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| Number | Title | Issue Date |
| 6890908 | Modified ribozymes The present invention refers to an RNA molecule with catalytic activity comprising at least one modified nucleoside, wherein the hydroxy group at the 2′-position of the ribose sugar is replaced by a modifier group, selected from halo, sulfhydryl, azido, amino, mon... | 05/10/2005 |
| 6548641 | PTP 1D: a novel protein tyrosine phosphatase A novel protein tyrosine phosphatase is the protein designated PTP 1D. The PTP 1D protein may be produced by recombinant means, for example using a nucleic acid construct encoding the protein as provided herein. Also disclosed is an antibody specific for ... | 04/15/2003 |
| 6506393 | Methods of treating protozoal diseases The invention concerns a new pharmaceutical agent for oral or topical administration in the treatment of protozoal diseases, in particular of leishmaniasis, which contains as the active substance one or several compounds having the general formula I ... | 01/14/2003 |
| 6492495 | PTP-S31: a novel protein tyrosine phosphatase A novel protein tyrosine phosphatase designated PTP-S31 and its subfamily are identified, as are nucleic acid molecule coding therefor. Included in this;family are PTP-S31 proteins or glycoproteins having one, two, or three identified amino acid changes i... | 12/10/2002 |
| 5980915 | Process for the production of a pharmaceutical agent for oral or topical administration in the treatment of leishmaniasis The invention concerns a new pharmaceutical agent for oral or topical administration in the treatment of protozoal diseases, in particular of leishmaniasis, which contains as the active substance one or several compounds having the general formula I ... | 11/09/1999 |
| 5916884 | Compositions containing a mixture of phosphorus compounds and alkylglycerols Cytotoxic therapeutic compositions contain as active ingredients compounds of the formula R--Y--POθ2 --X--R1 wherein R is a saturated or unsaturated hydrocarbon radical of 12 to 14 carbon atoms which may also be halogen-substi... | 06/29/1999 |
| 5885584 | Regeneration of oligodendrocytes The invention concerns a process for improving the regeneration of oligodendrocytes, in particular of human oligodendrocytes, in which oligodendrocytes are treated in cell culture with nerve growth factor (NGF) or active fragments of NGF. Furthermore a co... | 03/23/1999 |
| 5859331 | Modular promoter construct A modular promoter construct is described which possesses a promoter which is active in plant cells and a DNA sequence from exon 1 of the rice actin 1 gene. This modular promoter construct gives rise, where appropriate together with additional regulatory ... | 01/12/1999 |
| 5817635 | Modified ribozymes The claimed invention is drawn to RNA molecules with catalytic activity comprising at least one modified nucleoside having a modifier group replacing the hydroxy group at the 2'-position of the ribose sugar where the modifier group is an halo, amino, mono... | 10/06/1998 |
| 5780030 | Passive vaccine against Lyme disease The present invention provides a vaccine against Lyme disease, wherein it contains one or more monoclonal antibodies which are specific for the 31 kD antigen (OspA) or the 34 kD antigen (OspB) of Borrelia burgdorferi. The present invention also provides a... | 07/14/1998 |
| 5766847 | Process for analyzing length polymorphisms in DNA regions A process for analyzing length polymorphism in DNA regions wherein the following steps are carried out: (a) annealing at least one primer pair to the DNA to be analyzed, wherein one of the molecules of the primer pair is substantially complementary to one... | 06/16/1998 |
| 5747269 | Determination of peptide motifs on MHC molecules The present invention concerns a method for the determination of allele-specific peptide motifs on molecules of the major histocompatibility complex (MHC) of classes I and II as well as the peptide motifs which are obtainable by the method according to th... | 05/05/1998 |
| 5714765 | Method of fabricating a compositional semiconductor device A method of fabricating a compositional semiconductor device comprising a antum well wire or quantum dot superlattice structure, in particular a device selected from the group comprising lasers, photodiodes, resonant tunneling transistors, resonant tunnel... | 02/03/1998 |
| 5698687 | Modified ribozymls The present invention refers to an RNA molecule with catalytic activity comprising at least one modified nucleoside, wherein the hydroxy group at the 2'-position of the fibose sugar is replaced by a modifier group, selected from halo, sulfhydryl, azido, a... | 12/16/1997 |
| 5686267 | Nucleic acid molecule encoding antigen associated with lyme disease A vaccine against Lyme disease, wherein it contains one or more monoclonal antibodies which are specific for the 31 kD antigen (OspA) or the 34 kD antigen (OspB) of Borrelia burgdorferi. The present invention also provides a process for obtaining this vac... | 11/11/1997 |
| 5672695 | Modified ribozymes The claimed invention is drawn to RNA molecules with catalytic activity comprising at least one modified nucleoside having a modifier group replacing the hydroxy group at the 2'-position of the ribose sugar where the modifier group is an halo, amino, mono... | 09/30/1997 |
| 5624705 | Method of producing a device comprising a luminescent material Siloxene and siloxene derivatives are compatible with silicon and may be generated as epitaxial layer on a silicon monocrystal. This permits the production of novel and advantageous electroluminescent devices, such as displays, image converters, optoelect... | 04/29/1997 |
| 5610024 | Method for the determination of lupus anticoagulant antibodies that cause thrombosis In order to determine lupus anticoagulant (LA) antibodies in blood, plasma or tissue samples by means of the inhibitory effect of these antibodies on the neutralizing effect of protein C on the blood coagulation system, a defined amount of activated prote... | 03/11/1997 |
| 5582665 | Process for sealing at least one well out of a number of wells provided in a plate for receiving chemical and/or biochemical and/or microbiological substances, and installation for carrying out the process A plate having wells therein for receiving chemical substances is provided with a coverplate covering said filled wells. The process for sealing the wells by providing a joining seam running around the wells provides the joining seam such that it has a pr... | 12/10/1996 |
| 5578379 | Device comprising a luminescent material Siloxene and siloxene derivatives are compatible with silicon and may be generated as epitaxial layer on a silicon monocrystal. This permits the production of novel and advantageous electroluminescent devices, such as displays, image converters, optoelect... | 11/26/1996 |
| 5529792 | Inhibitors of endothelial cell proliferation In order to isolate an inhibitor of the proliferation of endothelial cells from the tissue of vertebrates the tissue selected as the starting material e.g. embryonic tissue or adult brain tissue from birds or mammals, is centrifuged, homogenized and subse... | 06/25/1996 |
| 5479013 | STM probe STM probe, in particular for use in an SEM for examining a surface of a sle by STM and/or SEM operation, comprising an outer and an inner piezotube; an object carrier plate mounted on the annular top face of the inner piezotube; a triangular head plate m... | 12/26/1995 |
| 5434077 | Borrelia burgdorferi strain 257 The present invention provides a vaccine against Lyme disease, wherein it contains one or more monoclonal antibodies which are specific for the 31 kD antigen (OspA) or the 34 kD antigen (OspB) of Borrelia burgdorferi. The present invention also provides a proc... | 07/18/1995 |
| 5404238 | Flashlight illuminating apparatus for a microscope Illuminating apparatus for a microscope including a semitransparent, in picular dichroic, microscope mirror for reflecting illuminating light from an external illuminating unit into a microscope beam path. The illuminating unit comprises a coupling-in un... | 04/04/1995 |
| 5400176 | Illuminating apparatus comprising a fiber light guide for a microscope Illuminating apparatus for a microscope comprising a light source and fil changer which is arranged in a beam path between the light source and a specimen location of the microscope. The light source and the filter changer are arranged in a unit spatiall... | 03/21/1995 |
| 5396089 | Method of generating active semiconductor structures by means of starting structures which have a 2D charge carrier layer parallel to the surface A unipolar electronic component is proposed with a quasi one dimensional carrier channel which has all the characteristics of an FET. This component can be very simply produced, has "self-alignment" and linear gates with a low capacity in place of planar ... | 03/07/1995 |
| 5365063 | Method and apparatus of quantitative non-resonant photoionization of neutral particles and the use of such apparatus A method and an apparatus for non-resonant photoionization of multiple species of neutral particles of a gas in which the neutral particles are ionized in an ionization space by a laser beam having a maximum intensity above the saturation intensity for io... | 11/15/1994 |
| 5338692 | Method of generating active semiconductor structures by means of starting structures which have a 2D charge carrier layer parallel to the surface A unipolar electronic component is proposed with a quasi one dimensional carrier channel which has all the characteristics of an FET. This component can be very simply produced, has "self-alignment" and linear gates with a low capacity in place of planar ... | 08/16/1994 |
| 5332911 | Semiconductor component with adiabatic transport in edge channels A semiconductor radiation detector with layer-wise construction and a contive region having a two-dimensional or quasi one-dimensional electron or hole gas is provided in which adiabatic transport in edge channels occurs at least regionally and in which ... | 07/26/1994 |
| 5322601 | Amperometric gas sensor to selectively determine the partial pressures of a gas The invention concerns as amperometric gas sensor for the selective deteration with high accuracy of a gas partial pressures. Such a gas sensor includes a solid electrolyte and inert electrodes. The solid electrolyte, contained in the sensor, is selected... | 06/21/1994 |
| 5312864 | -cyanoacrylate adhesive compositions The setting properties of an -cyanoacrylate adhesive composition are ccelerated by adding thereto a hydroxyl group derivative of an -, ଲ- or γ-cyclodextrin which is at least partly soluble in the -cyanoacrylate.... | 05/17/1994 |
| 5310655 | Process for the detection of kidney tubule functioning In the case of a process for the detection of the functionability of the kidney tubules, one specifically determines the content of THP in the urine as measure of the function of the kidney tubules. One uses this process for the control of the transplant ... | 05/10/1994 |
| 5303254 | Transversely discharge-pumped gas laser A transversely discharge-pumped gas laser has a discharge vessel, which encloses a laser gas and at least one pair of oppositely disposed elongated discharge electrodes which extend in a predetermined longitudinal direction and are separated by a discharg... | 04/12/1994 |
| 5301216 | Method of operating a nuclear reactor with emergency cooling system economy A new nuclear reactor or nuclear power plant, as a light water reactor (LWR), including a high-converting LWR, a heavy water reactor, a gas cooled reactor, a high temperature reactor, a fast breeder, with given maximum and effective output power (installe... | 04/05/1994 |
| 5300890 | Hot-cathode ionization pressure gauge including a sequence of electrodes arranged at a distance from one another in sequence along an axis A hot cathode ionization pressure gauge with the following electrodes, arged at a distance from one another in the specified sequence along an axis: (a) a thermionic cathode filament which has a central active part and lateral support parts; (b) an essen... | 04/05/1994 |
| 5290699 | Double mutants of bacteriorhodopsin Double mutants of bacteriorhodopsin are mutated in the amino acid positions 85 and 96 and are expressed in Halobacteria. The mutants have an altered absorption maximum of their ground state and of their intermediate with the longest life. These mutants pu... | 03/01/1994 |
| 5268270 | Process for producing proteins using gram negative host cells For the gene-technological production of proteins, a vector is introduced to gram-negative host cells which contains at least one gene coding translated. For the extracellular obtaining of the proteins its coding gene is so inserted into a vector which co... | 12/07/1993 |
| 5252475 | Methods and vectors for selectively cloning exons The invention relates to a method for selectively cloning exons in which an ukaryotic genomic DNA fragment to be assayed is cloned into a shuttle vector in a cloning site of an intron flanked by exons. Upon expression in eukaryotic cells, exons present in ... | 10/12/1993 |
| 5243589 | Method for recording information in an optically readable data memory In a method for recording information in an optical data memory by surface exturing, a substrate surface is first pre-treated or sensitized by selective irradiation at relatively low fluence. For selectivity of irradiation, a mask, a holographic imaging pr... | 09/07/1993 |
| 5202788 | Electrochromic device with ionically or mixed ionically-electronically conductive electrolyte The present invention provides an electrochromic device which is especially suitable as a window, mirror or display element, characterized by a multi-layer construction with at least one layer, enclosed between two coated electrodes, of a material which i... | 04/13/1993 |
