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| Number | Title | Issue Date |
| 7521566 | Process for preparation of perindopril and salts thereof A process for preparation of perindopril of formula (II) and salts thereof which is simple, safe, convenient and cost-effective. The process involves reaction of compound of formula (I), | 04/21/2009 |
| 7521469 | Phosphinic amino acid compounds Compounds of formula (I): wherein: R1 represents hydrogen, alkylcarbonyloxyalkyl or alkylcarbonylthioalkyl, R2 represents hydrogen, alkylcarbonyloxyalkyl, arylcarbonylthioalky... | 04/21/2009 |
| 7498466 | Process for the synthesis and crystalline form of agomelatine A process for the industrial synthesis and new crystalline form of the compound of formula (I): Medicinal products containing the same which are useful in treating disorders of the melatoninergic system. ... | 03/03/2009 |
| 7498465 | Process for the synthesis and crystalline form of agomelatine A process for the industrial synthesis and new crystalline form of the compound of formula (I): Medicinal products containing the same which are useful in treating disorders of the melatoninergic system. ... | 03/03/2009 |
| 7494995 | Phenylpyridylpiperazine compounds A compound selected from those of formula (I): wherein: R1 represents an NR3SO2R4 group wherein: R3 represents a hydrogen atom or an alkyl gro... | 02/24/2009 |
| 7494994 | Phenylpyridylpiperazine compounds A compound selected from those of formula (I): wherein: X represents a C(O) or SO2 group, R1 represents an aryl group or a group NR3R... | 02/24/2009 |
| 7479569 | Process for the synthesis of (7-methoxy-3,4-dihydro-1-naphthalenyl) acetonitrile and its application in the synthesis of agomelatine A process for the industrial synthesis of the compound of formula (I) Application in the synthesis of agomelatine. ... | 01/20/2009 |
| 7476751 | Process for the synthesis of (7-methoxy-1-naphthyl)acetonitrile and its application in the synthesis of agomelatine A process for the industrial synthesis of the compound of formula (I) Application in the synthesis of agomelatine. ... | 01/13/2009 |
| 7476668 | Thiadiazine derivatives and use thereof as positive AMPA receptor modulators Compounds of formula (I): wherein: A represents thienyl, furyl, pyrrolyl, oxathiol, thiazole, isothiazole, oxazole or imidazole, represents a single bond or a double bond... | 01/13/2009 |
| 7470683 | Tetracyclic compounds Compounds of formula I, of trans relative configuration: wherein: X represents an oxygen atom or an NR2 group, Y represents a group selected from —CH2 | 12/30/2008 |
| 7465733 | Piperazine compounds A compound selected from those of formula (I): wherein: R1, R2, R3 and R4, which may be the same or different, each represent an atom or group s... | 12/16/2008 |
| 7462741 | Naphthalene compounds A compound selected from those of formula (I): Medicinal products containing the same which are useful in the treatment of disorders of the melatoninergic system. ... | 12/09/2008 |
| 7462714 | Process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates Process for the industrial synthesis of the compound of formula (I): Application to the synthesis of bivalent salts of ranelic acid and more especially strontium ranelate and its hydrates. ... | 12/09/2008 |
| 7459568 | Alpha crystalline form of strontium ranelate Alpha crystalline form of strontium ranelate of formula (I): characterized by its powder X-ray diffraction diagram and by a water content of from 22 to 24%. Medicinal products containing the same which are useful in... | 12/02/2008 |
| 7442692 | Indanyl-piperazine compounds A compound selected from those of formula (I): wherein: R3 represents a hydrogen atom, and R1 and R2 together with the carbon atoms carrying them form a be... | 10/28/2008 |
| 7439263 | Pyrrolidine and thiazolidine compounds Compounds of formula (I): wherein: X1 represents an atom or group selected from CR4aR4b, O, S(O)q1 and NR5, wherein R4a, R... | 10/21/2008 |
| 7435850 | Naphthalene compounds A compound selected from those of formula (I): Medicinal products containing the same which are useful in the treatment of disorders of the melatoninergic system. ... | 10/14/2008 |
| 7423034 | Benzothiazine and benzothiadiazine compounds Compounds of formula (I): wherein: R1 represents hydrogen, a halogen or alkyl, R1a represents hydrogen or alkyl, R2 represents hydrogen, a halogen or h... | 09/09/2008 |
| 7388022 | Polysubstituted 1,1-pyridylaminocyclopropanamine compounds A compound selected from those of formula (I): wherein: n represents an integer from 1 to 6 inclusive, R1 and R2 represent a hydrogen atom, a (C1-C6)alky... | 06/17/2008 |
| 7384932 | δd-crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it A δd-crystalline form of ivabradine hydrochloride of formula (I): characterised by its powder X-ray diffraction data. Medicinal products containing the same which are useful as bradycardics. ... | 06/10/2008 |
| 7361757 | Method for synthesizing esters of N-[(S)-1-carboxybutyl]-(S)-alanine and use thereof for synthesizing perindopril A process for the synthesis of compounds of formula (I): wherein R represents a linear or branched (C1-C6)alkyl group. Application in the synthesis of perindopril and its pharmaceutically accep... | 04/22/2008 |
| 7361662 | Pyridopyrimidinone compounds, method for production thereof and medicaments comprising the same A compound of formula (I): wherein: R1, R2, R3, R4 are defined in the description, its enantiomers, diastereoisomers, tautomers and also addition salts thereof with a phar... | 04/22/2008 |
| 7361652 | βd-crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it A βd-Crystalline form of ivabradine hydrochloride of formula (I): characterized by its powder X-ray diffraction data. Medicinal products containing the same which are useful as bradycardics. ... | 04/22/2008 |
| 7361651 | γd-crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it A γd-Crystalline form of ivabradine hydrochloride of formula (I): characterised by its powder X-ray diffraction data. Medicinal products containing the same which are useful as bradycardics. ... | 04/22/2008 |
| 7361650 | γ-crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it A γ-Crystalline form of ivabradine hydrochloride of formula (I): characterised by its powder X-ray diffraction data. Medicinal products containing the same which are useful as bradycardics. ... | 04/22/2008 |
| 7361649 | β-crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it A β-Crystalline form of ivabradine of formula (I): characterised by its powder X-ray diffraction data. Medicinal products containing the same which are useful as bradycardics. ... | 04/22/2008 |
| 7358240 | δ-crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it A δ-crystalline form of ivabradine hydrochloride of formula (I): characterised by its powder X-ray diffraction data. Medicinal products containing the same which are useful as bradycardics. ... | 04/15/2008 |
| 7348344 | Polysubstituted 1,1-pyridyloxycyclopropanamine compounds A compound selected from those of formula (I): wherein: n represents an integer from 1 to 6 inclusive, R1 and R2 represent a hydrogen atom, a (C... | 03/25/2008 |
| 7339061 | 3-(4-oxo-4H-chromen-2-yl)-(1H)-quinolin-4-one derivatives, method for preparing same and pharmaceutical compositions containing same Compound of formula (I): wherein: R1, R2, R3, R4, R6, R8, R9 and R10, which may be the same or diffe... | 03/04/2008 |
| 7326794 | Process for the preparation of high purity perindopril and intermediates useful in the synthesis The invention relates to 1-{2(S)-[1(S)-(ethoxycarbonyl)butylamino]propionyl}-(3aS,7aS)octahydroindol-2(S)-carboxylic acid of the Formula I and the t-butylamine salt of the Formula I′ thereof free of contaminations derivable from dicyclohexyl carbodiimide, and a pr... | 02/05/2008 |
| 7288661 | Process for the synthesis of (2S,3aS,7aS)-1-[(S)-alanyl]-octahydro-1-indole-2-carboxylic acid compounds and application in the synthesis of perindopril Process for the synthesis of compounds of formula (I): wherein R represents a hydrogen atom or a protecting group for the amino function. Application in the synthesis of perindopril and pharmaceutically a... | 10/30/2007 |
| 7279595 | Process for the preparation of high purity perindopril The invention relates to 1-{2(S)-[1(S)-(ethoxycarbonyl)butylamino]propionyl}-(3aS,7aS)octahydroindol-2(S)-carboxylic acid of the Formula I and the t-butylamine salt of the Formula I′ thereof free of contaminations derivable from dicyclohexyl carbodiimide, and a pr... | 10/09/2007 |
| 7279583 | Process for the synthesis of perindopril and pharmaceutically acceptable salts thereof Process for the industrial synthesis of perindopril of formula (I): and pharmaceutically acceptable salts thereof. ... | 10/09/2007 |
| 7276512 | Benzo[a]pyrano[3,2-h]acridin-7-one compounds A compound selected from those of formula (I): wherein: X and Y represent a group selected from hydrogen, halogen, hydroxy, alkoxy, nitro, cyano, alkyl, trihaloalkyl and NR... | 10/02/2007 |
| 7268130 | Benzothiadiazine compounds The invention relates to compounds of formula (I): wherein: R1 represents alkyl substituted by one or more halogen atoms, R2 represents hydrogen, halogen or hydroxy... | 09/11/2007 |
| 7268129 | Fluorinated benzothiadiazine compounds Compounds of formula (I): wherein: RF represents monofluoro- or polyfluoro-alkyl or monofluoro- or polyfluoro-cycloalkylalkyl, R1 represents hydrogen or a group sel... | 09/11/2007 |
| 7262190 | Benzothiazine and benzothiadiazine compounds The invention relates to compounds of formula (I): wherein: R1 represents hydrogen, alkyl or cycloalkyl, R2 represents hydrogen, halogen or hydroxy, A ... | 08/28/2007 |
| 7259181 | β crystalline form of perindopril tert-butylamine salt A β crystalline form of the compound of formula (I): characterized by its powder X-ray diffraction data. Medicinal products containing the same which are useful as inhibitors of angiotensin I converting ... | 08/21/2007 |
| 7253162 | Benzothiazine and benzothiadiazine compounds Compounds of formula (I): wherein: R1 represents hydrogen, a halogen or alkyl, R1a represents hydrogen or alkyl, R2 ... | 08/07/2007 |
| 7253161 | Benzothiazine and benzothiadiazine derivatives method for preparing same and pharmaceutical compositions containing same Compounds of formula (I): wherein: R1 represents aryl or heteroaryl, R2 represents hydrogen, halogen or hydroxy, A represents CR4R5 | 08/07/2007 |
