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| Number | Title | Issue Date |
| 8088753 | Heparin conjugates and methods Heparin conjugates and methods of making and use thereof are disclosed. An illustrative heparin conjugate includes a composition wherein a bile acid is bonded to heparin through the 3-carbon of the bile acid. A spacer may be interposed between the bile acid and the ... | 01/03/2012 |
| 7638158 | Drug release from antithrombogenic multi-layer coated stent A stent having a multi-layered coating adhered to its surface which can prevent restenosis and thrombosis at the implant site. The stent coating is comprised of two layers. The first layer is a polymeric coating with one or more biologically active agent(s) disperse... | 12/29/2009 |
| 6702850 | Multi-coated drug-eluting stent for antithrombosis and antirestenosis A stent having a multi-layered coating adhered to its surface which can prevent restenosis and thrombosis at the implant site. The stent coating is comprised of two layers. The first layer is a polymeric coating with one or more biologically active agent(... | 03/09/2004 |
| 6656922 | Oral delivery of macromolecules Polysaccharides, which are widely used as an anticoagulation drugs, especially heparin, are clinically administered only by intravenous or subcutaneous injection because of their strong hydrophilicity and high negative charge. Amphiphilic heparin derivati... | 12/02/2003 |
| 6589943 | Formulation of amphiphilic heparin derivatives for enhancing mucosal absorption Formulations for enhanced mucosal absorption of heparin are disclosed. In one embodiment, a powdered heparin composition is made by dissolving an amphiphilic heparin derivative including heparin covalently bonded to a hydrophobic agent in a water phase, d... | 07/08/2003 |
| 6245753 | Amphiphilic polysaccharide derivatives Polysaccharides, which are widely used as an anticoagulation drugs, especially heparin, are clinically administered only by intravenous or subcutaneous injection because of their strong hydrophilicity and high negative charge. Amphiphilic heparin derivati... | 06/12/2001 |
