Assignee: Magainin Pharmaceuticals Inc.

Location: PlymouthMeeting, PA
No. of patents: 24

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Number	Title	Issue Date
6610866	Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds A method is described for stereoselectively reducing an unsaturated alkyl ketone substituent attached to a fused ring base. In this method, the unsaturated alkyl ketone reacts with a chiral oxazaborolidine reagent. This reaction stereoselectively reduces ...	08/26/2003
6262283	Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds A method is described for stereoselectively reducing an unsaturated alkyl ketone substituent attached to a fused ring base. In this method, the unsaturated alkyl ketone reacts with a chiral oxazaborolidine reagent. This reaction stereoselectively reduces ...	07/17/2001
6147060	Treatment of carcinomas using squalamine in combination with other anti-cancer agents A method for treating a tumor includes a first treatment procedure using a conventional cancer treatment technique, and a second treatment procedure which includes administering an effective amount of squalamine. The first treatment procedure may be a tre...	11/14/2000
6143738	Therapeutic uses for an aminosterol compound A pharmaceutical composition includes, as an active ingredient, a compound according to formula 1436 as shown in FIG. 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient. Various pharmaceutical products...	11/07/2000
6037149	DNA encoding human asthma associated factor 1 A C to T DNA variation at position 3365 in exon 5 of the human Asthma Associated Factor 1 (AAF1) produces the predicted amino acid substitution of a methionine for a threonine at codon 117 of AAF1. When this substitution occurs in both alleles in one indi...	03/14/2000
5994336	Method of inhibiting proliferation of cells by administering an aminosterol compound A method of inhibiting the proliferation of a wide variety of cells is described. This method includes administering an effective amount of a compound having the following structure: ##STR1## or a pharmaceutically acceptable salt thereof. The prolife...	11/30/1999
5847172	Certain aminosterol compounds and pharmaceutical compositions including these compounds Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well a...	12/08/1998
5840936	Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE) Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well a...	11/24/1998
5840740	Aminosterol compounds and a method of treating infection using the aminosterol compounds Disclosed are aminosterol compounds 1360 and 1361: ##STR1## which can be obtained in isolated or purified form from the liver of the dogfish shark....	11/24/1998
5795885	Method of inhibiting profileration of cells by administering an aminosterol compound Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also disclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well ...	08/18/1998
5792831	Analogues of magainin peptides containing D-amino acids Biologically active analogues of magainin peptides wherein each amino acid residue of the peptide is a D-amino acid residue or a glycine residue. Examples of such peptides wherein each amino acid residue is a D-amino acid residue or a glycine residue incl...	08/11/1998
5763430	Method of treating a viral infection by administering a steroid compound A method of treating a viral infection includes administering an effective amount of a compound having the following structure: ##STR1## or a pharmaceutically acceptable salt thereof. This compound treats the viral infection by suppressing the growth...	06/09/1998
5733899	Method for treating infection using steroid based pharmaceutical compositions A method of treating a bacterial or fungal infection in a patient by administering an effective amount of a compound of Formula (III): ##STR1## wherein, the substituents are as defined in the specification....	03/31/1998
5734015	Family of linear antimicrobial peptides from hagfish intestine A new family of linear antimicrobial peptide from hagfish intestine is described. This invention relates to proteins with antimicrobial properties isolated from hagfish intestine and their corresponding chemical sequences. The antibiotics obtained include...	03/31/1998
5721226	Method for inhibiting angiogenesis using squalamine and squalamine steroid derivatives A method of inhibiting angiogenesis in a patient includes administering to the patient an effective amount of squalamine or a pharmaceutically acceptable salt of squalamine. Alternatively, a compound according to the following Formula (III) (or a pharmace...	02/24/1998
5686563	Biologically active peptides having n-terminal substitutions An N-terminal substituted peptide or protein having the formula: ##STR1## X is a biologically active amphiphilic ion channel-forming peptide or protein. T is a lipophilic moiety, and preferably, T is: ##STR2## wherein R is a hydrocarbon (alkyl o...	11/11/1997
5654451	Amino acids and peptides having modified C-terminals and modified N-terminals Compounds which have one of the following structural formulae: ##STR1## AA is an amino acid residue or an amino acid chain of two or more amino acid residues, excluding the N-terminal and the C-terminal from said amino acid residue or amino acid chai...	08/05/1997
5635479	Treatment of gynecological malignancies with biologically active peptides A process for treating a gynecological malignancy in a host which comprises administering to the host at least one biologically active amphiphilic peptide or protein. The peptide or protein may be administered intralesionally, intravenously, or intraperit...	06/03/1997
5589364	Recombinant production of biologically active peptides and proteins The present invention relates to the recombinant production of amphiphilic peptides with biologically and therapeutically significant activities. In one embodiment, this invention relates to recombinantly producing an amphiphilic peptide by providing a pr...	12/31/1996
5550109	Inducible defensin peptide from mammalian epithelia The present invention relates to an inducible antimicrobial peptide designated lingual antimicrobial peptide (LAP) which has antibacterial and antifungal activity and which can be obtained from mammalian epithelium. The prepro- and the pro- precursors of ...	08/27/1996
5470950	Biologically active amphiphilic peptide compositions and uses therefor Biologically active amphiphilic peptides including one of the following basic structures: I. R1 --R2 --R2 --R1 --R2 --R2 --R1 --R1 --R2 --R1 --R1...	11/28/1995
5459237	Peptide compositions and uses therefor A biologically active amphiphilic peptide which in accordance with an aspect of the present invention, includes one of the following basic structures X1 through X7, wherein: X1 is --[R1 --R2 --R2	10/17/1995
5424290	Biologically active peptides and uses therefor Novel biologically active amphiphilic peptides having from 21 to 26 amino acid residues, and which may be employed as for inhibiting the growth of target cells, viruses and virally-infected cells....	06/13/1995
5221664	Composition and treatment with biologically active peptides and toxic cations A composition comprising a biologically active amphiphilic ion channel-forming peptide or ion channel forming protein and a toxic cation, such as a silver cation. Such compositions may be employed as pharmaceuticals, particularly for the treatment and pre...	06/22/1993

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Assignee: Magainin Pharmaceuticals Inc.