Did You Know...
...that when IBM conducted a market study of Chester Carlson's invention in 1959, the company concluded that it would take only 5000 units of his new product to saturate the market? IBM therefore declined to be part of the new product introduction. Too bad for IBM. Carlson's invention was the xerography process, and his new product was the beginning of the Xerox Corporation. It is estimated that every day, worldwide, 3,000,000,000 copies are made!!
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| Number | Title | Issue Date |
| 7960105 | Method of DNA analysis using micro/nanochannel Methods are provided for tagging, characterizing and sorting double-stranded biomolecules while maintaining the integrity of the biomolecules. ... | 06/14/2011 |
| 7867496 | Use of TGF-β antagonists to limit nephrotoxicity of immunosuppressive agents The disclosure relates to methods of ameliorating nephrotoxic side effects of immunosuppressive agents whose immunosuppressive activity is mediated via upregulation of TGF-β such as, for example, cyclosporine (CsA). The disclosure provides treatment modalities for ... | 01/11/2011 |
| 7838645 | Function of autophagy genes in cell death The present invention relates to a new molecular pathway in which activation of the receptor-interacting protein (RIP, a serine-threonine kinase) and Jun N-terminal kinase induce cell death with the morphology of autophagy. Further, autophagic death is induced by ca... | 11/23/2010 |
| 7642280 | Inhibitors of acyl glucosaminyl inositol amidase and methods of use The present invention provides compounds with activity as inhibitors of acyl glucosaminylinositol amidases with amidase activity against S-conjugate amides, particularly mycothiol-derived S-conjugate amides. Certain of the invention compounds are naturally occurring... | 01/05/2010 |
| 7291494 | Regulation of target protein activity through modifier proteins The present invention is based on the discovery that a polypeptide containing the JAB subunit or the JAM domain has peptidase activity, e.g., isopeptidase activity. The present invention provides polypeptides and crystalline polypeptides containing the JAM domain an... | 11/06/2007 |
| 7211696 | Antileishmanial dinitroaniline sulfanomides with activity against parasite tubulin Dinitroaniline compounds useful for the treatment of diseases caused by parasitic protozoa in subjects in need of such treatment. The compounds are particularly useful in the treatment of leishmaniasis. The compounds are preferably less cytotoxic to normal cells tha... | 05/01/2007 |
| 6589966 | Cytotoxic metal chelators and methods for making and using same A family of hexadentate Fe(II) chelators having marked antiproliferative activity against tumor cells is disclosed. The cytotoxic metal chelators and complexes of the present invention are represented by the general formula below: ##STR1## wherein: X... | 07/08/2003 |
| 6455249 | Method of amplifying DNA and RNA mismatch cleavage products Detection of probe fragment products of basepair mismatch cleavage indicate the presence and sequence of target DNA. Detection of the target is enhanced by amplification through recycling targets by maintaining an assay temperature between the melting poi... | 09/24/2002 |
| 6270958 | Detection of negative-strand RNA viruses A diagnostic assay for detecting a negative-strand RNA virus in a sample and a genetically engineered cell for use in the assay are disclosed. The cell expresses a heterologous DNA-dependent RNA polymerase that synthesizes a minigenome or miniantigenome o... | 08/07/2001 |
| 6117667 | Method for producing an adapted virus population from an African green monkey kidney cell line The invention described herein provides a method for selecting a novel African Green monkey kidney (AGMK) cell substrate, its cultivation and serial passage and its subsequent characterization. The invention provides a method for the use of the cell subst... | 09/12/2000 |
| 6025182 | Method for producing a virus from an african green monkey kidney cell line A method for producing novel African Green Monkey Kidney (AGMK) cell lines is taught. These cell lines which are free of viable adventitious microbial agents are useful as substrates for viruses and for the preparation of viral vaccines.... | 02/15/2000 |
| 5911998 | Method of producing a virus vaccine from an African green monkey kidney cell line A method for producing novel African Green Monkey Kidney (AGMK) cell lines is taught. These cell lines which are free of viable adventitious microbial agents are useful as substrates for viruses and for the preparation of viral vaccines.... | 06/15/1999 |
| 5851819 | Vectors carrying MDR1 cDNA which confer multidrug resistance on transduced cells The present invention provides for vectors carrying a cDNA containing the entire coding region of the human multidrug resistance gene (MDR1) and for a method for introducing MDR1 cDNA into cells thereby inducing a multidrug resistant phenotype.... | 12/22/1998 |
| 5736315 | Methods and compositions for detecting anti-hepatitis E virus activity The present invention provides antigenic peptides and polypeptides of hepatitis E virus. Also provided are mixtures of conjugated and unconjugated peptides of the present invention. Methods of detecting hepatitis E viral infection in a subject using the p... | 04/07/1998 |
| 5663066 | Assay using recombinant histidyl-tRNA synthetase Recombinant Histidyl tRNA synthetase produced by non-mammalian host cells is used in a sensitive assay to determine the presence of autoimmune diseases in mammals. Methods for isolating, cloning and expressing rHRS are described. In addition, a kit for de... | 09/02/1997 |
| 5646033 | African green monkey kidney cell lines useful for maintaining viruses and for preparation of viral vaccines A novel African Green Monkey Kidney (AGMK) cell line is taught as well as a method for the preparation thereof. The cell line which is free of viable adventitious microbial agents is useful as a substrate for viruses and for the preparation of viral vacci... | 07/08/1997 |
| 5472693 | Family of anti-carcinoembryonic antigen chimeric antibodies The present invention discloses novel chimeric monoclonal antibodies directed against human carcinoembryonic antigen, having antigen-specific variable regions. DNA constructs for the light and heavy chain variable regions comprising the novel antibodies o... | 12/05/1995 |
| 5346908 | Nitrogen-containing cyclohetero cycloheteroaminoaryl derivatives for CNS disorders Certain nitrogen-containing cyclohetero cycloalkylaminoaryl compounds are described for treatment of CNS disorders such as cerebral ischemia, psychoses and convulsions. Compounds of particular interest are of the formula: ##STR1## wherein each o... | 09/13/1994 |
| 5317009 | Anti-HIV proteins GAP 31, DAP 30 and DAP 32 and therapeutic uses thereof New proteins, termed GAP 31, obtainable from the seeds of Gelonium multiflorum, and DAP 30 and DAP 32, obtainable from the leaves or seeds of Dianthus caryophyllus, or the above proteins produced by recombinant means, are useful for treating HIV infection... | 05/31/1994 |
