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| Number | Title | Issue Date |
| 6831994 | System and apparatus for sequential processing of analytes An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside... | 12/14/2004 |
| 6806052 | Planar arrays of microparticle-bound polynucleotides An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside... | 10/19/2004 |
| 6720179 | Method and compositions for ordering restriction fragments The invention provides a method for constructing a high resolution physical map of a polynucleotide. In accordance with the invention, nucleotide sequences are determined at the ends of restriction fragments produced by a plurality of digestions with a plurality of ... | 04/13/2004 |
| 6654505 | System and apparatus for sequential processing of analytes An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar a... | 11/25/2003 |
| 6653077 | Method of screening for genetic polymorphism Method and materials are provided for screening for genetic polymorphism in a test population of DNA fragments. Heteroduplexes are formed between members of a test DNA population and their corresponding complements from a reference DNA population. Perfect... | 11/25/2003 |
| 6518023 | Method of mapping restriction sites in polynucleotides The invention provides a method for constructing a high resolution physical map of a polynucleotide. In accordance with the invention, the polynucleotide is digested successively with at least two different restriction endonucleases and the ends of the re... | 02/11/2003 |
| 6511802 | Solid phase selection of differentially expressed genes The invention provides a method and materials for monitoring and isolating differentially expressed genes. In accordance with the method of the invention, differently labeled populations of DNAs from sources to be compared are competitively hybridized wit... | 01/28/2003 |
| 6406848 | Planar arrays of microparticle-bound polynucleotides An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar a... | 06/18/2002 |
| 6352828 | Oligonucleotide tags for sorting and identification The invention provides a method of tracking, identifying, and/or sorting classes or subpopulations of molecules by the use of oligonucleotide tags. Oligonucleotide tags of the invention comprise oligonucleotides selected from a minimally cross-hybridizing... | 03/05/2002 |
| 6280935 | Method of detecting the presence or absence of a plurality of target sequences using oligonucleotide tags The invention provides a method of tracking, identifying, and/or sorting classes or subpopulations of molecules by the use of oligonucleotide tags. Oligonucleotide tags of the invention comprise oligonucleotides selected from a minimally cross-hybridizing... | 08/28/2001 |
| 6265163 | Solid phase selection of differentially expressed genes The invention provides a method and materials for monitoring and isolating differentially expressed genes. In accordance with the method of the invention, differently labeled populations of DNAs from sources to be compared are competitively hybridized wit... | 07/24/2001 |
| 6235475 | Oligonucleotide tags for sorting and identification The invention provides a method of tracking, identifying, and/or sorting classes or subpopulations of molecules by the use of oligonucleotide tags. Oligonucleotide tags of the invention comprise oligonucleotides selected from a minimally cross-hybridizing... | 05/22/2001 |
| 6228589 | Measurement of gene expression profiles in toxicity determination A method is provided for assessing the toxicity of a compound in a test organism by measuring gene expression profiles of selected tissues. Gene expression profiles are measured by massively parallel signature sequencing of cDNA libraries constructed from... | 05/08/2001 |
| 6214191 | Electrophoresis apparatus and method Disclosed are an apparatus, system, and method for two dimensional electrophoresis of analytes of interest, particularly polypeptides. The apparatus includes a sample separation cavity comprising (1) an electrophoresis region located along an upper portio... | 04/10/2001 |
| 6175002 | Adaptor-based sequence analysis An improvement in adaptor-based sequence analysis is provided that addresses the problems created by self-ligation of target polynucleotides that have complementary ends. The improvement includes preparation of target polynucleotides with dephosphorylated... | 01/16/2001 |
| 6172218 | Oligonucleotide tags for sorting and identification The invention provides a method of tracking, identifying, and/or sorting classes or subpopulations of molecules by the use of oligonucleotide tags. Oligonucleotide tags of the invention comprise oligonucleotides selected from a minimally cross-hybridizing... | 01/09/2001 |
| 6172214 | Oligonucleotide tags for sorting and identification The invention provides a method of tracking, identifying, and/or sorting classes or subpopulations of molecules by the use of oligonucleotide tags. Oligonucleotide tags of the invention comprise oligonucleotides selected from a minimally cross-hybridizing... | 01/09/2001 |
| 6169170 | Oligonucleotide N3'.fwdarw.N5'Phosphoramidate Duplexes Modified oligonucleotides 3'-NHP(O)(O-)O-5' phosphoramidates were synthesized on a solid phase support. The phosphoramidate analogs were found to have significantly increased resistance toward phosphodiesterase digestion. Thermal dissociation e... | 01/02/2001 |
| 6150516 | Kits for sorting and identifying polynucleotides The invention provides a method of tracking, identifying, and/or sorting classes or subpopulations of molecules by the use of oligonucleotide tags. Oligonucleotide tags of the invention comprise oligonucleotides selected from a minimally cross-hybridizing... | 11/21/2000 |
| 6140489 | Compositions for sorting polynucleotides The invention provides a method and materials for sorting polynucleotides with oligonucleotide tags. Oligonucleotide tags of the invention are capable of hybridizing to complementary oligomeric compounds consisting of subunits having enhanced binding stre... | 10/31/2000 |
| 6138077 | Method, apparatus and computer program product for determining a set of non-hybridizing oligonucleotides The invention provides a computerized method, associated apparatus, and computer program product for determining a set of non-hybridizing oligonucleotides. The invention represents a first oligonucleotide in the computer's memory, generates a set of oligo... | 10/24/2000 |
| 6048974 | Oligonucleotide clamps having diagnostic and therapeutic applications Compounds referred to herein as oligonucleotide clamps are provided that stably bind to target polynucleotides in a sequence-specific manner. The oligonucleotide clamps comprise one or more oligonucleotide moieties capable of specifically binding to a tar... | 04/11/2000 |
| 6013445 | Massively parallel signature sequencing by ligation of encoded adaptors The invention provides a method of nucleic acid sequence analysis based on the ligation of one or more sets of encoded adaptors to the terminus of a target polynucleotide. Encoded adaptors whose protruding strands form perfectly matched duplexes with the ... | 01/11/2000 |
| 6013165 | Electrophoresis apparatus and method Disclosed are an apparatus, system, and method for two dimensional electrophoresis of analytes of interest, particularly polypeptides. The apparatus includes a sample separation cavity comprising (1) an electrophoresis region located along an upper portio... | 01/11/2000 |
| 5998604 | Polynucleotide purification method A method of purifying a hydrophobically substituted polynucleotide by reverse phase HPLC is described. The hydrophobic substituent may be removed from the polynucleotide under non-acidic conditions; the purification method is thus especially useful for ac... | 12/07/1999 |
| 5969119 | DNA sequencing by parallel olgonucleotide extensions Disclosed are oligonucleotides probes which are useful for determining a sequence of nucleotides in a target ploynucleotide. In one embodiment, the probe is of the formula: HO-(3')(B)j(5')-OP(.dbd.O-)NH-(B)k-Bt*, wherein B is a nucleotide or an analog the... | 10/19/1999 |
| 5965720 | Oligonucleotide N3'.fwdarw.P5' phosphoramidates Modified oligonucleotides 3'-NHP(O)(O-)O-5' phosphoramidates were synthesized on a solid phase support. The phosphoramidate analogs were found to have significantly increased resistance toward phosphodiesterase digestion. Thermal dissociation e... | 10/12/1999 |
| 5962228 | DNA extension and analysis with rolling primers A novel "primer walking" method for DNA sequencing is provided that comprises repeated cycles nucleotide identification by selective extension and primer advancement along a template by template mutation. An important feature of the invention is providing... | 10/05/1999 |
| 5888737 | Adaptor-based sequence analysis An improvement in adaptor-based sequence analysis is provided that addresses the problems created by self-ligation of target polynucleotides that have complementary ends. The improvement includes preparation of target polynucleotides with dephosphorylated... | 03/30/1999 |
| 5863722 | Method of sorting polynucleotides The invention provides a method and materials for sorting polynucleotides with oligonucleotide tags. Oligonucleotide tags of the invention are capable of hybridizing to complementary oligomeric compounds consisting of subunits having enhanced binding stre... | 01/26/1999 |
| 5859233 | Synthons for synthesis of oligonucleotide N3-P5 phosphoramidates The invention provides a method of synthesizing oligonucleotide N3'.fwdarw.P5' phosphoramidates using an amine-exchange reaction of phosphoramidites in which a -deprotected 3'-amino group of a solid phase supported oligonucleotide chain is exhanged for th... | 01/12/1999 |
| 5856093 | Method of determining zygosity by ligation and cleavage The invention provides a method of nucleic acid sequence analysis based on repeated cycles of ligation to and cleavage of probes at the terminus of a target polynucleotide. At each such cycle one or more terminal nucleotides are identified and one or more... | 01/05/1999 |
| 5846719 | Oligonucleotide tags for sorting and identification The invention provides a method of tracking, identifying, and/or sorting classes or subpopulations of molecules by the use of oligonucleotide tags. Oligonucleotide tags of the invention comprise oligonucleotides selected from a minimally cross-hybridizing... | 12/08/1998 |
| 5837835 | Oligonucleotide N3'-P5' phosphoramidates: hybridization and nuclease resistance properties Modified oligonucleotides 3'-NHP(O)(O-)O-5' phosphoramidates were synthesized on a solid phase support. The phosphoramidate analogs were found to have significantly increased resistance toward phosphodiesterase digestion. Thermal dissociation e... | 11/17/1998 |
| 5830658 | Convergent synthesis of branched and multiply connected macromolecular structures The invention provides methods and compositons for convergent synthesis of branched polymers useful as molecular probes. The invention also includes several novel branched polymeric structures particularly useful for detecting target polynucleotides. Bran... | 11/03/1998 |
| 5831065 | Kits for DNA sequencing by stepwise ligation and cleavage The invention provides a method of nucleic acid sequence analysis based on repeated cycles of ligation to and cleavage of probes at the terminus of a target polynucleotide. At each such cycle one or more terminal nucleotides are identified and one or more... | 11/03/1998 |
| 5824793 | Solid phase synthesis of oligonucleotide N3'-P5' phosphoramidates The invention provides a method of synthesizing oligonucleotide N3'.fwdarw.P5' phosphoramidates using an amine-exchange reaction of phosphoramidites in which a deprotected 3'-amino group of a solid phase supported oligonucleotide chain is exhanged for the... | 10/20/1998 |
| 5817795 | Oligonucleotide clamps having diagnostic and therapeutic applications Compounds referred to herein as oligonucleotide clamps are provided that stably bind to target polynucleotides in a sequence-specific manner. The oligonucleotide clamps comprise one or more oligonucleotide moieties capable of specifically binding to a tar... | 10/06/1998 |
| 5780231 | DNA extension and analysis with rolling primers A novel "primer walking" method for DNA sequencing is provided that comprises repeated cycles nucleotide identification by selective extension and primer advancement along a template by template mutation. An important feature of the invention is providing... | 07/14/1998 |
| 5763175 | Simultaneous sequencing of tagged polynucleotides The invention provides a method for sequencing each polynucleotide of a population by using an oligonucleotide tag assigned to each such polynucleotide for transfering sequence information to a tag complement located on a spatially addressable array of su... | 06/09/1998 |
