Assignee: Lexicon Pharmaceuticals, Inc.

Location: The Woodlands, TX
No. of patents: 39

Browse patents
Browse applications

Number	Title	Issue Date
8153804	Aryl pyridines and methods of their use Aryl pyridines, compositions comprising them, and methods of their use for the treatment, prevention and management of a variety of diseases and disorders are disclosed. ...	04/10/2012
8093291	Methods of using and compositions comprising tryptophan hydroxylase inhibitors Methods and compositions comprising tryptophan hydroxylase inhibitors are disclosed. Particular methods are directed at reducing or avoiding serotonin-mediated adverse effects associated with some drugs. ...	01/10/2012
8093280	Methods of preparing imidazole-based compounds Methods of preparing imidazole-based compounds are disclosed. Particular compounds are of formula I. ...	01/10/2012
8093267	Methods of treating rheumatoid arthritis Imidazole-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed. Particular compounds are of formula I:	01/10/2012
8093246	O-linked pyrimidin-4-amine-based compounds, compositions comprising them, and methods of their use to treat cancer O-linked pyrimidin-4-amine-based compounds, pharmaceutical compositions comprising them, and methods of their use are described. Particular compounds of the invention are of formula I: ...	01/10/2012
8093245	4-amino-1H-pyrimidin-2-one based compounds, compositions comprising them and methods of their use 4-Amino-1H-pyrimidin-2-one-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of various diseases and disorders are disclosed. Particular compounds are of formula I:	01/10/2012
8092796	Monoclonal antibodies against ANGPTL4 Monoclonal antibodies that specifically bind to ANGPTL4 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL4 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided. ...	01/10/2012
8063057	Multicyclic amino acid derivatives and methods of their use Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders: ...	11/22/2011
8026347	Methods and compounds useful for the preparation of sodium glucose co-transporter 2 inhibitors Methods of synthesizing sodium glucose co-transporter 2 inhibitors, as well as compounds useful therein, are disclosed. Particular inhibitors are compounds of formula I: ...	09/27/2011
7998994	Solid forms of (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol and methods of their use Solid forms of (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol and hydrates thereof are disclosed, as well as compositions comprising them and methods of their use. ...	08/16/2011
7968729	1-phenyl-1H-pyrazole-based compounds Methods useful for preparing compounds of formula I: and salts thereof are disclosed. Also disclosed are intermediates useful in the preparation of such compounds. ...	06/28/2011
7968726	Methods of preparing imidazole-based bicyclic compounds Methods of preparing compounds of formula I are disclosed: ...	06/28/2011
7968559	Methods of using 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders: ...	06/28/2011
7951941	Process for preparing 5-alkyl-7H-pyrrolo[2,3-d] pyrimindine-2-ols Methods of preparing 5-alkyl-7H-pyrrolo[2,3-d]pyrimidin-4-ols are described, as are novel compounds useful in their preparation. A specific method encompassed by the invention is represented in the following scheme: ...	05/31/2011
7935796	Monoclonal antibodies against ANGPTL3 Monoclonal antibodies that specifically bind to ANGPTL3 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL3 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided. ...	05/03/2011
7919618	Synthesis of piperazines, piperidines and related compounds Novel methods of synthesizing piperazines, piperidines and related compounds are disclosed, as are compounds useful for their preparation. ...	04/05/2011
7897763	Process for the preparation of substituted phenylalanines Intermediates and synthetic processes for the preparation of substituted phenylalanine-based compounds (e.g., of Formula I) are disclosed: ...	03/01/2011
7846945	Piperdine-based inhibitors of sodium glucose co-transporter 2 and methods of their use Compounds and pharmaceutical compositions comprising them are disclosed that may be useful for the treatment of diseases and disorders such as diabetes and obesity. ...	12/07/2010
7875622	Methods and compositions for treating pulmonary hypertension and related diseases and disorders Methods of treating pulmonary hypertension are disclosed. Particular methods comprise the administration of a tryptophan hydroxylase inhibitor and at least one other active pharmaceutical ingredient to patient in need thereof. Pharmaceutical formulations are also di...	01/25/2011
7855291	Process for the preparation of substituted phenylalanines Intermediates and synthetic processes for the preparation of substituted phenylalanine-based compounds (e.g., of Formula I) are disclosed: ...	12/21/2010
7825150	Compositions and methods for treating immunological and inflammatory diseases and disorders Methods and compositions for treating immunological and inflammatory diseases and disorders are disclosed. Particular methods and compositions comprise the administration of an agent that inhibits S1P lyase activity and at least one additional immunosuppressive and/...	11/02/2010
7825142	Heterocyclic compounds, compositions comprising them and methods of their use Heterocyclic compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed. Particular compounds are of formula I:	11/02/2010
7812174	Methods of preparing imidazole-based compounds Methods of preparing imidazole-based compounds are disclosed. Particular compounds are of formula I: ...	10/12/2010
7781577	Inhibitors of sodium glucose co-transporter 2 and methods of their use Compounds and pharmaceutical compositions comprising them are disclosed that may be useful for the treatment of diseases and disorders such as diabetes and obesity. ...	08/24/2010
7723345	Multicyclic amino acid derivatives and methods of their use Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders: ...	05/25/2010
7709493	4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders: ...	05/04/2010
7655762	Monoclonal antibodies against ANGPTL4 Monoclonal antibodies that specifically bind to ANGPTL4 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL4 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided. ...	02/02/2010
7649098	Imidazole-based compounds, compositions comprising them and methods of their use Imidazole-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed. Particular compounds are of formula I:	01/19/2010
7598280	Heterocyclic compounds, compositions comprising them and methods of their use Heterocyclic compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed. Particular compounds are of formula I:	10/06/2009
7553840	4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders: ...	06/30/2009
7423043	4-Piperidin-1-yl-7-pyrrolo[2,3-]pyrimidine compounds Substituted 4-piperidin-1-yl-7H-pyrrolo[2,3-D]pyrimidine compounds are disclosed, as well as compositions comprising them and methods of their use for the treatment, prevention and management of various diseases and disorders. ...	09/09/2008
7402730	Knockout animals manifesting hyperlipidemia Genetically engineered cells and animals are described that incorporate a mutated GHP1 allele. Animals that are homozygous for the mutated GHP1 allele are useful for the production of monoclonal antibodies against GHP1. ...	07/22/2008
7374933	Human metalloprotease and polynucleotides encoding the same Novel human polynucleotide and polypeptide sequences are disclosed that can be used in thereapeutic, diagnostic, and pharmacogenomic applications. ...	05/20/2008
7374932	Human kinases and polynucleotides encoding the same, and uses thereof Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications. ...	05/20/2008
7332338	Vectors for making genomic modifications Methods and vectors (both DNA and retroviral) are provided for the construction of a Library of mutated cells. The Library will preferably contain mutations in essentially all genes present in the genome of the cells. The nature of the Library and the vectors allow ...	02/19/2008
7312079	Variants of FAM3C Polynucleotide and polypeptide sequences that encode novel variant FAM3C proteins are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications. ...	12/25/2007
7300949	Thiazolopyrazoles and methods of their use This invention concerns novel thiazolopyrazole compounds and compositions comprising them. Methods of using these compounds for the treatment, prevention and management of various diseases and disorders are also encompassed by the invention. ...	11/27/2007
7268222	Polynucleotides encoding human transporter proteins Novel human ATP binding cassette transporter polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications. ...	09/11/2007
7229790	Human GABA transporter protein and polynucleotides encoding the same Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications. ...	06/12/2007

PatentStorm

Did You Know...

PatentStorm News

Assignee: Lexicon Pharmaceuticals, Inc.