Assignee: MicroCHIPS, Inc.

Location: Bedford, MA
No. of patents: 33

Number	Title	Issue Date
7985386	Implantable medical device for diagnostic sensing An implantable medical device is provided for use with an external detector to detect an analyte in vivo. In one embodiment, the device consisting essentially of a substrate; a plurality of discrete reservoirs located in the substrate, each reservoir having at least...	07/26/2011
7917208	Medical device for controlled drug delivery and cardiac monitoring and/or stimulation Medical device and methods are provided for controlled drug delivery in a cardiac patient. The device includes an implantable drug delivery module comprising reservoirs containing a drug and a control means for selectively releasing an effective amount of drug from ...	03/29/2011
7910151	Method for making device for controlled reservoir opening by electrothermal ablation Devices and methods for the controlled release or exposure of reservoir contents, and methods of manufacture thereof, are provided. The device includes a reservoir cap formed of an electrically conductive material, which prevents the reservoir contents from passing ...	03/22/2011
7879019	Method of opening reservoir of containment device A method is provided for selectively opening a containment reservoir. The method includes providing a device which comprises a substrate in which at least one reservoir is located and covered by a reservoir cap; and directing laser light to the reservoir cap to caus...	02/01/2011
7776024	Method of actuating implanted medical device Methods are provided for medical treatment or diagnosis of a patient. The method includes implanting into the patient a device which comprises (i) a substrate in which at least one reservoir is located and covered by a first reservoir cap, (ii) a drug or sensor loca...	08/17/2010
7648677	Method for operating a reservoir-based sensor device Methods for operating a sensor device are provided, which may include (a) providing at a site (e.g., implanting in a patient) a device which comprises at least first and second reservoirs, a first sensor and corresponding first reference sensor located within the fi...	01/19/2010
7614135	Method for making reservoir-based sensor device Methods are provided for making a reservoir-based sensor device. The method may include fabricating a first substrate portion which comprises an upper surface, an opposed lower surface, a plurality of through holes defining reservoirs between said upper surface and ...	11/10/2009
7604628	Multi-cap reservoir devices for controlled release or exposure of reservoir contents Reservoir-based devices are provided in which an individual reservoir has at least two openings with a support structure therebetween and closed by reservoir caps covering the openings to control release or exposure of reservoir contents. In one embodiment, the devi...	10/20/2009
7599737	Medical device for neural stimulation and controlled drug delivery Medical devices and methods are provided for electrical stimulation of neural tissue and controlled drug delivery to a patient. The device includes an implantable drug delivery module which comprises a plurality of reservoirs, a release system comprising at least on...	10/06/2009
7582080	Implantable, tissue conforming drug delivery device A drug delivery device for implantation into a patient is provided that includes at least one device element that includes a substrate having a plurality of discrete reservoirs disposed therein, the reservoirs containing drug molecules and a degradable matrix materi...	09/01/2009
7537590	Multi-reservoir device for transdermal drug delivery and sensing Devices and methods are provided for transdermal administration of a pharmaceutical agent to a patient in need thereof. The device includes a substrate, a plurality of discrete reservoirs in the substrate, one or more pharmaceutical agents stored in the reservoirs, ...	05/26/2009
7534241	Micro-reservoir osmotic release systems and microtube array device Devices and methods are provided for controlled release of chemical molecules, such as drugs. One device comprises a plurality of reservoirs; a rupturable covering, such as a thin metal film, enclosing a first end of each reservoir; a release formulation in each res...	05/19/2009
7510551	Controlled release device and method using electrothermal ablation Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a reservoir cap formed of an electrically conductive material, which prevents the reservoir contents from passing out from the device and prevents expo...	03/31/2009
7497855	Method and device for the controlled delivery of parathyroid hormone Method and devices are provided for extended and controlled delivery of parathyroid hormone to a patient. The method includes implanting a medical device into the patient, the medical device comprising a substrate, a plurality of reservoirs in the substrate, a relea...	03/03/2009
7497846	Hermetically sealed microchip reservoir devices Devices are provided for the controlled exposure or release of contents stored in hermetically sealed reservoirs. The devices comprise a primary substrate having a front side and a back side, and including one or more hermetic sealing materials; a plurality of reser...	03/03/2009
7488316	Control of drug release by transient modification of local microenvironments Methods, formulations, and devices are provided for enhancing drug delivery from a medical device. The method is provided for increasing the rate or quantity of a drug formulation released from an implantable drug delivery device, which method comprises the step of ...	02/10/2009
7473248	Thermally-activated reservoir devices Methods are provided for controlled reservoir opening, including the steps of (a) providing a biocompatible implantable device which comprises at least one substrate, a plurality of reservoirs in the substrate, reservoir caps each of which covers one of the reservoi...	01/06/2009
7455667	Controlled release device and method using electrothermal ablation Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a reservoir cap formed of an electrically conductive material, which prevents the reservoir contents from passing out from the device and prevents expo...	11/25/2008
7445766	Medical device and method for diagnostic sensing Devices are provided for use in medical diagnostics which include a substrate, a plurality of discrete reservoirs located in the substrate, each reservoir having at least one opening, at least one diagnostic substance contained in each reservoir, and at least one no...	11/04/2008
7413846	Fabrication methods and structures for micro-reservoir devices Methods are provided for making a multi-reservoir device comprising (i) patterning one or more photoresist layers on a substrate; (ii) depositing onto the substrate at least one metal layer by a sputtering process to form a plurality of reservoir caps and conductive...	08/19/2008
7410616	Device for the controlled exposure of reservoir-based sensors Devices are provided for the controlled exposure of a sensor or sensor component. The device may include a substrate; at least one reservoir provided in the substrate; at least one sensor or sensor component located in the at least one reservoir; at least one reserv...	08/12/2008
7226442	Microchip reservoir devices using wireless transmission of power and data Devices, systems, and methods are provided for wirelessly powering and/or communicating with microchip devices used for the controlled exposure and release of reservoir contents, such as drugs, reagents, and sensors. In one embodiment, the system includes (1) a micr...	06/05/2007
7114312	Low temperature methods for hermetically sealing reservoir devices Methods are provided for hermetically sealing an opening in a reservoir of a containment device. The method comprises applying a polymeric material to an opening in a reservoir of a containment device, the reservoir comprising reservoir contents (such as a drug or a...	10/03/2006
6976982	Flexible microchip devices for ophthalmic and other applications Microchip device arrays that can conform to a curved surface are provided for the controlled release or exposure of reservoir contents. The arrays comprise two or more microchip device elements, each of which includes a plurality of reservoirs that contain molecules...	12/20/2005
6973718	Methods for conformal coating and sealing microchip reservoir devices Methods are provided for conformally coating microchip devices and for sealing reservoirs containing molecules or devices in a microchip device. One method comprises (i) providing a substrate having a plurality of reservoirs having reservoir openings in need of seal...	12/13/2005
6849463	Microfabricated devices for the storage and selective exposure of chemicals and devices Microchip devices and methods of use are provided for the controlled exposure of a secondary device. In one embodiment, the microchip device include a substrate, a plurality of reservoirs in the substrate, a secondary device in one or more of the reservoirs, at leas...	02/01/2005
6827250	Methods for hermetically sealing microchip reservoir devices Methods are provided for hermetically sealing the reservoirs of microchip devices and for hermetically sealing the substrate assemblies in a hermetic packaging structure. In one embodiment, the method comprises (1) providing a primary substrate having a front side a...	12/07/2004
6773429	Microchip reservoir devices and facilitated corrosion of electrodes Methods and devices are provided for enhancing corrosion of an electrode in a biocompatible fluid. The method comprises (1) placing a primary electrode and a counter electrode in an electroconductive biocompatible fluid to form an electrochemical cell; and (2) apply...	08/10/2004
6669683	Thermally-activated microchip chemical delivery devices Microchip delivery devices are provided that control both the rate and time of release of molecules. In one embodiment, an implantable microchip device is provided for the controlled delivery of drug molecules into a patient comprising at least one substr...	12/30/2003
6656162	Implantable drug delivery stents Devices for the controlled release of one or more drugs are provided. The devices include an implantable stent, at least two reservoirs in the stent, and a release system contained in each of the at least two reservoirs, wherein the release system compris...	12/02/2003
6551838	Microfabricated devices for the storage and selective exposure of chemicals and devices Microchip devices are provided which include a substrate having a plurality of reservoirs containing a secondary device, a reacting component, or a combination thereof. At least one barrier layer covers each reservoir to isolate the reservoir contents fro...	04/22/2003
6537256	Microfabricated devices for the delivery of molecules into a carrier fluid Apparatus and methods are provided for the delivery of molecules to a site via a carrier fluid. The apparatus include microchip devices which have reservoirs containing the molecules for release. The apparatus and methods provide for active or passive con...	03/25/2003
6527762	Thermally-activated microchip chemical delivery devices Microchip delivery devices are provided that control both the rate and time of release of molecules, wherein the device includes a substrate, at least one reservoir in the substrate containing the molecules, and a reservoir cap positioned on the reservoir...	03/04/2003

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Assignee: MicroCHIPS, Inc.