Assignee: Michigan Biotechnology Institute

Location: Lansing, MI
No. of patents: 37

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Number	Title	Issue Date
8119377	Recombinant microorganisms for increased production of organic acids Disclosed are recombinant microorganisms for producing organic acids. The recombinant microorganisms express a polypeptide that has the enzymatic activity of an enzyme that is utilized in the pentose phosphate cycle. The recombinant microorganism may include recombi...	02/21/2012
7937851	Process for treatment of biomass feedstocks A method and apparatus for continuously treating a moist biomass feedstock is disclosed. The method includes treating a biomass feedstock with a swelling agent in a pressurized first vessel, transferring the feedstock to a second vessel at a lower operating pressure...	05/10/2011
7204940	Conductive polymer-based material Disclosed are polymer-based coatings and materials comprising (i) a polymeric composition including a polymer having side chains along a backbone forming the polymer, at least two of the side chains being substituted with a heteroatom selected from oxygen, nitrogen,...	04/17/2007
6951902	Two dimensional polymer that generates nitric oxide A polymeric composition that generates nitric oxide and a process for rendering the surface of a substrate nonthrombogenic by applying a coating of the polymeric composition to the substrate are disclosed. The composition comprises: (1) a crosslinked chemical combin...	10/04/2005
6939554	Antimicrobial polymer A polymeric composition having antimicrobial properties and a process for rendering the surface of a substrate antimicrobial are disclosed. The composition comprises a crosslinked chemical combination of (i) a polymer having amino group-containing side chains along ...	09/06/2005
6797743	Antimicrobial polymer A polymeric composition having antimicrobial properties and a process for rendering the surface of a substrate antimicrobial are disclosed. The polymeric composition comprises a crosslinked chemical combination of (i) a polymer having amino group-containing side cha...	09/28/2004
6509104	Antithrombogenic polymer coating An article having a non-thrombogenic surface and a process for making the article are disclosed. The article is formed by (i) coating a polymeric substrate with a crosslinked chemical combination of a polymer having at least two amino substituted side cha...	01/21/2003
6495657	Two dimensional polyamides prepared from unsaturated carboxylic acids and amines A polyamide and a process for preparing the polyamide are disclosed. The process comprises reacting in a reaction mixture a monomer selected from unsaturated carboxylic acids, esters of unsaturated carboxylic acids, anhydrides of unsaturated carboxylic ac...	12/17/2002
6410077	Combined milk, juice, and cereal grain/polysaccharide blend for consumption and method for production thereof A stable mixture of milk, juice, and polysaccharide/cereal is disclosed. In a preferred version of the present invention, composition containing an amino acid, an organic or inorganic acid and a metal ion is added to further stabilize the milk proteins in...	06/25/2002
6399714	Crosslinked polyamide A crosslinked polyamide material and a process for preparing the crosslinked polyamide material are disclosed. The crosslinked polyamide material comprises a crosslinked chemical combination of (1) a polyamide of the formula: ##STR1## wherein n is be...	06/04/2002
6284904	Purification of organic acids using anion exchange chromatography Disclosed is a cost-effective method for purifying and acidifying carboxylic acids, including organic acids and amino acids. The method involves removing impurities by allowing the anionic form of the carboxylic acid to bind to an anion exchange column an...	09/04/2001
5723322	Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms A fermentation process for making succinic acid in high concentrations employs a bacteria obtained from the rumen contents of cattle. A preferred bacteria is Bacterium 130Z (ATCC No. 55618)....	03/03/1998
5618467	Luminescent materials, phosphors and compositions containing such phosphors The present invention relates to luminescent materials, phosphors, and compositions containing phosphors and methods of their use. More particularly, it relates to organic phosphors which are amino acid salts and methods of using those phosphors and compo...	04/08/1997
5573931	Method for making succinic acid, bacterial variants for use in the process, and methods for obtaining variants A method for producing succinic acid in high concentration by fermentation employs a variant of strain 130Z which is resistant to concentrations of about 1 g/l to about 8 g/l of sodium monofluoroacetate. The variant produces succinic acid in concentration...	11/12/1996
5525365	Method for processing food A method for processing food, and particularly fruit, wherein the leaching discharge stream is separated, for example by desalting electrodialysis, into reusable brine and residual solutions. First, the fruit is brined using conventional techniques. The f...	06/11/1996
5521075	Method for making succinic acid, anaerobiospirillum succiniciproducens variants for use in process and methods for obtaining variants A method for making succinic acid employs a fluoroacetate resistant variant of Anaerobiospirillum succiniciproducens. The fluoroacetate variant produces a succinic acid product which contains less acetic acid than the product obtained using the parent str...	05/28/1996
5504004	Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms A fermentation process for making succinic acid in high concentrations employs a bacteria obtained from the rumen contents of cattle. A preferred bacteria is Bacterium 130Z (ATCC No. 55618)....	04/02/1996
5490634	Biological method for coal comminution A method for reducing the size of coal particles includes the steps of inoculating a coal sample with an anaerobic bacteria or decarboxylating enzyme therefrom and incubating the inoculated sample. The microbes and/or decarboxylating enzymes biochemically...	02/13/1996
5464651	Phosphors, compositions containing such phosphors and methods of use The present invention relates to phosphors, composition containing phosphors and methods of their use. More particularly, it relates to organic phosphors which are amino acid salts compositions containing the phosphors and methods of using those phosphors...	11/07/1995
5266475	Glucose isomerases with improved affinity for D-glucose A genetically engineered glucose isomerase with improved affinity for D-glucose and the method of preparation of such a glucose isomerase are disclosed. The glucose isomerase is obtained by mutagenizing the gene of a naturally occurring glucose isomerase ...	11/30/1993
5229161	Metal free and low metal salt substitutes containing lysine Salts containing lysine, chloride ion and succinic acid in which the lysine is present in greater molar concentration than the chloride or succinic acid possess a salty flavor making them useful as table salt substitutes and flavor enhancers. Low sodium a...	07/20/1993
5192673	Mutant strain of C. acetobutylicum and process for making butanol A biologically pure asporogenic mutant of Clostridium acetobutylicum is produced by growing sporogenic C. acetobutylicum ATCC 4259 and treating the parent strain with ethane methane sulfonate. The mutant which as been designated C. acetobutylicum ATCC 550...	03/09/1993
5167799	Apparatus for simulating a full scale belt filter press An apparatus for simulating the operation of a full-scale belt filter press consists of a support base, a filter belt and a press belt each anchored at one end to the support base and passing over a static curved pressure face and a winch for exerting a p...	12/01/1992
5166069	Bacillus sp. A30-1 ATCC no. 53841 A thermostable lipase is produced by aerobically culturing a microorganism having the identifying characteristics of Bacillus sp.A30-1 ATCC No. 53841 on a nutrient medium under growth conditions until a recoverable lipolytic activity is detectable and the...	11/24/1992
5034105	Carboxylic acid purification and crystallization process A process for preparing a carboxylic acid of high purity comprises preparing an undersaturated solution of a salt of the carboxylic acid; subjecting the undersaturated salt solution to water-splitting electrodialysis to form base and a supersaturated solu...	07/23/1991
4997665	Dietary fibers and a process for their production Dietary fiber of enhanced functional properties and a novel antioxidant activity is prepared by mixing a slurry of a lignocellulose plant fiber while heating it and maintaiing it as a liquid until the functional properties of the fiber are enhanced and th...	03/05/1991
4885247	Recovery and purification of lactate salts from whole fermentation broth by electrodialysis A process for producing, recovering and purifying lactate from a fermentation broth so that it can be efficiently and economically converted to lactic acid is disclosed. The process comprises growing a high lactate producing, microorganism on an inexpensi...	12/05/1989
4869819	Apparatus for biomethanation An improved process for the biomethanation of an organic substrate includes treating the substrate in a first reactor to form organic acid anions, passing an aqueous preparation containing dissolved organic anions through an ion exchanger so that the orga...	09/26/1989
4830963	Production of acetic acid by an improved fermentation process A formate salt is used as part of the fermentable carbon-containing material in an anaerobic fermentation to produce acetic acid. Acetate salt formed in the fermentation is converted to free acetic acid with formic acid, which in turn is changed to format...	05/16/1989
4820880	Process for the production of 3,4-dideoxyhexitol A process for the production of 3,4-dideoxyhexitol and for its cyclodehydration to 2,5-bis(hydroxymethyl)tetrahydrofuran. The 3,4-dideoxyhexitol is obtained by hydrogenolysis in the presence of a copper chromite catalyst, of hexitols, or of compound which...	04/11/1989
4814273	Production of organic acids by an improved fermentation process Acetic, propionic, and butyric acids are produced by a two-step fermentation process. Lactate salts formed in the second fermentation step, a biochemical acidification step, are used as the carbon source in the first fermentation step....	03/21/1989
4814267	Method for preparing high conversion syrups and other sweeteners An improved method of preparing high maltose conversion syrups and other sweeteners from starch substrates comprises saccharifying the starch at higher temperatures than presently used with environmentally compatible thermostable ଲ-amylase and other...	03/21/1989
4781836	Method for biomethanation An improved process for the biomethanation of an organic substrate includes treating the substrate in a first reactor to form organic acid anions, passing an aqueous preparation containing dissolved organic anions through an anion exchanger so that the or...	11/01/1988
4737459	Regulation and enhancement of enzyme production A method is disclosed for producing catabolite repression-resistant mutant strains of C. thermosulfurogenes and C. thermohydrosulfuricum. The method comprises challenging a wild strain of the organism with nitrosoguanidine, followed by enrichment on 2-deo...	04/12/1988
4647538	Thermostable beta-amylase A thermostable and thermoactive, extracellular ଲ-amylase is produced by Clostridium thermosulfurogenes. Methods of producing the ଲ-amylase and using it to convert starch to maltose are also disclosed....	03/03/1987
4628031	Thermostable starch converting enzymes A thermostable pullulanase and a thermostable glucoamylase are produced by Clostridium thermohydrosulfuricum. Methods of producing the enzymes and using them to hydrolyze starch are also disclosed....	12/09/1986
4604352	Co-culture production of thermostable enzymers and ethanol Starch is converted directly to ethanol by growing a co-culture of Clostridium thermosulfurogenes and Clostridium thermohydrosulfuricum under anaerobic conditions on a starch containing substrate in a medium comprising essential vitamins, minerals and gro...	08/05/1986

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Assignee: Michigan Biotechnology Institute