Assignee: Massachusetts Eye & Ear Infirmary

Location: Boston, MA
No. of patents: 44

Number	Title	Issue Date
8173121	Lysyl oxidase-like 1 (LOXL1) and elastogenesis Described are methods of treating and preventing conditions associated with a loss of elastic fibers. Also provided herein are methods of screening for agents useful in treating such conditions, and animal models of conditions associated with a loss of elastic fiber...	05/08/2012
8128618	Targeted muscle ablation for reducing signs of aging A method and system for delivering energy to affect the signs of aging is described. Energy is delivered to a target volume of a muscle such that the energy creates a lesion in the target volume. A characteristic of the lesion is controlled to affect movement of the...	03/06/2012
8092398	Multi-axis tilt estimation and fall remediation Among other things, a vestibular prosthesis includes a wearable motion sensing system, the motion sensing system generating a motion signal indicative of a motion thereof, wherein the motion includes rotation about two distinct axes; a signal processor in communicat...	01/10/2012
8007435	Tissue retraction device A self-retaining retractor is described. The retractor can be sized for small patients, such as young children or infants or some animals. The retractor has two blades that are capable of holding tissue separated during a procedure, such as a tracheotomy. ...	08/30/2011
7962217	Vestibular stimulator A method for providing relief from Meniere's disease, includes reversibly disabling vestibular function following detection of an attack of Meniere's disease following detection of an attack of Meniere's disease. ...	06/14/2011
7933654	Vestibular stimulator An apparatus for stimulating the vestibular system includes an actuator disposed to interact with the vestibular nerve and a controller for causing the actuator to interact with the vestibular nerve. The result of the interaction is that the brain receives a station...	04/26/2011
7912542	Sensor signal alignment Methods and systems, including computer readable mediums, are provided for transforming a measurement made relative to a first reference frame into a corresponding measurement relative to a second reference frame. Sensor signals that are produced by sensors in respo...	03/22/2011
7897581	Methods and compounds for promoting vessel regression The present invention relates, at least in part, to methods and compositions for treating and diagnosing disorders associated with neovascularization, and methods for identifying targets and compositions used in treating and diagnosing such disorders. ...	03/01/2011
7811235	Aerodynamic tissue driver An apparatus for causing air flow to vibrate a selected tissue includes a tube and a deflector. The tube defines a passage for guiding air flow from an inlet to an outlet thereof. The deflector is disposed to receive the air flow from the outlet of the tube. The con...	10/12/2010
7789838	Audible range oculocometry for assessment of vestibular function A method for assessing vestibular system function includes stimulating the inner ear with an audible range signal; collecting data representative of audible range ocular motion; and on the basis of the data, evaluating vestibular system function. ...	09/07/2010
7753952	Vision prosthesis orientation A vision prosthesis includes an optical element having a surface that is shaped to be positioned near a cornea of an eye, and a magnetic element embedded in the optical element. ...	07/13/2010
7730892	Mechanical vestibular stimulator An apparatus to stimulate the vestibular system of an individual. The apparatus comprises an actuator configured to mechanically stimulate a semicircular canal, and a control module coupled to the actuator that controls the actuator in response to motion information...	06/08/2010
7674458	Lysyl oxidase-like 1 (LOXL1) and elastogenesis Described are methods of treating and preventing conditions associated with a loss of elastic fibers. Also provided herein are methods of screening for agents useful in treating such conditions, and animal models of conditions associated with a loss of elastic fiber...	03/09/2010
7662945	Neostatins The invention provides fragments of type XVIII collagen termed neostatins, and methods for their use in the treatment of ophthalmological disorders associated with angiogenesis. ...	02/16/2010
7488341	Method for optical stimulation of the vestibular system An apparatus to stimulate the vestibular system of an individual. The apparatus comprises an optical stimulator configured to optically stimulate a nerve area affecting a person's balance, and a control module coupled to the optical stimulator, the control module be...	02/10/2009
7457434	Adaptively focusing extra-ocular vision prostheses A vision prosthesis includes an actuator in communication with an extra-ocular lens. The actuator providing a focusing stimulus to vary a focal length of the lens. A rangefinder estimates a range to an object and provides the range estimate to a controller. The cont...	11/25/2008
7454246	Sensor signal alignment Methods and systems, including computer readable mediums, are provided for transforming a measurement made relative to a first reference frame into a corresponding measurement relative to a second reference frame. Sensor signals that are produced by sensors in respo...	11/18/2008
7402175	Vision prosthesis orientation A vision prosthesis includes an optical element having a surface that is shaped to be positioned near a cornea of an eye, and a magnetic element embedded in the optical element. ...	07/22/2008
7341345	Ocular wavefront-correction profiling Providing multi-focal visual correction includes determining a plurality of pupil conditions for an eye and determining a target wavefront profile on the basis of the plurality of pupil conditions. ...	03/11/2008
7331668	Ocular wavefront-correction profiling Providing multi-focal visual correction includes determining a plurality of visual conditions to which an eye is to be exposed, determining effects of the visual conditions on a pupil of the eye, and determining a target wavefront profile on the basis of the effects...	02/19/2008
7270677	Polarization-sensitive vision prosthesis A vision prosthesis includes a first detector disposed to detect a polarization state of light reflected from a retina, and a controller in communication with the first detector. The controller is configured to receive, from the detector, a measurement signal indica...	09/18/2007
7261736	Vision prosthesis with artificial muscle actuator A visual prosthesis includes an artificial muscle configured to deform in response to a focusing signal. The artificial muscle is coupled to at least a portion of an optical system for changing a focal point thereof. ...	08/28/2007
7255857	Lysyl oxidase-like 1 (LOXL1) and elastogenesis Described are methods of treating and preventing conditions associated with a loss of elastic fibers. Also provided herein are methods of screening for agents useful in treating such conditions, and animal models of conditions associated with a loss of elastic fiber...	08/14/2007
7255856	Lysyl oxidase-like 1 (LOXL1) and elastogenesis Described are methods of treating and preventing conditions associated with a loss of elastic fibers. Also provided herein are methods of screening for agents useful in treating such conditions, and animal models of conditions associated with a loss of elastic fiber...	08/14/2007
7229476	Intraocular lens positioning An optical element is adapted for implantation into a vitreous chamber of an eye, and a suspension system is configured to position a portion of the optical element to intersect a visual axis of an eye. ...	06/12/2007
7186233	Dry eye treatment A dry-eye treatment method includes collecting fluid from the inside of the eye and transporting the collected fluid into the eyelid fornix, where it accumulates. At each blink, accumulated fluid from the fornix is spread across the surface of the eye. ...	03/06/2007
7156821	Shunt with enclosed pressure-relief valve A shunt for relief of intra-ocular pressure includes a pressure-relief valve and a jacket enclosing the pressure relief valve. When implanted on the sclera of an eye, the jacket protects the valve from interference by a capsule formed on the shunt. ...	01/02/2007
7141065	Polarization-sensitive vision prosthesis A method for controlling a vision prosthesis having an optical system in optical communication with the retina, the method including detecting a polarization state of light reflected from a retina; and at least in part on the basis of the polarization state, generat...	11/28/2006
7041133	Vision prosthesis A vision prosthesis includes a lens having an index of refraction that varies in response to a focusing stimulus. An actuator in communication with the lens provides the focusing stimulus on the basis of a range estimate from a rangefinder. A controller coupled to t...	05/09/2006
7014657	Middle-ear implant This invention relates to surgical methods and prosthetic devices for ameliorating hearing loss in patients having ailments of the middle ear. The implant of the invention includes a gas-filled balloon having a pliant membrane of biocompatible material. The balloon ...	03/21/2006
7015039	Separating epithelium from stroma in LASEK surgery A method of separating the epithelium and the stroma of a cornea includes providing a solution that includes a detaching agent diluted in a culture medium and applying the solution to the surface of the cornea. ...	03/21/2006
6976998	Minimally invasive retinal prosthesis An ocular device that can more safely and effectively perform all functions needed of a retinal prosthesis with electronic components that are placed outside the wall of an eye, are powered wirelessly provided by an external power source, and which provide a patient...	12/20/2005
6968228	Measurement of electrophysiologic response A method for estimating an electrophysiologic response contained in a measured signal includes obtaining a plurality of samples and defining a plurality of bins, each of which corresponds to a range of values of a sorting parameter associated with each of the sample...	11/22/2005
6758823	Assessment of retinal function A method for assessing a patient's retinal function includes selecting a test site on a retina of the patient and stimulating the test site. In a healthy retina, this stimulation results in the generation of an entoptic signal, which is then detected. The method thu...	07/06/2004
6758852	Corneal flap slicer An apparatus for forming a corneal flap includes a housing from which extend a shaft and a reciprocating member. An aplanating member is mounted at a distal end of the shaft to aplanate a region of the cornea. A cutting blade is mounted to the reciprocating member a...	07/06/2004
6743183	Simultaneous stimulation of an auditory system A method for measuring an electrophysiologic response of a sensory system includes stimulating the sensory system with a first stimulus train having stimuli temporally separated from each other by a first inter-stimulus interval and simultaneously stimulating the se...	06/01/2004
6718199	Measurement of electrophysiologic response A method for estimating an electrophysiologic response contained in a measured signal includes obtaining a plurality of samples and defining a plurality of bins, each of which corresponds to a range of values of a sorting parameter associated with each of the sample...	04/06/2004
6638304	Vision prosthesis A vision prosthesis includes a lens having an index of refraction that varies in response to a focusing stimulus. An actuator in communication with the lens provides the focusing stimulus on the basis of a range estimate from a rangefinder. A controller c...	10/28/2003
6546291	Balance prosthesis A wearable balance prosthesis provides a information indicative of a wearer's spatial orientation. The balance prosthesis includes an motion sensing system to be worn by the wearer and a signal processor in communication with the motion sensing system. Th...	04/08/2003
6372463	Mutations in nucleic acid molecules encoding 11-CIS retinol dehydrogenase, the mutated proteins, and uses thereof The invention relates to mutations in the gene encoding 11-cis retinal dehyrogenase. The mutations in the gene and in the resulting encoded protein are correlated to ocular disorders, such as fundus albipunctatus....	04/16/2002

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Assignee: Massachusetts Eye & Ear Infirmary