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| Number | Title | Issue Date |
| 7297478 | Creation of variable length and sequence linker regions for dual-domain or multi-domain molecules Disclosed are methods and compositions for creating a DNA, RNA or protein molecule with two or more nucleic acid or polypeptide domains, respectively, joined by a linker region. These methods are used to generate random linker libraries of nucleic acids that encode ... | 11/20/2007 |
| 7270825 | Production of a parvovirus vaccine in plants as viral coat protein fusions The present invention relates to foreign peptide sequences fused to recombinant plant viral structural proteins and a method of their production. Fusion proteins are economically synthesized in plants at high levels by biologically contained tobamoviruses. The fusio... | 09/18/2007 |
| 7235386 | Method of increasing complementarity in a heteroduplex We describe here an in vitro method of increasing complementarity in a heteroduplex polynucleotide sequence. The method uses annealing of opposite strands to form a polynucleotide duplex with mismatches. The heteroduplex polynucleotide is combined with an effective ... | 06/26/2007 |
| 7217514 | Method of increasing complementarity in a heteroduplex We describe here an in vitro method of increasing complementarity in a heteroduplex polynucleotide sequence. The method uses annealing of opposite strands to form a polynucleotide duplex with mismatches. The heteroduplex polynucleotide is combined with an effective ... | 05/15/2007 |
| 7192740 | Recombinant viral nucleic acids The present invention relates to a recombinant viral nucleic acid selected from a (+) sense, single stranded RNA virus possessing a native subgenomic promoter encoding for a first viral subgenomic promoter, a nucleic acid sequence that codes for a viral coat protein... | 03/20/2007 |
| 7179638 | Microarrays and their manufacture by slicing Microarrays are prepared by using a separate fiber for each compound being used in the microarray. The fibers are bundled and sectioned to form a thin microarray that may be glued to a backing. ... | 02/20/2007 |
| 7132588 | Viral expression vectors The present invention provides nucleic acid sequences having an altered viral movement protein and 126/183 kDa replicase proteins further characterized in its ability tostabilize a transgene contained in a virus that expresses the altered movement protein. The prese... | 11/07/2006 |
| 7133544 | Reference database Data acquisition and cataloging are used to classify polypeptides into a reference index or database. The database can be used to identify previously unidentified samples. New polypeptides are characterized and added to the database. ... | 11/07/2006 |
| 7130459 | Reference database Data acquisition and cataloging are used to classify polypeptides into a reference index or database. The database can be used to identify previously unidentified samples. New polypeptides are characterized and added to the database. ... | 10/31/2006 |
| 7084256 | Self antigen vaccines for treating B cell lymphomas and other cancers A polypeptide self-antigen useful in a tumor-specific vaccine mimics one or more epitopes of an antigen uniquely expressed by cells of the tumor. The polypeptide is preferably produced in a plant that has been transformed or transfected with nucleic acid encoding th... | 08/01/2006 |
| 7078211 | Nucleic acid molecules encoding endonucleases and methods of use thereof We describe here an in vitro method of increasing complementarity in a heteroduplex polynucleotide sequence. The method uses annealing of opposite strands to form a polynucleotide duplex with mismatches. The heteroduplex polynucleotide is combined with an effective ... | 07/18/2006 |
| 7056740 | Mismatch endonucleases and methods of use We describe here restriction endonucleases and their uses. Restriction endonucleases are useful in finding single nucleotide polymorphisms. They are also useful in an in vitro method of redistributing sequence variations between non-identical polynucleotide sequence... | 06/06/2006 |
| 7048211 | Flexible processing apparatus for isolating and purifying viruses, soluble proteins and peptides from plant sources A flexible automated apparatus for isolating and purifying viruses, proteins and peptides of interest from a plant material is disclosed, the apparatus being applicable for large scale purification and isolation of such substances from plant material. The flexible a... | 05/23/2006 |
| 7049134 | Rolling circle replicon expression vector A rolling circle DNA replicon which replicates in a host eukaryotic cell is disclosed which has a truncated replication cycle. The rolling circle DNA replicon comprises the following elements present on the same DNA molecule. It contains a Rep gene open reading fram... | 05/23/2006 |
| 7034128 | Method for recovering proteins from the interstitial fluid of plant tissues A method for extracting proteins from the intercellular space of plants is provided. The method is applicable to the large scale isolation of many active proteins of interest synthesized by plant cells. The method may be used commercially to recover recombinantly pr... | 04/25/2006 |
| 7033835 | Production of peptides in plants as viral coat protein fusions The present invention relates to foreign peptide sequences fused to recombinant plant viral structural proteins and a method of their production. Fusion proteins are economically synthesized in plants at high levels by biologically contained tobamoviruses. The fusio... | 04/25/2006 |
| 6987213 | Method for conferring herbicide, pest, or disease resistance in plant hosts The present invention relates to a method for conferring herbicide, pest, and disease resistance in plant hosts. Specifically, the present invention employs transient viral expression vectors to express proteins or enzymes conferring resistance in plant hosts. In ad... | 01/17/2006 |
| 6927779 | Web-based well plate information retrieval and display system A graphical user interfaces (GUI) depicts multiple wells of a well plate that represents biological samples stored in an actual well-plate. Each well includes visual representations of data that corresponds to results of analyses of the corresponding biological samp... | 08/09/2005 |
| 6906172 | Flexible processing apparatus for isolating and purifying viruses, soluble proteins and peptides from plant sources A flexible automated apparatus for isolating and purifying viruses, proteins and peptides of interest from a plant material is disclosed, the apparatus being applicable for large scale purification and isolation of such substances from plant material. The flexible a... | 06/14/2005 |
| 6890748 | Production of lysosomal enzymes in plants by transient expression The invention relates to α-galactosidase truncated at the carboxy terminus and the production of enzymatically active recombinant human and animal lysosomal enzymes involving construction and expression of recombinant expression constructs comprising coding sequenc... | 05/10/2005 |
| 6887696 | Production of lysosomal enzymes in plants by transient expression The invention relates to α-galactosidase truncated at the carboxy terminus and the production of enzymatically active recombinant human and animal lysosomal enzymes involving construction and expression of recombinant expression constructs comprising coding sequenc... | 05/03/2005 |
| 6852846 | Viral amplification of recombinant messenger RNA in transgenic plants A novel method of over expressing genes in plants is provided. This method is based on the RNA amplification properties of plus strand RNA viruses of plants. A chimeric multicistronic gene is constructed containing a plant promoter, viral replication origins, a vira... | 02/08/2005 |
| 6846968 | Production of lysosomal enzymes in plants by transient expression The invention relates to the production of enzymatically active recombinant human and animal lysosomal enzymes involving construction and expression of recombinant expression constructs comprising coding sequences of human or animal lysosomal enzymes in a plant expr... | 01/25/2005 |
| 6841659 | Method for recovering proteins from the interstitial fluid of plant tissues A method for extracting proteins from the intercellular space of plants is provided. The method is applicable to the large scale isolation of many active proteins of interest synthesized by plant cells. The method may be used commercially to recover recombinantly pr... | 01/11/2005 |
| 6817970 | Centrifuge for extracting interstitial fluid A centrifuge is provided for recovering material of interest from the interstitial fluids of plant tissues. The centrifuge includes a rotatable centrifuge bowl having a radially outer wall inclined outwardly so that during centrifugation liquid in the bowl climbs th... | 11/16/2004 |
| 6800748 | Cytoplasmic inhibition of gene expression and expression of a foreign protein in a monocot plant by a plant viral vector The present invention relates to recombinant viral vectors encoding a transcriptional unit, that encodes a fusion protein, or a foreign protein or a gene of interest to be silenced, which can be expressed in a host. The present invention also relates to the use of t... | 10/05/2004 |
| 6740740 | Process for isolating and purifying proteins and peptides from plant sources The present invention features a method for isolating and purifying proteins and peptides of interest from a plant host, which is applicable on a larger scale. Moreover, the present invention provides a more efficient method for isolating proteins and peptides of in... | 05/25/2004 |
| 6730306 | Parvovirus vaccine as viral coat protein fusions The present invention relates to foreign peptide sequences fused to recombinant plant viral structural proteins and a method of their production. Fusion proteins are economically synthesized in plants at high levels by biologically contained tobamoviruses. The fusio... | 05/04/2004 |
| 6720183 | Cytoplasmic inhibition of gene expression The invention provides novel genetic constructions for the expression of inhibitory RNA in the cytoplasm of eukaryotic cells. The inhibitory RNA may be an anti-sense RNA or a co-suppressor RNA, and functions to reduce the expression of a gene of interest in the targ... | 04/13/2004 |
| 6700040 | Cytoplasmic gene inhibition or gene expression in transfected plants by a tobraviral vector This invention is directed to a monopartite RNA viral vector comprising modified tobravirus RNA-1 comprising an inserted foreign RNA sequence. This invention is also directed to a bipartite RNA viral vector derived from a tobravirus, wherein the vector co... | 03/02/2004 |
| 6660500 | Production of peptides in plants as viral coat protein fusions The present invention relates to foreign peptide sequences fused to recombinant plant viral structural proteins and a method of their production. Fusion proteins are economically synthesized in plants at high levels by biologically contained tobamoviruses... | 12/09/2003 |
| 6656726 | Viral expression vectors The present invention provides nucleic acid sequences having an altered viral movement protein and 126/183 kDa replicase proteins further characterized in its ability to stabilize a transgene contained in a virus that expresses the altered movement protei... | 12/02/2003 |
| 6617435 | Method for recovering proteins from the interstitial fluid of plant tissues A method for extracting proteins from the intercellular space of plants is provided. The method is applicable to the large scale isolation of many active proteins of interest synthesized by plant cells. The method may be used commercially to recover recom... | 09/09/2003 |
| 6601050 | Trainable adaptive focused replicator network for analyzing data Electronic data is classified using adaptive focused replicator networks (AFRNs). AFRNs are sets of array elements, each array element being trainable in order to replicate a predetermined sub-group of data. Unknown data is inputted into each and every ar... | 07/29/2003 |
| 6507664 | Two-dimensional gels for separation, identification and characterization of biomolecules The present invention provides an integrated, fully automated, high-throughput system for two-dimensional electrophoresis comprised of gel-making machines, gel processing machines, gel compositions and geometries, gel handling systems, sample preparation ... | 01/14/2003 |
| 6479239 | Detection and characterization of microorganisms A method for separating microorganisms, especially infectious agents, from a mixture by two dimensional centrifugation on the basis of sedimentation rate and isopycnic banding density, for sedimenting such microorganisms through zones of immobilized reage... | 11/12/2002 |
| 6479291 | Cytoplasmic inhibition of gene expression by viral RNA The invention provides novel genetic constructions for the expression of inhibitory RNA in the cytoplasm of eukaryotic cells. The inhibitory RNA may be an anti-sense RNA or a co-suppressor RNA, and functions to reduce the expression of a gene of interest ... | 11/12/2002 |
| 6468745 | Method for expressing a library of nucleic acid sequence variants and selecting desired traits The present invention relates to a method for using viral vectors to bear populations of sequence variants and using plant hosts to select the sequences that exhibit the desired traits.... | 10/22/2002 |
| 6462255 | Viral amplification of recombinant messenger RNA in transgenic plants A novel method of over expressing genes in plants is provided. This method is based on the RNA amplification properties of plus strand RNA viruses of plants. A chimeric multicistronic gene is constructed containing a plant promoter, viral replication orig... | 10/08/2002 |
| 6448046 | Recombinant animal viral nucleic acids The present invention relates to a recombinant viral nucleic acid selected from a (+) sense, single stranded RNA virus possessing a native subgenomic promoter encoding for a first viral subgenomic promoter, a nucleic acid sequence that codes for a viral c... | 09/10/2002 |
