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| Number | Title | Issue Date |
| 7413878 | Recombinant host cells expressing atoAD and capable of making a polyketide using a starter unit Host cells, such as E. coli, are provided with an expression system for making starter units required for biosynthesis of polyketides using the ato pathway. ... | 08/19/2008 |
| 7405208 | Benzoquinone ansamycins The invention relates to benzoquinone ansamycin analogs useful for the treatment of cancer and other diseases or conditions characterized by undesired cellular proliferation or hyperproliferation. Therapies involving the administration of such benzoquinone ansamycin... | 07/29/2008 |
| 7402421 | Recombinant methods and materials for producing epothilone and epothilone derivatives Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) are used to express recombinant PKS genes in host cells for the production of epothilones, epothilone derivatives, and polyketides that are useful as cancer chemothera... | 07/22/2008 |
| 7375230 | Fermentation and purification of migrastatin and analog Migrastatin and a migrastatin analog can be produced by fermentation of Streptomyces platensis NRRL 18993 and used in pharmaceutical formulations to treat cancer and/or inhibit metastasis of cancer cells. ... | 05/20/2008 |
| 7364877 | Polynucleotides encoding disorazole polyketide synthase polypeptides The sequence of the disorazole polyketide synthase protein gene is disclosed. Domains of disorazole polyketide synthase and polynucleotides encoding them are provided. Methods to prepare disorazoles in pharmaceutically useful quantities are described, as are methods... | 04/29/2008 |
| 7342124 | Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided. ... | 03/11/2008 |
| 7332576 | Biosynthetic gene cluster for ambruticins and the encoded proteins Domains of ambruticin polyketide synthase and modification enzymes and polynucleotides encoding them are provided. Methods to prepare ambruticin in pharmaceutically useful quantities are described, as are methods to prepare ambruticin analogs and other polyketides u... | 02/19/2008 |
| 7323573 | Production of polyketides Recombinant Myxococcus host cells can be used to produce polyketides, including epothilone and epothilone analogs that can be purified from the fermentation broth and crystallized. ... | 01/29/2008 |
| RE39836 | Macrolide antinfective agents Compounds of the formula wherein Ra is H; substituted or unsubstituted alkyl (1-10C); substituted or unsubstituted alkenyl (2-10C); substituted or unsubstituted alkynyl (2-10C); subst... | 09/11/2007 |
| RE39762 | Polyketide synthase enzymes and recombinant DNA constructs therefor Polyketide compounds of the formula but not including FK-506, FK-520, 18-hydroxy-FK520 and 18-hydroxy-FK-506. ... | 08/07/2007 |
| 7241754 | 2-Desmethyl ansamycin compounds 2-Desmethyl ansamycins having a structure according to formula I, where R1, R2, R3, R4, R5 and R6 are as defined herein, and other 2-desmethyl ansamycins are useful as antiproliferative agents ... | 07/10/2007 |
| 7189549 | Recombinant polynucleotides encoding pro-geldanamycin producing polyketide synthase and accessory proteins, and uses thereof The invention relates to recombinant polyketide synthase enzymes, polyketide modifying proteins, and other proteins involved in polyketide biosynthesis or function. The invention provides domains of geldanamycin and herbimycin polyketide synthases, polynucleotides t... | 03/13/2007 |
| 7176235 | Epothilone derivatives and methods for making and using the same This invention relates to compounds of formula (I) and to pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R5, W, X, Y, and Ar... | 02/13/2007 |
| 7138279 | Transposon-based transformation system A transposon-based mutagenesis method for altering DNA in Sorangium and other Myxococcales host cells is provided, along with vectors and transposases for use in the method. ... | 11/21/2006 |
| 7067286 | host cells containing heterologous PKS genes for the synthesis of polykedtides Recombinant host cells of the suborder Cystobacterineae, genus Stizmatella, containing recombinant expression vectors that encode heterologous epothilone polyketide synthase (PKS) genes and can produce epothilones at high levels are provided. ... | 06/27/2006 |
| 7033818 | Recombinant polyketide synthase genes Regions of sequence identity are recurrent in some modular polyketide synthase (PKS) gene clusters. Such sequences are potentially detrimental to the stability of PKS gene clusters and expression plasmids for the genes in the gene cluster. PKS gene and gene cluster ... | 04/25/2006 |
| 7022825 | Polyketides and antibiotics Facile methods for preparing diketide and triketide thioesters are disclosed. The resulting thioesters may be used as intermediates in the synthesis of desired polyketides, and may contain functional groups which ultimately reside in side chains on the resulting pol... | 04/04/2006 |
| 7011959 | Heterologous production of polyketides Recombinant E. coli host cells that comprise recombinant DNA expression vectors that drive expression of methylmalonyl CoA mutase from Propionibacterium shermanii or Streptomyces cinnamonensis as well as Propionibacterium shermanii epimer... | 03/14/2006 |
| 6998256 | Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate Methods are provided for purification of epothilone D and epothilone D analogs from epothilone producing cells such as, for example, Sorangium cellulosum and Myxococcus xanthus (recombinant). Epothilone can be purified from fermentation broth, for exam... | 02/14/2006 |
| 6984515 | Macrolide analogs A polyketide or glycosylated polyketide which has the formula: wherein R* is methyl or ethyl; each of R1-R6 is methyl; X1 is OH or H; and/or X2 ... | 01/10/2006 |
| 6946482 | Motilide compounds Motilide compounds having the formula (I), wherein R1, R2, R3, and R4 are as defined herein, and methods for their preparation and use in the treatment of diseases or conditi... | 09/20/2005 |
| 6939861 | Amido macrolides Various macrolide compounds such as those having the following formulas are provided where the variables have the values provided herein. ... | 09/06/2005 |
| 6921650 | Recombinant methods and materials for producing epothilone and epothilone derivatives Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) are used to express recombinant PKS genes in host cells for the production of epothilones, epothilone derivatives, and polyketides that are useful as cancer chemothera... | 07/26/2005 |
| 6902913 | Recombinant narbonolide polyketide synthase Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antib... | 06/07/2005 |
| 6887993 | 11-O-methylgeldanamycin compounds Compounds having a structure according to formula I wherein the groups R1 and R4 are as defined in the specification, are useful as anti-proliferative agents. ... | 05/03/2005 |
| 6875576 | Method for evaluating therapeutic efficacy The present invention relates to in vitro methods for evaluating compounds that better correlate with therapeutic efficiency than evaluating compounds based on potency alone. In general, the inventive method comprises: (i) determining a potency value for a compound ... | 04/05/2005 |
| 6875863 | 11-O-methylgeldanamycin compounds Compounds having a structure according to formula I wherein the groups R1 and R4 are as defined in the specification, are useful as anti-proliferative agents. ... | 04/05/2005 |
| 6872715 | Benzoquinone ansamycins The invention relates to benzoquinone ansamycin analogs useful for the treatment of cancer and other diseases or conditions characterized by undesired cellular proliferation or hyperproliferation. Therapies involving the administration of such benzoquinone ansamycin... | 03/29/2005 |
| 6870049 | 11-O-methylgeldanamycin compounds Compounds having a structure according to formula I wherein the groups R1 and R4 are as defined in the specification, are useful as anti-proliferative agents. ... | 03/22/2005 |
| 6858411 | Recombinant methods and materials for producing epothilone and epothilone derivatives Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) are used to express recombinant PKS genes in host cells for the production of epothilones, epothilone derivatives, and polyketides that are useful as cancer chemothera... | 02/22/2005 |
| 6855705 | 11-O-methylgeldanamycin compounds Compounds having a structure according to formula I wherein the groups R1 and R4 are as defined in the specification, are useful as anti-proliferative agents. ... | 02/15/2005 |
| 6838265 | Overproduction hosts for biosynthesis of polyketides Generic overproduction host cells can be used to produce any polyketide and obviate the need for performing conventional strain improvement. ... | 01/04/2005 |
| 6828126 | Methods for introducing hydroxyl or epoxide groups into polyketides using OleP The heterologous expression of the oleandomycin polyketide synthase (OlePKS) in Streptomyces lividans, produces 8,8 a-deoxyoleandolide, an aglycone precursor of oleandomycin. The co-expression with deoxyerythronolide B synthase (DEBS) in S. lividans of... | 12/07/2004 |
| 6815463 | Laulimalide derivatives Laulimalide compounds, intermediates thereto and methods for their preparation, and methods for their use in the treatment of diseases characterized by cellular hyperproliferation. ... | 11/09/2004 |
| 6794366 | Macrolide antiinfective agents Compounds of the formula or the 10,11-anhydro forms therefor, wherein Ra is H or OH; Rb is H or halogen; Rc is H or a protecting group; Rd is... | 09/21/2004 |
| 6762168 | Macrolide antiinfective agents The invention is directed towards antibacterial compounds. The invention concerns macrolide antibiotics useful as antiinfective agents. ... | 07/13/2004 |
| 6759536 | Polynucleotides encoding the fkbA gene of the FK-520 polyketide synthase gene cluster Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the FK-520 polyketide. Recombinant DNA constructs comprising one or more FK-520 polyketide synthase domains, modules, open readin... | 07/06/2004 |
| 6750047 | Fermentation and purification of migrastatin and analog Migrastatin and a migrastatin analog can be produced by fermentation of Streptomyces platensis NRRL 18993 and used in pharmaceutical formulations to treat cancer and/or inhibit metastasis of cancer cells. ... | 06/15/2004 |
| 6750205 | Motilide compounds The present invention provides novel macrolide compounds of the formulas wherein: R is hydroxyl or methoxy; R1 is selected from the group consisting of hydrogen, hydroxyl, halide, NH2,... | 06/15/2004 |
| 6670389 | Laulimalide derivatives Laulimalide compounds, intermediates thereto and methods for their preparation, and methods for their use in the treatment of diseases characterized by cellular hyperproliferation. ##STR1##... | 12/30/2003 |
