Assignee: Mercian Corporation

Location: Tokyo, JP
No. of patents: 40

Number	Title	Issue Date
7932083	DNA participating in hydroxylation of macrolide compound The present invention provides a DNA participating in biological transformation of a macrolide compound 11107B. The present invention provides, particularly, a DNA participating in biological transformation of a macrolide compound 11107B represented by the formula (...	04/26/2011
7893068	Physiologically active substances The present invention relates to a compound represented by the formula (I): (wherein, R3, R6, R7 and R21 are the same as or different from one another and each represents a hydrox...	02/22/2011
7790887	Macrolide compound in solid form, process for preparation thereof, and pharmaceutical composition containing the same The present invention provides the compound of formula (I) in a solid form which, as a bulk medicament for pharmaceutical manufacture, is uniform, has a high purity, and is easy to work with. The invention further provides a process for preparing this compound, and ...	09/07/2010
7745198	Method of producing macrolide compound The present invention provides a novel method of producing the 12-membered ring macrolide compound 11107D having an antitumor activity by biological transformation. Starting material which is the 12-membered ring macrolide compound 11107B represented by the formula ...	06/29/2010
7655442	Method for stabilizing macrolide compounds The present invention provides a method for stabilizing a macrolide compound, and an efficient method for producing the compound. Specifically, it provides a method for stabilizing a macrolide compound, in which a 12-membered ring macrolide compound, such as a compo...	02/02/2010
7619100	Physiologically active substances The present invention relates to a compound represented by the formula (I): (wherein, R3, R6, R7 and R21 are the same as or different from one another and each represents a hydrox...	11/17/2009
7576204	Heterocyclic macrolide pharmaceutical agent, a method of producing the same and use of the same A compound represented by the following general formula (I): (I) wherein R7 and R21 are the same or different and each represents optionally substituted C2-22 alkoxy, etc.; a pharmaceuticall...	08/18/2009
7256178	Physiologically active substances Compounds represented by the following general formula (I), pharmacologically acceptable salts thereof or hydrates of the same: (I) wherein W represents and R3, R7, R16, R17	08/14/2007
7247729	Method for producing pipecolamide derivative A method of manufacturing a pipecolamide derivative, characterized in that pipecolic acid or an acid salt thereof is reacted with an amine in an inert solvent in the presence of a condensing agent such as dicyclohexylcarbodiimide, 1-ethyl-2-(2-dimethylaminopropyl)ca...	07/24/2007
7235388	Isolated nucleic acid encoding L-lysine: 2-oxoglutaric acid 6-aminotransferase Provided are an isolated gene capable of participating in the production of L-homoglutamic acid, and a production system of L-homoglutamic acid by using this gene. The gene is derived from the genome of Flavobacterium lutescens. ...	06/26/2007
7115412	Process for the preparation of optically active 7-substituted-3-(2-aminopropyl)indole derivatives and intermediates therefor Disclosed are a process for preparation of an optically active 7-substituted 3-(2-aminopropyl)indole compound and an intermediate therefor. In the above preparation process, 7-substituted indole is reacted with L- or DL-serine in the presence of a tryptophan-synthes...	10/03/2006
7060821	Osteoclast differentiation inhibitors A compound represented by formula (I); a process for producing a compound (substance F-1490) of formula (I), wherein X represents —O— and R represents a hydroxyl group, by using a microorganism belonging to the genus Cunninghamella; and a Cunninghamell...	06/13/2006
7026352	Physiologically active substances The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incuba...	04/11/2006
7022502	Process for the biological production of L-pipecolic acid A process for the production of L-pipecolic acid which comprises the step of reducing delta-1-piperideine-6-carboxylic acid by the use of pyrroline-5-carboxylate reductase. The delta-1-piperideine-6-carboxylic acid is obtained by the step of converting L-lysine by t...	04/04/2006
6900340	Preparation of isocoumarin derivatives and intermediates for the synthesis thereof A method of preparing optically active isocoumarin-3-yl-acetic acid derivatives represented by Formula (I): wherein a specific isocoumarin-ketene derivative is subjected to an addition reaction with an optically active...	05/31/2005
6890746	Gene participating in the production of homo-glutamic acid and utilization thereof Provided are an isolated gene capable of participating in the production of L-homoglutamic acid, and a production system of L-homoglutamic acid by using this gene. The gene is derived from the genome of Flavobacterium lutescens. ...	05/10/2005
6747012	Crystalline anthracycline antibiotic and process for producing the same Disclosed are a crystalline form of anthracycline antibiotic having specific characteristic 2θ values as measured by the X-ray diffraction method, and a process for producing the crystalline form. This process comprises the step of crystallization involving the com...	06/08/2004
6653455	Crystallization of doxorubicin hydrochloride Disclosed are a crystallizing method of doxorubicin hydrochloride from a doxorubicin hydrochloride-containing solution, particularly a method for carrying out the crystallization under a condition of 40° C. or higher, and a doxorubicin hydrochloride crys...	11/25/2003
6589981	Tumor radiosensitization and/or chemopotentiation using isocoumarin derivatives A method for enhancing the efficacy of chemotherapy and/or radiation in the treatment of cancer in animals, particularly humans, is provided wherein certain isocoumarin derivatives which exhibit unique radiosensitization activity and/or chemopotentiation ...	07/08/2003
6566394	Salicylamide derivatives Salicylamide derivatives represented by formulae (1a) and (1b); intermediates in the production thereof; a process for producing the same; and drugs containing the same as the active ingredient. The salicylamide derivatives represented by formulae (1a) an...	05/20/2003
6548695	Process for producing isocoumarins and intermediates for the same Provided is a process for producing an isocoumarin-3-yl-acetic acid derivative, characterized by reacting a homophthalic acid derivative represented by a formula: ##STR1## (wherein Rc, R2 and R are mainly protecting groups) with a ...	04/15/2003
6426420	Process for producing isocoumarines and intermediates for the same Provided is a process for producing an isocoumarin-3-yl-acetic acid derivative, characterized by reacting a homophthalic acid derivative represented by a formula: ##STR1## (wherein Rc, R2 and R are mainly protecting groups) with a ...	07/30/2002
6410759	Dihydroxycholesterol hydroxylated at 17- and 25-positions A method for preparing at least one hydroxycholesterol chosen from the group consisting of 25-hydroxycholesterol, 17,25-dihydroxycholesterol and 25,26-dihydroxycholesterol by biological hydroxylation of cholesterol, and the aforementioned dihydroxycholest...	06/25/2002
6388058	Method of purifying daunomycin The present invention relates to a method in which daunomycin is eluted from a hydrophobic porous synthetic resin carrier onto which daunomycin is adsorbed from crude daunomycin with a buffered aqueous solution containing a water-miscible organic solvent ...	05/14/2002
6361987	Gene encoding a protein having asymmetric hydrolase activity for 4-substituted 1,4-dihydropyridine derivatives and its expression product This invention provides DNA fragments for efficiently preparing a protein having asymmetric hydrolase activity for 4-substituted 1,4-dihydropyridine derivatives, transformants obtained by using such a DNA fragment, and a process for preparing the aforesai...	03/26/2002
6146844	Process for producing hydroxylated cholesterols and dihydroxycholesterols using amycolata A method for preparing at least one hydroxycholesterol chosen from the group consisting of 25-hydroxycholesterol, 17,25-dihydroxycholesterol and 25,26-dihydroxycholesterol by biological hydroxylation of cholesterol, and the aforementioned dihydroxycholest...	11/14/2000
6143541	Gene encoding a protein having symmetric hydrolase activity for 4-substituted 1,4-dihydropyridine derivatives and its expression product This invention provides DNA fragments for efficiently preparing a protein having asymmetric hydrolase activity for 4-substituted 1,4-dihydropyridine derivatives, transformants obtained by using such a DNA fragment, and a process for preparing the aforesai...	11/07/2000
6133443	Optically active 1,4-dihydropyridine derivatives and process for the preparation thereof Optically active 1,4-dihydropyridine derivatives represented by general formula (I) and anion salts thereof and a production method therefor: ##STR1## (wherein R1 represents a C1-6 alkyl group, R2 represents a nitroge...	10/17/2000
6043050	Biological process for producing steroids hydroxylated at the 25-position A biological process for producing steroids hydroxylated at the 25-position thereof comprises adding steroids (excluding cholesterol) to the cells or culture liquid of a microorganism of the genus Amycolata or Sphingomonas capable of hydroxylating the ste...	03/28/2000
5906927	Process for producing L-2-aminoadipic acid A process for producing L-2-aminoadipic acid, which comprises converting an aminomethyl group of L-lysine into a carboxyl group by use of a culture of a microorganism of the genus Flavobacterium. By this process, L-2-aminoadipic acid can be obtained direc...	05/25/1999
5760238	1,4-dihydropyridine derivatives Disclosed are 1,4-dihydropyridine derivatives represented by the general formula (I) and salts thereof, as well as optical active 1,4-dihydropyridine derivatives represented by the general formula (II) and salts thereof which are obtained from the derivat...	06/02/1998
5395941	Optically active 1,4-hydropyridine compounds Optically active 1,4-dihydropyridine derivatives represented by general formula (I), process for preparing compounds (Ic) (in general formula (I) , R1 is a lower alkyl group), process for preparing compounds represented by general formula (II) ...	03/07/1995
5376537	Process for production of cyclodextrins A process for the production of cyclodextrins, comprising reacting non-treated starch with cyclodextrin-glycosyl-transferase produced by Bacillus ohbensis (FERM BP-3180), or produced by a mutant derived from Bacillus ohbensis (e.g., FERM BP-3180), or prod...	12/27/1994
5322937	Genes encoding a 3-acylation enzyme for macrolide antibiotics A DNA fragment or a restriction enzyme-digested DNA fragment, the DNA fragment containing a gene, acyA, encoding a 3-acylation enzyme for macrolide antibiotics, characterized by being derived from a strain belonging to the genus Streptomyces, having a siz...	06/21/1994
5252304	Formalin sterilization apparatus A reaction chamber is disposed between a heating chamber and an outlet line of the heating chamber, and performs a reaction of ammonia gas vaporized in the heating chamber with formaldehyde circulated from a room to be sterilized. A filter is disposed bet...	10/12/1993
5232943	Antibiotics Mer-AF1032A and Mer-AF1032B Antibiotic Mer-AF1032A represented by the following formula (I) and its isomer antibiotic Mer-AF1032B are disclosed. Also disclosed are a method for preparing the antibiotics comprising the cultivation of a strain belonging to genus Penicillium and a phar...	08/03/1993
5223519	4-hydroxypyridine derivatives, useful for treating circulatory diseases 4-Hydroxypyridine derivative represented by the following formula ##STR1## wherein R represents a methyl group or an isopropyl group, and the method for preparing the derivative comprising the step of cultivating a strain belonging to Streptomyces ka...	06/29/1993
5183883	Conjugate of adriamycin and cyclodextrin Adriamycin derivatives represented by formula (I) ##STR1## wherein R denotes a divalent hydrocarbon group, CD denotes a cyclodextrin residue, m is 1 to 8, and n is 0 to 8. The compounds exhibit excellent anti-cancer activity over a wide administration ran...	02/02/1993
5149802	Process for producing azetidinone derivatives A process for producing 2-azetidinone derivatives represented by formula ##STR1## wherein R1 denotes a protecting group of a hydroxyl group, Z denotes a hydrogen atom or a protecting group of an amino group, and Q denotes ##STR2## in whic...	09/22/1992
5132136	Condensed wine composition for cooking and method of preparing the same A condensed wire composition containing an extract content of no less than 18% (w/v) is obtained by vacuum condensing a wine at a temperature of 5° to 60° C., preferably 20° to 35° C. to a concentration by at least 8 times as high as the original, ret...	07/21/1992

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Assignee: Mercian Corporation