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| Number | Title | Issue Date |
| 8153402 | Emulsion compositions An emulsion is useful in allowing a wide variety of gene products to be expressed via eukaryotic in vitro expression. The emulsion comprises a silicone based surfactant, a hydrophobic phase and a hydrophilic phase; wherein the hydrophilic phase comprises a plurality... | 04/10/2012 |
| 8133673 | Compartmentalized self tagging The present invention relates to the development of a novel method for the selection of nucleic acid processing and other enzymes. In particular the invention relates to a method for the selection of nucleic acid polymerases and other enzymes with desired properties... | 03/13/2012 |
| 8103455 | Method of assessing the proliferation or differentiation behaviour of a population of target cells in a biological system The invention relates to a method of assessing the proliferation or differentiation behavior of a population of target cells in a biological system, said method comprising the steps of; [a] measuring the value of at least one proliferation characteristic of said cel... | 01/24/2012 |
| 8063019 | Scaffold polypeptides for heterologous peptide display The present invention relates to the use of Stefin A as a scaffold protein for the display of inserted peptides, particularly wherein the Stefin A is a human Stefin A. Several mutations are advantageously made in the wild type stefin A sequence to improve it as a sc... | 11/22/2011 |
| 8021851 | Thr51 phosphorylated HP 1β protein for the assessment of DNA damage This invention relates to the finding that HP1β is phosphorylated at Thr51 at an early stage in the DNA damage response in cells. Thr51P HP1β is therefore a biomarker for DNA damage which may be useful, for example, in assessing DNA damage, cancer susceptibility o... | 09/20/2011 |
| 7993651 | Chimeric human immunodeficiency virus (HIV) immunogens comprising GAG P24-P17 fused to multiple cytotoxic T lymphocyte (CTL) epitopes Disclosed is an immunogen in sterile form suitable for administration to a human subject, the immunogen comprising: at least a portion of the gag protein of HIV, said gag protein being from an HIV clade or having a consensus sequence for one or more HIV clades, and ... | 08/09/2011 |
| 7981430 | Multi-clade chimeric immunogens derived from highly conserved regions of the human immunodeficiency virus type 1 (HIV-1) consensus proteome The present invention provides artificial fusion proteins (AFPs) designed to elicit an anti-HIV immune response, as well as nucleic acid molecules and expression vectors encoding those proteins. The AFPs of the invention may comprise domains from various HIV protein... | 07/19/2011 |
| 7947468 | Methods A method for identifying a compound expected to be useful in modulating a LRRK2 protein kinase activity, the method comprising the steps of (1) determining whether a test compound modulates the protein kinase activity of a LRRK2 polypeptide on a substrate Ezrin/Radi... | 05/24/2011 |
| 7943664 | Phosphate binding materials and their uses Phosphate binding materials and compositions comprising them which are solid ligand-modified poly oxo-hydroxy metal ion materials are disclosed that are based on ferric iron oxo-hydroxides modified with carboxylic acid ligands, or ionized forms thereof. These materi... | 05/17/2011 |
| 7897347 | Selection of intracellular immunoglobulins A general immunoglobulin-target assay system is provided, in which a positive outcome (the generation of a signal) depends only on the intracellular interaction of immunoglobulin with target. This can be accomplished for many immunoglobulins expressed in yeast and/o... | 03/01/2011 |
| 7897341 | Optical sorting method The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their r... | 03/01/2011 |
| 7888293 | Compositions and methods relating to orthogonal ribosome mRNA pairs Orthogonal ribosome orthogonal mRNA pairs are provided, as are methods for their selection involving a novel positive-negative selection approach, and methods for their use. Also provided are cellular logic circuits involving orthogonal ribosomes. ... | 02/15/2011 |
| 7858359 | Method for tapping the immunological repertoire The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are ... | 12/28/2010 |
| 7842488 | Polynucleotides encoding a human 3-phosphoinositide- dependent protein kinase The present invention provides for isolated polynucleotides encoding a human 3-phosphoinositide-dependent protein kinase, and vectors and host cells comprising the isolated polynucleotides. ... | 11/30/2010 |
| D628305 | Sitting-drop microwell plate for crystalization | 11/30/2010 |
| 7820442 | Activation Induced Deaminase (AID) The present invention identifies that the expression of Activation Induced Deaminase (AID) or its homologues in cells confers a mutator phenotype and thus provides a method for generating diversity in a gene or gene product as well as cell lines capable of generatin... | 10/26/2010 |
| 7792665 | Method for designing a compound based on the three dimensional structure of phosphoinositide dependent protein kinase 1 (PDK1) A method for selecting a compound for modulating the activity of phosphoinositide dependent protein kinase 1 (PDKI) is provided. The method may comprise modelling a three dimensional structure of a plurality of molecules in a computer, comparing with the three dimen... | 09/07/2010 |
| 7741051 | Soluble ectodomain fragments of MET and uses thereof The invention relates a fragment derived from the MET ectodomain which the inventors have found is capable, in monomer form, of binding to HGF/SF either in the presence or absence of heparin. The availability of soluble, monomeric forms of the MET receptor enabled s... | 06/22/2010 |
| 7737169 | Anionically substituted 7-nitroindoline derivatives and their uses Anionically substituted 7-nitroindoline derivatives are disclosed and their uses as caged compounds from which effector species such as neurotransmitters and amino acids are releasable on irradiation with light. ... | 06/15/2010 |
| 7723270 | Methods for producing members of specific binding pairs A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genet... | 05/25/2010 |
| 7718578 | Method of synthesis and testing of combinatorial libraries using microcapsules The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalizing two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming seco... | 05/18/2010 |
| 7718391 | Assays for identifying modulators of rhomboid polypeptides The present invention relates to proteins of the conserved Rhomboid family, which are involved in various signalling pathways within cells. Rhomboid proteins are found to possess a novel serine protease activity which cleaves within the transmembrane domain of a pol... | 05/18/2010 |
| 7700559 | Gonadotropin releasing hormone analogues conjugates with steroid hormones A compound comprising a gonadotrophin releasing hormone analogue conjugated to a hormone moiety, or a derivative thereof, which is able to bind to a plasma hormone binding protein. The compounds may be used to treat hormone-dependent disorders such as cancer, or as ... | 04/20/2010 |
| 7691576 | Compartmentalized self tagging The present invention relates to the development of a novel method for the selection of nucleic acid processing and other enzymes. In particular the invention relates to a method for the selection of nucleic acid polymerases and other enzymes with desired properties... | 04/06/2010 |
| 7687060 | Method for the treatment or prophylaxis of tuberculosis The invention provides the use of intravenous immunoglobulin (IVIg) in the preparation of a medicament for the treatment and/or prophylaxis of mycobacterial infection. ... | 03/30/2010 |
| 7677197 | Treatment of tissue specimens Apparatus for treating tissue specimens comprises a stationary outer casing (2) in the top of which is positioned an annular trough (3) for holding a liquid. Rotatably mounted in the outer casing (2) is a central hub (5) supporting a disc... | 03/16/2010 |
| 7662557 | Methods for producing members of specific binding pairs A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genet... | 02/16/2010 |
| 7655435 | Emulsion compositions An emulsion is useful in allowing a wide variety of gene products to be expressed via eukaryotic in vitro expression. The emulsion comprises a silicone based surfactant, a hydrophobic phase and a hydrophilic phase; wherein the hydrophilic phase comprises a plurality... | 02/02/2010 |
| 7635666 | Methods for producing members of specific binding pairs A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genet... | 12/22/2009 |
| 7615210 | Treatment of endometriosis A method of combating menorrhagia, dysmenorrhoea or endometriosis in a female individual that includes administering to the individual at least one agent that reduces the effect of prokineticin 1 on a prokineticin receptor. ... | 11/10/2009 |
| 7606670 | Crystal structure of the 30S ribosome and its use The invention provides an X-ray crystal structure of the 30S ribosome, obtained from Thermus thermophilus 30S subunit, having a tetragonal space group P41212 with unit cell dimensions of a=401.4±4.0 â„«, b=401.4±4.0 â„«, c=175.9±5.0 â... | 10/20/2009 |
| 7582446 | In vitro sorting method The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce thei... | 09/01/2009 |
| 7582062 | Methods of neural centre location and electrode placement in the central nervous system A method of locating the position of a selected neural centre in the central nervous system of an animal is disclosed. The method comprises the steps of (a) stimulating neurons at a first central nervous system position; (b) measuring the field potential evoked at a... | 09/01/2009 |
| 7514210 | Compartmentalised self replication method for in vitro evolution of molecular libraries We describe a method of selecting an enzyme having replicase activity, the method comprising the steps of: (a) providing a pool of nucleic acids comprising members each encoding a replicase or a variant of the replicase; (b) subdividing the pool of nucleic acids int... | 04/07/2009 |
| 7498421 | Degradation fragments A pharmaceutical composition comprising a compound of formula (I) wherein X is an electron withdrawing group, Y1 is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, —SO2R4, —CO2R4, —CONHR4 | 03/03/2009 |
| 7429467 | Emulsion compositions An emulsion is useful in allowing a wide variety of gene products to be expressed via eukaryotic in vitro expression. The emulsion comprises a silicone based surfactant, a hydrophobic phase and a hydrophilic phase; wherein the hydrophilic phase comprises a plurality... | 09/30/2008 |
| 7368111 | Human antibodies specific for TGFβ2 Specific binding members comprising human antibody antigen binding domains specific for human transforming growth factor beta (TGFβ) bind specifically isoforms TGFβ2 and TGFβ1 or both, preferentially compared with TGFβ3. Specific binding members may be isolated ... | 05/06/2008 |
| 7368259 | Method for generating diversity The invention relates to a method for preparing an antibody-producing cell line capable of directed constitutive hypermutation of a specific nucleic acid region, comprising the steps of: a) screening a clonal cell population for V gene diversity; b) isolating one or... | 05/06/2008 |
| 7344870 | 3-phosphoinositide-dependent protein kinase The present invention provides for a substantially pure human or rabbit 3-phosphoinositide-dependent protein kinase. ... | 03/18/2008 |
| 7297506 | Assay for nucleotide triphosphate using a modified nucleoside diphosphate kinase comprising a fluorescent label Nucleoside diphosphates (NDPs) are detected or measured by following the dephosphorylation of the phosphoenzyme form of nucleoside diphosphate kinase (NDPK), and nucleoside triphosphates (NTPs) are detected or measured by following the phosphorylation of NDPK to its... | 11/20/2007 |
