William F. Semple, a dentist, was awarded the first US Patent on chewing gum in 1869. His recipe contained powdered chalk.
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| Number | Title | Issue Date |
| 5024743 | Methylendioxyphenathrene and stilben derivatives, process for the preparation thereof, pharmaceutical compositions using these, and therapeutic applications The present invention provides compounds of the general formula: ##STR1## where R1 is a hydrogen atom or a methoxy or ethoxy radical and R2 and R3 are hydrogen atoms or R2 and R3 together represe... | 06/18/1991 |
| 4859664 | Derivatives of 2,3,4,5,6,7-hexahydro-2,7-methano-1,5-benzoxazonines and -1,4-benzoxazonines, processes for their production and their use as pharmaceuticals New 2,3,4,5,6,7-hexahydro-2,7-methano-1,5-benzoxazonine and -1,4-benzoxazonine compounds of the formula ##STR1## have useful pharmaceutical properites. They are prepared from ketones of the formula ##STR2## via a lactone intermediate. In th... | 08/22/1989 |
| 4855422 | Process for the preparation of azoniaspironortropanol esters A method for preparing azoniaspironotropanol esters, esters thus produced, and methods of use for these is disclosed. The esters are effective as broncholytics and as agents in therapy of asthmatic conditions.... | 08/08/1989 |
| 4780476 | Azoniaspironortropanol esters as asthma therapeutics and broncholytics The present invention is concerned with the use of azoniaspironortropanol esters of the general formula: ##STR1## wherein R signifies one of the following radicals: (a) an alkylene radical of the general formula: ##STR2## in which R3 | 10/25/1988 |