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Assignee: Ligand Pharmaceuticals Incorporated


Location: San Diego, CA
No. of patents: 13

NumberTitleIssue Date
78163726-cycloamino-2-quinolinone derivatives as androgen receptor modulator compounds
The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR. Also provided are methods of making such compounds and pharmaceutical compositions. ...
10/19/2010
7727980Tricyclic androgen receptor modulator compounds and methods
This invention relates to non-steroidal tricyclic compounds that are modulators of androgen receptors and to methods for making and using such compounds. ...
06/01/2010
7696246Bicyclic androgen and progesterone receptor modulator compounds and methods
The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agon...
04/13/2010
7214690Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods
Novel non-steroidal tricyclic quinolinone and tricyclic quinoline compounds and compositions that are agonists, partial agonists and/or antagonists for androgen receptors (AR), their preparation and their uses are described. ...
05/08/2007
71639465-substituted 7,9-difluoro-5H-chromeno[3,4-f]quinoline compounds as selective progesterone receptor modulator compounds
The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by progesterone receptor. Also provided are methods of making such compounds and pharmaceutical compositions. ...
01/16/2007
7115728Human peroxisome proliferator activated receptor γ
The present invention relates to a novel human peroxisome proliferator activated receptor, hPPARγ. hPPARγ differs from the mouse peroxisome proliferator activated receptor γ in the nucleotide sequence and the amino acid sequence. The invention provides isolated, ...
10/03/2006
7098025Human peroxisome proliferator activated receptor gamma (pparγ) gene regulatory sequences and uses therefor
This invention relates to the isolation and cloning of the promoter and other control regions of human PPARγ gene. It provides a method for identifying and screening for agents useful for the treatment of diseases and pathological conditions affected by the level o...
08/29/2006
70841515-(1',1'-cycloalkyl/alkenyl)methylidene 1,2-dihydro--chromeno[3,4-ƒ]quinolines as selective progesterone receptor modulator compounds
The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by Progesterone Receptor. Also provided are methods of making such compounds and pharmaceutical compositions. ...
08/01/2006
70712055-cycloalkenyl 5H-chromeno[3,4-f]quinoline derivatives as selective progesterone receptor modulator compounds
The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by Progesterone Receptor. Also provided are methods of making such compounds and pharmaceutical compositions. ...
07/04/2006
7026484Tricyclic androgen receptor modulator compounds and methods
This invention relates to non-steroidal tricyclic compounds that are modulators of androgen receptors and to methods for making and using such compounds. ...
04/11/2006
6964973Bicyclic androgen and progesterone receptor modulator compounds and methods
The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agon...
11/15/2005
6951942Glucocorticoid-selective anti-inflammatory agents
Compounds having Formula I are useful for partially or fully antagonizing, repressing, agonizing, or modulating the glucocorticoid receptor and treating immune, autoimmune and inflammatory diseases in a mammal. Also di...
10/04/2005
6180794Process for the preparation of 1,2-dihydroquinolines
A method for preparing 1,2-dihydroquinolines that is more flexible than the Skraup reaction is provided. The method comprises treating an ortho-alkenyl aniline with a ketone in the presence of a Lewis acid. Novel intermediates and products of this method ...
01/30/2001
 
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