Assignee: Mitsubishi Tanabe Pharma Corporation

Location: Osaka-shi, JP
No. of patents: 48

Number	Title	Issue Date
8168429	Method of amplifying hematopoietic stem cell and hematopoietic progenitor cell The present invention provides useful means in an expansion culture system for a hematopoietic cell (hematopoietic stem cell, hematopoietic progenitor cell). Specifically, the present invention provides a composition for expanding a hematopoietic cell (hematopoietic...	05/01/2012
8158640	Tetrahydroquinoline derivatives and a process for preparing the same A novel compound of the formula (I): wherein R1 is alkoxycarbonyl or the like, R2 is alkyl or the like; R3 is hydrogen or the like; R4 is alkylene or the like; R5 is op...	04/17/2012
8129361	Amine compound and pharmaceutical use thereof Provided is a novel amine compound represented by the following formula (I) having a superior peripheral blood lymphocyte decreasing action and superior in the immunosuppressive action, rejection suppressive action and the like, which shows decreased side effects of...	03/06/2012
8044042	Thienotriazolodiazepine compound and medicinal use thereof A thienotriazolodiazepine compound of the following formula (I) a pharmaceutical agent containing the compound as an active ingredient, and a production intermediate and a production method of the thienotriazolodiazepine co...	10/25/2011
8044019	Cell penetrating peptide According to the present invention, it is possible to provide a novel cell penetrating peptide that transports proteins into cells and/or into nuclei at higher frequency than conventional cell penetrating peptides, and a pharmaceutical containing the peptide. ...	10/25/2011
8026370	Carboxylic acid derivative containing thiazole ring and pharmaceutical use thereof According to the present invention, a compound represented by the following formula (I) having a superior PPARα agonist action and concurrently showing a hypolipidemic action can be provided, and further, a compound useful as a synthetic intermediate for...	09/27/2011
8022059	Indazole acrylic acid amide compound A compound of the formula: wherein ring X is benzene or pyridine; R1 is substituted alkyl; R2 is optionally substituted aryl or optionally substituted heterocyclic group; R3 is hydrogen or a...	09/20/2011
8003790	Salt of proline derivative, solvate thereof, and production method thereof The present invention provides 3-{(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl}thiazolidine (compound I) useful as a dipeptidyl peptidase-IV inhibitor, which has superior properties of stability and hygroscopicity, and repro...	08/23/2011
7994196	Indazole compound and pharmaceutical use thereof The present invention can provide a cancer treatment drug containing, as an active ingredient, a substance selected from the group consisting of an indazole compound of the following formula (I), a pharmaceutically acceptable salt, a hydrate, a water adduct and a so...	08/09/2011
7989627	Optically active cyclic alcohol compound and method for preparing the same The present invention relates to a method for preparing an optically active cyclic alcohol compound represented by general formula [I]: [wherein R represents a hydrogen atom or a protecting group for amino group, and * repr...	08/02/2011
7972836	Method of enzymatic optical resolution of racemic 4-hydroxy-1,2,3,4-tetrahydroquinoline The present invention relates to a method for preparing an optically active 4-hydroxy-1,2,3,4-tetrahydroquinoline compound [I], which comprises the steps of: treating a racemic 4-hydroxy-1,2,3,4-tetrahydroquinoline compound represented by general formul...	07/05/2011
7943788	Glucopyranoside compound A compound of the formula: wherein Ring A and Ring B are: (1) Ring A is an optionally substituted unsaturated monocyclic heterocyclic ring, and Ring B is an optionally substituted unsaturated monocyclic heterocyclic ring, a...	05/17/2011
7943582	Crystalline form of 1-(β-D-glucopyransoyl)-4-methyl-3-[5-(4-fluorophenyl)-2- thienylmethyl]benzene hemihydrate A novel crystal form of 1-(β-D-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]benzene hemihydrate, and having favorable characteristics, is characterized by its x-ray powder diffraction pattern and/or by its infra-red spectrum. ...	05/17/2011
7935674	Indole derivatives Novel indole derivatives of formula (I) or a pharmaceutically acceptable salt thereof: wherein R1 is halogen, or alkyl, R2 is hydrogen, or halogen, Ar is phenyl, or thienyl, which may be substituted wi...	05/03/2011
7906517	Trisubstituted amine compound The present invention relates to a compound of the general formula (1): wherein, Y is a methylene group, and the like; A is an optionally substituted heterocyclic group, and the like; B is an optionally substituted phenyl g...	03/15/2011
7846933	4-imidazolin-2-one compounds The present invention relates to a compound of the formula [I]: wherein G1 is an alkyl which is substituted by a halogen atom or an alkoxy, or a group of the formula: w...	12/07/2010
7872126	Tetrahydroquinoline derivatives and a process for preparing the same A novel compound of the formula (I): wherein R1 is alkoxycarbonyl or the like, R2 is alkyl or the like; R3 is hydrogen or the like; R4 is alkylene or the like; R5 is op...	01/18/2011
7868019	Dermatitis treating agent The present invention is to provide a topical dermatitis treating agent which comprises a pyridine compound represented by the following formula [I]: wherein R1 and R2 each rep...	01/11/2011
7855297	Amide derivatives and medicinal use thereof The present invention relates to an amide derivative of the formula (1), having a C5a receptor antagonistic action wherein each symbol is as defined in the specification. The above-mentioned amide derivative, an opt...	12/21/2010
7851617	Indole derivatives Novel indole derivatives of formula (I) or a pharmaceutically acceptable salt thereof: wherein R1 is fluorine, or chlorine, and R2 is hydrogen, or fluorine, which are SGLT inhibitors and are useful for...	12/14/2010
7790725	Thiazolidine derivatives and medicinal use thereof A thiazolidine derivative represented by the formula (I) wherein each symbol is as defined in the specification, and a pharmaceutically acceptable salt thereof exhibit a potent DPP-IV inhibitory activity, and can be provide...	09/07/2010
7781443	Tetrahydronaphthyridine derivatives and a process for preparing the same A novel compound of the formula (I): wherein R1 is alkoxycarbonyl or the like, R2 is alkyl or the like; R3 is hydrogen or the like; R4 is alkylene or the like; R5 is op...	08/24/2010
7781184	Method of assaying substance capable of changing mitochondrial membrane potential The present invention aims to provide a convenient and high precision evaluation method of a pharmaceutical agent that changes the mitochondrial membrane potential, using a mitochondrial membrane potential of a cultured cell as an index. The present invention...	08/24/2010
7759373	Large conductance calcium-activated K channel opener A large conductance calcium-activated K channel opener comprising as an active ingredient a nitrogen-containing 5-membered heterocyclic compound represented by the following formula (I): wherein X r...	07/20/2010
7737161	Condensed furan compounds The present invention provides a condensed furan compound of the formula (I): wherein Ring X is benzene, pyridine, or the like; Y is an optionally substituted amino, an optionally substituted cycloalkyl, an optionally subst...	06/15/2010
7718703	Norvaline derivative and method for preparation thereof Norvaline derivative of the formula [I] or pharmaceutically acceptable salt thereof, method for preparing the same, pharmaceutical composition containing the same, and use of the compound for inhibiting transporting activity of glycine transporter type 2 (GlyT2)...	05/18/2010
7700771	Heterocyclic compound which may be used as a medicine having p38 MAP kinase inhibitory activity The present invention is to provide a novel heterocyclic compound of the formula [I]: wherein R1 is a halogen, nitro, an alkyl, etc.; R2 is hydrogen, an alkyl, etc.; Ring A is ...	04/20/2010
7659273	Composition for accelerating bone fracture healing A composition for accelerating fracture healing, which has a PDE4 inhibitor as an active ingredient, specifically a composition having a PDE4 inhibitor and a biocompatible and biodegradable polymer is provided, which composition, when formulated into a form suitable...	02/09/2010
7605158	Carbamoyl-type benzofuran derivatives The present invention provides a carbamoyl-type benzofuran derivative of the formula [1]: wherein Ring Z is a group of the formula: etc.; A is a single bond, and the like; Y is a ...	10/20/2009
7591999	Powdery preparation for nasal administration According to the present invention, a powdery preparation for nasal administration comprising a physiologically active substance, a non-water-absorbing and hardly water-soluble powder(s) and one or two selected from the group consisting of a mucolytic agent and a no...	09/22/2009
7572793	3-Substituted-4-pyrimidone derivatives A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof having inhibitory activity against tau protein kinase 1: wherein R1 represents a C1-C	08/11/2009
7572630	Method for differentiating primate embryonic stem cell into vascular cell To provide a technique of the differentiation from a primate embryonic stem cell into a vascular cell, and techniques using the same. A method for differentiating a primate embryonic stem cell into a vascular cell, comprising differentiating a primate embryonic stem...	08/11/2009
7550476	Condensed polycyclic compounds The present invention provides a novel a condensed polycyclic compound useful as a phosphodiesterase 4 inhibitor, which is shown by the formula [I]: or a pharmaceutically acceptable salt thereof and a pharmaceutical composi...	06/23/2009
7550475	Condensed polycyclic compounds The present invention provides a novel a condensed polycyclic compound useful as a phosphodiesterase 4 inhibitor, which is shown by the formula [I]: or a pharmaceutically acceptable salt thereof and a pharmaceutical composi...	06/23/2009
7531655	Large conductance calcium-activated K channel opener There are disclosed a large conductance calcium-activated K channel opener comprising a compound of the formula (I): wherein ring A is a 5-membered heterocyclic ring containing any one of O, N or S,...	05/12/2009
7531537	Benzofuran derivative The present invention provides a benzofuran derivative of the formula [1]: wherein x is a group of the formula: —N═ or —CH═; Y is an optionally substituted amino group, an optionally substituted cycloalkyl group or ...	05/12/2009
7521430	N-glucoside compounds having an inhibitory activity against sodium-dependent glucose transporter A compound of the formula: wherein Ring A and Ring B are (1) Ring A is an optionally substituted unsaturated monocyclic heterocyclic ring, and Ring B is an optionally substituted unsaturated monocyclic heterocyclic ring, an...	04/21/2009
7514449	Fused furan compound The present invention provides a condensed furan compound of the formula (I): wherein Ring X is benzene, pyridine, or the like; Y is an optionally substituted amino, an optionally substituted cycloalkyl, an optionally subst...	04/07/2009
7514439	Oxime derivative and preparations thereof The problem of the present invention is to provide a useful compound as a glucokinase activating agent, which is the oxime derivative of the formula [I]: wherein Ring A is aryl or heteroaryl; ...	04/07/2009
7501409	Preparations for oral administration The present invention provides a preparation for oral administration containing a medicinal substance having cGMP-specific phosphodiesterase inhibitory activity and showing decrease of solubility in the neutral and alkaline regions, wherein an acidic substance is co...	03/10/2009

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Assignee: Mitsubishi Tanabe Pharma Corporation