Did You Know...
...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
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| Number | Title | Issue Date |
| 6245520 | Methods for introducing nucleic acids into mammalian cells using imidazolium lipids Methods for introducing nucleic acids into mammalian cells are provided which use imidazolium lipids. The imidazolium lipids have the formula: ##STR1## wherein R1 and R2 each independently represent a C8 -C24 sa... | 06/12/2001 |
| 6121457 | Compositions and methods using novel substituted imidazolium lipids Compounds of the formula: ##STR1## are provided, in which R1 and R2 each independently represent a C8 -C24 saturated or unsaturated hydrocarbon chain, which is optionally interrupted by from 1 to 3 heteroat... | 09/19/2000 |
| 6011148 | Methods for purifying nucleic acids Methods are provided for producing highly purified compositions of nucleic acids by using tangential flow ultrafiltration. A scaleable process for producing pharmaceutical grade plasmid DNA, useful for gene therapy, is provided, which is efficient and avo... | 01/04/2000 |
| 5958894 | Amphiphilic biguanide derivatives Cationic derivatives of biguanide are provided, which are useful in the preparation of lipid carriers for mediating transfection of mammalian cells in vivo and in vitro.... | 09/28/1999 |
| 5902802 | Cationic amphiphiles Cationic amphiphiles are provided that are alkyl or alkoxyalkyl O-phosphate esters of diacylphosphatidyl zwitterionic compounds such as phosphatidylcholine or phosphatidyl ethanolamine. The amphiphiles can be used as carriers for delivering macromolecules... | 05/11/1999 |
| 5830878 | Cationic lipid: DNA complexes for gene targeting This invention herein describes pharmaceutical compositions and methods for targeted delivery of functional genes into cells and tissues in vivo. The invention discloses DNA:lipid complexes, methods of making such complexes and methods of using such compl... | 11/03/1998 |
| 5736395 | Amphiphilic imidazolinium derivatives Amphiphiles containing an imidazdinium ring system are provided that are non-toxic to the host mammal. The amphiphiles are used to produce liposomes useful as carriers for delivering macromolecules intracellularly.... | 04/07/1998 |
| 5705655 | Amphiphilic nitrogen containing imidazolinium derivative compounds and uses Amphiphiles containing an imidazdinium ring system are provided that are non-toxic to the host mammal. The amphiphiles are used to produce liposomes useful as carriers for delivering macromolecules intracellularly.... | 01/06/1998 |
| 5665879 | Amphiphilic derivatives of piperazine Novel, heterocyclic cationic amphiphile and compounds thereof are prepared that are degraded in vivo. Liposomes are produced from the cations that are used as carriers for delivering macromolecules intracellularly and may be targeted to a specific cell ty... | 09/09/1997 |
