Did You Know...
...Chester Carlson was a patent agent who tired of having to make multiple copies of patent applications using the only duplication method available at the time: carbon paper. In 1959 he came up with a new copying system and took it to IBM for evaluation. The "experts" at IBM determined potential sales to be only 5,000 units because people wouldn't want to use a bulky machine when they had carbon paper. Carlson's invention was the xerography process, the company founded on the system is Xerox.
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| Number | Title | Issue Date |
| 7834222 | Process for the preparation of bicyclo[3.1.0]hexanols A process for the preparation of a the formula (I): which process comprises the intramolecular cyclopropanation of an epoxide of me formula (II); in the presence of 0.05 to 0.75 equivalents of a secondary amine base and at least one equivalent of an alkyl lithium ba... | 11/16/2010 |
| 7449585 | Indazol-3-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1 receptor (VR1) Compounds of formula (I), which are useful as therapeutic compounds, particularly in the treatment of pain and other conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1). ... | 11/11/2008 |
| 7442701 | Amino-heterocycles as VR-1 antagonists for treating pain The present invention provides a compound of formula (I): wherein V represents NR5, O, S, SO or S(O)2; W and X each independently represent CH or N; Y represents N, CH or C—Ar2, with the proviso that at least one, but no more than ... | 10/28/2008 |
| 7288655 | α v integrin receptor antagonists The present invention relates to the synthesis of intermediates for the preparation of compounds of formula (A): wherein n is 2 or 3 and various salt forms of these compounds. The compounds of formula (A) are useful as ανβ3 receptor antagonists ... | 10/30/2007 |
| 7226926 | 8-fluoroimidazo 1,2-a pyridine derivatives as ligands for GABA receptors A class of 8-fluoroimidazo[1,2-α]pyridine derivatives, substituted at the 3-position by an optionally substituted five-membered or six-membered heteroaromatic ring, being selective ligands for GABAA receptors, in particular having high affinity for the ... | 06/05/2007 |
| 7226922 | Imidazo[1,2-b]pyridazine analogues as anxiolytics and cognition enhancers The present invention provides a compound of formula I: wherein X1 represents hydrogen, halogen, C1-6 alkyl, trifluoromethyl or C1-6 alkoxy; | 06/05/2007 |
| 7176203 | Imidazo-triazine derivatives as ligands for gaba receptors A class of imidazo[1,2b][1,2,4]triazine derivatives, substituted at the 7-position by an optionally substituted five-membered or six-membered heteroaromatic ring, being selective ligands for GABAA receptors, in particular having good affinity for t... | 02/13/2007 |
| 7161006 | Sulphones for inhibition of gamma secretase The invention provides compounds of formula I: which are inhibitors of γ-secretase and hence useful in the treatment or prevention of Alzheimer's disease. ... | 01/09/2007 |
| 7157249 | Delta subunit of human GABAA receptor The present invention relates to the cloning of novel cDNA sequences encoding the α4 and δ receptor subunits of the human GABA A receptor; to stably co-transfected eukaryotic cell lines capable of expressing a human GABAA receptor,... | 01/02/2007 |
| 7157478 | Oxadiazole derivatives for inhibition of gamma secretase Compounds of formula I: wherein X represents a 5-(R-substituted)-1,2,4-oxadiazole-3-yl moiety are inhibitors of gamma-secretase, and hence useful for treating Alzheimer's disease ... | 01/02/2007 |
| 7153868 | N-(3-(4-substituted-1-piperidinyl)-1-phenylpropyl) substituted sulfonamides as NK-3 receptor antagonists The present invention provides a method of treatment of a subject suffering from a disease, such as schizophrenia, for which the administration of an NK-3 antagonist is indicated which comprises administering to that subject a therapeutically effective amount of a c... | 12/26/2006 |
| 7148222 | Substituted pyrido-pyridazine derivatives which enhance cognition via the GABA-receptors The present invention discloses a compound of formula 1, or a pharmaceutically acceptable salt thereof: wherein X1 represents hydrogen, halogen, C1-6 alkyl, trifluoromethyl or C1-6 alkoxy; X2 represents hydrogen or halogen... | 12/12/2006 |
| 7144910 | Sulfonamides, sulfamates and sulfamides as gamma-secretase inhibitors Compounds of formula I: inhibit the processing of APP by gamma-secretase, and hence are useful in treating or preventing Alzheimer's disease. ... | 12/05/2006 |
| 7144887 | Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition The present invention provides a compound of formula (I) in which R1 is generally hydrogen or CF3, R2 is generally hydrogen, W is a cyclic amine, a heterocycle or a group L-Y—X where L-Y is a linking portion and X is generally an a... | 12/05/2006 |
| 7138400 | Sulfamides as gamma-secretase inhibitors Novel sulfamides of formula (I) are disclosed. The compounds exert an inhibitory action on the processing of APP by gamma-secretase, and are therefore useful in the treatment or prevention of Alzheimer's disease. ... | 11/21/2006 |
| 7105509 | Benzodiazepine derivatives as APP modulators A novel class of 1,4- and 1,5-benzodiazepines of formula (I) is disclosed. The compounds modulate the processing of amyloid precursor protein by γ-secretase, and hence find use in the treatment or prevention of conditions associated with the deposition of β-amyloi... | 09/12/2006 |
| 7105507 | Cyclohexane derivatives and their use as therapeutic agents The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and (e); and R1, R2, R3, R4, R | 09/12/2006 |
| 7101895 | Cyclohexyl sulphone derivatives as gamma-secretase inhibitors Compounds of formula I: wherein Ar1 and Ar2 are optionally substituted aryl or heteroaryl, L is a bond, ═CH— or —(CHRa)n—, and X is SCN, SR1, S(O)R | 09/05/2006 |
| 7101892 | Sulfone derivatives as 5-HT7 receptor ligands The present invention relates to sulfone derivatives of formula (I): Ar—SO2—CR2R3-L-N(R1)2I wherein Ar, L, R1, R2 and R3 are as defined herein, and pharma... | 09/05/2006 |
| 7060710 | Isoxazole pyrazoloindane derivatives as cognition enhancing GABAα5 subtype ligands The present invention provides compounds of formula I: in which: one of X and Y is a nitrogen atom substituted by a group R6′ and the other is a carbon atom substituted by an isoxazole group ... | 06/13/2006 |
| 7041689 | Heteroaryl substituted spriocyclic sulfamides for inhibition of gamma secretase Compounds of formula I are disclosed: in which X is a 5-membered heteroaryl ring and R is as defined herein. The compounds are inhibitors of the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease | 05/09/2006 |
| 7041688 | Alkynly-substituted spirocyclic sulfamides for the treatment of alzheimer's disease Compounds of formula (I) are disclosed. The compounds inhibit gamma-secretase and hence find use in treatment of Alzheimer's disease ... | 05/09/2006 |
| 7030128 | Imidazo-pyrimidine derivatives as ligands for GABA receptors A class of imidazo[1,2-α]pyrimidine derivatives, substituted at the 3-position by an optionally substituted five-membered or six-membered heteroaromatic ring, are selective ligands for GABAA receptors, in particular having good affinity for the α2 and/o... | 04/18/2006 |
| 7022724 | Cognition enhancing derivatives of isoxazole triazoloindane GABA-A α5 receptor subunit ligands The present invention relates to compounds of formula I: in which R1 is a linear group or a five membered heterocycle optionally fused to a phenyl ring, R2 is a 5-membered ... | 04/04/2006 |
| 7015224 | 7-Tert-butyl-3-(2-fluorophenyl)-6-(2H-(1,2,4)triazol-3-ylmethoxy)-(1,2,4)triazolo (4,3b) pyridazine for the treatment of anxiety and convulsions The compound (I) is a GABAa receptor ligand, functionally selective for the α2 and/or α3 subunit, and is useful in the treatment of deleterious mental states, in particular anxiety. ... | 03/21/2006 |
| 7005431 | Imidazo-triazine derivatives as ligands for gaba receptors A class of 7-phenylimidazo[1,2-b][1,2,4]triazine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group which is directly attached or bridged by an oxygen atom or a —NH— linkage, and substituted on ... | 02/28/2006 |
| 6995155 | Benzodiazepine derivatives as inhibitors of gamma secretase Compounds of formula (I) are disclosed. The compounds inhibit the action of gamma secretase, and hence find use in the treatment and prevention of Alzheimer's disease. ... | 02/07/2006 |
| 6984663 | Cyclohexyl sulphones Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease. ... | 01/10/2006 |
| 6984626 | Gamma-secretase inhibitors A class of compounds is disclosed which are diasteroisomers of a known class of protease inhibitors. The compound inhibit gamma-secretase, and find use in the treatment of and/or prevention of Alzheimer's disease. ... | 01/10/2006 |
| 6969716 | 5-phenyl[1,2,4]triazines as ligands for GABA-A α2/α3 receptors for treating anxiety or depression The present invention provides a compound of formula I, or an N-oxide thereof or a pharmaceutically acceptable salt thereof: wherein X1 represents hydrogen, halogen, C1-6 alkyl, trifluorom... | 11/29/2005 |
| 6964981 | Tetrahydrofuran derivatives and their use as NK-1 antagonists The present invention relates compounds that are NK-1 antagonists and that are of use in the treatment or prevention of depression, anxiety, pain, inflammation, migaine, emesis or postherpetic neuralgia. ... | 11/15/2005 |
| 6960598 | (1,8) naphthyridines as gaba ligands, their pharmaceutical compositions and uses A class of [1,8] naphthyridine analogues which are substituted in the 4-position by a substituted phenyl ring. These compounds are ligands for GABAA receptors and useful in the therapy of deleterious mental states such as anxiety. ... | 11/01/2005 |
| 6949549 | Imidazolophthalazine derivatives as ligands for GABAA receptors A class of substituted imidazolo[5,1-a]phthalazine derivatives as ligands for GABAA receptors of formula I which are partial or full inverse agonists of an α5 receptor subunit while being relatively free of... | 09/27/2005 |
| 6946461 | Imidazolophthalazine derivatives as ligands for GABAA receptors A class of substituted imadazolo[2,1-a]phthalazine derivatives as ligands for GABAA receptors of formula I: which are partial or full inverse agonists of an α5 receptor subunit while being relatively free o... | 09/20/2005 |
| 6936608 | Imidazo-triazine derivatives as ligands for GABA receptors A class of 7-phenylimidazo[1,2-b][1,2,4]triazine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group which is directly attached or bridged by an oxygen atom or a —NH— linkage, being selective lig... | 08/30/2005 |
| 6914060 | Imidazotriazinone derivatives as ligands for GABA receptors The present invention relates to imidazo[2,1-f]triazin-4-one analogues which are substituted in the 7-position by a substituted phenyl ring, being ligands for GABAA receptors and accordingly of benefit in the therapy of deleterious neurological disorders.... | 07/05/2005 |
| 6914065 | Imidazo[1,2-C]pyrimidine derivatives as ligands for gaba receptors A class of 3-phenylimidazo[1,2-c]pyrimidine derivatives, of the formula I: (wherein R1, X, Y, and Z are defined herein) are selective ligands for GABA-A receptors and are useful in the treatment or preventio... | 07/05/2005 |
| 6914063 | Imidazo-pyrazine derivatives as ligands for GABA receptors A class of imidazo[1,2-α]pyrazine analogues substituted in the 3-position by a substituted phenyl ring, being selective ligands for GABAA receptors which interact more favourably with the α2 and/or α3 subunit than with the α1 subunit, are accordingly ... | 07/05/2005 |
| 6906085 | Tetrahydropyran derivatives as neurokinin receptor antagonists The present invention relates compounds of the formula (I): wherein R1, R2, R3, R4, R5, R6, R7 and R8 represent a variety of subst... | 06/14/2005 |
| 6900215 | Imidazo-pyrimidine derivatives as ligands for gaba receptors A class of 3-phenylimidazo[1,2-α]pyrimidine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group which is directly attached or bridged by an oxygen atom or a —NH— linkage, and further substituted... | 05/31/2005 |
