates to a PCR primer pair for amplication of chaperonin-60 (cpn60) targets having high G+C content and to a PCR primer “cocktail” to improve the representation of diverse sequences in chaperonin-60 based PCR product libraries derived f... | 03/24/2009 |
| 7462474 | B1,4-N-acetylglucosaminyl (GALNAC) transferase polypeptides This invention provides prokaryotic β1,4-N-acetylgalactosaminyl (GalNAc) transferases involved in synthesis of lipooligosaccharide (LOS). β1,4-GalNAc transferases are obtained from, for example, Campylobacter species, including C. jejuni. In addition... | 12/09/2008 |
| 7456152 | Peptide inhibitors of thrombin as potent anticoagulants The tetrapeptide Phe-Asn-Pro-Arg (SEQ ID NO: 3) is a structurally-optimized sequence for binding to the active site of thrombin. By conjugating this tetrapeptide or variants thereof to a C-terminal fragment of hirudin, we were able to generate a series of new multiv... | 11/25/2008 |
| 7430897 | Method and apparatus for detecting and locating gas leaks The invention provides an apparatus and method for detecting the location of a gas leak within a test region. The invention comprises an array of calibrated sensors for measuring a plurality of gas concentrations, a control system coupled to the sensor array for cal... | 10/07/2008 |
| 7425434 | Gene encoding cyclododecanone monooxygenase The invention relates to a new strain of Pseudomonas putida (designated as HI-70) and to the isolation, cloning, and sequencing of a cyclododecanone monooxygenase-encoding gene (named cdnB) from said strain. The invention also relates to a new cyclododecanone... | 09/16/2008 |
| 7393440 | Hydrogen generation system The present invention provides a system for generating hydrogen gas in an aqueous solution based electrolytic or galvanic cell wherein the cathode is made from aluminum or an aluminum alloy. In a preferred arrangement the cell is a galvanic cell and cathode is made ... | 07/01/2008 |
| 7381544 | Nucleic acid that encodes a fusion protein This invention provides fusion polypeptides that include a glycosyltransferase catalytic domain and a catalytic domain from an accessory enzyme that is involved in making a substrate for a glycosyltransferase reaction. Nucleic acids that encode the fusion polypeptid... | 06/03/2008 |
| 7376308 | Optical off-chip interconnects in multichannel planar waveguide devices The multichannel waveguide device includes an array of waveguides located in a plane. Each waveguide channel has a redirecting element for redirecting a guided wave out of said plane, or vice versa. The redirecting elements are staggered in the direction of the wave... | 05/20/2008 |
| 7371838 | Nucleic acids encoding β 1,4-N-acetylgalactosaminyltransferases from This invention provides prokaryotic β1,4-N-acetylglucosaminyl (GalNAc) traosferases involved in synthesis of lipooligosaccharide (LOS). The β1,4-GalNAc transferases can be obtained from, for example, Campylobacter species, including C. jejuni. In add... | 05/13/2008 |
| 7366310 | Microphone array diffracting structure The present invention increases the aperture size of a microphone array by introducing a diffracting structure into the interior of a microphone array. The diffracting structure within the array modifies both the amplitude and phase of the acoustic signal reaching t... | 04/29/2008 |
| 7364739 | lipopolysaccharide inner-core oligosaccharide epitopes as vaccines for the prevention of infections The present invention relates to a lipopolysaccharide moiety comprising a conserved triheptosyl inner-core moiety of lipopolysaccharide substantially free of variable outer core oligosaccharide chain extension, and to vaccines obtaines therefrom which are cross-reac... | 04/29/2008 |
