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Assignee: Massachusetts Eye and Ear Infirmary


Location: Boston, MA
No. of patents: 28

NumberTitleIssue Date
8045177Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy
An apparatus and method according to an exemplary embodiment of to the present invention can provide imaging information associated with at least one portion of a sample. For example, at least two first different wavelengths of at least one first electro-magnetic ra...
10/25/2011
7972787Methods for detecting age-related macular degeneration
The invention provides methods and compositions for determining whether a subject is at risk of developing age-related macular degeneration, for example, the wet or neovascular form of age-related macular degeneration. The method involves determining whether the sub...
07/05/2011
7901076Ocular wavefront-correction profiling
Providing multi-focal visual correction includes determining a plurality of visual conditions to which an eye is to be exposed, determining effects of the visual conditions on a pupil of the eye, and determining a target wavefront profile on the basis of the effects...
03/08/2011
7867193Drug delivery apparatus
An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a body cavity of a patient over a period of time, which includes a hollow member that defines at least one lumen for facilitating a unidirectional recirculating flow of a therapeutic...
01/11/2011
7811832Methods for preserving the viability of photoreceptor cells by anti-FAS-ligand/anti-FAS-receptor antibodies
Provided are methods and compositions for maintaining the viability of photoreceptor cells following retinal detachment. The viability of photoreceptor cells can be preserved by administering an apoptosis inhibitor to a mammal having an eye with retinal detachment. ...
10/12/2010
7803375Methods and compositions for treating conditions of the eye
Provided are methods and compositions for treating ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example, neovascular age-related macular degeneration. The selectivity and sensitivity of, for example, a photodynamic therap...
09/28/2010
7666912Compositions and methods for reducing body fat
The present invention relates to compositions, such as bimatoprost, latanoprost and travoprost, and methods to reduce fat in the body of an individual, for example, by topical administration, injection, and/or implantation of such compositions. ...
02/23/2010
7592330Methods and compositions for preserving the viability of photoreceptor cells
Provided are methods and compositions for maintaining the viability of photoreceptor cells following retinal detachment. The viability of photoreceptor cells can be preserved by administering a neuroprotective agent, for example, a substance capable of suppressing e...
09/22/2009
7563255Implantable drug delivery device and use thereof
The invention provides a miniaturized, implantable drug delivery device and a method of delivering over a prolonged period of time one or more drugs using such a device. The drug delivery device can be adapted for attachment to the outer surface of an eye. Once atta...
07/21/2009
7419666Treatment of ocular disorders
The invention includes a method of treating an intraocular disorder in a mammal, the method comprising administering to the mammal a Very Late Antigen-4 (VLA-4) antagonist for the treatment of selected ocular disorders. ...
09/02/2008
7384735Retinoblastoma nucleic acids
This invention relates to nucleic acid, or fragments thereof, encoding the retinoblastoma polypeptide, the retinoblastoma polypeptide itself, methods of detecting a defective retinoblastoma gene in human patients, and methods of treating these patients. ...
06/10/2008
7223842Detection of proteins whose absence is associated with a neoplasm
This invention relates to nucleic acid, or fragments thereof, encoding the retinoblastoma polypeptide, the retinoblastoma polypeptide itself, methods of detecting a defective retinoblastoma gene in human patients, and methods of treating these patients. ...
05/29/2007
7125542Methods and compositions for treating conditions of the eye
Provided are methods and compositions for the photodynamic therapy (PDT) of ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example, neovascular age-related macular degeneration. The selectivity and sensitivity of the PDT me...
10/24/2006
6610679Use of green porphyrins to treat neovasculature in the eye
Photodynamic therapy of conditions of the eye characterized by unwanted neovasculature, such as age-related macular degeneration, is effective using green porphyrins as photoactive agents, preferably as liposomal compositions....
08/26/2003
6482854Glaucoma treatment
Elevated glutamate levels are associated with glaucoma, and damage to retinal ganglion cells can be controlled by administering to the patient a compound capable of reducing glutamate induced excitotoxicity in a concentration effective to cause reduction ...
11/19/2002
6324429Chronically implantable retinal prosthesis
A combination of silicon processing technology advances and increased understanding of the mechanisms underlying phosphene generation in human retinas by surface electrical stimulation has now made it possible to conceive of a chronically implantable reti...
11/27/2001
6225303Use of green porphyrins to treat neovasculature in the eye
Photodynamic therapy of conditions of the eye characterized by unwanted neovasculature, such as age-related macular degeneration, is effective using green porphyrins as photoactive agents, preferably as liposomal compositions....
05/01/2001
6120538Intra-ocular lens system including microelectric components
Dynamically functional intra-ocular prosthesis. The prosthesis includes an implantable intra-ocular lens and microelectronic components mounted on the lens. One embodiment is a variable focal length implantable intra-ocular lens system for adjusting the f...
09/19/2000
5922773Glaucoma treatment
Elevated glutamate levels are associated with glaucoma, and damage to retinal ganglion cells can be controlled by administering to the patient a compound capable of reducing glutamate induced excitotoxicity in a concentration effective to cause reduction ...
07/13/1999
5863948Increasing aqueous humor outflow
A method of increasing aqueous humor outflow in the eye of a human patient to treat glaucoma, the method comprising topically administering to the eye an outflow-increasing amount of an analog of ethacrynic acid having a margin of safety of at least 2.0 a...
01/26/1999
5853988Diagnosis of retinoblastoma
This invention relates to nucleic acid, or fragments thereof, encoding the retinoblastoma polypeptide, the retinoblastoma polypeptide itself, methods of detecting a defective retinoblastoma gene in human patients, and methods of treating these patients....
12/29/1998
5729658Evaluating intelligibility of speech reproduction and transmission across multiple listening conditions
A method of calculating a single number summarizing the performance of a device for transmitting, amplifying, or reproducing acoustic speech signals. The number can be used for evaluation and comparison of characteristics of devices for conveying speech, ...
03/17/1998
5627195Treatment for ocular inflammation
A method of treating a subject with ocular inflammation associated with keratitis or conjunctivitis, which method includes administering to the subject an amount of a pharmaceutical composition containing tetrandrine or a tetrandrine agonist, the amount b...
05/06/1997
5597381Methods for epi-retinal implantation
A method for epi-retinal implantation of an object into a subject is disclosed. The method includes rendering the normally transparent cortical vitreous visible and separating at least a portion of a cortical vitreous of the subject away from an adherent ...
01/28/1997
5306731Method and products for treating the eye
This invention is directed to improved treatment for glaucoma. It involves delivering to the eye molecules which increase the outflow of aqueous humor, in conjunction with masking agents. The masking agents reduce the side effects of the therapeutically a...
04/26/1994
5005230Patient transporter
A patient-transporting system including a combined transport stretcher/operating room table, means for securely transporting medications and medical records, and a patient-jumpsuit. The means for securely transporting medications and medical records is mo...
04/09/1991
4807617Scavenging mask
Removable apparatus suitable for scavenging gas from the vicinity of a gas delivery mask applied to a face. The mask has a convex outer surface, and the apparatus comprises a cup having an inner concave surface adapted to form a gap between it and the con...
02/28/1989
4757089Increasing aqueous humor outflow
A method of increasing aqueous humor outflow in the eye of a human patient including topically administering to the eye an outflow increasing amount of a compound characterized in that it contains one or more groups capable of reacting with sulfhydryl gro...
07/12/1988
 
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