...that after Parker Brothers executives turned down the game of Monopoly because it had "52 fundamental errors" (including taking too long to play), a copy of the game wound up in the home of the company president who stayed up until 1 a.m. to finish playing it? He was so impressed by the game that the next day he wrote to inventor Charles Darrow and offered to buy it!
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| Number | Title | Issue Date |
| 7310547 | Fluorescent fiberoptic probe for tissue health discrimination A system and method for the in situ discrimination of healthy and diseased tissue. A fiberoptic based probe is employed to direct ultraviolet illumination onto a tissue specimen and to collect the fluorescent response radiation. The response radiation is observed at... | 12/18/2007 |
| 7309867 | Methods and apparatus for characterization of tissue samples The invention provides methods for determining the probability that a given region of a tissue sample contains tissue of a given category, such as CIN 1 (cervical intraepithelial neoplasia, grade 1), CIN 2/3 (cervical intraepithelial neoplasia grades 2 and/or 3), no... | 12/18/2007 |
| 7282723 | Methods and apparatus for processing spectral data for use in tissue characterization The invention provides methods for processing tissue-derived spectral data for use in a tissue classification algorithm. Methods of the invention comprise application of spectral and/or image masks for automatically separating ambiguous or unclassifiable spectral da... | 10/16/2007 |
| 7260248 | Image processing using measures of similarity The invention provides methods of relating a plurality of images based on measures of similarity. The methods of the invention are useful in the segmentation of a sequence of colposcopic images of tissue, for example. The methods may be applied in the determination ... | 08/21/2007 |
| 7187810 | Methods and systems for correcting image misalignment The invention provides methods of determining a correction for a misalignment between at least two images in a sequence of images due at least in part to sample movement. The methods are applied, for example, in the processing and analysis of a sequence of images of... | 03/06/2007 |
| 7136518 | Methods and apparatus for displaying diagnostic data The invention provides methods for displaying diagnostic results obtained from a tissue sample. In general, the invention assigns tissue-class probability values to discrete regions of a patient sample, and creates an overlay for displaying the results. The overlay ... | 11/14/2006 |
| 7127282 | Optical methods and systems for rapid screening of the cervix A method and a system is provided for discriminating between healthy cervical tissue and pathologic cervical tissue based on the fluorescence response of the tissue to laser excitation (LIF) and the backscatter response to illumination by white light (in the spectra... | 10/24/2006 |
| 7103401 | Colonic polyp discrimination by tissue fluorescence and fiberoptic probe A system and method for the in situ discrimination of healthy and diseased tissue. A fiberoptic based probe is employed to direct ultraviolet illumination onto a tissue specimen and to collect the fluorescent response radiation. The response radiation is observed at... | 09/05/2006 |
| 6933154 | Optimal windows for obtaining optical data for characterization of tissue samples The invention provides methods for determining a characteristic of a tissue sample, such as a state of health, using spectral data and/or images obtained within an optimal period of time following the application of a chemical agent to the tissue sample. The inventi... | 08/23/2005 |
| D507349 | Sheath for cervical optical probe | 07/12/2005 |
| 6902935 | Methods of monitoring effects of chemical agents on a sample The invention provides methods and systems for monitoring effects of chemical agents on optical signals produced by samples in response to the chemical agents. Preferred methods comprise application of multiple chemical agents that interact to alter an optical signa... | 06/07/2005 |
| 6847490 | Optical probe accessory device for use in vivo diagnostic procedures The present invention recognizes that optical probes function both as medical access devices and as instruments which collect complex optical data. The invention provides an optical probe accessory device which can access luminal spaces within the body of a patient ... | 01/25/2005 |
| 6839661 | System for normalizing spectra A method and system for normalizing optical spectra using a non-uniform segment normalization. A spectrum is obtained and is represented as a function of wavelength as an amplitude at each of a plurality of wavelengths. At least one segment of the spectrum is select... | 01/04/2005 |
| D500134 | Sheath for cervical optical probe | 12/21/2004 |
| 6826422 | Spectral volume microprobe arrays Methods and apparatus are provided for determining a characteristic of a sample of a material by the interaction of electromagnetic radiation with the sample. The apparatus includes an optical assembly and a protective barrier. The optical assembly sequentially illu... | 11/30/2004 |
| 6818903 | Method and apparatus for identifying spectral artifacts The invention provides an apparatus and methods for determining whether spectral data obtained from a region of a tissue sample are affected by an artifact. Artifacts include, for example, lighting artifacts such as glare and shadow and obstruction artifacts, such a... | 11/16/2004 |
| 6768918 | Fluorescent fiberoptic probe for tissue health discrimination and method of use thereof A system and method for the in situ discrimination of healthy and diseased tissue. A fiberoptic based probe is employed to direct ultraviolet illumination onto a tissue specimen and to collect the fluorescent response radiation. The response radiation is observed at... | 07/27/2004 |
| 6760613 | Substantially monostatic, substantially confocal optical systems for examination of samples The present invention relates to systems and methods for examining a sample using a substantially monostatic, substantially confocal optical system comprising transmitting optics that focus an illuminating light upon the sample and receiving optics that collect ligh... | 07/06/2004 |
| 6411838 | Systems and methods for optical examination of samples The present invention relates to systems and methods for examining a sample using a substantially monostatic, substantially confocal optical system comprising transmitting optics that focus an illuminating light upon the sample and receiving optics that c... | 06/25/2002 |
| 6411835 | Spectral volume microprobe arrays Methods and apparatus are provided for determining a characteristic of a sample of a material by the interaction of electromagnetic radiation with the sample. The apparatus includes a source of electromagnetic radiation, an optical assembly and a detector... | 06/25/2002 |
| 6385484 | Spectroscopic system employing a plurality of data types A system and method for classifying specimens using a plurality of spectral data types. Spectra are recorded as amplitudes at a series of discrete wavelengths. Pluralities of reference spectra are recorded for specimens having known conditions. A spectrum... | 05/07/2002 |
| 5813987 | Spectral volume microprobe for analysis of materials An optical probe collects light emanating from a specimen that selectively andpreferentially represents a localized volume element within the sample, with illuminationintensity and collection efficacy both dropping off away from the localized volume eleme... | 09/29/1998 |