Did You Know...
...that a workman who left the soap mixing machine on too long was responsible for making Ivory Soap? He was so embarrassed by his mistake that he threw the mess in a stream. Imagine his dismay when the evidence of his error floated to the surface! Result: Ivory soap, the soap that floats.
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| Number | Title | Issue Date |
| 7714131 | Process for the stereoselective preparation of (−)-halofenate and derivatives thereof The present invention provides a compounds the formula (IV): and methods for producing an α-(phenoxy)phenylacetic acid compound of the formula: wherein R1 is a member ... | 05/11/2010 |
| 7642358 | Substituted phenylacetic acids Substituted phenylacetic acids, phenylethanols and related compounds are provided that are useful in treating or controlling a number of diseases associated with glucose metabolism, lipid metabolism and insulin secretion. ... | 01/05/2010 |
| 7576131 | Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia The present invention provides the use of (−) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives and compositions in the treatment of insulin resistance, Type 2 diabetes, hyperlipidemia and hyperuricemia. ... | 08/18/2009 |
| 7510851 | Compositions and methods for diagnosing and treating diabetes, insulin resistance and dyslipidemia The present invention provides compositions and methods for diagnosing and treating diabetes, insulin resistance and dyslipidemia. In particular, the invention provides methods of identifying modulators of AKR1C as well as methods of diagnosing diabetes by measuring... | 03/31/2009 |
| 7491533 | Polynucleotides encoding an isolated β-islet cell two-pore domain potassium channel The present invention provides polynucleotides encoding potassium channels as well as methods of using the potassium channels to treat and diagnose diabetes and a predisposition for diabetes. ... | 02/17/2009 |
| RE40624 | Compositions and methods of using apoptosis signaling kinase related kinase (ASKRK) The invention provides apoptosis signaling kinase related kinase (ASKRK) nucleic acid and polypeptide sequences and methods of using such sequences to identify modulators of ASKRK. Such modulators can be used for the treatment of diabetes or for delaying the onset o... | 01/20/2009 |
| 7432394 | Resolution of α-(phenoxy) phenylacetic acid derivatives with naphthyl-alkylamines The present invention provides a methods and compounds for producing an enantiomerically enriched α-(phenoxy)phenylacetic acid compound of the formula: from a mixture of its enantiomers, where R1 is alkyl or hal... | 10/07/2008 |
| 7405289 | Pancreatic islet transcription factor and uses thereof The present invention provides a pancreatic islet transcription factor and methods of treating and diagnosing diabetes. ... | 07/29/2008 |
| 7371888 | α-(Trifluoromethyl-substituted aryloxy, arylamino, arylthio or arylmethyl)-trifluoromethyl-substituted phenylacetic acids and derivatives as antidiabetic agents Compounds having a formula: or a pharmaceutically acceptable salt or prodrug thereof, are provided, and are useful for the treatment of metabolic disorders. ... | 05/13/2008 |
| 7344844 | Compositions and methods of using apoptosis signaling kinase related kinase (ASKRK) The invention provides apoptosis signaling kinase related kinase (ASKRK) nucleic acid and polypeptide sequences and methods of using such sequences to identify modulators of ASKRK. Such modulators can be used for the treatment of diabetes or for delaying the onset o... | 03/18/2008 |
| 7323480 | Substituted triazoles as modulators of PPAR and methods of their preparation The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and p... | 01/29/2008 |
| 7294698 | Methods and reagents for diagnosis and treatment of diabetes The invention relates to methods and reagents for diagnosing and treating diabetes. ... | 11/13/2007 |
| 7199259 | Resolution of α-(phenoxy)phenylacetic acid derivatives The present invention provides a method for producing an enantiomerically enriched α-(phenoxy)phenylacetic acid compound of the formula (I): from its enantiomeric mixture, where R1 is alkyl or haloalk... | 04/03/2007 |
| 7144985 | Methods and reagents for diagnosis and treatment of diabetes The invention relates to methods of determining islet cell activity by detecting the level of Archipelin or a fragment thereof and comparing the level to a baseline level or range associated with a known islet cell activity. Such methods are useful in diagnosing and... | 12/05/2006 |
| 7109021 | Compositions and methods of using apoptosis signaling kinase related kinase (ASKRK) The invention provides apoptosis signaling kinase related kinase (ASKRK) nucleic acid and polypeptide sequences and methods of using such sequences to identify modulators of ASKRK. Such modulators can be used for the treatment of diabetes or for delaying the onset o... | 09/19/2006 |
| 7087394 | Methods and compositions for treating and diagnosing diabetes and related diseases involving beta-TRP Expression of beta-TRP is enriched in islet cells. Introduction of expression cassettes encoding beta-TRP into diabetic islet cells improved glucose-stimulated insulin production. Therefore, the invention provides methods of identifying beta-TRP modulators for treat... | 08/08/2006 |
| 7078421 | Substituted phenylacetic acids Substituted phenylacetic acids, phenylethanols and related compounds are provided that are useful in treating or controlling a number of diseases associated with glucose metabolism, lipid metabolism and insulin secretion. ... | 07/18/2006 |
| 7053180 | Isolated islet beta-cell two-pore domain potassium channel The present invention provides polynucleotides encoding potassium channels as well as methods of using the potassium channels to treat and diagnose diabetes and a predisposition for diabetes. ... | 05/30/2006 |
| 6646004 | Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia The present invention provides the use of (-)(3-trihalomethylphenoxy)(4-halophenyl)acetic acid derivatives and compositions in the treatment of insulin resistance, Type 2 diabetes and hyperlipidemia.... | 11/11/2003 |
| 6624194 | Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia The present invention provides the use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives and compositions in the treatment of insulin resistance, Type 2 diabetes, hyperlipidemia and hyperuricemia. It further provides (-) (3-trihalomet... | 09/23/2003 |
| 6613802 | Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia The present invention provides the use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives and compositions in the treatment of insulin resistance, Type 2 diabetes, hyperlipidemia and hyperuricemia.... | 09/02/2003 |
| 6020200 | Encapsulation compositions and methods The present invention generally relates to novel encapsulation compositions and methods. In particular, the invention relates to stabilized microcapsule compositions which comprise a layer of a crosslinked, mixed functionality, polymer matrix, and methods... | 02/01/2000 |
| 5916790 | Encapsulation compositions, and methods The present invention generally relates to novel encapsulation compositions and methods. In particular, the invention relates to stabilized microcapsule compositions which comprise a layer of a crosslinked, mixed functionality, polymer matrix, and methods... | 06/29/1999 |
| 5738876 | Method of solution overcoating with gelling polymer The present invention generally relates to novel overcoating/encapsulation processes which are carried out in solution without the use of droplet generation devices. The processes may be used in the overcoating or encapsulation of a variety of materials, ... | 04/14/1998 |
| 5693514 | Non-fibrogenic high mannuronate alginate coated transplants, processes for their manufacture, and methods for their use A transplant with a core of a viable, physiologically active, cell(s) and a non-fibrogenic coating of alkaline earth metal alginate having a high mannuronate to guluronate molar ratio and free from fibrogenic amounts of fucose, sulfate, phloroglucinol and... | 12/02/1997 |
