Assignee: Leiras Oy

Location: Turku, FI
No. of patents: 37

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Number	Title	Issue Date
6616945	Method for making a pharmaceutical formulation The invention concerns a method for preparing a physically stable and homogeneous powdered preparation containing particles of an active agent. The particles are suspended in a suspending agent in which the particles are insoluble, and the suspending agen...	09/09/2003
6476079	Devices for the delivery of drugs having antiprogestinic properties A device for the controlled release over a prolonged period of time of a drug having antiprogestinic properties, the device including a core containing the drug, optionally a membrane encasing the core, where at least one of the core and membrane, when pr...	11/05/2002
6326363	Methylenebisphosphonic acid derivatives The object of the invention are novel halogen substituted methylenebisphosphonic acid anhydrides, ester anhydrides, amide anhydrides, and ester amide anhydrides, processes for the preparation of these novel compounds, as well as pharmaceutical preparation...	12/04/2001
6300452	Block copolymers and preparation thereof The invention relates to a new polysiloxane-based block copolymer having a formula T(AB)x AT (I) wherein A=--(SiR'R"O)n SiR'R"--, wherein R' and R" are the the same or different and represent a lower alkyl group or a phenyl group, wherei...	10/09/2001
6299894	Drug delivery device, especially for the delivery of gestodene The invention relates to a delivery device for the controlled release of the therapeutically active agent gestodene, over a prolonged period of time, at a release rate of 0,1-300 μg/day, said device comprising a core comprising at least said therapeutica...	10/09/2001
6132394	Medicament chamber in an inhalation apparatus The invention relates to a medicament chamber (6) included in an inhalation apparatus and provided with a container (2) containing a desiccant. The chamber (6) is tightly sealed and has a moisture permeability as poor as possible, and the container (2) is...	10/17/2000
6117442	Drug delivery device, especially for the delivery of androgens The invention relates to a delivery device for the controlled release of a therapeutically active agent, especially an androgen, over a prolonged period of time, said device including a core containing the therapeutically active agent, and a membrane enca...	09/12/2000
6066677	Use of xylitol and pharmaceutical compositions therefor A method of treating respiratory infections or complications derived therefrom in mammals, especially acute otitis media in humans, which includes administering to the mammal an effective amount of xylitol. The invention further concerns the use of xylito...	05/23/2000
6063395	Drug delivery device especially for the delivery of progestins and estrogens The invention relates to a delivery device for the controlled release of a therapeutically active agent, especially a progestin or an estrogen, over a prolonged period of time, said device including a core which contains the therapeutically active agent, ...	05/16/2000
6056976	Elastomer, its preparation and use The invention relates to a siloxane-based elastomer intended for controlling the permeation of drugs, wherein the elastomer includes 3,3,3,-trifluoropropyl groups attached to the Si-atoms of the siloxane units. The invention relates also to a method for t...	05/02/2000
6004580	Pharmaceutical compositions derived from microemulsion-based gels A pharmaceutical composition containing a microemulsion made up of a hydrophilic component, a lipophilic component, a surfactant and a drug, where the hydrophilic component, the lipophilic component and the surfactant form, when examined on a macroscopic ...	12/21/1999
5866556	Pyridinylbisphosphonates for use as a therapeutical agent The present invention relates to certain optionally ring substituted pyridinylaminomethylidene bisphosphonic acid tetralkyl esters (I) and their use for the treatment of bone diseases, such as osteolytic bone diseases due to malignancy, Paget's disease an...	02/02/1999
5785053	Inserter for the positioning of an intrauterine device An inserter for the positioning of an intrauterine device in the uterus, which inserter includes a plunger, a handle attached to the plunger, a string for the removal of the IUD, a locking device to lock the string in such a way that the IUD remains immob...	07/28/1998
5776499	Process for preparing a clodronate preparation The object of the invention is a process for preparing a clodronate preparation. The process is characterized in that clodronate is crystallized as disodium clodronate tetrahydrate from an aqueous solution of disodium clodronate; the resulting disodium cl...	07/07/1998
5733564	Method of treating endo-osteal materials with a bisphosphonate solution An endo-osteal material which includes an endo-osteal material treated with a solution of a bisphosphonate of formula (1) wherein X is H, OH, Cl, F or a methyl group and Y is Cl, OH, --(CH2)2 --N(CH3)--(CH2)	03/31/1998
5719196	Method of treating respiratory infections or complications derived therefrom in humans which includes oral administration of xylitol A new use of xylitol is disclosed. The invention relates to a method of treating respiratory infections, especially acute otitis media, in humans which method comprises oraly administering to the human an effective amount of xylitol....	02/17/1998
5694947	Intravaginal delivery system Intravaginal delivery system including a flexible support means, and a delivery means carried by the support means and containing an active agent wherein the support means comprises a core member substantially in the form of an open ring, and the delivery...	12/09/1997
5626148	Device for intrauterine use Device for intrauterine use comprising means (7, 8) for attaching the device to the interior wall of the uterus, as well as a member (1) releasing active agent and connected to the said attachment means. The invention is characterized in that the active a...	05/06/1997
5620697	Method for preparing matrix-type pharmaceutical compositions through ultrasonic means to accomplish melting An ultrasonic processing method by which polymer/drug composites can be quickly and efficiently molded to form matrix-type drug delivery systems is disclosed. The advantages of the method include speed and good control of the process. It also causes less ...	04/15/1997
5574151	Process for the preparation of sennosides A and B The invention concerns a process for the preparation of sennosides A and B, wherein rheinanthrone-8-glucoside is oxidized with oxygen or an oxygen source to the sennosides A and B. According to the invention, the oxidation is carried out using active carb...	11/12/1996
5558637	Implant injection device An implant injection device for once-only use includes an elongated implant housing (10), a cannula (11) and a plunger (20) which is longitudinally movable in the implant housing. The surface (21) of the plunger and the inner wall (15) of the implant hous...	09/24/1996
5541184	S-timolol hemihydrate treatment process A process for pharmaceutically treating a subject with S-(-)-3-morpholino-4-(3-tert-butylamino-2-hydroxypropoxy)-1,2,5-thiadiazol e hemihydrate comprising preparing a composition containing the hemihydrate and topically applying the prepared composition to...	07/30/1996
5525354	Pharmaceutical preparation and process for its manufacture In a pharmaceutical preparation for oral use containing a pharmacologically acceptable salt of a bisphosphonic acid, the improvement comprising: a drug delivery form of the preparation which is enteric coated with a film which dissolves at a pH-value of f...	06/11/1996
5442101	Methylenebisphosphonic acid derivatives The invention relates to novel methylenebisphosphonic acid ester amide derivatives of general formula (I), in which formula W1, W2, W3 and W4 are independently the group OR1 or the group NR2	08/15/1995
5438048	Methylenebisphosphonic acid derivatives Novel pharmacologically active methylenebisphosphonates having formula (I) wherein R1, R2, R3 and R4 independently are straight or branched, optionally unsaturated C1 -C10 -alkyl, optionally ...	08/01/1995
5409816	Process for producing immunosuppressives and a novel microbial species to be employed therein The invention relates to a process for producing a cyclosporin, especially cyclosporin A, by cultivating the strain (LEA3) of the novel Tolypocladium species aerobically at a temperature of 20°-30 ° C. in a nutrient medium containing carbon sources, nit...	04/25/1995
5403829	Use of bisphosphonates in endo-osteal bone surgery A method of enhancing the formation of bone tissue and/or eliminating late complications subsequent to bone surgery comprising administering an amount, which is safe and sufficient to promote the formation of bone tissue and/or eliminate late complication...	04/04/1995
5400804	Method and an equipment for installing a medicine capsule on a support The invention relates to a method and an equipment for inserting a tubular medicinal capsule on a support. In accordance with the invention, the opening extending through the capsule is expanded by blowing pressurized air into the opening immediately ahea...	03/28/1995
5393748	Methylenebisphosphonic acid derivatives Novel pharmacologically active methylenebisphosphonates having formula (I) wherein R1 -R4 independently are C1 -C10 -alkyl, C3 -C10 -cycloalkyl, aryl, aralkyl, silyl SiR3 or hydrogen,...	02/28/1995
5376649	Partial esters of (Di) chloromethanediphosphonic acid useful for treating disorders relating to the metabolism of calcium Novel pharmaceutically active bisphosphonic acid derivatives of formula (I), in which R1, R2, R3 and R4 independently are C1 -C22 -alkyl, C2 -C22 -alkenyl, C2 -C...	12/27/1994
5369943	Equipment for providing a medicine rod with a shell The invention relates to providing a medicinal rod with a shell. The shell is formed from a hose, which is expanded by pressurizing its inner space. The medicinal rod is pushed into the expanded hose, after which the pressure is relieved. The hose tighten...	12/06/1994
5347794	Equipment for manufacturing of subcutaneous capsules Apparatus for manufacturing a subcutaneous capsules filled with a selected medicine comprising: a tube cutting mechanism which cuts a continuous length of tubing into a plurality of tubular capsules, each capsule having an open top end and an open bottom ...	09/20/1994
5348062	Equipment for manufacturing of subcutaneous capsules Apparatus for filling a plurality of capsules with a selected medicine, the capsules each having a closed lower end and an open top end and being mounted in the apparatus for filling the medicine into the capsules through the open top end, the apparatus c...	09/20/1994
5295479	Device intended for measuring a dose of powdered medicament for inhalation The invention relates to a device intended for measuring a dose of powdered medicament for inhalation, including a medicament container (1), through which extends a shaft (3) provided with at least one dosage recess (5). Container (1) is provided with at ...	03/22/1994
5237094	Process for the preparation of methylenebisphosphonic acids The present invention concerns a novel process for the preparation of methylenebisphosphonic acids of the formula I ##STR1## wherein Q1 and Q2 are independently hydrogen or halogen, by hydrolyzing the corresponding methylenebisp...	08/17/1993
5231095	S-timolol hemihydrate A novel compound and compositions containing S-(-)-3-morpholino-4-(3-tert-butylamino-2-hydroxypropoxy)-1,2,5 thiadiazole hemihydrate useful for administration to a patient particularly for topical administration as a pharmaceutical agent for treating...	07/27/1993
5175376	Process for the purification of 2,6-diisopropyl phenol The object of the invention is a new method for the purification of 2,6-diisopropyl phenol (propofol). The invention is characterized in that the raw product obtained from the alkylation of propene with phenol is crystallized at a temperature where propof...	12/29/1992

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Assignee: Leiras Oy