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| Number | Title | Issue Date |
| 4963578 | Organic compounds and their pharmaceutical use There are described compounds of formula ##STR1## in which n is 0, 1 or 2, R1 is a hydrocarbyl group optionally substituted with an optionally substituted phenyl group and containing from 5 to 30 carbon atoms, R2 is optionally s... | 10/16/1990 |
| 4845200 | Immunoglobulin conjugates A conjugate comprising a vinca moiety convalently linked at the 4-position via a group of the formula --OCOXCO-- where X represents a single chemical bond or an optionally substituted C1-10 chain, to an immunoglobulin or an immunoglobulin fragm... | 07/04/1989 |
| 4845110 | Organic compounds and their pharmaceutical use There are provided anti-allergic pharmaceutical compounds of formula: ##STR1## in which n is 0, 1 or 2; R1 is a hydrocarbyl group containing 6 to 30 carbon atoms and optionally substituted with an optionally substituted phenyl group; R | 07/04/1989 |
| 4841056 | Substituted hexahydro-4H-indolo[6,5,4-cd]indoles There are disclosed intermediates to pharmaceutical compounds of the formula ##STR1## in which R1 is an aliphatic or aromatic function, and R2 and R3 are each hydrogen, C1-4 alkyl or a protecting group; and... | 06/20/1989 |
| 4801735 | Pharmaceutical compounds Compounds are described of the following formula ##STR1## in which R1 and R2 are each hydrogen, C1-12 alkyl or C2-12 alkenyl, at least one of R1 and R2 being C1-12 alkyl or ... | 01/31/1989 |
| 4755389 | Chewable capsules A hard gelatin capsule is filled with a chewable composition containing an ingredient for buccal absorption or having buccal activity.... | 07/05/1988 |
| 4742075 | Substituted hexahydro-4H-indolo[6,5,4-cd]indoles There are disclosed pharmaceutical compounds of the formula ##STR1## in which R1 is an aliphatic or aromatic function, and R2 and R3 are each hydrogen, C1-4 alkyl or a protecting group; and salts thereof.... | 05/03/1988 |
| 4740514 | Tetrazole substituted compounds and their anti-allergic use There are described compounds of the formula ##STR1## in which R1 is hydrogen or C1-6 alkyl, R2 is hydrogen, C1-6 alkyl or C3-6 alkenyl, X and Y are each oxygen, sulphur, sulphinyl or sulphonyl, ... | 04/26/1988 |
| 4720498 | 2-alkyl-thioergolines and their use for treating anxiety There is described a compound of the formula ##STR1## in which R1 is hydrogen or C1-4 alkyl, R2 is hydrogen, C1-4 alkyl, hydroxy C1-4 alkyl, C1-4 alkoxy C1-4 alkyl, HSC... | 01/19/1988 |
| 4705807 | Amine derivatives Novel amines of formula: where R is cis-2-phenylbicyclo[2,2,2]octane or 2-phenylbicyclo[2,2,2]oct-2-ene nucleus, n is 1 to 3, R1 is C1-3 alkyl and R2 is hydrogen or C1-3 alkyl, and acid-addition salts thereof, w... | 11/10/1987 |
| 4675334 | Tetrazolyl compounds and their use as anti allergic agents Compounds of formula ##STR1## wherein R1, R2 and R3 are each independently selected from H, OH, C1 -C4 alkyl, R4 --CO and halogen, where R4 is C1 -C4 a... | 06/23/1987 |
| 4675335 | Sulfur containing alkenylenyl substituted benzoic acids and phenyl tetrazoles and their use as anti-allergic agents Pharmaceutical compounds are described of the formula ##STR1## in which R1 is (i) R4 O(CH2 CH2 O)n (CH2)m --, where R4 is hydrogen or C1-5 alkyl, n is 0 ... | 06/23/1987 |
| 4675333 | N-[4-[ω-(4-acyl-3-hydroxyphenoxy)alkoxy]-p henyl]1H-tetrazole-5-carboxamides and use thereof as anti-allergics There are described compounds of the formula ##STR1## in which R1 is hydrogen or C1-6 alkyl, R2 is hydrogen, C1-6 alkyl or C3-6 alkenyl, R3 is hydrogen or C1-6 alkyl, R... | 06/23/1987 |
| 4665189 | Oxiranes There are described compounds of formula ##STR1## in which n is 0, 1 or 2, R1 is a hydrocarbyl group optionally substituted with an optionally substituted phenyl group and containing from 5 to 30 carbon atoms, R2 is optionally s... | 05/12/1987 |
| 4640798 | Intermediates for the preparation of penicillin and cephalosporin compounds There is described a process for preparing a sulphoxide of the formula ##STR1## in which R1, R2, R3 and R4, taken individually, are alkyl, alkoxy or aryl groups, X is an alkylene group, R5 is a c... | 02/03/1987 |
| 4636165 | Stripper rings for capsule pins A ring for stripping capsule sections from a tapered capsule-forming pin has an annular outer member 11 with a tapered surface 12 engaging tapered surfaces 13 on four angularly spaced sections 14 forming an inner member and with inner surfaces 15 defining... | 01/13/1987 |
| 4596676 | Bifunctional ester derivatives of 4-desacetyl indole-dihydroindole alkaloids Bifunctional ester derivatives at C-4 carbon of dimeric indole-dihydroindole alkaloids; e.g., VLB 4-hemisuccinate.... | 06/24/1986 |
| 4595540 | Benzonitrile and benzothiocyano intermediates There are described compounds of the formula ##STR1## in which R1 is hydrogen or C1-6 alkyl, R2 is hydrogen, C1-6 alkyl or C3-6 alkenyl, X and Y are each oxygen, sulphur, sulphinyl or sulphonyl, ... | 06/17/1986 |
| 4558124 | Preparation of cephalosporin intermediate compounds There is described a process for preparing a sulphoxide of the formula ##STR1## in which R1, R2, R3 and R4, taken individually, are alkyl, alkoxy or aryl groups, X is an alkylene group, R5 is a c... | 12/10/1985 |
| 4542131 | Substituted diazolo[b][1,5]benzodiazepines and their use as CNS agents Compounds are described of the formula ##STR1## or an acid addition salt thereof; in which R1, R2, R3 and R4 independently represent hydrogen, C1-4 alkyl, C2-4 alkenyl, C3-7... | 09/17/1985 |
| 4532257 | Certain aurones and their use in the treatment of allergies There are described compounds of the formula ##STR1## in which either R1 and R2 are both hydrogen or R1 is carboxyl and R2 is hydrogen, C3-4 alkenyl or C1-4 alkyl, and R3, R... | 07/30/1985 |
| 4513005 | SRS-A antagonists There are described pharmacologically active compounds, useful in the treatment of allergic/inflammatory disorders involving SRS-A as causal mediator and which, in free acid form, are of formula I, ##STR1## in which R1 is (i) an aliphatic,... | 04/23/1985 |
| 4492699 | Triazolobenzodiazepine derivatives These are described compounds of formula (I) ##STR1## or an acid addition salt thereof; in which R1, R2, R3 and R4 independently represent hydrogen, C1-4 alkyl, C2-4 alkenyl, halogen, ... | 01/08/1985 |
| 4486591 | 4-Substituted-1-(3-[2-aminoanilino]-1-pyrazole-4-carbonyl)piperazine Compounds are described of the formula ##STR1## or an acid addition salt thereof; in which R1, R2, R3 and R4 independently represent hydrogen, C1-4 alkyl, C2-4 alkenyl, C3-7... | 12/04/1984 |
| 4482484 | Compounds and hapten-immunoglobulin conjugates derived from them Compounds of formula (I) ##STR1## in which n is 1 or 2, R1 is C1-4 alkyl, C1-4 alkoxy, nitro, amino, halo or hydroxy, m is 0, 1 or 2, R2 is an immunogenic determinant and x is 1 or 2, provided that when n i... | 11/13/1984 |
| 4471129 | 6-Substituted pyranone compounds and their use as pharmaceuticals Compounds are described of the formula ##STR1## in which R1 is COOR5, CONHR5, cyano, 5-tetrazolyl or R6, where R5 is hydrogen or C1-8 alkyl and R6 is phenyl or naphthyl, the... | 09/11/1984 |
| 4448787 | 6-Substituted pyranone compounds and their use as pharmaceuticals Compounds are described of the formula ##STR1## in which R1 is COOR5, CONHR5, cyano, 5-tetrazolyl or R6, where R5 is hydrogen or C1-8 alkyl and R6 is phenyl or naphthyl, the... | 05/15/1984 |
| 4442032 | Isothiocyanato-azobenzene-sulfonic, arsonic and substituted-glutamic acid haptens Compounds of formula (I) ##STR1## in which n is 1 or 2, R1 is C1-4 alkyl, C1-4 alkoxy, nitro, amino, halo or hydroxy, m is 0, 1 or 2, R2 is an immunogenic determinant and x is 1 or 2, provided that when n i... | 04/10/1984 |
| 4416892 | Method of treating hypersensitivity disease with benzoxazole derivatives The invention relates to a method for the prophylactic or therapeutic treatment of an immediate hypersensitivity disease, which comprises administering to a mammal, including a human, a compound of the following formula ##STR1## in which the gro... | 11/22/1983 |
| 4404137 | Pyrazolo [3,4-b][1,5]benzodiazepine compounds Compounds are described of the formula ##STR1## or an acid addition salt thereof; in which R1, R2, R3 and R4 independently represent hydrogen, C1-4 alkyl, C2-4 alkenyl, C3-7... | 09/13/1983 |
| 4390541 | Quinolone derivatives and their use in a method of controlling an immediate hypersensitivity disease Compounds of the following formula are described: ##STR1## in which n is 0, 1 or 2, R1 is C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 alkylsulphonyl, trifluoromethyl, halo or nitro, and R2... | 06/28/1983 |
| 4364956 | 5-Substituted pyranone compounds and their use as pharmaceuticals to treat an immediate hypersensitivity condition Compounds are described of the formula ##STR1## in which R1 is COOR5, CONHR5, cyano, 5-tetrazolyl or 5-tetrazolylaminocarbonyl, where R5 is hydrogen or C1-6 alkyl; R2 is hydrogen or C | 12/21/1982 |
| 4304728 | 6-Substituted pyranone compounds and their use as pharmaceuticals Compounds are described of the formula ##STR1## in which R1 is COOR5, CONHR5, cyano, 5-tetrazolyl or R6, where R5 is hydrogen or C1-8 alkyl and R6 is phenyl or naphthyl, the... | 12/08/1981 |
| 4301280 | Preparation of 3-substituted cephalosporins There is described a process for preparing an enamine of formula (IX): ##STR1## where R2 is a carboxylic acid protecting group and R3 is the residue of a carboxylic acid derived acyl group and where R5 and R6 | 11/17/1981 |
| 4293563 | Thenyl hydantoins and anti-asthmatic compositions thereof Novel hydantoin compounds are described of the formula (I): ##STR1## wherein Ar is phenyl optionally substituted by up to three radicals selected from the group comprising C1-6 alkoxy, halogen, 1,3-dioxol-2-yl, hydroxy C1-4 alko... | 10/06/1981 |
| 4281017 | Pharmaceutically active indane derivatives Compounds of formula I ##STR1## wherein either R1 and R2 are both hydrogen or R1 and R2, taken together, represent a group of formula (a): ##STR2## in which R5 is hydrogen, halogen or C... | 07/28/1981 |
| 4277480 | Tetrahydroindoloisoquinolines Isoquinoline compounds of the following formula are described: ##STR1## wherein the moiety A-B represents a group of formula; wherein R3 represents hydrogen, C1-6 alkyl, C3-6 cycloalkyl, C3-6 cycloalkyl C1-... | 07/07/1981 |
| 4260357 | Stripper ring for capsule pins This invention relates to a ring form of a rigid and durable material with a metal insert arranged in its passageway. The ring is employed to strip thin walled gelatin capsules from capsule-forming pins which are slightly tapered along their entire length... | 04/07/1981 |
| 4259340 | Aurone derivatives Substituted aurones of formula (I): ##STR1## wherein R1, R2, R3, R4, R5 and R6 are the same or different and can each represent hydrogen, halogen, C1-6 alkyl, C1-6 | 03/31/1981 |
| 4259343 | Oxazole carbamates, formulations and asthma treatment A class of novel 2-oxazolyl ureas and carbamates having anti-allergic activity are described together with methods of making such compounds and pharmaceutical compositions containing the active compounds of the invention.... | 03/31/1981 |
