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Assignee: Mallinckrodt Specialty Chemicals Company


Location: Chesterfield, MO
No. of patents: 7

NumberTitleIssue Date
5312991Surfactant improvement for para-aminophenol process
The compound p-aminophenol is prepared by catalytically hydrogenating nitrobenzene in an acidic reaction medium containing an amine of the formula (I) ##STR1## wherein R represents an alkyl group having from 6 to about 20 carbon atoms; R1
05/17/1994
5312970Method of preparing D-propoxyphene
D-propoxyphene can be prepared by reacting d-oxyphene and propionic anhydride. Preferably, an excess of propionic anhydride is used. The reaction easily proceeds at temperatures of 70° to 80° C. and produces yields exceeding 95 percent of theory. The fr...
05/17/1994
5306507Process and composition containing pamabrom and pyrilamine maleate
A product and process for preparing a pharmaceutical composition for forming tablets, the composition containing pamabrom and pyrilamine maleate. In preferred embodiments, the composition also contains acetaminophen. A fluid bed granulator is charged with...
04/26/1994
5284975Method of preparing ଱-d-phenylalkylbenzyl carbinol
A method of preparing an ଱-d-phenylalkylbenzyl carbinol by the reaction of a phenylbenzyl ketone with an alkali metal enolate of an amide to form an aldol adduct, which is reduced and purified to form an ଱-d-phenylalkylbenzyl carbinol, wherein...
02/08/1994
5254776Synthesis of bromobiphenyls
Bromobiphenyls (such as 2-fluoro-4-bromobiphenyl) are synthesized by reacting together a phenylboronic acid (such as phenylboronic acid) and a bromoiodobenzene (such as 2-fluoro-4-bromoiodobenzene). The reaction generally takes place with the aid of a cat...
10/19/1993
5227526Resolution of 3-dimethylamino-2-methylpropiophenone (3-DAMP)
In a process for resolving 3-dimethylamino-2-methylpropiophenone (3-DAMP) material, a methanol solution containing a mixture of both 1- and d-enantiomers of 3-DAMP is formed. To this solution, ditoluyl-(L)-tartaric acid or ditoluyl-(D)-tartaric acid is ad...
07/13/1993
5104648High ibuprofen content granulations
A granular pharmaceutical composition containing 85 to 99 percent ibuprofen, 0.9 to 15.0 percent binder, and 0.1 to 5.0 percent polyvinylpyrrolidone, wherein the polyvinylpyrrolidone forms a film with a portion of said binder to form agglomerates, is disc...
04/14/1992
 
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