Assignee: Mount Sinai School of Medicine

Location: New York, NY
No. of patents: 28

Number	Title	Issue Date
8158605	Azacytidine analogues and uses thereof The present invention is directed toward compounds of Formula (I) as follows: wherein, R is H, R5C(O); R1 is	04/17/2012
8137676	Genetically engineered equine influenza virus and uses thereof The present invention relates, in general, to attenuated equine influenza viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. In particular, the i...	03/20/2012
8124101	Genetically engineered swine influenza virus and uses thereof The present invention relates, in general, to attenuated swine influenza viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. In particular, the in...	02/28/2012
8106033	Composition and methods for the treatment of proliferative diseases Methods and compositions are provided for treating proliferative disorders, wherein the composition comprises at least one compound according to Formula I: wherein R1 is selected from the group consisting of —O...	01/31/2012
8097283	Methods and compositions for imaging The present invention is directed to synthetic nanoparticles useful as imaging agents for use in MRI, CT, Gamma-scintigraphy, or optical imaging techniques. The synthetic nanoparticles comprise at least one apolipoprotein that is not an apoB lipoprotein, at least on...	01/17/2012
8057803	Attenuated negative strand viruses with altered interferon antagonist activity for use as vaccines and pharmaceuticals The present invention relates, in general, to attenuated negative-strand RNA viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. The invention als...	11/15/2011
8030013	Methods and compositions for the diagnosis for early hepatocellular carcinoma Methods and compositions are provide to allow discrimination of dysplastic nodules from early HCC nodules. More specifically, it has been determined that TERT, GPC3, gankyrin, survivin, TOP2A, LYVE1, Ecadherin, IGFBP3, PDGFRA, TGFA, cyclin D1 and HGF are differentia...	10/04/2011
8012490	Recombinant influenza viruses expressing tumor-associated antigens as antitumor agents The present invention relates to the engineering of recombinant influenza viruses that express tumor-associated antigens. Expression of tumor-associated antigens by these viruses can be achieved by engineering specific epitopes into influenza virus proteins, or by e...	09/06/2011
7955849	Method of enriching a mammalian cell population for mesoderm cells The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy. ...	06/07/2011
7947460	Method for diagnosis and therapy of hazelnut-induced systemic reaction The present invention is directed to methods for predicting or diagnosing a hazelnut-induced systemic reaction, and for methods for treating such a reaction. ...	05/24/2011
7939057	Methods and compositions for modulating the mobilization of stem cells Methods and compositions for modulating the mobilization of stem cells, particularly for promoting or increasing the mobilization of hematopoietic stem cells from the bone marrow to the peripheral blood are disclosed. In particular, the invention relates to the use ...	05/10/2011
7935525	Inhibition of ATF2 activity to treat cancer The present invention relates to novel therapies for cancer and, in particular, to therapies that are particularly suited to tumor cells resistant to other types of therapies such as radiation, chemotherapy, or combinations of both approaches. The invention provides...	05/03/2011
7919276	ZA loops of bromodomains The present invention provides the structural determination of a bromodomain determined by NMR spectroscopy. The present invention also provides a binding partner for the bromodomain. In addition, the present invention provides methodology for related drug discovery...	04/05/2011
7888066	Methods for identifying substances for the treatment of Alzheimer's disease The present invention relates to a method for diagnosing Alzheimer's disease and Parkinson's disease in a subject by analyzing the expression of Semaphorin 3 and downstream effectors. It also provides a method for identifying a substance useful in the prevention or ...	02/15/2011
7799326	Methods and compositions for cathespin k complex-mediated disorders Methods and compositions for the amelioration of symptoms mediated by the collagenolytic activity of cathepsin K complex are provided. Methods of specifically modulating the collagenolytic activity of cathepsin K without substantial interference in other biologicall...	09/21/2010
7764814	Display and analysis of multicontrast-weighted magnetic resonance images A multicontrast-weighted acquisition of three images is performed with an MRI system. Each image is normalized and then mapped to a separate color channel. A composite color image is formed by combining all the color channels, and this image is displayed or analyzed...	07/27/2010
7754687	Methods of inhibiting viral infection The present invention is directed to methods of preventing and/or treating infectious disease. In a particular aspect, the invention is directed to treating viral infections by administering an isolated Prothymosin alpha molecule (SEQ ID NO: 2) to a subject in a the...	07/13/2010
7723023	Use of intrinsic reporters of cell signaling for high content drug profiling and toxicity screening The present invention identifies essentially all of the members of a specific group of genes that are preferentially transcribed upon the initialization of a signal transduction pathway. The present invention also discloses methods for detecting and/or quantifying t...	05/25/2010
7645857	Methods of indentifying modulators of the FGF receptor The present invention provides fragments of SNT and FGFR which can form a binding complex that is amenable to structural determinations by NMR spectroscopy. The three-dimensional structural data is also included as part of the invention. In addition, the present inv...	01/12/2010
7452540	Enhanced immunization and suppression of oral tolerance This invention provides for methods of immunizing mammals against tumors expressing a carcinoembryonic antigen using a carcinoembryonic immunogen modified to lack cellular immunosuppressive activity or CD1d binding. The invention further provides for use of a carcin...	11/18/2008
7369887	Rapid multislice black blood double-inversion recovery technique for blood vessel imaging DIR imaging of blood vessels by administering a series of DIR preparation pulse modules at a repetition interval short enough that at least two DIR preparation pulse modules generally occur within each RR interval, and by acquiring image data for a plurality of slic...	05/06/2008
7314716	Gustducin γ subunit materials and methods Gustducin is a taste receptor cell heterotrimeric guanine nucleotide binding protein. Disclosed herein is the amino acid sequence of the gamma (γ) subunit of gustducin, as well as polynucleotide sequences encoding the γ subunit. Also disclosed are methods of modif...	01/01/2008
7261729	Treatment of vitiligo Disclosed herein is a novel method of treating vitiligo by using an excimer laser that emits light in the UVB range. The invention includes a method of incrementally increasing exposure of affected vitiligo areas with UVB laser light from an excimer laser to restore...	08/28/2007
7179614	Screening methods to identify compounds that modulate type I phosphodiesterase (PDE) activity The present invention relates to novel methods of signal transduction in cells. In particular, the invention relates to signal transduction via a class of enzymes known as phosphodiesterase enzymes or PDEs. The invention also relates to a class of signaling molecule...	02/20/2007
7108984	Methods of identifying modulators of the FGF receptor The present invention provides fragments of SNT and FGFR which can form a binding complex that is amenable to structural determinations by NMR spectroscopy. The three-dimensional structural data is also included as part of the invention. In addition, the present inv...	09/19/2006
7045617	Bisbubstrate inhibitors of kinases Protein kinase inhibitors have applications as anti-cancer therapeutic agents and biological tools in cell signalling. Potent and selective bisubstrate inhibitors for the insulin receptor tyrosine kinase are based on a phosphoryl transfer mechanism involving a disso...	05/16/2006
6979327	Treatment of vitiligo Disclosed herein is a novel method of treating vitiligo by using an excimer laser that emits light in the UVB range. The invention includes a method of incrementally increasing exposure of affected vitiligo areas with UVB laser light from an excimer laser to restore...	12/27/2005
6740519	Immortalized, homozygous stat1-deficient mammalian cell lines and their uses The present invention is directed to immortalized STAT1-deficient mammalian cell lines. STAT1 is a signal transducer and activator of transcription that becomes phosphorylated when cells are treated with type I or type II interferons and leads to induction of specif...	05/25/2004

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Assignee: Mount Sinai School of Medicine