Assignee: Medical College of Ohio

Location: Toledo, OH
No. of patents: 39

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Number	Title	Issue Date
7605130	Albumin-based colloid composition and method of use in treating hypovolemia and multiorgan dysfunction A composition comprising an albumin-based colloid and its use in treating hypovolemic conditions such as capillary leak syndrome and shock are disclosed. ...	10/20/2009
7592422	Modified plasminogen activator inhibitor type-1 and methods based thereon The present invention is based upon the discovery that modified plasminogen activator inhibitor type-I (PAI-1) in which two or more amino acid residues that do not contain a sulfhydryl group have been replaced with amino acid residues that contain a sulfhydryl group...	09/22/2009
7348312	Albumin-based colloid composition and method of use in treating hypovolemia and multiorgan dysfunction A composition comprising an albumin-based colloid and its use in treating hypovolemic conditions such as capillary leak syndrome and shock are disclosed. ...	03/25/2008
7262027	Polypeptide and DNA immunization against . infections The present invention provides compositions of novel polypeptides and polynucleotides encoding the polypeptides, which polypeptides are useful for generating an immunological response in an individual and in therapeutic application of Coccidioides spp. infect...	08/28/2007
7037895	Albumin-based colloid composition and method of use in treating hypovolemia and multiorgan dysfunction A composition comprising an albumin-based colloid and its use in treating hypovolemic conditions such as capillary leak syndrome and shock are disclosed. ...	05/02/2006
6291237	Cancer diagnosis and therapy based on mutations in TGF-ଲ receptors This invention is based on the discovery that the type II TGFଲ receptor (RII) is a cancer suppressor gene which is genetically inactivated (mutated) in approximately 25% of colon cancers, including nearly all colon cancers of the class identified as...	09/18/2001
6075128	Materials and methods for isolating IgA immunoglobulins The subject invention concerns novel polynucleotide sequences which code for polypeptides which bind IgA. A further aspect of the invention are hybrid proteins (and genes encoding these hybrid proteins) which comprise binding domains for both IgA and IgG....	06/13/2000
6025351	Method of treating blood which comprises use of diels alder adducts of vinyl porphyrins and metal complexes thereof Families of Diels Alder adducts and of metal complexes of Diels Alder adducts, which are useful as particularly active compounds for use in photodynamic therapy, are disclosed. The Diels Alder adducts and a preferred family of metal complexes have the str...	02/15/2000
5876978	Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction A method and apparatus for quantitative measurement of gene expression through multiplex competitive reverse transcriptase polymerase chain reaction amplification are disclosed. The method and apparatus are especially useful for analysis of small specimen...	03/02/1999
5866323	Cancer diagnosis prognosis and therapy based on mutation of receptors for transforming growth factor ଲ and homologous growth controlling factors This invention is based on the discovery that the type II TGF-ଲ receptor (RII) is a cancer suppressor gene which is genetically inactivated (mutated) in approximately 25% of colon cancers, including nearly all colon cancers of the class identified a...	02/02/1999
5853450	Method for treating bioorganic and wastewater sludges The method of treating wastewater or bioorganic sludges containing odor, animal viruses, pathogenic bacteria, and parasites to produce a bioactive but stabilized product that is useful as a soil substitute or as a fertilizer which can be applied directly ...	12/29/1998
5853590	Method for treating bioorganic and wastewater sludges A method of treating sludge to provide a stable product for use as a beneficial soil or fertilize for agricultural lands is disclosed which includes the steps of: (a) mixing sludge with at least one alkaline material in an amount sufficient to raise pH of...	12/29/1998
5837484	Stable cell lines capable of expressing the adeno-associated virus replication gene Stable packaging cell lines derived from human 293 cells which are transfected with an AAV vector having the AAV rep gene operably line to a heterologous transcription promoter, such as the metallothionein promoter, or an AAV Rep78 insensitive homologous ...	11/17/1998
5744598	Imines of porphyrins, of porphyrin derivatives, and of related compounds, and pharmaceutical compositions containing such imines Purified imines of porphyrins, chlorins, bateriochlorins, chlorophylls, bacteriochlorophylls, purpurins, reduced purpurins, verdins, Diels Alder adducts, benzochlorins and metal complexes of the foregoing imines are disclosed. The formulas of the benzochl...	04/28/1998
5714334	Gene and method for production of an IgA binding protein The subject invention concerns novel polynucleotide sequences which code for polypeptides which bind IgA. A further aspect of the invention are hybrid proteins (and genes encoding these hybrid proteins) which comprise binding domains for both IgA and IgG....	02/03/1998
5665347	IL-12 inhibition of B1 cell activity The invention relates to a method of suppressing B1 cell activity in a host (e.g., mammalian, including human) comprising administering to the host an effective amount of IL-12 that significantly suppresses or inhibits B1 cell activity. In addition, the i...	09/09/1997
5644030	Gene and method for production of an IgA binding protein The subject invention concerns novel polynucleotide sequences which code for polypeptides which bind IgA. A further aspect of the invention are hybrid proteins (and genes encoding these hybrid proteins) which comprise binding domains for both IgA and IgG....	07/01/1997
5587394	Production and use of diels alder adducts of vinyl porphyrins, of metal complexes thereof, and of compositions containing such adducts and complexes Families of Diels Alder adducts and of metal complexes of Diels Alder adducts, which are useful as particularly active compounds for use in photodynamic therapy, are disclosed. The Diels Alder adducts and a preferred family of metal complexes have the str...	12/24/1996
5563262	Diels alder adducts of vinyl porphyrins Families of Diels Alder adducts and of metal complexes of Diels Alder adducts, which are useful as particularly active compounds for use in photodynamic therapy, are disclosed. The Diels Alder adducts and a preferred family of metal complexes have the str...	10/08/1996
5552134	Uses of benzochlorins, verdins and porphyrin derivatives and of compositions containing such benzochlorins, verdins and porphyrin derivatives A family of benzochlorins, a family of verdins, a family of porphyrin derivatives and metal complexes thereof are disclosed. The benzochlorins have the formula of FIG. 3 of the attached drawings; their metal complexes have the formula of FIG. 1. The verdi...	09/03/1996
5534506	Use of purpurins, chlorins and purpurin- and chlorin-containing compositions The treatment of blood and other body fluids and tissues, the detection of tumors and the treatment of patients is disclosed. The treatment and detection involve the use of families of chlorins, families of purpurins and families of metal complexes of chl...	07/09/1996
5514669	Use of photodynamic therapy to treat prostatic tissue The present invention provides a method for diagnosing or treating prostatic tissue in a human or animal patient which comprises sensitizing the prostatic tissue with an effective amount of a photosensitive composition which accumulates in the prostatic t...	05/07/1996
5486459	Biologically relevant methods for the rapid determination of sterility The invention is directed to biological processes and apparatus for determining the efficacy of a sterilization cycle based upon the recovery of activity of interactive enzyme systems comprising enzymes, coenzymes, catalysts, cofactors, substrates or any ...	01/23/1996
5438051	Compositions of porphyrin derivatives A family of benzochlorins, a family of verdins, a family of porphyrin derivatives and metal complexes thereof are disclosed. The benzochlorins have the formula of FIG. 3 of the attached drawings; their metal complexes have the formula of FIG. 1 . The verd...	08/01/1995
5424305	Production and use of imines of porphyrins, of porphyrin derivatives and of related compounds, and of compositions containing such imines Purified imines of porphyrins, chlorins, bateriochlorins, chlorophylls, bacteriochlorophylls, purpurins, reduced purpurins, verdins, Diels Alder adducts, benzochlorins and metal complexes of the foregoing imines are disclosed for retarding growth of cance...	06/13/1995
5413918	Gene and method for production of a 40-45-kDa IgA binding protein The subject invention concerns novel polynucleotide sequences which code for polypeptides which bind IgA. A further aspect of the invention are hybrid proteins (and genes encoding these hybrid proteins) which comprise binding domains for both IgA and IgG....	05/09/1995
5405369	Photochemical ablation of gastro-intestinal tissue for augmentation of an organ The present invention provides a method for treating a human or animal patient amenable an organ augmentation with gastro-intestinal tissue which is, or will be surgically transplanted into the patient's organ. The gastro-intestinal tissue is sensitized w...	04/11/1995
5354858	Production and use of Diels Alder adducts of vinyl porphyrins and of compositions containing such adducts Families of Diels Alder adducts and of metal complexes of Diels Alder adducts, which are useful as particularly active compounds for use in photodynamic therapy, are disclosed. The Diels Alder adducts and a preferred family of metal complexes have the str...	10/11/1994
5216012	Production and use of purpurins, chlorins and purpurin- and chlorin-containing compositions Families of chlorins, families of purpurins and metal complexes thereof are disclosed. The purpurins and their metal complexes have the structures of FIGS. 1, 7, 14-18, 29-38, 44-48 and 54-58 of the attached drawings. The chlorins and their metal complexe...	06/01/1993
5055448	Linear derivatives of arginine vasopressin antagonists Compounds acting as antagonists of the antidiuretic/and or vasopressor activity of arginine vasopressin are those of the formula A--CH2 CO--D--Tyr(R)--Phe--Y--Asn--T--U--Z--Q wherein A is a-adamantyl, cyclohexyl, cyclopentyl, 1-mercaptocyclohexyl, 1...	10/08/1991
5051415	Production and use of purpurins, chlorins and purpurin- and chlorin-containing compositions Families of chlorins, families of purpurins and metal complexes thereof are disclosed. The purpurins and their metal complexes have the structures of FIGS. 1, 7, 14-18, 29-38, 44-48 and 54-58 of the attached drawings. The chlorins and their metal complexe...	09/24/1991
5032572	Polymers containing cross-linked azo bonds, which polymers are useful for releasing therapeutic agents into the lower gastrointestinal tract Polymers from ethylenically unsaturated monomers, cross-linked by a substituted divinylazobenzene are useful as pharmaceutical compositions for the delivery of medicaments. The polymers are degraded by the enzymes of the upper gastrointestinal tract or ar...	07/16/1991
4988808	Production and use of porphyrin derivatives and of compositions containing such derivatives A family of benzochlorins, a family of verdins, a family of porphyrin derivatives and metal complexes thereof are disclosed. The benzochlorins have the formula of FIG. 3 of the attached drawings; their metal complexes have the formula of FIG. 1. The verdi...	01/29/1991
4928958	Exercise device An exercise device for the lower extremities that can be mounted on a support and has a frame having a first leg and a second leg. The first and second legs have a first end and a second end. The first end of the first and second legs are pivotally connec...	05/29/1990
4772586	Novel derivatives of arginine vasopressin antagonists Compounds acting as antagonists of the antidiuretic/and or vasopressor activity of arginine vasopressin are those of the formula ##STR1## wherein n is 4 or 5; X is (D- or L-)Tyr(R), D-Phe, D-Val, D-Leu, D-Ile, D-Nva, D-Nle, D-Cha, D-Abu, D-Thr, D-Asn...	09/20/1988
4714696	Novel derivatives of arginine vasopressin antagonists Compounds acting as antagonists of the antidiuretic/and or vasopressor activity of arginine vasopressin are those of the formula ##STR1## wherein n is 4 or 5; X is (D- or L-)Tyr(R), D-Phe, D-Val, D-Leu, D-Ile, D-Nva, D-Nle, D-Cha, D-Abu, D-Thr, D-Asn...	12/22/1987
4713057	Mechanical assist device for inserting catheters The application discloses a mechanical assist device for the insertion of a catheter unit into the vein of a patient. The device includes a needle unit, a catheter unit, and a handle member having at least one strut member which engages the catheter unit....	12/15/1987
4663308	Method of use of polymers containing cross-linked azo bonds for releasing therapeutic agents into the lower gastrointestinal tract Polymers from ethylenically unsaturated monomers, cross-linked by a substituted or unsubstituted divinylazobenzene are useful as carriers or capsules for medicaments, which are degraded by the enzymes of the upper gastrointestinal tract or which must be t...	05/05/1987
4649130	Novel derivatives of arginine vasopressin antagonists Compounds acting as antagonists of the antidiuretic/and or vasopressor activity of arginine vasopressin are those of the formula ##STR1## wherein n is 4 or 5; X is (D- or L-)Tyr(R), D-Phe, D-Val, D-Leu, D-lle, D-Nva, D-Nle, D-Cha, D-Abu, D-Thr, D-Asn...	03/10/1987

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Assignee: Medical College of Ohio