Assignee: Kissei Pharmaceutical Co., Ltd.

Location: Nagano, JP
No. of patents: 87

Number	Title	Issue Date
8058245	Fused heterocycle derivative, medicinal composition containing the same, and medicinal use thereof The present invention provides fused heterocyclic derivatives represented by the following general formula (I) or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exhibit an inhibitory activity in human SGLT and are useful as agents for the prev...	11/15/2011
8022192	Process for production of glucopyranosyloxypyrazole derivative The present invention relates to a method for preparing the glucopyranosyloxypyrazole derivatives which are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications, obesity or the like. A g...	09/20/2011
8003694	Crystal of hydroxynorephedrin derivative hydrochloride ¼ hydrate The present invention provides ethyl (−)-2-[4-[2-[[1S,2R]-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-2,5-dimethylphenoxyacetate hydrochloride ¼ hydrate or a crystal thereof which can be determined by characteristic diffraction peaks of the powder X-...	08/23/2011
7998975	Nitrogenous fused-ring derivatives, medicinal compositions containing the derivatives, and use thereof as drugs The present invention provides nitrogen-containing fused-ring derivatives represented by the following general formula, or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT and are useful as ...	08/16/2011
7989424	Glucopyranosyloxypyrazole derivatives and use thereof in medicines The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug; one of Q and T represents a gr...	08/02/2011
7923462	Catechol derivative, pharmaceutical composition containing the same, use of the catechol derivative, and use of the pharmaceutical composition The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen, lower acyl, lower alkoxycarbonyl or the lik...	04/12/2011
7888487	Pyrazole derivative, medicinal composition containing the same, medicinal use thereof and intermediate in producing the same Pyrazole derivatives represented by the general formula: wherein R1 represents H, an optionally substituted C1-6 alkyl group etc.; one of Q and T represents a group selected from the following groups: ...	02/15/2011
7888382	Combined pharmaceutical preparation for treatment of type 2 diabetes For controlling the condition of type 2 diabetes, a pharmaceutical including a combination of mitiglinide, a pharmacologically acceptable salt thereof or a hydrate thereof and an α-glucosidase inhibitor such as voglibose or acarbose, and a therapeutic method using ...	02/15/2011
7847107	Asymmetric reduction method The present invention is to provide a novel method for producing (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid which is useful as a therapeutic agent for diabetes. The present invention relates to a method for producing (2S)-2-benzyl-3-(cis-he...	12/07/2010
7834193	Indoline compound and process for producing the same The present invention provides an industrial method production of silodosin, which is useful for a therapeutic agent for dysuria associated with benign prostatic hyperplasia. The production of silodosine is characterized by mixing 3-{7-cyano-5-[(2R)-2-({2-[2-(2,2,2-...	11/16/2010
7795236	Purine nucleoside derivative modified in 8-position and medical use thereof The present invention provides an 8-modified purinenucleoside derivative which is useful for diseases associated with an abnormality of plasma uric acid level. An 8-modified purinenucleoside derivative represented by the following formula (I), a prodrug thereof or a...	09/14/2010
7763654	Crystal polymorph of hydroxynorephedrin derivative hydrochloride The present invention provides a novel crystal polymorph of ethyl (−)-2-[4-[2-[[1S,2R]-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-2,5-dimethylphenoxyacetate hydrochloride which can be determined by characteristic diffraction peaks of the powder X-ray...	07/27/2010
7750145	1-substituted-3-β-D-glucopyranosylated nitrogenous hetero-cyclic compounds and medicines containing the same A compound having an SGLT1 and/or SGLT2 inhibitory activity which is usable as an agent for the prevention or treatment of diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complications, obesity, etc. It is a 1-substituted-3-(β-D-glycopyra...	07/06/2010
7749972	1-substituted-7-(β-D-glycopyranosyloxy)(aza)indole compound and pharmaceutical containing the same The present invention provides a compound having an SGLT1 and/or SGLT2 inhibitory activity which is usable as an agent for the prevention or treatment of diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complications, obesity or the like.	07/06/2010
7732596	Fused heterocycle derivative, medicinal composition containing the same, and medicinal use thereof The present invention provides nitrogen-containing fused cyclic derivatives represented by the following general formula or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT and are useful as...	06/08/2010
7674938	Amino alcohol derivatives, pharmaceutical compositions containing the same, and use thereof The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen or lower alkyl; R3, R4...	03/09/2010
7655633	Nitrogen-containing heterocyclic derivatives, medicinal compositions containing the same and medicinal use thereof The present invention provides nitrogen-containing heterocyclic derivatives represented by the general formula: wherein X1 represents N or CR1; X2 represents N or CR2; X3	02/02/2010
7655632	Pyrazole derivative, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof The present invention provides pyrazole derivatives represented by the general formula: wherein R1 represents H, an optionally substituted C1-6 alkyl group etc.; one of Q and T represents a group repre...	02/02/2010
7635684	Pyrazole derivatives, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof The present invention provides pyrazole derivatives represented by the general formula: wherein R1 represents H, an optionally substituted C1-6 alkyl group etc.; one of Q and T represents a group repre...	12/22/2009
7589126	5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is a hydrogen atom or an optionally substituted lower alkyl group;	09/15/2009
7576064	Pyrazole derivative, drug composition containing the same and production intermediate therefor The present invention provides pyrazole derivatives represented by the general formula: wherein R1 represents H, an optionally substituted C1-6 alkyl, etc.; one of Q and T represents a group selected f...	08/18/2009
7576063	Pyrazole derivative, medicinal composition containing the same, medicinal use thereof and intermediate in producing the same The present invention provides pyrazole derivatives represented by the general formula: wherein R1 represents H, an optionally substituted C1-6 alkyl group etc.; one of Q and T represents a group selec...	08/18/2009
7566699	Fused heterocyclic derivative, medicinal composition containing the same, and medicinal use thereof The present invention provides fused heterocyclic derivatives represented by the general formula: wherein R1 represents H, halogen, OH, etc.; R2 represents H, halogen or an alkyl group; R3 a...	07/28/2009
7563822	Agents for the prevention or treatment of renal diseases The present invention relates to an agent for the prevention or treatment of a renal disease comprising as an active ingredient a 5-amidino-2- hydroxybenzenesulfonamide derivative represented by the general formula: ...	07/21/2009
7541341	Glucopyranosyloxybenzylbenzene derivatives and medicinal use thereof The present invention provides glucopyranosyloxybenzylbenzene derivatives represented by the general formula: wherein P represents a hydrogen atom or a group forming a prodrug; R1 represents a hydrogen atom, an o...	06/02/2009
7465713	Glucopyranosyloxypyrazole derivatives and use thereof in medicines The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug; one of Q and T represents a	12/16/2008
7465712	Glucopyranosyloxy benzylbenzene derivatives, medicinal compositions containing the same and intermediates for the preparation of the derivatives The present invention relates to glucopyranosyloxybenzylbenzene derivatives represented by the general formula: wherein R1 represents a hydrogen atom or a hydroxy(lower alkyl) group; and R2 represents ...	12/16/2008
7446128	Agent for treating interstitial cystitis A compound which can be used as an agent for treating interstitial cystitis. An agent for treating interstitial cystitis, which comprises a phenoxyacetic acid derivative represented by a general formula (I) wherein R1 ...	11/04/2008
7429568	Glucopyranosyloxypyrazole derivatives and use thereof in medicines The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug; one of Q and T represents a gr...	09/30/2008
7423185	Amino alcohol derivatives, pharmaceutical compositions containing the same, and use thereof The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen or lower alkyl; R3, R4...	09/09/2008
7417169	Amino alcohol derivatives, medicinal composition containing the same, and use of these The present invention provides compounds represented by general formula (I): a prodrug thereof, or pharmaceutical acceptable salts thereof, wherein R1 is hydrogen or lower alkyl; each of R2 and R3 is independentl...	08/26/2008
7402692	Intermediates in producing phenoxyacetic acid derivatives and method of using the same The present invention provides novel intermediates represented by general formula (I) etc. for preparing a phenoxyacetic acid derivative represented by general formula (X) or a pharmaceutically acceptable salt thereof, which has β3-adrenoceptor stimulating activity...	07/22/2008
7396954	Intermediates in producing phenoxyacetic acid preventives and method of using the same The present invention provides novel intermediates represented by general formula (I) etc. for preparing a phenoxyacetic acid derivative represented by general formula (X) or a pharmaceutically acceptable salt thereof, which has β3-adrenoceptor stimulating activity...	07/08/2008
7393968	Intermediates in producing phenoxyacetic acid derivatives and method of using the same The present invention provides novel intermediates represented by general formula (I) etc. for preparing a phenoxyacetic acid derivative represented by general formula (X) or a pharmaceutically acceptable salt thereof, which has β3-adrenoceptor stimulating activity...	07/01/2008
7393838	Glucopyranosyloxypyrazole derivatives and use thereof in medicines The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug; one of Q and T represents a	07/01/2008
7375113	Nitrogenous fused-ring derivatives, medicinal compositions containing the derivatives, and use thereof as drugs The present invention provides nitrogen-containing fused-ring derivatives represented by the following general formula, or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT and are useful as ...	05/20/2008
7375087	Pyrazole derivative, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof The present invention provides pyrazole derivatives represented by the general formula: wherein R1 represents H, an optionally substituted C1-6 alkyl group etc.; one of Q and T represents a group repre...	05/20/2008
7371730	Crystals of glucopyranosyloxybenzyl benzene derivative The present invention provides crystals of 2-(4-methoxybenzyl)phenyl 6-O-ethoxycarbonyl-β-D-glucopyranoside, pharmaceutical compositions containing the same and their uses, which exhibit excellent SGLT2 inhibitory activities, and are useful for treating or preventi...	05/13/2008
7329771	Intermediates in producing phenoxyacetic acid derivatives and method of using the same The present invention provides novel intermediates represented by general formula (I) etc. for preparing a phenoxyacetic acid derivative represented by general formula (X) or a pharmaceutically acceptable salt thereof, which has β3-adrenoceptor stimulating activity...	02/12/2008
7294618	Glucopyranosyloxypyrazole derivatives and medicinal use thereof The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R1, R2 and R3 represent a hydrogen atom or a halogen atom; R4...	11/13/2007

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Assignee: Kissei Pharmaceutical Co., Ltd.