Did You Know...
...that the inventor of the electric motor was a blacksmith named Thomas Davenport? Described as "a brilliantly unsuccessful inventor", Davenport invented the first rotary electric motor. In 1836 he headed out -- on foot -- from his Vermont home to file a patent application at the Patent Office in Washington, D.C. By the time he got there, he had squandered away his money and couldn't afford the $30 filing fee so he turned around and went home. When he later mailed in his application with money he'd raised, the Patent office was destroyed in a fire. He did finally get credit for his invention on Feb. 5, 1837.
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| Number | Title | Issue Date |
| 6974677 | Human MEKK proteins, corresponding nucleic acid molecules, and uses therefor Isolated nucleic acid molecules encoding human MEKK proteins, and isolated MEKK proteins, are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells in... | 12/13/2005 |
| 6495331 | Regulation of cytokine production in a hematopoietic cell A method useful for regulating cytokine production by a hematopoietic cell by regulating an MEKK/JNKK-contingent signal transduction pathway in such a cell is disclosed. Methods of identifying compounds capable of specifically regulating an MEKK/JNKK-cont... | 12/17/2002 |
| 6333170 | Method and product for regulating cell responsiveness to external signals The present invention relates to isolated MEKK proteins, nucleic acid molecules having sequences that encode such proteins, and antibodies raised against such proteins. The present invention also includes methods to use such proteins to regulate signal tr... | 12/25/2001 |
| 6312934 | Human MEKK proteins, corresponding nucleic acid molecules, and uses therefor Isolated nucleic acid molecules encoding human MEKK proteins, and isolated MEKK proteins, are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, ho... | 11/06/2001 |
| 6264888 | Ultraviolet germicidal apparatus and method A germicidal method and apparatus for destroying airborne pathogenic bacteria such as tuberculosis bacteria using ultraviolet light. Air is drawn through a filter and into a sterilization chamber that is irradiated with ultraviolet light, and out through ... | 07/24/2001 |
| 5981265 | Methods for regulating MEKK protein activity The present invention relates to isolated MEKK proteins, nucleic acid molecules having sequences that encode such proteins, and antibodies raised against such proteins. The present invention also includes methods to use such proteins to regulate signal tr... | 11/09/1999 |
| 5914268 | Embryonic cell populations and methods to isolate such populations The present invention relates to novel pluripotent embryonic cell populations derived from embryonic stem cell populations and methods to produce such pluripotent embryonic cell populations. Disclosed is an embryonic stem cell-derived pluripotent embryoid... | 06/22/1999 |
| 5910417 | Regulation of cytokine production in a hematopoietic cell A method useful for regulating cytokine production by a hematopoietic cell by regulating an MEKK/JNKK-contingent signal transduction pathway in such a cell is disclosed. Methods of identifying compounds capable of specifically regulating an MEKK/JNKK-cont... | 06/08/1999 |
| 5854043 | MEKK-related signal transduction kinases The present invention relates to isolated MEKK proteins, nucleic acid molecules having sequences that encode such proteins, and antibodies raised against such proteins. The present invention also includes methods to use such proteins to regulate signal tr... | 12/29/1998 |
| 5840700 | Methods of producing transfer factor The invention relates to substantially pure transfer factor with a specific activity of at least 5000 units per absorbance unit at 214 nm. The present invention also relates to a process for preparing the transfer factor from cell lysates. The present inv... | 11/24/1998 |
| 5820866 | Product and process for T cell regulation The present invention relates to a product and process for regulating the activity of T cells using major histocompatibility complexes (MHC) stably linked to antigenic peptides. Disclosed is an antigenic peptide covalently linked to a major histocompatibi... | 10/13/1998 |
| 5776708 | Method for identifying T cells involved in autoimmune disease The invention relates to a method for identifying T cell populations involved in autoimmune diseases. This involves determining levels of a Vଲ element in a body fluid sample of a patient and comparing this to normal levels. Variation from normal lev... | 07/07/1998 |
| 5753446 | Mitogen ERK kinase kinase (MEKK) assay The present invention relates to isolated MEKK proteins, nucleic acid molecules having sequences that encode such proteins, and antibodies raised against such proteins. The present invention also includes methods useful for identifying compounds capable o... | 05/19/1998 |
| 5705151 | Gene therapy for T cell regulation The present invention provides a nucleic acid-based therapeutic composition to treat an animal with disease by controlling the activity of effector cells, including T cells, macrophages, monocytes and/or natural killer cells, in the animal. The present in... | 01/06/1998 |
| 5698679 | Product and process for targeting an immune response The present invention relates to a product and process for regulating an immune system using an immunoglobulin fusion protein capable of targeting a specific peptide precursor to a specific antigen presenting cell. Disclosed is a peptide precursor associa... | 12/16/1997 |
| 5641488 | Method for producing an antibody to a chosen antigen The invention relates to a method for producing antibodies of desired specificity. In particular, the method involves immunizing a subject animal with the chosen antigen following prior stimulation of the non-human animal's B cells. The prior stimulation ... | 06/24/1997 |
| 5616472 | Process for producing monoclonal antibodies against human T cell receptor elements using recombinant DNA vectors, and cells transfected thereby Recombinant DNA vectors which express chimeric T cell receptors are disclosed. These chimeric T cell receptors contain one human element, and the rest of the elements are all of the same, non-human animal species, such as a mouse. Of particular interest a... | 04/01/1997 |
| 5585465 | Isolated toxin associated with Kawasaki syndrome The invention relates to the isolated toxin associated with Kawasaki syndrome and the bacteria from which these are isolated.... | 12/17/1996 |
| 5567590 | Methods of diagnosing steroid-resistant inflammation due to type I or type II nuclear glucocorticoid receptor binding abnormalities Disclosed is a method for diagnosing inflammation in an animal which includes analyzing cells to assess glucocorticoid receptor binding affinity or glucocorticoid receptor number. A low binding affinity and high receptor number are each indicative of infl... | 10/22/1996 |
| 5476767 | Isolated nucleic acid molecule coding for toxin associated with Kawasaki Syndrome and uses thereof The invention relates to isolated nucleic acid molecules coding for toxins associated with Kawasaki Syndrome. Also described are various applications of the nucleic acid molecules.... | 12/19/1995 |
| 5470835 | Transfer factor and methods of use The invention relates to substantially pure transfer factor with a specific activity of at least 5000 units per absorbance unit at 214 nm. The present invention also relates to a process for preparing the transfer factor from cell lysates. The present inv... | 11/28/1995 |
| 5460813 | Method for treating Kawasaki syndrome by administration of an anti-TSST-1 agent which is not gamma globulin The invention relates to various methodologies for diagnosing Kawasaki syndrome. Various bacteria, including TSST-1 producing Staphylococcus aureus, and SPEB and SPEC producing streptococcus have been found to be indicative of the pathological condition. ... | 10/24/1995 |
| 5336598 | Method for diagnosing a superantigen caused pathologial condition via assay of T-cells The invention teaches a method for determining levels of T-cell surface antigens in humans, specifically, Vଲ molecules. Measurement of such levels allows for diagnosis of pathological conditions, such as infections, where changes in these levels are... | 08/09/1994 |
| 5298396 | Method for identifying T cells disease involved in autoimmune disease The invention relates to a method for identifying T cell populations involved in autoimmune diseases. This involves determining levels of a Vଲ element in a body fluid sample of a patient and comparing this to normal levels. Variation from normal lev... | 03/29/1994 |
| 5286623 | Method for screening for Kawasaki disease The invention relates to screening of patients to determine the possible presence of Kawasaki Disease. The screening involves assaying for levels of V댢 or V댨.1 by immunoassay, or for the mRNA expressing either of these Vଲ elements. The... | 02/15/1994 |
| 5266312 | Method for treating a steroid resistant condition via administration of gamma interferon The invention relates to a method for a steroid resistant condition via administration of gamma interferon to a subject, such as a human, afflicted with the condition. The gamma interferon is administered in an amount sufficient to alleviate at least one ... | 11/30/1993 |
| 5200320 | Method for identifying useful polypeptide vaccines A method of identifying potential polypeptide vaccines to an agent, such as viruses, bacteria, and parasites. A critical binding segment of a first polypeptide known to bind to a first MHC type, is ascertained. The effect of replacing each of the amino ac... | 04/06/1993 |
| 4963565 | In vivo treatment of mycobacterial infections with 6-cyclo octylamino-5,8-quinoline quinone 6-cyclo-octylamino-5,8-quinoline quinone, a Vitamin K analogue, shows surprising efficacy as an in vivo therapeutic agent for treatment of tuberculosis and leprosy. Mycobacteria species, intracellulare, tuberculosis, and leprae are inhibited following adm... | 10/16/1990 |
| 4802492 | Method for determining respiratory function A method for determining respiratory function in subjects, as well as the apparatus thus employed. The method involves blocking exhalation while the subject inhales spontaneously. Increased volume in the lungs and face mask pressure are measured to determ... | 02/07/1989 |
