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| Number | Title | Issue Date |
| 8153588 | Methods useful in the treatment of bone resorption diseases The invention relates to a combined pharmaceutical preparation comprising parathyroid hormone and a bone resorption inhibitor, said preparation being adapted for (a) the administration of parathyroid hormone during a period of approximately 6 to 24 months; (b) after... | 04/10/2012 |
| 8148508 | Method for enzymatic production of GLP-2(1-33) and GLP-2(1-34) peptides The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any... | 04/03/2012 |
| 8148394 | Azaindoles having serotonin receptor affinity Described herein are compounds with affinity for the 5-HT6 receptor, which have the general formula I: wherein A, B, D, E, R1 to R3 and n are described herein. Also ... | 04/03/2012 |
| 7902401 | Fluorinated compounds Compounds of Formula I are useful in the treatment of epilepsy, neuropathic pain, acute and chronic inflammatory pain, migraine, tardive dyskinesia and other related CNS disorders. wherein: A and R1 ... | 03/08/2011 |
| 7888317 | Glucagon-like peptide-2 and its therapeutic use Glucagon-like peptide 2, a product of glucagon gene expression, and analogs of glucagon-like peptide 2, have been identified as gastrointestinal tissue growth factors. Their effects on the growth of small bowel and pancreatic islets are described. Their formulation ... | 02/15/2011 |
| 7847061 | Treatment of short bowel syndrome patients with colon-in-continuity Intestinal absorption is enhanced in short bowel syndrome patients presenting with colon-in-continuity by treatment with a GLP-2 receptor agonist, such as teduglutide. ... | 12/07/2010 |
| 7829307 | Production of glucagon-like peptide 2 GLP-2 peptides and analogs thereof are produced in high yield and with desired, authentic termini by isolation from a GLP-2 peptide multimer in which at least two units of GLP-2 peptide are coupled through a linker that presents an N-terminal acid cleavage site and ... | 11/09/2010 |
| 7816408 | Calcium receptor active compounds A novel calcium receptor active compound having the formula is provided: Ar1—[CR1R2]p—X—[CR3R4]q—[CR5R6]—NR7—[CR8R9 | 10/19/2010 |
| 7781567 | Method for enzymatic production of GLP-2(1-33) and GLP-2(1-34) peptides The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any... | 08/24/2010 |
| 7781401 | Glucagon-like peptide-2 analogs Analogs of glucagon-like peptide 2, a product of glucagon gene expression, have been identified as intestinal tissue growth factors. Their formulation as pharmaceutical, and therapeutic use in treating disorders of the small bowel, are described. ... | 08/24/2010 |
| 7749543 | Methods useful in the treatment of bone resorption diseases The invention relates to a combined pharmaceutical preparation comprising parathyroid hormone and a bone resorption inhibitor, said preparation being adapted for (a) the administration of parathyroid hormone during a period of approximately 6 to 24 months; (b) after... | 07/06/2010 |
| 7708732 | Methods of administering therapeutic injections Methods of administering an injection are provided including methods of administering injections by individuals exhibiting deteriorated motor skills or impaired hand function. The method includes establishing a hand position about an injection device, including plac... | 05/04/2010 |
| 7642241 | Methods of enhancing functioning of the large intestine The invention relates to glucagon-related peptides and their use for the prevention or treatment of disorders involving the large intestine. In particular, it has now been demonstrated that GLP-2 and peptidic agonists of GLP-2 can cause proliferation of the tissue o... | 01/05/2010 |
| 7498141 | Assay system for GLP-2 receptor ligands Disclosed herein is a method for measuring the contractility of intestinal tissue upon treatment with GLP-2 or a GLP-2 ligand. Also disclosed is an assay which directly measures the activity of GLP-2 or GLP-2 ligands ex vivo and permits the screening of putative GLP... | 03/03/2009 |
| 7473537 | Cloned glucagon-like peptide-2 receptors The invention relates to nucleotides and amino acid sequences encoding glucagon-like peptide 2 receptors, recombinant host cells transformed with such nucleotides, and methods of using the same in drug screening and related applications. ... | 01/06/2009 |
