Assignee: Medivir AB

Location: Huddinge, SE
No. of patents: 63

Number	Title	Issue Date
8158779	Antiviral nucleosides 4-Amino-1-((2R,3S,4S,5R)-5-azido-4-hydroxy-5-hydroxymethyl-3-methyl-tetrahydrofuran-2-yl)-1H-pyrimidin-2-one (22) and prodrugs thereof are hepatitis C (HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-mediat...	04/17/2012
8143396	1-[2′, 3′ -dideoxy-3′ C- (hydroxymethyl)—beta-D-erythro-pentofuranosyl] cytosine derivatives as HIV inhibitors Novel bicyclic tetrahydrofuran compounds and derivatives, and pharmaceutically acceptable salts thereof, according to the formula: These compounds have utility in the treatment of retroviruses such as HIV, especially reverse ...	03/27/2012
8124609	Acyclic nucleoside derivatives Methods and novel intermediates for the preparation of and the treatment with acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group ...	02/28/2012
8022092	(2,5-dioxoimidazolidin-1-yl)-N-hydroxy-acetamides as metalloproteinase inhibitors The invention provides compounds of the formula (I) wherein the variables are as defined in the specification. The compounds of the invention are inhibitors of metalloproteinase MMP-12 and are among other things useful for the treatment of obstructive airway disease...	09/20/2011
8017620	Dutpase inhibitors Deoxyuridine derivatives of the formula where R1 is H or various substituents; D is —NHCO—, —CONH—, —O—, —C(═O)—, —CH═CH, —C≡C—, —NR5—; ...	09/13/2011
8012939	Macrocyclic inhibitors of hepatitis C virus Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers thereof, wherein each variable has specific definitions. Pharmaceutical compositions containing compounds (I) and process for preparing...	09/06/2011
7935681	Antiviral nucleosides 4-Amino-1-((2R,3S,4S,5R)-5-azido-4-hydroxy-5-hydroxymethyl-3-methyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one (22) and prodrugs thereof are hepatitis C (HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-media...	05/03/2011
7915300	Cysteine protease inhibitors A compound of the formula II wherein one of R1 and R2 is halo and the other is H or halo; R3 is C1-C4 straight or br...	03/29/2011
7915295	Non-nucleotide reverse transcriptase inhibitors Compounds of the formula Z: where; A is CH or N; R1 is a substituent to a carbon atom in the ring containing A selected from —S(═O)pRa, where Ra is —C1-C4 alkyl, —ORx, —NRxRx, —NHNRxRx, —NHNHC(═O)ORx, —NR...	03/29/2011
7893067	Cysteine protease inhibitors Compounds of the formula II: wherein R2 is the side chain of leucine, isoleucine, cyclohexylglycine, O-methyl threonine, 4-fluoroleucine or 3-methoxyvaline; R3 is H, methyl or F;	02/22/2011
7888367	1-[2′,3′ -dideoxy-3′ C-(hydroxymethyl)—beta-D-erythro-pentofuranosyl] cytosine derivatives as HIV Compounds of the formula (I) wherein: R1 is independently H1—OR3, —NHR4; C1-C4 alkyl; or, when n is 2, adjacent R1 together define an olefinic bond; R2 is H; or when the gem ...	02/15/2011
7829548	Compounds useful in the treatment of HIV There is provided inter alia use of 2′,3′-dideoxy-3′-hydroxymethylcytidine or a prodrug or salt thereof in the manufacture of a medicament for the treatment of HIV infection wherein the reverse transcriptase of the HIV bears at least one mutation that allows a...	11/09/2010
7825239	Antiviral nucleosides 4-Amino-1-((2R,3S,4S,5R)-5-azido-4-hydroxy-5-hydroxymethyl-3-methyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one (22) and prodrugs thereof are hepatitis C(HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-mediat...	11/02/2010
7825238	Antiviral methods employing double esters of 2′, 3′-dideoxy-3′-fluoroguanosine A method for treatment of HBV and HIV infections comprising administering the compound or salt of formula Ig ...	11/02/2010
7807677	HIV protease inhibitors Compounds of the formula I: wherein R1, R2, X and N are as defined in the specification; E is N, CH; A′ and A″ are terminal groups as defined in the specifica...	10/05/2010
7795270	DUTPase inhibitors Deoxyuridine derivatives of the formula (I) where R1 is H or various substituents; D is —NHCO—, —CONH—, -0-, —C(═O)—, —CH═CH, —C≡C—, —NR5—; R4 is hydrogen or various substituents; R5 is H, C	09/14/2010
7700552	Macrocyclic inhibitors of hepatitis C virus Compounds of the formula (I): and N-oxides, salts and stereoisomers thereof wherein A is OR1, NHS(═O)pR2, NHR3, NRaRb, C(═O)NHR3 or C(═O)NRaRb wherein; R1 is hydrogen, C1-C6	04/20/2010
7671032	HCV NS-3 serine protease inhibitors Peptidomimetic compounds are described which inhibit the NS3 protease of the hepatitis C virus (HCV). The compounds have the formula where the variable definitions are as provided in the specification. The compounds comprise a carbocyclic P2 unit in conjunction with...	03/02/2010
7666856	Antiviral nucleosides 4-Amino-1-((2R,3S,4S,5R)-5-azido-4-hydroxy-5-hydroxymethyl-3-methyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one (22) and prodrugs thereof are hepatitis C (HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-media...	02/23/2010
7608590	HCV NS-3 serine protease inhibitors Compounds of the formula where the variables are as defined in the specification inhibit the NS3 protease of flavivirus such as hepatitis C virus (HCV). The compounds comprise a novel linkage between a heterocyclic P2 unit ...	10/27/2009
7601702	Dutpase Inhibitors Deoxyuridine derivatives of Formula (I′); where A is O, S or CH2; B is O, S or CHR3; R1 is H, or various substituents; R2 is H, F; R3 is H, F, OH, NH2; or R2 and R3 together fo...	10/13/2009
7517992	Non-nucleoside reverse transcriptase inhibitors A compound of the formula (Y): where; R1 is O, S; R2 is a nitrogen-containing heterocycle; R3 is H, C1-C3 alkyl; X is —(CR8R8′)n-D-(CR8R8′)m	04/14/2009
7432274	Acyclic nucleoside derivatives Methods and novel intermediates for the preparation of and the treatment with acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group ...	10/07/2008
7405310	Non-nucleoside reverse transcriptase inhibitors This invention relates to non-nucleoside reverse transcriptase inhibitors active against HIV-1 and having an improved resistance and pharmacokinetic profile. The invention further relates to novel intermediates in the synthesis of such compounds and the use of the c...	07/29/2008
7223387	Antiviral formulations comprising propylene glycol and an isopropyl alkanoic acid ester A topical composition comprising an antiinflammatory glucocorticoid and a nucleoside analogue antiviral agent in a pharmaceutical carrier characterized in that the carrier comprises about 15 to about 25 weight % propylene glycol and about 10 to about 25 weight perce...	05/29/2007
7189849	Synthesis of acyclic nucleoside derivatives Novel processes towards the synthesis of the antiviral valomaciclovir stearate in which an esterified guanine acetal is reduced to the corresponding alcohol, reacted with an activated amino acid and N-deprotected. The esterified guanine acetal is prepared from a 9-g...	03/13/2007
7148243	Antivirals Compounds of the formula I: wherein Rx is cyano or bromo; R1 is halo; R2 is C114 C3 alkyl, and pharmaceutica...	12/12/2006
RE39264	Pharmaceutical combination The invention relates to pharmaceutical compositions for topical administration comprising a topically acceptable antiviral substance and an antiinflammatory glucocorticoid in a pharmaceutically acceptable carrier. The pharmaceutical composition can be used in the p...	09/05/2006
7071173	Antiviral methods employing double esters of 2′, 3′-dideoxy-3′-fluoroguanosine A method for treatment of HBV and HIV infections comprising administering the compound or salt of formula Ig ...	07/04/2006
6974802	Treatment of viral infections using prodrugs of 2′,3-dideoxy,3′-fluoroguanosine A method of treating HBV or HIV infections comprising administering to an individual an effective amount of the compound of formula IId′: wherein R2 is the residue of an aliphatic ...	12/13/2005
6894177	Intermediate compounds of non-nucleoside reverse transcriptase inhibitors Compounds of the formula I: where; R1 is O, S; R2 is an optionally substituted nitrogen-containing heterocycle, wherein the nitrogen is located at the 2 position relative...	05/17/2005
6878844	Synthesis of acyclic nucleoside derivatives Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 ...	04/12/2005
6716850	Non-nucleoside reverse transcriptase inhibitors Compounds of the formula I: where; R1 is O, S; R2 is an optionally substituted nitrogen-containing heterocycle, wherein the nitrogen is located at the 2 position relative to the (thio)...	04/06/2004
6703394	Acyclic nucleoside derivatives Methods and novel intermediates for the preparation of and the treatment with acyclic nucleoside derivatives of the formula: ##STR1## where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2	03/09/2004
6613936	Synthesis of acyclic nucleoside derivatives Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: ##STR1## where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a --C(O)C3	09/02/2003
6610714	Non-nucleoside reverse transcriptase inhibitors Compounds of the formula I: ##STR1## where; R1 is O, S; R2 is an optionally substituted nitrogen-containing heterocycle, wherein the nitrogen is located at the 2 position relative to the (thio)urea bond; R3 is ...	08/26/2003
6576763	Acyclic nucleoside derivatives Compounds of the Formula I ##STR1## where one of R1 and R2 is --C(O)CH(CH(CH3)2)NH2 or --C(O)CH(CH(CH3)CH2 CH3)NH2 ; the other of R1 and R2 is -...	06/10/2003
6489364	Antiviral protease inhibitors Compounds of formula (I), wherein A' and A" are independently the same or different group of formula (II) wherein: R' is H, CH3, C(CH3)2, --ORa, --N(Ra)2, --N(Ra)ORa or ...	12/03/2002
6486183	Antivirals Compounds of formula (I): wherein Rx is cyano or bromo; R1 is halo; R2 is C1 -C3 alkyl, and pharmaceutically acceptable salts and prodrugs thereof have activity as antiretrovirals....	11/26/2002
6458772	Prodrugs Compounds of the formula I ##STR1## or corresponding monohydroxynucleoside derivatives wherein: R1 is hydroxy, amino or carboxy: optionally having esterified/amide bonded thereon; a C4 -C22 saturated or unsaturated, optionally ...	10/01/2002

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Assignee: Medivir AB