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| Number | Title | Issue Date |
| 6353089 | Method for stimulating CTLs with peptides Tumor rejection antigens derived from tumor rejection precursor MAGE-3 have been identified. These "T-RAS" bind to the MHC-class I molecule HLA-A2, and the resulting complexes stimulate the production of cytolytic T cell clones which lyse the presenting c... | 03/05/2002 |
| 6338947 | Methods for determining breast cancer and melanoma by assaying for a plurality of antigens associated therewith The invention relates to assays for determining breast cancer or melanoma. It has been found that the accuracy of such assays can be improved by assaying samples for three or more known tumor rejection antigen precursors. For breast cancer, the tumor reje... | 01/15/2002 |
| 6339149 | Isolated nucleic acid molecules which encode tumor rejection antigens found in dage A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as DAGE tumor rejection antigen precursors, and the nucleic acid molecules whic... | 01/15/2002 |
| 6328955 | Method for regulating IL-10 with IL-9, and applications thereof The invention involves the recognition of IL-9 as a molecule involved in induction of IL-10. Administration of IL-9 leads to protection against conditions where IL-10 production is warranted, such as infections by Gram negative bacteria. Examples of such ... | 12/11/2001 |
| 6291658 | Isolated nucleic acid molecules encoding SSX family members and thereof The invention relates to members of the SSX family of genes, as well as their uses.... | 09/18/2001 |
| 6280997 | Isolated nucleic acid molecule which codes for a 32 KDA protein having 11-CIS retinol dehydrogenase activity, and which associates with P63, a portion of a retinol binding protein receptor In accordance with this invention, an RPE cell membrane associated protein which has a molecular weight of about 32 kd, as determined by SDS-PAGE, has been discovered. This protein, referred to an "p32," forms an oligomeric protein complex with the previo... | 08/28/2001 |
| 6277956 | Isolated nona- and decapeptides which bind to HLA molecules, and the use thereof Nonapeptides and decapeptides which bind to HLA molecules and provoke proliferation of cytolytic T cells are disclosed. The decapeptides terminate in Valine, and are restricted in their first three amino acid positions. Other useful nonapeptides are also ... | 08/21/2001 |
| 6274710 | Antibodies which specifically bind T Cell inducible factors (TIFs) The invention involves isolation of nucleic acid molecules, the expression of which are upregulated by interleukin-9. The amino acid sequences of the proteins which correspond to the nucleic acid molecules show some structural features of cytokines. In ad... | 08/14/2001 |
| 6252052 | Antibodies which bind to NY-ESO-1 cancer associated proteins, and hybridomas which produce these antibodies The invention relates to antibodies which bind to the cancer associated antigen NY-ESO-1. Both polyclonal and monoclonal antibodies are part of the invention, as are chimeric forms of the antibodies, and binding portions of antibodies. Uses of these antib... | 06/26/2001 |
| 6251603 | Method for determining status of a cancerous condition by determining antibodies to NY-ESO-1 in a patient sample The invention relates to methods for determining tumor status by determining antibodies specific to NY-ESO-1 in patient samples. One can determine whether a cancerous condition is progressing, regressing, or remaining stable by determining antibodies agai... | 06/26/2001 |
| 5621081 | Glial mitogenic factors The invention is concerned with new glial growth factors, such as the molecule referred to as GGF2. These factors are mitogenic factors for, e.g., Schwann cells.... | 04/15/1997 |
| 5605839 | Methods and apparatus for use in sequential chemical reactions This invention relates to methods and apparatus for carrying out chemical reactions between a plurality of reactants and in particular it is amenable to micro or nano scale operation and to the sequential chemical reactions required during such processes ... | 02/25/1997 |
| 5558995 | Peptides which are derived from tumor rejection antigen precursor molecule MAGE-1, which complex to MHC molecule HLA-C clone 10, and uses thereof The invention relates to the identification of complexes of HLA-C-clone 10 and MAGE-1 derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.... | 09/24/1996 |
| 5516698 | Methods and apparatus allowing sequential chemical reactions A first reactant is immobilized i.e. in a porous matrix (50), adjacent a sample electrode (46) within a reaction chamber. Energizing of the electrode (46) electrophoretically attracts a mobile second reactant and/or electrolytically induces appropriate re... | 05/14/1996 |
| 5346993 | Isolated, large latent complexes of TGF-댢 and TGF-댣, and new binding protein for latent form TGF-댡, TGF-댢 and TGF-댣 LTBP-2 The invention relates to large latent complexes of TGF-댢 and TGF-댣, and methods for isolating these. The complex consists of a dimerized form of TGF-댢 or TGF-댣, the appropriate latency associated peptide, and the latent TGF-&#x... | 09/13/1994 |
| 5316937 | Conditioned medium useful for sustaining growth of colonic crypt cells The invention describes a colonic crypt cell stimulating mitogen, and conditioned medium containing it. In particular, cell line LIM 2537 is described which, when cultivated in medium, secretes a mitogen which stimulates the proliferation o colonic crypt ... | 05/31/1994 |
| 5227302 | DNA encoding platelet derived endothelial cell growth factor (PD-ECGF) Platelet-derived endothelial cell growth factor (PD-ECGF) is a 45 kDa endothelial cell mitogen that has been purified to homogeneity from human platelets. It does not bind to heparin and does not stimulate the proliferation of fibroblasts, in contrast to ... | 07/13/1993 |
