Assignee: Liposome Technology, Inc.

Location: MenloPark, CA
No. of patents: 34

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Number	Title	Issue Date
5534259	Polymer compound and coated particle composition A composition of polymer-coated particles, and a polymer compound used in forming the particles are disclosed. The polymer compound is composed of a hydrophilic polymer attached to a lipophilic moiety through a linking segment which contains chemical grou...	07/09/1996
5395619	Lipid-polymer conjugates and liposomes A lipid-polymer conjugate for use in forming long-circulating liposomes is disclosed. The conjugate includes a vesicle-forming lipid having covalently attached to its polar head group, one of the polymers: polyvinylpyrrolidone, polyvinylmethylether, polyh...	03/07/1995
5356633	Method of treatment of inflamed tissues A method of and composition for concentrating a therapeutic agent in an inflamed dermal region are disclosed. The composition, which is also used in the method, is a liposomal composition. The liposomes contain the therapeutic agent in entrapped form and ...	10/18/1994
5340587	Liposome/bronchodilator method & System A method and system for treating bronchial constriction. The system includes a liposome composition containing a 댢 -adrenoreceptor agonist in a liposome-entrapped form, and a device for aerosolizing a metered quantity of the composition....	08/23/1994
5225212	Microreservoir liposome composition and method A liposome composition for extended release of a therapeutic compound into the bloodstream. The liposomes are composed of vesicle-forming lipids and between 1-20 mole percent of a vesicle-forming lipid derivatized with hydrophilic polymer, have sizes in a...	07/06/1993
5213804	Solid tumor treatment method and composition A liposome composition for localizing an anti-tumor compound to a solid tumor via the bloodstream. The liposomes, which contain the agent in entrapped form, are composed of vesicle-forming lipids and between 1-20 mole percent of a vesicle-forming lipid de...	05/25/1993
5194266	Amphotericin B/cholesterol sulfate composition and method An amphotericin B composition containing particles of amphotericin B and cholesterol sulfate, in a molar ratio of between about 1:1 to 2:1. The particles, when stored in lyophilized form and reconstituted in an aqueous suspension, have particle sizes pred...	03/16/1993
5192528	Corticosteroid inhalation treatment method A method for delivering a therapeutic dosage of corticosteroid drug to the lungs, for treating a lung condition or disease. An aqueous suspension of sized liposomes containing the drug in liposome-entrapped form is aerosolized under conditions which produ...	03/09/1993
5185154	Method for instant preparation of a drug containing large unilamellar vesicles This invention describes a simple, fast, reproducible economic, and convenient method of preparation of very large unilamellar liposome vesicles of uniform size distribution. The populations of these vesicles are homogeneous and suitable for encapsulation...	02/09/1993
5180713	Stabilized liposome/amphotercin B composition and method A method of administering a liposome/amphotericin B composition having a predetermined size distribution in 0.2-0.5 micron size range. The method includes preparing a suspension of heterogeneously sized amphotericin B liposomes in an aqueous solution cont...	01/19/1993
5064655	Liposome gel composition and method A liposome gel composition and method of preparing the same. The composition is composed of charged liposomes, at a relatively low lipid concentration, in a low-conductivity medium. The composition preferably contains a zwitterionic compound at its isoele...	11/12/1991
5049389	Novel liposome composition for the treatment of interstitial lung diseases A non-conventional lipid particle formulation for the sustained release and delivery of steroids into deep lung is disclosed. The formulation provides prolonged release of the drug, improved therapeutic ratio, lower toxicity, reduced systemic side effects...	09/17/1991
5043165	Novel liposome composition for sustained release of steroidal drugs This invention relates to a novel, non-conventional liposome formulation for the sustained release and delivery of steroids. The formulation provides prolonged release of the drug, improved therapeutic ratio, lower toxicity, reduced systemic side effects ...	08/27/1991
5032582	Method for treating fungal infections with amphotericin B/cholesterol sulfate composition An amphotericin B composition containing particles of amphotericin B and cholesterol sulfate, in a molar ratio of between about 1:1 to 1:4. The particles, when stored in lyophilized form and reconstituted in an aqueous suspension, have particle sizes pred...	07/16/1991
5030442	Non-crystalline minoxidil composition An aqueous, noncrystalline minoxidil composition for topical use which has significantly improved flux of the drug through human cadaver skin. The composition contains minoxidil complexed with an amphipathic compound, oleic acid and with pharmaceutically ...	07/09/1991
5023087	Efficient method for preparation of prolonged release liposome-based drug delivery system A method for selectively controlling the rate of release of a liposome-entrapped compound from an intramuscular or subcutaneous injection site. The method includes selecting the average size, amount, and lipid composition of liposomes injected into the si...	06/11/1991
5013556	Liposomes with enhanced circulation time A liposome composition which contains between 1-20 mole percent of an amphipathic lipid derivatized with a polyalkylether, as exemplified by phosphatidylethanolamine derivatized with polyethyleneglycol. The derivatized lipid enchances the circulation time...	05/07/1991
5000887	Preparation of uniform-size liposomes A method of forming liposomes with a uniform size distribution, and an average size of about 300 nm or less. Vesicles-forming lipids are dissolved in a water-miscible solvent, such as ethanol, and an aqueous medium is added to a water:solvent ratio at whi...	03/19/1991
4994213	Method of preparing lipid structures A method of forming lipid structures, such as liposomes is disclosed. Lipids are dissolved in a solvent system containing a water-miscible solvent, such as ethanol, and an aqueous medium. The water:solvent ratio is raised by removing water and solvent in ...	02/19/1991
4952405	Method of treating M. avium infection A method of selectively enhancing efficacy of gentamicin, when used in the treatment of Mycobacterium avium Complex (MAC), by intravenous administration of the drug in liposomal form. Gentamicin-liposomes are comparable to amikacinliposomes in activity ag...	08/28/1990
4944948	EGF/Liposome gel composition and method A composition and method for treating a wound or surgical incision, by sustained-released delivery of epidermal growth factor (EGF). The composition includes a high-viscosity aqueous dispersion of negatively charged liposomes with liposome-entrapped EGF. ...	07/31/1990
4927571	Preparation of injectable doxorubicin/liposome suspension An doxorubicin/lyposome composition which can be reconstituted from a lyophilized form to an injectable liposome suspension having selected liposome sizes in the size range between 0.1 and 0.5 microns, and between about 85-95% liposome-entrapped doxorubic...	05/22/1990
4927637	Liposome extrusion method A suspension of heterogeneous size liposomes is passed through a polymer filter having a web-like construction providing a network of interconnected, tortuous-path capillary pores, and a membrane thickness of at least about 100 microns. The processed lipo...	05/22/1990
4895719	Method and apparatus for administering dehydrated liposomes by inhalation A system and method for administering a drug, at a selected dose, via the respiratory tract. Spray-dried liposome particles containing the selected dose of the entrapped drug are released into the air in aerosolized form, either by entrainment in an air o...	01/23/1990
4873088	Liposome drug delivery method and composition A method for enhancing the therapeutic effectiveness of adriamycin, in the treatment of cancer, is disclosed. Liposomes containing coentrapped adriamycin and a secondary compound effective to reduce the toxicity of adriamycin or enhance the induction by a...	10/10/1989
4839175	Liposomes with enhanced retention on mucosal tissue A liposome composition designed for enhanced binding to mucosal tissue, The liposomes contain about 10-40 mole percent of an amine-derivatized lipid component in which a charged amine group is spaced from a lipid polar head region by a carbon-containing s...	06/13/1989
4828837	Non-crystalline minoxidil composition, its production and application An aqueous, noncrystalline minoxidil composition for topical use. The composition contains minoxidil complexed with an amphipathic compound having a pK less than about 5 and containing a single lipophilic chain moiety and a sulfate, sulfonate, phosphate a...	05/09/1989
4822777	Amphotericin B/cholesterol sulfate composition An amphotericin B composition containing particles of amphotericin B and cholesterol sulfate, in a molar ratio of between about 1:1 to 1:4. The particles, when stored in lyophilized form and reconstituted in an aqueous suspension, have particle sizes pred...	04/18/1989
4818537	Liposome composition for treating dry eye A liposome composition useful in the treatment of dry eye. The composition includes an aqueous suspension of liposomes whose lipid composition preferably includes about 70-85 mole percent of hydrogenated phosphatidylcholine, and 15-30 mole percent of ...	04/04/1989
4804539	Ophthalmic liposomes A liposome composition with enhanced retention on ocular surfaces, for use in ophthalmic drug delivery and dry eye treatment. The liposomes contain about 10-40 mole percent of an amine-derivatized lipid component in which a charged amine group is spaced f...	02/14/1989
4766046	Stabilized liposome/amphotericin composition and method A dehydrated liposome/amphotericin B composition which, upon addition of an aqueous medium, forms a suspension of liposomes (a) having a predetermined size distribution in size range less than about 1 micron, and (b) containing at least about 1 mole perce...	08/23/1988
4762915	Protein-liposome conjugates A lipid coupling reagent for use in coupling amine-containing molecules, such as proteins, to liposomes. The reagent includes phosphatidylethanolamine coupled to a 3-20 atom carbon-containing spacer arm terminating at a carboxyl or thiocarboxyl group. Als...	08/09/1988
4752425	High-encapsulation liposome processing method A method of preparing a suspension of liposomes containing a water-soluble compound predominantly in liposome-encapsulated form. A solution of vesicle-forming lipids in a chlorofluorocarbon solvent is infused under selected conditions into an aqueous medi...	06/21/1988
4737323	Liposome extrusion method A suspension of liposomes whose sizes are predominantly greater than about 1 micron is passed through an asymmetric ceramic filter whose inner-surface pore size is about 1 micron. The processed liposomes have a selected average size of about 0.4 microns o...	04/12/1988

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Assignee: Liposome Technology, Inc.