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| Number | Title | Issue Date |
| 4975186 | Container for fine separation of blood and blood components Blood and blood component container having in continuous communication therewith a receptacle adapted to receive and define a given component or sub-component when contents in the container are separated. In preferred embodiments, the container is a flexi... | 12/04/1990 |
| 4969882 | Bag for separation and isolation of blood components A generally flat, elongated edge-sealed polymeric blood bag having a length to width ratio of at least 2 to 1 and one end portion in tapering communication with a connected tubing. When the bag is filled with a mixture of blood components which are then s... | 11/13/1990 |
| 4948877 | Preparation of retrovirus-free immunoglobulins Immune serum globulins (ISG) can be made substantially free of infectious retroviruses by storing the ISG in a liquid state at conditions of pH, temperature and time sufficient to inactivate substantially all infectious retroviruses. Preferred inactivatio... | 08/14/1990 |
| 4938744 | Needle assembly Double-protected needle assembly comprising a needle-handle portion and a needle-protecting portion. The needle-handle portion includes a bevel-tipped needle attached to and extending from it into the needle-protector portion. The needle protecting portio... | 07/03/1990 |
| 4915848 | Red blood cell filtering system Closed filtering system for relatively fast and efficient removal of white blood cells from a red blood cell mixture. System comprises at least two blood bags in closed communication with each other via an intermediate filter assembly comprising a housing... | 04/10/1990 |
| 4892537 | Bag for separation and isolation of blood components A generally flat, elongated edge-sealed polymeric blood bag having a length to width ratio of at least 2 to 1 and one end portion in tapering communication with a connected tubing. When the bag is filled with a mixture of blood components which are then s... | 01/09/1990 |
| 4880425 | Blood bag having label providing enhanced gas transmissibility Blood bag having affixed thereto a label, portions of which are adapted to permit enhanced gas transmissibility between the interior and exterior of the bag. In preferred embodiments the affixed label has an outwardly facing surface adapted to provide use... | 11/14/1989 |
| 4857068 | Universal spike for use with rigid and collapsible parenteral fluid dispensing container A universal piercer device for a parenteral fluid dispensing container can be vented and non-vented, alternatively, for use with rigid and collapsible dispensing containers. The universal piercer device includes a venting passage with an air filter, and a... | 08/15/1989 |
| 4857190 | Container for fine separation of blood and blood components Blood and blood component container having in continuous communication therewith a receptacle adapted to receive and define a given component or sub-component when contents in the container are separated. In preferred embodiments, the container is a flexi... | 08/15/1989 |
| 4855063 | Red blood cell filtering system Closed filtering system for relatively fast and efficient removal of white blood cells from a red blood cell mixture. System comprises at least two blood bags in closed communication with each other via an intermediate filter assembly comprising a housing... | 08/08/1989 |
| 4851389 | Use of nikkomycin compounds to treat infections of dimorphic, highly chitinous fungi Method of treating an infection of dimorphic, highly chitinous fungi, the method comprising administering therapeutically effective amounts of a nikkomycin or derivative thereof. Treatment is especially suited for infections of medically significant fungi... | 07/25/1989 |
| 4850993 | Blood bag system incorporating quinolone carboxylic, acid derivatives A method and system is disclosed for introducing anti-bacterial agents, for example, quinolone carboxylic acid derivatives into blood bag systems for preventing massive bacteria growth in stored blood and blood components. The quinolone carboxylic acid de... | 07/25/1989 |
| 4841026 | Virally inactivated, non-toxic, human transferrin preparation Method and composition for providing a non-toxic, sterile, virally inactivated human transferrin preparation for use in cell culture systems. The method comprises saturation of the transferrin with an excess of iron, removal of free iron radicals and unwa... | 06/20/1989 |
| 4840960 | Treatment of glomerulonephritis A method for treating a patient suffering from glomerulonephritis comprising administering to the patient an effective amount of nitrendipine.... | 06/20/1989 |
| 4829054 | Method of decreasing lung damage in a host following the onset of gram negative septicemia/endotoxemia There is disclosed a process for treating gram negative septicemia/endotoxemia to decrease lung damage in a host by parenterally administering a therapeutically effective amount of antithrombin III and alpha-1-proteinase inhibitor.... | 05/09/1989 |
| 4810378 | Red blood cell filtering system Closed filtering system for relatively fast and efficient removal of white blood cells from a red blood cell mixture. System comprises at least two blood bags in closed communication with each other via an intermediate filter assembly comprising a housing... | 03/07/1989 |
| 4801450 | High titer pseudomonas immune serum globulin Normal plasma from donors who have not been vaccinated with a P seudomonas vaccine or had a Pseudomonas infection can be screened for higher than normal titers of naturally occurring antibody to four or, preferably, two of seven Fisher Immunotypes of Pseu... | 01/31/1989 |
| 4795806 | Phospholipid affinity purification of Factor VIII:C Affinity purification of Factor VIII:C, both plasma derived and genetically engineered, using coupled phosphatidylserine (PS) as the predominant phospholipid (PH) results in a high degree of purity of Factor VIII:C, similar to that previously demonstrated... | 01/03/1989 |
| 4772465 | Method of treating polymicrobial burn wound sepsis with a combination therapy of ciprofloxacin and pseudomonas immune globulin A method for increasing the survival rate in hypercatabolic mammals following the onset of burn wound sepsis. The method comprises orally administering to the mammal, sufficient doses of ciprofloxacin to attain high concentrations in extra vascular fluid,... | 09/20/1988 |
| 4772464 | Protective antibodies to serotypic determinants of flagellar antigens Monoclonal antibodies specific to serotypic determinants on the flagella of a microorganism and found to be useful in inhibiting motility.... | 09/20/1988 |
| 4767541 | Method of removing platelets and white cells from a red cell concentrate A multiple blood bag system is disclosed having at least two blood bags and conduit means providing sealed flow communication between the bags and a filtering means integrally disposed between two of the bags for removing platelets and white cells from a ... | 08/30/1988 |
| 4762714 | Preparation of retrovirus-free immunoglobulins Immune serum globulins (ISG) can be made substantially free of infectious retroviruses by preparing the ISG from human plasma using a cold ethanol plasma fractionation process at a pH equal to or less than 5.4 and then storing the ISG at either of two spe... | 08/09/1988 |
| 4755058 | Device and method for measuring light diffusely reflected from a nonuniform specimen A device for making accurate, reproducible light reflectance measurements on an optically nonuniform specimen comprises means for holding the specimen in a fixed position. In one embodiment the specimen is illuminated by light sources that are arranged at... | 07/05/1988 |
| 4753797 | Enhancing platelet morphology prior to patient use Platelet morphology in platelet concentrates is significantly enhanced by subjecting the platelets to a gentle heating step. Platelets heated at 37° C. for one hour have at least a 25% increase in the number of disc-like forms over non-heated platelets. ... | 06/28/1988 |
| 4749783 | Viral inactivation and purification of active proteins Preparation of active therapeutic proteins comprising two essential steps. In the first step an active protein source is treated under conditions sufficient to inactivate any viruses present (e.g. via heat or chemical treatment). In the second step, the t... | 06/07/1988 |
| 4742080 | Therapeutic method for producing bronchodilation by administration of 15-deoxy-16-hydroxy prostaglandin esters A therapeutic method for producing bronchodilation in an individual for whom such therapy is indicated is disclosed. The method comprises administering to said individual an effective bronchodilation amount of certain derivatives of 15-deoxy-16-hydroxy-pr... | 05/03/1988 |
| 4738823 | Test strip with adjustable sample absorption capacity A test strip with a sample absorption capacity which can be preselected comprises a support member capable of supporting along at least two edges a reagent strip in which the support member also has absorbent material positioned to remove excess sample ap... | 04/19/1988 |
| 4734375 | Ion specific test method A test means for detecting the presence of a specific ion in an aqueous test sample and for determining its concentration comprises a substantially nonpolar, nonporous carrier matrix which is incorporated with an ionophore capable of selectively forming a... | 03/29/1988 |
| 4729657 | Method of calibrating reflectance measuring devices A method of calibrating reflectance measuring devices, such as spectrophotometers, that incorporate automatic gain or sensitivity setting capability. According to the method, offset reflectance and reflectance of a secondary reflectance standard for sever... | 03/08/1988 |
| 4728613 | Method for the recovery of extracellular enzymes from whole fermentation beer Extracellular enzymes can be recovered from a whole fermentation beer by adding to the whole beer a mixture of a polymer and an inorganic salt. This total mixture produces an enzyme-rich polymer phase and a cell debris-containing, enzyme-poor salt phase w... | 03/01/1988 |
| 4724203 | Caproylamidobiotinylated peroxidase A new compound, carboylamidobiotinylated horseradish peroxidase, is produced. It has utility in immunohistochemical measurement procedures.... | 02/09/1988 |
| 4724208 | Process for the production of solution stable alpha-amylase and liquid alpha-amylase produced thereby This invention contemplates a novel process for the preparation of solution stable alpha-amylase obtained from Bacillus licheniformis, and to the high potency liquid enzyme product prepared by this process. Typically, the enzyme-containing solution from a... | 02/09/1988 |
| 4723020 | Chromogenic amino acid esters and peptide esters The present invention relates to new chromogenic amino acid esters and peptide esters of hydroxybenzo(iso)thiazoles and hydroxybenzopyrazoles, processes for their preparation and the use of the new esters as substrates for the analytical detection of este... | 02/02/1988 |
| 4722900 | Method for increasing the milk clotting activity of thermolabile rhizomucor pusillus rennet Disclosed is a method for increasing the milk clotting ability and reducing the thermal stability of microbial rennet from Rhizomucor pusillus. The method involves treating the rennet with a methionine oxidizing composition and the anhydride of a dicarbox... | 02/02/1988 |
| 4721572 | Purfication of blood clotting factors and other blood proteins on non-carbohydrate sulfated matrices There is disclosed a non-carbohydrate sulfated matrix and the use thereof to isolate and purify blood clotting factors and other blood proteins by a procedure involving the adsorption of at least one of such factors and proteins onto the non-carbohydrate ... | 01/26/1988 |
| 4720385 | Protein compositions substantially free from infectious agents Compositions containing therapeutically or immunologically active proteins are rendered substantially free from infectious agents such as viable viruses and bacteria without substantial loss of therapeutic or immunologic activity by mixing the protein com... | 01/19/1988 |
| 4720460 | Process for preserving acid producing bacteria and compositions produced thereby Described is a method to stabilize or preserve acid-producing bacteria in a buffered solution. A carrier may be added that is not a specific substrate for the bacteria in order to give texture, most preferably the carrier being polyethylene glycol or sodi... | 01/19/1988 |
| 4717662 | Thermal stabilization of alpha-amylase Disclosed is a method for enhancing the thermal stability of microbial alpha-amylase. The method involves adding a stabilizing amount of an amphiphile to the enzyme in its aqueous solution. Also included within the scope of the invention is the stabilized... | 01/05/1988 |
| 4717766 | Method of preparing high titer anti-respiratory syncytial virus intravenous immune globulin Normal plasma from donors who have not necessarily been vaccinated with a respiratory syncytial virus vaccine can be screened for higher than normal titers of naturally occurring antibody to respiratory syncytial virus (e.g. minimum ELISA titer of at leas... | 01/05/1988 |
| 4717564 | High titer varicella-zoster immune globulin for intravenous administration Normal plasma from donors who have not been vaccinated with a varicella-zoster vaccine can be screened for higher than normal titers of naturally occurring antibody to varicella-zoster virus. Those plasmas with high titers of such antibody can be pooled a... | 01/05/1988 |
