Assignee: Nanostream, Inc.

Location: Pasadena, CA
No. of patents: 42

Number	Title	Issue Date
7318912	Microfluidic systems and methods for combining discrete fluid volumes Microfluidic devices capable of combining discrete fluid volumes generally include channels for supplying different fluids toward a sample chamber and means for establishing fluid communication between the fluids within the chamber. Discrete fluid plugs are defined ...	01/15/2008
7261812	Multi-column separation devices and methods Chromatographic separation devices include multiple batch-processed columns joined by a body structure and adapted to perform parallel analyses. Both slurry-packed and monolithic column embodiments are provided. One or more liquid-permeable frits of various types ma...	08/28/2007
7214320	Systems and methods for high throughput sample analysis Systems and methods for analyzing a plurality of samples in parallel include a plurality of liquid phase separation regions, a plurality of microfluidic storage regions, and a common mass spectrometer. Samples are separated in parallel in the separation regions to y...	05/08/2007
7178386	Parallel fluid processing systems and methods A parallel fluid processing system including multiple fluid process regions containing solid material in fluid communication with a common first fluid source may be used to conduct analyses and/or synthesis in parallel. A parallel fluid processing data correction me...	02/20/2007
7153421	Frit material and bonding method for microfluidic separation devices A multi-layer microfluidic separation device comprises a polymeric membrane frit that may be securely bonded within the device and minimizes lateral wicking. Stationary phase material having an average particle size is retained by a frit having an average pore size ...	12/26/2006
7132650	High throughput multi-dimensional sample analysis High throughput analytical systems and methods employing multiple liquid phase separation process regions coupled to a common mass spectrometer are provided. Disclosed systems and methods permits parallel separation and parallel storage of discrete eluate fractions,...	11/07/2006
7077152	Microfluidic metering systems and methods Systems and methods for metering microfluidic volumes are provided. A discrete plug may be separated from a larger volume of first fluid by injecting a second fluid, such as a gas, into a channel containing the first fluid. The injection of the second fluid to isola...	07/18/2006
7074327	Sample preparation for parallel chromatography Systems and methods are provided for preparing samples for chromatographic separations and then chromatographically separating the prepared samples, preferably in a high-throughput fashion utilizing multiple parallel first (fluid) processing regions in fluid communi...	07/11/2006
7028536	Sealing interface for microfluidic device A threadless interface for a fluidic system includes a microfluidic device having an outer surface and an internal near-surface channel having a first width and disposed at a first depth relative to the outer surface, with the first width being less than about two t...	04/18/2006
7027683	Optical devices with fluidic systems Fluidic systems, including microfluidic systems, are used to manipulate light by light-fluid interaction so as to affect reflection, refraction, absorption, optical filtering, or scattering of the beam. One or more fluids may be provided to a channel or chamber and ...	04/11/2006
7010964	Pressurized microfluidic devices with optical detection regions Microfluidic analytical devices and systems have at least one porous element disposed downstream of one or more optical detection regions in a pressure-based separation system. A porous element elevates the backpressure within an optical detection region, thus suppr...	03/14/2006
6987263	High throughput systems and methods for parallel sample analysis Systems for analyzing multiple samples in parallel using mass spectrometric preferably coupled with fluid phase separation techniques are provided. A multi-analyzer mass spectrometer includes multiple inlets, multiple mass analyzers, and multiple transducers to cond...	01/17/2006
6981522	Microfluidic devices with distributing inputs Microfluidic devices having a plurality of functional features for performing one or more fluidic operations in parallel are provided. Reagents, samples or other fluids common to multiple functional features (“common fluids”) may be input into a microfluidic dev...	01/03/2006
6976384	Parallel detection chromatography systems High throughput liquid chromatography systems include multiple separation columns and multiple flow-through detection regions in sensory communication with a common radiation source and a multi-channel detector. Preferred detector types include a multi-anode photomu...	12/20/2005
6935772	Fluidic mixer in microfluidic system Microfluidic devices capable of efficiently mixing two or more fluid are provided. Two or more microfluidic inlet channels defined in different sheets of material meet at an overlap region in fluid communication with an outlet channel. The channels are defined throu...	08/30/2005
6936167	System and method for performing multiple parallel chromatographic separations Systems and methods for performing multiple parallel chromatographic separations are provided. Microfluidic cartridges containing multiple separation columns allow multiple separations to be performed in a limited space by a single instrument containing high-pressur...	08/30/2005
6923907	Separation column devices and fabrication methods Pressure-driven microfluidic separation devices, such as may be used for performing high performance liquid chromatography, are provided. Multiple separation columns may be defined in a single device and packed with stationary phase material retained by porous frits...	08/02/2005
6919046	Microfluidic analytical devices and methods Modular microfluidic systems includes a plurality of microfluidic modules, each capable of performing fluidic operations including, but not limited to, filtering, splitting, regulating pressure, mixing, metering, reacting, diverting, heating, cooling, and condensing...	07/19/2005
6890093	Multi-stream microfludic mixers Robust microfluidic mixing devices mix multiple fluid streams passively, without the use of moving parts. In one embodiment, these devices contain microfluidic channels that are formed in various layers of a three-dimensional structure. Mixing may be accomplished wi...	05/10/2005
6880576	Microfluidic devices for methods development Microfluidic devices with multiple fluid process regions for subjecting similar samples to different process conditions in parallel are provided. One or more common fluid inputs may be provided to minimize the number of external fluid supply components. Solid materi...	04/19/2005
6877892	Multi-stream microfluidic aperture mixers Robust microfluidic mixing devices mix multiple fluid streams passively, without the use of moving parts. In one embodiment, these devices contain microfluidic channels that are formed in various layers of a three-dimensional structure. Mixing may be accomplished wi...	04/12/2005
6867857	Flow cell for optical analysis of a fluid A flow cell for performing optical analysis of a fluid is provided. The flow cell comprises a monolithic cell housing that defines a detection chamber, fluid inlet and outlet ports and illumination and detection ports. Optical fibers are inserted in the illumination...	03/15/2005
6848462	Adhesiveless microfluidic device fabrication A method for fabricating a microfluidic device where first and second substantially flat platens are provided. Multiple substantially planar, substantially metal-free, adhesiveless polymer device layers, the device layers including a first cover layer, second cover ...	02/01/2005
6845787	Microfluidic multi-splitter A splitter for multi-layer microfluidic devices is provided. The splitter includes multiple forked channels defined in two or more device layers. The forked channels communicate fluidically at overlap regions. The overlap regions, in combination with symmetrical cha...	01/25/2005
6827095	Modular microfluidic systems A modular microfluidic system includes a plurality of discrete microfluidic modules each capable of performing at least one operation and at least one microfluidic coupling device for fluidically coupling the modules to perform a sequence of operations. The microflu...	12/07/2004
6814859	Frit material and bonding method for microfluidic separation devices A frit for use in multi-layer microfluidic separation devices is provided. The frit comprises a polymeric membrane that may be securely bonded within the device and minimizes lateral wicking. A secure bond is ensured by treating the polymer to match its surface ener...	11/09/2004
6814938	Non-planar microfluidic devices and methods for their manufacture Non-planar microfluidic devices and methods for transferring fluids between vessels and microfluidic devices are provided. The devices may be contoured to physically contact non-planar vessels, such as pipes, tubes, vials, or syringes to establish fluid communicatio...	11/09/2004
6812458	Systems and methods for high-throughput microfluidic sample analysis Systems and methods for collecting the output of multiple simultaneously operated chromatography columns and providing the outputs to a single mass spectrometer are provided. Such systems utilize predetermined lengths of microfluidic tubing that act as storage buffe...	11/02/2004
6811695	Microfluidic filter Multi-layer microfluidic devices incorporating a filter element are provided. A filter element is compressively restrained between device layers, such that the compression promotes a tight seal between device layers and resists fluid leakage around the filter elemen...	11/02/2004
6755211	Microfluidic systems with inter-channel impedances Microfluidic systems and devices having integrated fluidic impedances are provided. Such impedances hinder the passage of fluid at low differential pressures, but allow fluid flow at higher differential pressures. Impedances are formed at the overlap of two or more ...	06/29/2004
6748978	Microfluidic devices with porous regions Microfluidic devices having porous materials that restrict fluid flow rate for a given pressure are provided. Multiple porous regions can be constructed in a single device so that they have different valving capabilities or impedances, and in unison can control the ...	06/15/2004
6739576	Microfluidic flow control device with floating element A microfluidic flow control device includes a fluidic chamber, a first and a second microfluidic channel, at least one sealing surface between the first and the second channels, and a floating element disposed within the chamber. The floating element is capable of i...	05/25/2004
6729352	Microfluidic synthesis devices and methods A microfluidic reactor for performing chemical and biological synthesis reactions, including chemical and biological syntheses of organic, polymer, inorganic, oligonucleotide, peptide, protein, bacteria, and enzymatic products is provided. Two fluids are input into ...	05/04/2004
6676835	Microfluidic separators Microfluidic separators for separating multiphase fluids are described. Two or more microfluidic outlet channels within the device meet at an overlap region. The overlap region may be in fluid communication with an inlet channel. The inlet channel and eac...	01/13/2004
6644944	Uni-directional flow microfluidic components Microfluidic fluid control devices are provided. One microfluidic fluid control device can be used as a uni-directional valve within a microfluidic system. The invention also provides a microfluidic pump mechanism having two unidirectional valves separate...	11/11/2003
6619311	Microfluidic regulating device Microfluidic flow control devices are provided. In one embodiment, a regulating device includes overlapping channel segments separated by a deformable membrane in fluid communication with one another. Pressure differentials between the channel segments de...	09/16/2003
6561208	Fluidic impedances in microfluidic system The invention provides microfluidic devices with embedded fluidic impedances. Such impedances do not allow fluid to pass at a low differential pressure, but allow fluid to flow at a higher differential pressure. Impedances are formed by the three dimensio...	05/13/2003
6536477	Fluidic couplers and modular microfluidic systems Microfluidic coupling devices capable of connecting more than one microfluidic module together to form a larger, integrated system are described. These devices are constructed in a number of ways. In a certain embodiments, the coupler is constructed from ...	03/25/2003
6501654	Microfluidic devices for heat transfer In accordance with the present invention there is provided a microfluidic heat exchange system for cooling heat-generating components of electronic equipment, computers, lasers, analytical instruments, medical equipment and the like. Both direct contact a...	12/31/2002
6499499	Flow control in multi-stream microfluidic devices Microfluidic devices for splitting an established fluidic flow through a microfluidic channel among multiple downstream microfluidic channels include a plurality of elevated flow resistance regions to promote precise and predictable splitting. Each elevat...	12/31/2002

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Assignee: Nanostream, Inc.