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Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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| Number | Title | Issue Date |
| 8178300 | Method for the identification of the clonal source of a restriction fragment The present invention relates to a high throughput method for the identification and detection of molecular markers wherein restriction fragments are generated and suitable adaptors comprising (sample-specific) identifiers are ligated. The adapter-ligated restrictio... | 05/15/2012 |
| 7970548 | AFLP-based method for integrating physical and genetic maps The invention pertains to a method for the integration of physical and genetic maps and markers. The method is based on the use of AFLP fingerprinting with primers of varying selectivity on a library of artificial chromosomes such as a BAC library. The fingerprintin... | 06/28/2011 |
| 7947872 | Nucleotide sequences involved in plant disease resistance The present invention relates to methods for producing plants having enhanced disease resistance. NRC1 proteins and nucleic acid sequences encoding these are provided, as well as transgenic plants producing NRC1 proteins. ... | 05/24/2011 |
| 7935488 | Selective restriction fragment amplification: fingerprinting The invention relates to a process for the controlled amplification of at least one part of a starting DNA containing a plurality of restriction sites for a determined specific restriction endonuclease, and of which at least part of its nucleic acid is unknown. This... | 05/03/2011 |
| 7846657 | Detection of target nucleotide sequences using ligation assays with improved oligonucleotide probe pairs A pair of oligonucleotide probes comprising a first oligonucleotide probe that comprises a first clamp section that is capable of hybridising to a second clamp section of a second oligonucleotide probe and a first target section that is capable of hybridising to a f... | 12/07/2010 |
| 7572583 | Selective restriction fragment amplification: fingerprinting The invention relates to a process for the controlled amplification of at least one part of a starting DNA containing a plurality of restriction sites for a determined specific restriction endonuclease, and of which at least part of its nucleic acid is unknown. ... | 08/11/2009 |
| 7563445 | CD40 binding molecules and CTL peptides for treating tumors Disclosed is a method and composition for treating tumors or infectious diseases, wherein the composition includes CD40 binding molecules together with CTL-activating peptides, e.g., tumor antigens. Such composition is useful for enhancing the anti-tumor effect of a... | 07/21/2009 |
| 7459604 | Methods for generating resistance against CGMMV in plants The present invention relates to methods for generating resistance against Cucumber Green Mottle Mosaic Virus (CGMMV) in plants, in particular in plants susceptible to infection by CGMMV, such as Cucurbitaceae species, including melon, cucumber, watermelon and bottl... | 12/02/2008 |
| 7320892 | Nucleotide sequences involved in plant disease resistance The present invention relates to methods for producing plants having enhanced disease resistance. NRC1 proteins and nucleic acid sequences encoding these are provided, as well as transgenic plants producing NRC1 proteins. ... | 01/22/2008 |
| 7217516 | Methods and kits comprising AFLP primers, and ramp primers with a part complementary to a compound microsatellite repeat and an anchor part complementary to nucleotides adjacent to the repeat The present invention discloses methods for identifying and analysing microsatellite-associated polymorphisms between different DNA samples. Different DNA samples, e.g. from different individuals, are analysed using a PCR based on the combination of a RAMP-primer an... | 05/15/2007 |
| 7205451 | Nucleotide sequences coding signal transduction components in durable and broad-range resistance strategies based on plant defence Nucleotide sequences coding signal transduction components in durable and broad-range resistance strategies based on plant defense. The invention relates to nucleotide sequences derived from a plant genorne, capable of encoding a polypeptide product which can be act... | 04/17/2007 |
| 7169552 | Detection of polymorphisms in AFLP fragments using primer extension techniques The present invention relates to a method for determining the genotypes of polymorphic loci amplified in a mixture of restriction fragments, using an oligonucleotide sequence that is essentially complementary to part of the target restriction fragment, and located a... | 01/30/2007 |
| 7166429 | Method for generating oligonucleotides, in particular for the detection of amplified restriction fragments obtained using AFLP® The invention relates to a method for generating, and optionally detecting, an oligonucleotide, comprising at least the steps of: a) providing a first dsDNA; b) ligating the first dsDNA to a second dsDNA, in which said second dsDNA sequence comprises within its sequ... | 01/23/2007 |
| 7026115 | Selective restriction fragment amplification: fingerprinting The invention relates to a process for the controlled amplification of at least one part of a starting DNA containing a plurality of restriction sites for a determined specific restriction endonuclease, and of which at least part or its nucleic acid is unknown. ... | 04/11/2006 |
| 6791007 | Polynucleotide and its use for modulating a defence response in plants The present invention relates to stimulating a defense response in plants, with a view to providing the plants with enhance pathogen resistance. ... | 09/14/2004 |
| 6613962 | Tomato nucleic acid encoding protein that confers resistance to aphids and nematodes and plants transformed therewith The invention relates to tomato nucleic acid sequences encoding protein that confers resistance to nematodes and/or aphids, vectors, plant cells, plants and seeds comprising said nucleic acid sequences. The invention further relates to a process of transf... | 09/02/2003 |
| 6300071 | Method for detecting nucleic acid methylation using AFLP™ The invention relates to a method for analyzing of determining the methylation pattern of a starting DNA and/or for distinguishing between methylated and non-methylated sites in the starting DNA, comprising at least (A) generating a first DNA fingerprint,... | 10/09/2001 |
| 6218119 | Amplification of simple sequence repeats The invention relates to a process for the selective amplification of restriction fragements comprising simple sequence repeats. The process of the invention can be used in a range of fields including but not limited to plant and animal breeding, genetic ... | 04/17/2001 |
| 6045994 | Selective restriction fragment amplification: fingerprinting The invention relates to a process for the controlled amplification of at least one part of a starting DNA containing a plurality of restriction sites for a determined specific restriction endonuclease, and of which at least part of its nucleic acid is un... | 04/04/2000 |
| 5874215 | Amplification of simple sequence repeats The invention relates to a process for the selective amplification of restriction fragements comprising simple sequence repeats. The process of the invention can be used in a range of fields including but not limited to plant and animal breeding, genetic ident... | 02/23/1999 |
