William F. Semple, a dentist, was awarded the first US Patent on chewing gum in 1869. His recipe contained powdered chalk.
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| Number | Title | Issue Date |
| 5093044 | Triglyercide nutrient for humans and animals The invention relates to a nutrient for humans and animals, which is characterized in that the nutrient contains at least one non-readily water-soluble glyceride of at least one keto acid or hydroxy acid. The nutrient can be administered together with foo... | 03/03/1992 |
| 5052562 | Method and apparatus for sorting round objects A method and apparatus for sorting round objects which are received in a first sorter in which objects not meeting a predetermined minimum dimension are passed out of the apparatus and taken away, whereas objects meeting the predetermined minimum dimensio... | 10/01/1991 |
| 5039529 | Novel heparin derivatives A novel complex of (a) a metal ion selected from copper, calcium, manganese, iron, and zinc ions, and (b) a fraction of heparin, heparan sulfate, low molecular weight heparin, low molecular weight heparan sulfate, heparin fragments, heparan sulfate fragme... | 08/13/1991 |
| 5033158 | Apparatus for washing oriented stoppers in a closed environment An apparatus for washing position oriented stoppers in a closed environment while retaining the orientation comprises a closed chamber, and a chain conveyor located in the closed chamber for receiving position oriented stoppers. The chain conveyor include... | 07/23/1991 |
| 4987726 | Bottle filling and sealing apparatus An apparatus for aseptically filling and sealing bottles with a liquid preparation includes a plurality of treatment stations in which bottles are successively placed in bottle holding devices, evacuated and flushed or rinsed with an inert gas, filled wit... | 01/29/1991 |
| 4968299 | Method and device for injection A dual-chamber cylinder ampoule is used for the mixture of a sensitive, solid medicament, with liquid which is caused to flow calmly through the medicament in order to avoid any shaking and mechanical influence. The mixing is preferably carried out at a p... | 11/06/1990 |
| 4958649 | Apparatus for treating articles with a gaseous and/or liquid medium The present invention relates to an apparatus for treating a plurality of articles with a gaseous or liquid medium. The apparatus includes a cylindrical chamber in which the articles (14) are arranged in an ordered array in channels (16) which are configu... | 09/25/1990 |
| 4944659 | Implantable piezoelectric pump system A dispensing device for use in an implantable drug delivery system for ambulatory patients comprises a pump in a drug reservoir and a piezoelectric disc element bonded to a diaphragm member forming one wall of a pump chamber and a battery and electrical c... | 07/31/1990 |
| 4917880 | Iodine-containing emulsion The invention relates to an emulsion for use as an X-ray contrast agent and containing one or more iodinated lipids emulsified in an aqueous phase. The emulsion contains one or more amino acids, fatty acids or their salts, fat-soluble vitamins and/or urea... | 04/17/1990 |
| 4877614 | Biologically active fragments of human antihemophilic factor and method for preparation thereof Novel, biologically active fragments of human antihemophilic factor, processes for their preparation, pharmaceutical preparations containing them and the use of such fragments in the treatment of patients suffering from hemophilia.... | 10/31/1989 |
| 4797472 | New peptide derivatives Tripeptide derivatives, characterized by the general formula: wherein R1 is hydrogen, - or ଲ-naphtyl residue, lower alkyl residue which may be substituted with a carboxyl group, unsubstituted or substituted phenyl- or phenylalkyl residu... | 01/10/1989 |
| 4749780 | Biologically active fragments of human antihemophilic factor and method for preparation thereof Novel, biologically active fragments of human antihemophilic factor, processes for their preparation, pharmaceutical preparations containing them and the use of such fragments in the treatment of patients suffering from hemophilia.... | 06/07/1988 |
| 4748116 | Peptide substrates for determination of protease activity Peptide sequences consisting of 2-4 amino acids with high affinity and comparatively high specificity to a number of various, physiologically important proteases are known to have been synthetized before. Such sequences with an added C-terminal marker hav... | 05/31/1988 |
| 4693997 | Novel pharmaceutical composition A novel complex of carrageenan and a member of the group consisting of emepronium, doxycycline, and propranolol, pharmaceutical preparations containing such a complex, and its use in medicine.... | 09/15/1987 |
| 4623718 | Novel composition of matter of antithrombin III bound to a heparin fragment Novel chemical compounds which are heparin fragments with a molecular weight of from 2,000 to 5,500 covalently bound to antithrombin III, and their use in medicine.... | 11/18/1986 |
| 4592743 | Apparatus for mixing liquids This invention relates to a device for dosing and mixing of two or more liquids. According to the invention, the liquids are led to a chamber (26) where they are mixed, an outlet (30) from the chamber being closed at the same time. When the chamber (26) h... | 06/03/1986 |
| 4567045 | Isotonic glycerol free intravenous fat emulsion Sterile, glycerol free lipid emulsion suitable for parenteral administration and including alanine in an amount sufficient to provide pharmaceutically acceptable osmolality.... | 01/28/1986 |
| 4563354 | Oil-in-water emulsion for parenteral administration An emulsifier adapted for use in a nutritive oil-in-water emulsion suitable for parenteral administration is produced by extracting vegetable lecithin with alkyl alcohols having from 1 to 3 carbon atoms, or mixtures thereof, followed by fractional precipi... | 01/07/1986 |
| 4537896 | Thrombin inhibiting arylsulfonyl guanidinophenylalanine amides New thrombin inhibiting N -arylsulfonyl-p-guanidinophenylalanine amides of the formula ##STR1## wherein Ar is a substituted aryl and R1 and R2 are an alkyl group having 1-5 carbon atoms or together with the ami... | 08/27/1985 |
| 4536495 | Novel pharmaceutical composition A novel complex of carrageenan and a member of the group consisting of emepronium, doxycycline, and propranolol, pharmaceutical preparations containing such a complex, and its use in medicine.... | 08/20/1985 |
| 4528197 | Controlled triglyceride nutrition for hypercatabolic mammals Method and composition for enhancing protein anabolism in an hypercatabolic mammal. The method comprises parenterally administering to the mammal nutritionally sufficient sources for amino acids, carbohydrates and lipids, the lipids comprising a controlle... | 07/09/1985 |
| 4496550 | Oligosaccharides having selective anticoagulation activity The invention relates to an oligosaccharide which contains 4-8 monosaccharide units and which is characterized in that it contains at least one glucosamine unit which is 3-0-sulfated, and at least one additional glucosamine unit, whereby these units are l... | 01/29/1985 |
| 4483867 | Antifibrinolytically active derivatives of tranexamic acid Novel antifibrinolytically active compounds of the formula ##STR1## and therapeutically acceptable salt thereof, wherein R1 is selected from the group consisting of (a) alkyl groups containing 1-4 carbon atoms, (b) alkoxy groups containing 1-4 carbo... | 11/20/1984 |