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Assignee: McLean Hospital Corporation


Location: Belmont, MA
No. of patents: 19

NumberTitleIssue Date
8168169Methods and compositions for the treatment of medical disorders
In general, the invention relates to marrow-derived adult progenitor cells (MAPCs) and their use in methods of treating various medical disorders, typically caused by or involving loss of cells or loss of cell function. These cells, when administered, e.g., intranas...
05/01/2012
8047979Magnetic field treatment techniques
The invention involves enhancing brain function by stimulating the brain using magnetic fields. Applications of the new methods include improving the condition of individuals with cognitive disorders, such as depression, and studying the effects of neural stimulatio...
11/01/2011
7945392Methods and systems for drug screening and computational modeling based on biologically realistic neurons
A method for screening a test composition for potential efficacy in treatment of a disorder includes a first computer model representative of a volume of disease-afflicted neural tissue comprising biologically realistic neurons exposed to the test composition; and p...
05/17/2011
7570049Inter-subject coherence in DT-MRI
A method for estimating a value of a diffusion tensor includes obtaining, from a plurality of test subjects, DT-MRI data from which an initial estimate of the tensor can be derived. Values indicative of intra-subject variation and inter-subject variation in the data...
08/04/2009
7291628Treatment of cocaine abuse using N-substituted derivatives of morphinan
The invention is based in part on the discovery that nonselective κ agonists that possess μ receptor-mediated effects in addition to their κ agonist effects can decrease cocaine self-administration more effectively and with fewer undesirable side effects than can...
11/06/2007
7282021Magnetic field stimulation techniques
The invention involves enhancing brain function by stimulating the brain using magnetic fields. Applications of the new methods include improving the condition of individuals with cognitive disorders, such as depression, and studying the effects of neural stimulatio...
10/16/2007
7268551Inter-subject coherence in DT-MRI
A method for estimating a value of a diffusion tensor includes obtaining, from a plurality of test subjects, DT-MRI data from which an initial estimate of the tensor can be derived. Values indicative of int-subject variation and inter-subject variation in the data a...
09/11/2007
7037260Method and apparatus for determining attention deficit hyperactivity disorder (ADHD) medication dosage and for monitoring the effects of ADHD medication on people who have ADHD using complementary tests
A method for determining the appropriate dosage of a medication to treat Attention Deficit Hyperactivity Disorder (ADHD) in an individual who has ADHD. The method comprises sampling the peripheral skin temperature of left and right like extremities of an individual ...
05/02/2006
7033312Magnetic field stimulation techniques
The invention involves enhancing brain function by stimulating the brain using magnetic fields. Applications of the new methods include improving the condition of individuals with cognitive disorders, such as depression, and studying the effects of neural stimulatio...
04/25/2006
6861840Generation of synthetic nuclear magnetic resonance signals
The invention involves an active phantom that transmits a waveform based on data reflecting free induction decay signals. The methods and apparatuses of the invention can be used, for example, to test and calibrate a magnetic resonance scanner; evaluate image acquis...
03/01/2005
6844438N-substituted derivatives of morphinan and uses thereof
The invention is based in part on the discovery that nonselective κ agonists that possess μ receptor-mediated effects in addition to their κ agonist effects can decrease cocaine self-administration more effectively and with fewer undesirable side effects than can...
01/18/2005
6804384Color magnetic resonance imaging
The invention involves color magnetic resonance imaging using both a magnetic resonance property and a function of the magnetic resonance property. These enhanced color images provide greater informational content to the viewer. Applications include color imaging of...
10/12/2004
6617169Two-dimensional MR spectroscopy techniques
The invention features methods of selecting chemical peaks from two-dimensional magnetic resonance spectra for one-dimensional extraction and quantification methods using these one-dimensional extractions. The methods permit enhanced differentiation of pa...
09/09/2003
6572528Magnetic field stimulation techniques
The invention involves enhancing brain function by stimulating the brain using magnetic fields. Applications of the new methods include improving the condition of individuals with cognitive disorders, such as depression, and studying the effects of neural...
06/03/2003
6181832Methods and systems for removing artifacts introduced by image registration
The invention features a method for determining a set of post-registration correction terms that correct for artifacts introduced by an algorithm used to register images represented by values at an array of points, the method including: providing a series...
01/30/2001
6130048Method of diagnosing Alzheimer's disease
Disclosed is a method of diagnosing Alzheimer's disease in a patient by measuring the level of a lysosomal hydrolase or lysosomal protease inhibitor in the patient's cerebrospinal fluid. The invention also features methods of measuring the progression of ...
10/10/2000
6083713Cloning and expression of 댪PP-C100 receptor (C100-R)
The present invention relates to the cloning of 댪PP-C100 receptor (C100-R), and genetically engineered host cells which express the C100-R. Such engineered cells may be used to evaluate and screen drugs and analogs of ଲ-APP involved in Alzhei...
07/04/2000
5854392ଲ APP-C100 receptor
The present invention relates to the cloning of 댪PP-C100 receptor (C100-R), and genetically engineered host cells which express the C100-R. Such engineered cells may be used to evaluate and screen drugs and analogs of ଲ-APP involved in Alzhei...
12/29/1998
5149626Multiple antigen immunoassay
The invention relates to an assay for one or more analytes which comprises contacting a sample suspected of containing one or more analytes with a solid phase containing one or more different antigen specific antibodies separately immobilized to defined a...
09/22/1992
 
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