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| Number | Title | Issue Date |
| 7728022 | (4, 5, 6, 7-tetrahydro-1-H-indol-7-yl) acetic acid derivatives for treatment of Alzheimer's disease Compounds of formula I: are disclosed. The compounds are useful in treating or preventing diseases associated with deposition of Aβ in the brain. ... | 06/01/2010 |
| 7514459 | Gamma-secretase inhibitors Compounds of formula I: are potent inhibitors of gamma-secretase and hence find use in treatment or prevention of diseases associated with deposition of β-amyloid. ... | 04/07/2009 |
| 7468393 | Diarylsulfones as 5-HT2A antagonists Compounds of formula I: are potent and selective antagonists of the human 5-HT2A receptor, and hence useful in treatment of a variety of adverse conditions of the CNS. ... | 12/23/2008 |
| 7435748 | Gamma-secretase inhibitors Compounds of formula I: inhibit gamma-secretase and hence find use in treatment of Alzheimer's disease. ... | 10/14/2008 |
| 7411088 | Stereoselective synthesis of a 4,4-disubstituted cyclohexanepropanoic acid There is provided stereoselective route to a compound of formula I: wherein R represents H or an alkali metal, Ar1 represents 4-chlorophenyl and Ar2 represents 2,5-difluorophenyl. ... | 08/12/2008 |
| 7411004 | Sulphones which modulate the action of gamma secretase Disclosed are sulphones which modulate the action of gamma-secretase. The compounds are useful in the treatment or prevention of Alzheimer's disease. ... | 08/12/2008 |
| 7410964 | Cyclohexyl sulphones as gamma-secretase inhibitors Compounds of formula I: inhibit gamma-secretase and hence find use in treatment or prevention of Alzheimer's disease. ... | 08/12/2008 |
| 7381725 | Pyridazine derivatives as ligands for GABA receptors A class of pyridazine derivatives, substituted in the 4-position by an optionally substituted heteroaromatic ring, being selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of b... | 06/03/2008 |
| 7371771 | Alkenyl-substituted spirocyclic sulfamides as inhibitors of gamma-secretase Compounds of formula (I) are disclosed: wherein R4 is an alkenyl group of defined structure. The compounds inhibit gamma-secretase, and hence are useful for treatment of Alzheimer's disease. ... | 05/13/2008 |
| 7365196 | Sulphonamido-substituted bridged bicycloalkyl derivatives A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease. ... | 04/29/2008 |
| 7300955 | Method and materials for treatment of Alzheimer's disease The invention provides the combined use of an inhibitor of formation or release of β-amyloid and a nitric oxide releaser for the treatment or prevention of Alzheimer's disease. ... | 11/27/2007 |
| 7271191 | Pyrazole derivatives as gamma-secretase inhibitors useful in the treatment of Alzheimer's disease The compounds of formula I: inhibit gamma secretase and hence are of utility in the treatment or prevention of Alzheimer's Disease. ... | 09/18/2007 |
| 7262300 | Polymorphic forms of a GABAagonist Two new crystalline monhydrates and two new crystalline anhydrates of gaboxadol are disclosed together with methods for preparing them. ... | 08/28/2007 |
| 7205434 | Sulphonamides for control of beta-amyloid production There is disclosed a novel class of sulphonamido-substituted bridged bicycloalkyl derivatives comprising a substitute on the bridgehead position. The compounds modulate the production of the β-amyloid precursor protein, and hence are useful in the treatment of Alzh... | 04/17/2007 |
