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...that Kleenex tissue was originally designed to be a gas mask filter? It was developed at the beginning of World War I to replace cotton, which was then in short supply as a surgical dressing.
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| Number | Title | Issue Date |
| 8007830 | Granule formation The present invention relates to oral granules of montelukast sodium. ... | 08/30/2011 |
| 7687524 | Cathepsin cysteine protease inhibitors This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, s... | 03/30/2010 |
| 7560559 | Polymorphic form of montelukast sodium The invention provides novel polymorphic form of montelukast sodium, as well as methods of using and pharmaceutical compositions containing saud novel form. Also provided are montelukast sodium: acetonitrile solvates, which are intermediates in the formation of crys... | 07/14/2009 |
| 7439260 | 7-(1,3-thiazol-2-YL)thio-coumarin derivatives and their use as leukotriene biosynthesis inhibitors The instant invention provides compounds of Formula (I) which are leukotriene biosynthesis inhibitors. Compounds of formula (I) are useful as anti-asthmatic, anti-allergic, anti-inflammatory, cytoprotective and anti-artherosclerotic agents. | 10/21/2008 |
| 7407959 | Cathepsin cysteine protease inhibitors This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, s... | 08/05/2008 |
| 7405229 | Cathepsin cysteine protease inhibitors This invention relates to a class of compounds having the general formula (I) which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone r... | 07/29/2008 |
| 7375134 | Cathepsin cysteine protease inhibitors This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, s... | 05/20/2008 |
| 7371747 | Cyanoalkylamino derivatives as protease inhibitors The present invention is directed to novel cyanoalkylamino derivatives that are inhibitors of cysteine protease such as cathepsins K, S, B and L, in particular cathepsin K Pharmaceutical composition comprising these compounds, method of treating diseases mediated by... | 05/13/2008 |
| 7348433 | Quinolinones as prostaglandin receptor ligands This invention encompasses a method for treating a prostaglandin E mediated disease or condition comprising administering to a mammalian patient in need of such treatment a compound of Formula (A) in an amount that is effective to treat the prostaglandin E mediated ... | 03/25/2008 |
| 7312353 | Cathespin cysteine protease inhibitors This invention relates to a novel class of compounds, represented by the formula below, wherein the meanings of G, E, E, n, R1, R2, R3 et R4 are indicated therein, which are cysteine protease inhibitors, including but not ... | 12/25/2007 |
| 7279478 | Cathepsin cysteine protease inhibitors This invention relates to class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as o... | 10/09/2007 |
| 7183425 | Diastereoselective reductive amination process This invention describes a reductive amination process whereby perfluorinated ketones or ketals are combined with α-aminoesters under basic conditions to form metal carboxylates. Diastereoselective reductions of the metal carboxylates enable access to two diastereo... | 02/27/2007 |
| 6835727 | Cathepsin cysteine protease inhibitors This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of Cathepsins K and L. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as... | 12/28/2004 |
| 6677351 | 1-biaryl-1,8-naphthyridin-4-one phosphodiesterase-4 inhibitors Compounds represented by Formula (I): ##STR1## or a pharmaceutically acceptable salt thereof, are phosphodiesterrase 4 inhibitors useful in the treatment of asthma and inflammation.... | 01/13/2004 |
| 6365592 | Phosphonic and carboxylic acid derivatives as inhibitors of protein tyrosine phosphatase-1B (PTP-1B) The invention encompasses compounds represented by formula I: ##STR1## as well as compositions and methods of treatment. The compounds are inhibitors of the PTP-1B enzyme.... | 04/02/2002 |
| 6329421 | Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2 The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of ... | 12/11/2001 |
| 6329137 | Intact cell assay for protein tyrosine phosphatases using recombinant baculoviruses The invention relates to an intact cell assay for direct quantitation of protein tyrosine phosphatase (PTP) activity using the baculovirus expression system. A PTP expressed in transformed host insect cells is processed and localized in their predicted su... | 12/11/2001 |
| 6180650 | Heterosubstituted pyridine derivatives as PDE 4 inhibitors The invention encompasses the novel compound of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE 4). ##STR1## The ... | 01/30/2001 |
| 6110701 | DNA encoding precursor of interleukin-1ଲ converting enzyme--related cysteine proteinase II (ICErel -II) A complementary DNA (cDNA) encoding full length form of ICErel -II is identified, sequenced and isolated. The cDNA is cloned into expression vectors for expression in recombinant hosts. The cDNA is useful to produce recombinant full length ICE | 08/29/2000 |
| 6107087 | High level expression of human cyclooxygenase-2 The invention discloses a cDNA consisting of human cyclooxygenase-2 cDNA attached to 3'flanking sequence of human cyclooxygenase-1 methods for increasing the expression of human cyclooxygenase-2 in transformed cell and assays for preferentially and indepe... | 08/22/2000 |
| 5516652 | DNA encoding prostaglandin receptor IP A novel prostaglandin receptor has been identified and DNA encoding the receptor has been isolated, purified, sequenced and expressed in host cells. This DNA encoding the novel prostaglandin receptor and host cells expressing the receptor are used to iden... | 05/14/1996 |
