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| Number | Title | Issue Date |
| 5529996 | 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace The present invention relates to novel 2-substituted indane-2-mercaptoacetylamide derivatives which are useful as inhibitors of enkephalinase and ACE.... | 06/25/1996 |
| 5529995 | Aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ACE The present invention relates to novel aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ACE.... | 06/25/1996 |
| 5525633 | Triaryl-ethylene derivatives The present invention relates to novel triaryl-ethylene derivatives that are useful as anti-neoplastic agents, antiatherosclerotic agents, and hypocholesterolemic agents.... | 06/11/1996 |
| 5514688 | Carbocyclic adenosine analogs useful as immunosuppressants This invention relates to carbocyclic adenosine compounds of the formula (1) ##STR1## wherein the hydroxy substituent on the cyclopentanyl ring is in the CIS configuration relative to the bicyclic substituent, Y3, Y7, Y8 | 05/07/1996 |
| 5512177 | Narrow poly- and mono-dispersed anoinic oligomers, and their uses, formulations and process The narrow poly- or mono-dispersed oligomers of the present invention are polyureas, polycarbonates, polyesters or polyamides having a recurring unit of from 3 to 50. These oligomers are water-soluble, preferably have a rigid backbone, have recurring unit... | 04/30/1996 |
| 5504078 | -glucosidase inhibitors This invention relates to novel polyglycosidyl derivatives of 1-deoxy-nojirimycin, to the processes for their preparation and to their end-use applications, particularly as to their use in the treatment of diabetes.... | 04/02/1996 |
| 5500419 | NMDA antagonists The present invention is directed to a new neuroprotective agent. The agent is R-4-oxo-5-phosphononorvaline. This agent is useful in the treatment of ischemic and hypoxic conditions such as stroke.... | 03/19/1996 |
| 5498778 | Cyclic nitrone compounds useful in treating stroke The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents.... | 03/12/1996 |
| 5494932 | Sulfonic stilbene derivatives in the treatment of viral disease Sulfonic acid stilbenes block the infection of cells by HSV, and CMV and these compounds can be used to treat viral infection.... | 02/27/1996 |
| 5491153 | 3-amidoindolyl derivative The present invention is directed to a new class of 3-amido and 3-sulfamido-indolyl NMDA antagonists and their use in the treatment of a number of disease states.... | 02/13/1996 |
| 5491142 | 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase The present invention relates to novel 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives which are useful as inhibitors of Enkephalise.... | 02/13/1996 |
| 5491141 | 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase The present invention relates to novel 2-substitited indane-2-mercaptoacetylamide tricyclic derivatives which are useful as inhibitors of Enkephalise.... | 02/13/1996 |
| 5491136 | 2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aromatase, 19-hydroxylaser inhibitors and methods of their use in the treatment of estrogen mediated disorders The present invention is directed to a method of using a certain compounds which are 2,19-methyleneoxy or 2,19 methylenethio bridged steroids, and related steroidal compounds as inhibitors of the enzyme steroid aromarase, 19-hydroxylase and as treatment f... | 02/13/1996 |
| 5491143 | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE The present invention relates to certain novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and of ACE.... | 02/13/1996 |
| 5489579 | Potentation of NMDA antagonists The present invention is directed to a method for poteniating the therapeutic effects of selected NMDA antagonists.... | 02/06/1996 |
| 5488188 | Process for the preparation of (E)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane, novel processes for preparing an intermediate thereof, and novel intermediates thereof The present invention relates to a novel process for preparing (E)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane, also known in the art as (E)-(p-fluorophenethyl)-3-fluoroallylamine, novel intermediates thereof, a novel process for the preparing ... | 01/30/1996 |
| 5488048 | Aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ace The present invention relates to novel aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ACE.... | 01/30/1996 |
| 5488047 | Carboxyalkyl tricylic derivatives useful as inhibitors of enkephalinase and ace The present invention relates to compounds of the formula ##STR1## wherein B1 and B2 are each independently hydrogen; hydroxy; --OR2 wherein R2 is a C1 -C4 alkyl or an Ar-Y group where... | 01/30/1996 |
| 5486513 | 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors or enkephalinase and ace The present invention relates to novel 2-substituted indane-2-mercaptoacetylamide derivatives which are useful as inhibitors of enkephalinase and ACE.... | 01/23/1996 |
| 5486511 | 4-amino-17ଲ-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17ଲ-(cyclopropylamino)androst-4-en-3-one and related compounds as C17-20 lyase and 5-reductase This invention is directed to 4-amino-17ଲ-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17ଲ-(cyclopropylylamino)androst-4-en-3-one and related compounds, a process for their synthesis, a pharmaceutical composition having C17-20 l... | 01/23/1996 |
| 5484814 | NMDA antagonists The present invention is directed to a class of 4,6-disubstituted tryptophan derivatives, 4,6-disubstituted kynurenines, their use as NMDA antagonists and to pharmaceutical compositions containing these compounds.... | 01/16/1996 |
| 5484783 | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives The present invention relates to the use of certain mercaptoacetylamide and benzazapine derivatives in treating patients suffering from hypertriglyceridemia, atherosclerosis and hypercholesterolemia.... | 01/16/1996 |
| 5484810 | Tissue protective tocopherol analogs This invention relates to alkylated sulfonium alkylene derivatives of certain 2H-1-benzopyrans, to the intermediates and processes useful for their preparation, to their free-radical scavenger and cardioprotective properties and to their end-use applicati... | 01/16/1996 |
| 5478811 | Orally-active elastase inhibitors This invention relates to novel morpholinourea and related derivatives of pentafluoroethyl peptides which are orally active elastase inhibitors. These compounds are useful in the treatment of various inflammatory diseases and emphysema.... | 12/26/1995 |
| 5478846 | 1-piperidinyl alkanoylanyl sulfonamides for treatment of cardiac arrhythmia The present invention is direct to a new class of 1-piperidinyl alkanoarylsulfonamides of the formula I ##STR1## wherein R, X, m, n, and Alk are defined in the specification, and their use as antiarrhythmic agents.... | 12/26/1995 |
| 5476861 | Piperidinyl thiacyclic derivatives Piperidinyl thiacyclic derivatives of the formula ##STR1## wherein X, Y, R1, R2, R3 and R4 are defined in the specification, are useful in the treatment of allergic diseases and diseases responding to antag... | 12/19/1995 |
| 5473099 | Ethyl 4-trichloroacetamido-4-hexenoate This invention relates to a novel synthesis of 4-amino-5-hexenoic acid by thermal rearrangements, and to the novel intermediates produced thereby.... | 12/05/1995 |
| 5472959 | Carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace The invention relates to compounds of the formula ##STR1## wherein B1 and B2 are each independently hydrogen; hydroxy; --OR2 wherein R2 is a C1 -C4 alkyl or an Ar--Y group wherein Ar i... | 12/05/1995 |
| 5470844 | Heterocyclic-NMDA antagonists The present invention is directed to a class of 3-phosphono-pyrrolidine derivatives as described by Formula I and their use as NMDA antagonists. ##STR1##... | 11/28/1995 |
| 5470870 | NMDA antagonists The present invention is directed to a class of 4,6-disubstituted tryptophan derivatives, 4,6-disubstituted kynurenines, their use as NMDA antagonists and to pharmaceutical compositions containing these compounds.... | 11/28/1995 |
| 5470837 | 5'-vinylhalo-aristeromycin/adenosine analogs and immunosuppressants The present invention relates to a method of effecting immunosuppression in a patient in need thereof comprising administering to said patient an effective immunosuppressive amount of certain 5'-vinylhalo-aristeromycin/adenosine analogs.... | 11/28/1995 |
| 5468745 | Amino and nitro containing tricyclic compounds useful as inhibitors of ace The present invention relates to compounds of the formula ##STR1## wherein A is methylene, oxygen, sulfur or N--B wherein B is R1 or COR2 wherein R1 is hydrogen, a C1 -C4 alkyl or an Ar--Z--group... | 11/21/1995 |
| 5463181 | Farnesyl: protein transferase inhibitors as anticancer agents The present invention relates to certain inhibitors of farnesyl:protein transferase which are useful as antineoplastic agents.... | 10/31/1995 |
| 5460807 | Antiproliferative oligomers The oligomers of the present invention are polyureas or polyamides having a number average molecular weight of | 10/24/1995 |
| 5457196 | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE The present invention relates to novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE.... | 10/10/1995 |
| 5455242 | Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace The present invention relates to compounds of the formula ##STR1## wherein B1 and B2 are each independently hydrogen; hydroxy; --OR2 wherein R2 is a C1 -C4 alkyl or an Ar--Y group wher... | 10/03/1995 |
| 5447911 | Ghilanten antimetastatic principle from the south american leech, Haementeria ghilianii A method for the inhibition of tumor metastases is described herein. The method makes use of the administration of an antimetastatic factor isolated from the leech Haementeria ghilianii.... | 09/05/1995 |
| 5446068 | 1-phenyl-3-phenyl-2-propyne-1-ones as calcium uptake inhibitors This invention relates to 1-phenyl-3-phenyl-2-propyne-1-ones, the use of these compounds as calcium uptake inhibitors in leukocytes and thrombocytes, and pharmaceutical compositions containing these compounds as active ingredients, and the process of thei... | 08/29/1995 |
| 5441963 | Potentiation of NMDA antagonists The present invention is directed to a composition and method for poteniating the therapeutic effects of a class of known NMDA antagonists.... | 08/15/1995 |
| 5440065 | Process for preparing 4-amino-5-hexenoic acid This invention relates to a novel synthesis of 4-amino-5-hexenoic acid by thermal rearrangements, and to the novel intermediates produced thereby.... | 08/08/1995 |
