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| Number | Title | Issue Date |
| 7262280 | G-protein fusion receptors and constructs encoding same The present invention features G-protein fusion receptors and chimeric GABAB receptors (GABABRs), nucleic acid encoding such receptors, and the use of such receptors and nucleic acid. G-protein fusion receptors comprise at least one domain from... | 08/28/2007 |
| 7241863 | Human metabotropic glutamate receptor A novel human metabotropic glutamate receptor (mGluR) protein is identified, sequenced, and cloned. The receptor may be used to screen for compounds that modulate the activity of the mGluR. The recombinant mGluR, as well as compounds that modulate mGluR activity, ma... | 07/10/2007 |
| 7235258 | Sustained-release formulations for treating CNS-mediated disorders Sustained-release compositions for delivering therapeutic concentrations of isovaleramide, isovaleric acid, and certain structurally related compounds are provided for the treatment for a variety of pathological conditions, including epilepsy and spasticity, which a... | 06/26/2007 |
| 7202261 | Calcilytic compounds The present invention features calcilytic compounds. “Calcilytic compounds” refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial effect i... | 04/10/2007 |
| 7112595 | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed. ... | 09/26/2006 |
| 7109238 | Calcilytic compounds Novel calcilytic compounds and methods of using them are provided. ... | 09/19/2006 |
| 7087765 | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hypoxia-induced nerve cell damage, epilepsy, anxiety, neuropsychiatric or cognitive deficits... | 08/08/2006 |
| 7074809 | Compounds The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, X3, X4, X5, R, R1, R2, R3, R4,... | 07/11/2006 |
| 7053104 | Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases The present invention provides compounds, and pharmaceutical compositions containing those compounds, that are active at metabotropic glutamate receptors. The compounds are useful for treating neurological diseases and disorders. Methods of preparing the compounds a... | 05/30/2006 |
| 6939895 | Calcium receptor-active compounds A novel calcium receptor active compound having the formula is provided: Ar1—[CR1R2]p—X—[CR3R4]q—[CR5R6]—NR7—[CR8R9 | 09/06/2005 |
| 6818660 | Calcilytic compounds The present invention features calcilytic compounds. “Calcilytic compounds” refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial effect i... | 11/16/2004 |
| 6796967 | Injection needle assembly A needle assembly for use with an injection device including a pair of housing members slidably coupled with one another. A needle is structurally attached to one of the housing members such that it is positioned within the two housing members. A first membrane is d... | 09/28/2004 |
| 6750244 | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hypoxia-induced nerve cell damage, epilepsy, anxiety, neuropsychiatric or cognitive deficits... | 06/15/2004 |
| 6750255 | Calcium receptor-active compounds A novel calcium receptor active compound having the formula is provided: Ar1—[CR1R2]p—X—[CR3R4]q—[CR5R6]—NR7—[CR8R | 06/15/2004 |
| 6710088 | Inorganic ion receptor-active compounds The present invention features compounds able to modulate one or more activities of an inorganic ion receptor and methods for treating diseases or disorders using such compounds. Preferred compounds can mimic or block the effect of extracellular calcium on a cell su... | 03/23/2004 |
