Assignee: Juridical Foundation The Chemo-Sero-Therapeutic Research Institute

Location: Kumamoto, JP
No. of patents: 66

Number	Title	Issue Date
8067221	Von Willebrand factor (vWF)-cleaving protease This invention is intended to isolate and identify a vWF-specific cleaving protease. The vWF-specific cleaving protease cleaves a bond between residues Tyr 842 and Met 843 of vWF and comprises a polypeptide chain having Leu-Leu-Val-Ala-Val (SEQ ID NO: 1) as a partia...	11/29/2011
7829306	Protein highly producing recombinant animal cell, method for preparing the same, and method for mass-producing protein using the same A gene encoding a production amount-potentiating factor is introduced into an animal cell to transform the cell. Alternatively, a protein production gene and the gene encoding the production amount-potentiating factor are introduced into the animal cell to transform...	11/09/2010
7575872	Antibody against von Willebrand factor cleaving enzyme and assay system using the same It is intended to provide an antibody showing immunoreactivity selectively to ADAMTS-13 and applications of this antibody in epitope analysis or diagnosis of an ADAMTS-13 autoantibody-positive patient. Alternatively, it is intended to provide a process for producing...	08/18/2009
7361748	von Willebrand factor (vWF)—cleaving protease This invention is intended to isolate and identify a vWF-specific cleaving protease. The vWF-specific cleaving protease cleaves a bond between residues Tyr 842 and Met 843 of vWF and comprises a polypeptide chain having Leu-Leu-Val-Ala-Val (SEQ ID NO: 1) as a partia...	04/22/2008
7214785	Human-type anti-blood coagulation factor VIII antibody The present invention provides a human antibody against blood coagulation factor VIII (hereinafter also referred to as “FVIII”) and an antibody fragment that binds to human FVIII and specifically inhibits the coagulation activity of human FVIII. ScFv display pha...	05/08/2007
7199097	Peptide fragments having cell death inhibitory activity The present invention provides a peptide fragment or a series of peptide fragments having a cell death-inhibitory activity, having the amino acid sequence consisting of 103 amino acid residues at the C-terminal of selenoprotein P, or having said amino acid sequence ...	04/03/2007
7132243	Clonal expansion of T cells of unknown specificity and identification of ligand recognized by the clonally expanded T cells A process for clonally expanding T cells of unknown specificity and a process for identifying a peptide ligand recognized by said T cells are provided. A process for clonally expanding T cells of unknown specificity which comprises co-culturing said T cells o...	11/07/2006
7112666	Von Willebrand Factor (Vwf)-cleaving protease This invention is intended to isolate and identify a vWF-specific cleaving protease. The vWF-specific cleaving protease cleaves a bond between residues Tyr 842 and Met 843 of vWF and comprises a polypeptide chain having Leu-Leu-Val-Ala-Val as a partial sequen...	09/26/2006
7001885	Method for removing multimers of human serum albumin Multimers of human serum albumin are removed from a solution of human serum albumin containing the multimers by bringing the human serum albumin solution into contact with an anion-exchanger equilibrated with a buffer containing a salt in a concentration ranging fro...	02/21/2006
6919080	Polypeptide for Haemophilus paragallinarum and process for preparing the same A novel peptide obtained from Haemophilus paragallinarum has been found useful for preventing avian infectious coryza. This polypeptide induces production of hemagglutination-inhibition antibody and prevents infection and onset of avian infectious coryza. The...	07/19/2005
6908749	Method for preparing human serum albumin containing heat-treatment A method for preparing human serum albumin comprises the step of heat-treating a human serum albumin solution containing contaminants at a pH value in the proximity to the isoelectric point of the contaminants. ...	06/21/2005
6881721	Medicinal compositions for treating and preventing diseases based on abnormal blood coagulation The present invention provides a pharmaceutical composition for treatment and prevention of hemorrhage associated with blood coagulation disorders, comprising activated Factor VII (FVIIa) and Factor X (FX) as an active ingredient. The pharmaceutical composition of t...	04/19/2005
6869934	Method of purifying calcium ion-binding protein The present invention relates to a method for purifying a calcium ion-binding protein by cation exchange chromatography. The present invention provide a method for isolating and purifying a calcium ion-binding protein in a simple and efficient manner from a liquid s...	03/22/2005
6855319	Gene encoding merozoite protein of Babesia caballi, recombinant protein obtained therefrom and utilization thereof The present invention provides a gene encoding a protein from merozoite of Babesia caballi, a recombinant protein of Babesia caballi, and an antibody capable specifically binding to a 48 kDa protein of rhoptry of Babesia caballi merozoite. In ac...	02/15/2005
6825036	Cell usable in serum-free culture and suspension culture and process for producing virus for vaccine by using the cell A novel MDCK-derived cell line (B-702) is provided that can be grown in the absence of fetal calf serum and in suspension culture for allowing a tank culture on the production scale and needs no carrier in suspension culture, as well as a process for producing virus...	11/30/2004
6544519	Polypeptide originating in haemophilus paragallinarum and process for producing the same A novel peptide obtained from Haemophilus paragallinarum has been found useful for preventing avian infectious coryza. This polypeptide induces production of hemagglutination-inhibition antibody and prevents infection and onset of avian infectious coryza....	04/08/2003
6518045	Feline cytokine protein A novel feline cytokine protein having the activity to enhance the cytotoxic activity of feline cytotoxic T lymphocytes, a DNA sequence coding for said protein, a recombinant DNA for expressing said protein, an expression vector comprising said recombinan...	02/11/2003
6472509	Feline cytokine protein A novel feline cytokine protein having the activity to enhance the cytotoxic activity of feline cytotoxic T lymphocytes, a DNA sequence coding for said protein, a recombinant DNA for expressing said protein, an expression vector comprising said recombinan...	10/29/2002
6429286	Immunoregulatory molecules for costimulatory signal transduction An immunoregulatory molecule that regulates costimulatory signal transduction through interaction with the molecules involved in costimulatory signal transduction present on antigen presenting cells and/or T cells in the activation of T cells by antigen p...	08/06/2002
6410222	In ovo vaccination of marek's disease type I virus The preset invention provides a method for immunizing chickens which comprises inoculating into growing egg a composition comprising either cell-free attenuated viruses of Marek's disease type 1 or cells infected with attenuated viruses of Marek's disease...	06/25/2002
6300100	Process for preparing tissue factor pathway inhibitor In a process for preparing Tissue Factor Pathway Inhibitor (TFPI) by the genetically engineered technique by the use of a transformed animal cell wherein a DNA encoding human TFPI is introduced, the improvement which comprises culturing said transformed a...	10/09/2001
6251370	Tissue adhesive suitable for spray application An adhesive for tissue capable of uniformly forming a high concentration of fibrin so as to provide a high closing effect is disclosed. The adhesive for tissue comprises a fibrinogen solution and a thrombin solution which solutions are separated from each...	06/26/2001
6191113	Peptide for inhibiting growth of smooth muscle cells A peptide comprising a peptide (A) of an amino acid sequence being abundant in basic amino acid residues and a peptide (B) of an amino acid sequence comprising at least two consecutive, hydrophobic amino acid residues wherein the peptide (B) is linked to ...	02/20/2001
6139838	Tissue plasminogen activator medicinal composition The present invention provides a t-PA medicinal preparation obtained by remarkably improving the solubility and stability of t-PA or modified t-PA. Nicotinamide or a derivative thereof is incorporated into t-PA or modified t-PA-containing solvent system. ...	10/31/2000
6124432	Process for purifying dermonecrotic toxin produced by Bordetella and toxoid The present invention aims at providing a method for preparing dermonecrotic toxin, an improved toxoid of dermonecrotic toxin produced by Bordetelia and a toxoid mixture comprising said improved toxoid of dermonecrotic toxin produced by Bordetella and a t...	09/26/2000
6114143	Anti-HIV monoclonal antibody A monoclonal antibody useful for clinical application which recognizes the conserved region of V3-PND region of glycoprotein antigen having a molecular weight of about 1.2×105 daltons (gp120) on a coating membrane of human immunodeficiency vir...	09/05/2000
6060449	Neovascularization inhibitor containing tissue factor pathway inhibitor There is provided an inhibitor of angiogenesis induced by growth of the vascular endothelial cells that comprises Tissue Factor Pathway Inhibitor (TFPI) as an active ingredient. The TFPI-containing preparation of the present invention can effectively inhi...	05/09/2000
6013261	Recombinant Marek's disease virus (MDV) and vaccine A recombinant herpes virus is provided which efficiently expresses an exogenous protein of interest in an inoculated animal host to thereby endow the host with excellent immunization. A recombinant herpes virus which incorporates an exogenous gene express...	01/11/2000
5962299	Method of stabilizing protein C or activated protein C and the stabilized composition obtained by said method A method for stabilizing protein C or activated protein C and a preparation obtained by said method are provided, said method and preparation being applicable during procedures such as isolation and purification, lyophilization, heating, etc. or when stor...	10/05/1999
5880274	Cat-mouse heterohybridoma and gene fragment coding for constant region of feline immunoglobulin A Gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of feline immunoglobulin λ chain; a gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of feline immuno...	03/09/1999
5852183	Dog-mouse heterohybridoma and gene fragment coding for constant region of canine immunoglobulins A gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of canine immunoglobulin lambda chain; a gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of canine im...	12/22/1998
5831025	Human activated protein C and process for preparing same A human Activated Protein C preparation with a high specific activity of 3500 U/mg or more and substantially free from thrombin or other proteases which can convert Protein C into Activated Protein C is provided. A process for preparing this human Activat...	11/03/1998
5814321	Oil adjuvant vaccine and method for preparing same A water-in-oil type oil adjuvant vaccine comprises 20 to 90% by weight of an oil phase A) which is in a liquid state at ordinary temperature; 0.5 to 30% by weight of an emulsifying agent comprising a non-ionic surfactant B) which is a partial ester derive...	09/29/1998
5811260	Exogenous gene expression vector containing chick ଲ-actin gene promoter An expression vector for the expression of an exogenous gene in an animal cell, which contains a chick ଲ-actin gene promoter and a restriction enzyme site for incorporating an exogenous gene at the downstream of said promoter and a process for expre...	09/22/1998
5811279	Method for activating prothrombin with polyethylene glycol A method for activating prothrombin to thrombin is presented which comprises treating an aqueous solution containing prothrombin with polyethylene glycol in the presence or absence of the calcium salt. The method enables conversion of prothrombin to throm...	09/22/1998
5785968	Anti-feline calicivirus recombinant antibody and gene fragment encoding the same Anti-FCV (feline calicivirus) feline-type recombinant antibody effective for treatment, prevention and diagnosis of FCV infection and a gene fragment useful for preparation of said antibody are provided. Cell line 1D7 capable of producing a mouse monoclon...	07/28/1998
5773247	Recombinant anti-HIV antibody and process for preparing the same The present invention relates to a gene fragment coding for a variable region of an antibody having a neutralizing activity against human immunodeficiency virus (HIV) and a process for preparing the same. A mouse-human chimeric antibody and a mouse-human ...	06/30/1998
5770400	Exogenous gene expression vector containing chick ଲ-actin gene promoter An expression vector for the expression of an exogenous gene in an animal cell, which contains a chick ଲ-actin gene promoter and a restriction enzyme site for incorporating an exogenous gene at the downstream of said promoter and a process for expre...	06/23/1998
5760185	Anti-feline herpes virus-1 recombinant antibody and gene fragment coding for said antibody An anti-FHV-1 recombinant antibody efficacious for treatment, prevention and diagnosis of feline herpes virus-1 (FHV-1) and a gene fragment useful for preparing the same are provided. A cell producing a mouse monoclonal antibody having an excellent neutra...	06/02/1998
5712373	HIV monoclonal antibody specific for the HTLV-III_mn gp120 envelope glycoprotein A murine monoclonal antibody which specifically binds to a glycoprotein antigen having a molecular weight of about 12×104 daltons (gp120) present in the envelope of human T-lymphotropic virus IIIMN (HTLV-IIIMN) and capabl...	01/27/1998

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Assignee: Juridical Foundation The Chemo-Sero-Therapeutic Research Institute