Assignee: Joslin Diabetes Center, Inc.

Location: Boston, MA
No. of patents: 41

Number	Title	Issue Date
8178492	Methods and compositions for modulating adipocyte function Methods and compositions for treating obesity and related disorders. The methods include the use of BMP-2, -4, -6 and -7. ...	05/15/2012
8080374	Methods of diagnosing cardiovascular disease Described herein are methods for diagnosing increased risk of cardiovascular disease in a subject, based on the presence or absence of polymorphisms in the D36 gene. ...	12/20/2011
8003606	Inhibiting serum response factor (SRF) to improve insulin sensitivity Described are methods of improving glycemic control/improving insulin sensitivity by administering an inhibitor of serum response factor (SRF) activity, and methods of identifying new compounds for use in the described methods of treatment. ...	08/23/2011
7825098	Methods and compositions for modulating Necdin function Described herein are methods for identifying and using inhibitors of Necdin function to promote brown adipose tissue (BAT) differentiation, thereby treating obesity. ...	11/02/2010
7700555	Methods of treating diabetes The invention provides methods of screening for compounds that increase levels or activity of Aryl hydrocarbon Nuclear Receptor Translocator (ARNT) and/or Hypoxia Inducible Factor 1α (HIF1α), for the treatment and prevention of diabetes-related disorders, includin...	04/20/2010
7695961	Insulin related transcription factor and uses thereof The invention provides isolated mMafA polypeptides, nucleic acids, vectors and host cells containing them, which encode a novel insulin related transcription factor. Diagnostic methods, methods of selecting and differentiating insulin-producing cells, and methods of...	04/13/2010
7576052	Methods and compositions for modulating adipocyte function Methods and compositions for treating obesity and related disorders. The methods include the use of BMP-2, -4, -6 and -7. ...	08/18/2009
7560244	Method of evaluating a subject for risk or predisposition of reduced renal function over time The invention includes diagnostic, predictive, prognostic and monitoring methods and reagents for loss of renal function, e.g., diabetic nephropathy and end stage renal disease (ESRD). ...	07/14/2009
7524492	Insulin related transcription factor and uses thereof The invention provides isolated mMafA polypeptides, nucleic acids, vectors and host cells containing them, which encode a novel insulin related transcription factor. Diagnostic methods, methods of selecting and differentiating insulin-producing cells, and methods of...	04/28/2009
7410756	Methods of modulating angiogenesis Featured are methods of modulating angiogenesis, e.g., by modulating PKC delta. The methods are useful in the treatment of disorders characterized by aberrant and/or increased blood vessel formation and/or increased permeability. The methods are also useful for trea...	08/12/2008
7338167	Retinal imaging system A retinal imaging system includes a light source and optics which receive light from the light source and which transmit the light to produce a beam that is substantially convergent. The beam penetrates a lens of an eye and diverges following penetration of the lens...	03/04/2008
7256176	Methods of modulating β cell function Methods of modulating pancreatic function by modulating MCH signaling in a β cell. ...	08/14/2007
7175844	Methods of modulating fibrosis The invention features methods of modulating fibrosis and/or angiogenesis by inhibiting components of the VEGF signaling pathway. The methods are useful in the treatment of fibrotic and or angiogenesis related disorders. ...	02/13/2007
7101845	Methods of modulating β cell function Methods of modulating pancreatic function by modulating MCH signaling in a β cell. ...	09/05/2006
7033585	Immunologically privileged cells and uses thereof The invention is directed to immunologically privileged cells, e.g., autologous, allogeneic, and xenogeneic intermediate lobe pituitary cells, for delivering polypeptides, e.g., insulin, to a subject, and to methods of using the same. ...	04/25/2006
6930181	Antigen associated with type 1 Diabetes Mellitus A 69 kD protein, designated PM-1, is expressed in human pancreatic islet cells and a human insulinoma. The amino acid sequence of the protein has been determined. Autoantibodies to the PM-1 protein have been found in sera of prediabetic patients. Natural, synthetic ...	08/16/2005
6815203	Methods of making pancreatic islet cells The invention features methods of promoting dedifferentiation of pancreatic cells, methods of obtaining pancreatic islet cells from the dedifferentiated pancreatic cells, and methods of treating a subject having a disorder characterized by insufficient pancreatic is...	11/09/2004
6811993	Diagnostic and screening methods based on monocyte PKC activity The invention features a method for evaluating PKC activity in vascular tissues. The invention also features methods for diagnosing cardiovascular and diabetes related disorders, and for identifying and evaluating treatments for cardiovascular or diabetes related di...	11/02/2004
6753341	Inhibition of PKC to treat permability failure The invention features a method of treating a subject, e.g., a subject having permeability disjunction, which includes administering to the subject peritoneal dialysis fluid which includes an inhibitor of PKC, e.g., an inhibitor of PKC β. The invention also feature...	06/22/2004
6630312	Method for identifying compounds for treatment of insulin resistance The invention features a method of identifying, evaluating or making a compound or agent, e.g., a candidate compound or agent, for treatment of a disorder characterized by insulin resistance. The method includes evaluating the ability of a compound or age...	10/07/2003
6468755	Method for identifying compounds for treatment of insulin resistance The invention features a method of identifying, evaluating or making a compound or agent, e.g., a candidate compound or agent, for treatment of a disorder characterized by insulin resistance. The method includes evaluating the ability of a compound or age...	10/22/2002
6326141	Methods for determining risk for Type I and Type II diabetes Purified DNA including a sequence encoding Diabetogene rad....	12/04/2001
6322978	Repeat polymorphism in the frataxin gene and uses therefore The invention provides methods of determining whether a subject is at risk for a disorder characterized by an intermediate GAA repeat length polymorphism in the frataxin gene....	11/27/2001
6156551	Activated mutants of SH2-domain-containing protein tyrosine phosphatases and methods of use thereof The invention relates to novel mutant SH2 domain containing protein tyrosine phosphatases wherein the phosphatase is partially or constitutively active; and whose ability to regulate biological processes are different from the wildtype protein tyrosine ph...	12/05/2000
6114320	Therapeutic treatment for VEGF related ocular diseases A method for inhibiting VEGF stimulated endothelial cell growth, such as associated with macular degeneration, and VEGF stimulated capillary permeability, such as associated with macular edema are disclosed, particularly using the isozyme selective PKC in...	09/05/2000
5993001	Stereoscopic imaging system for retinal examination with remote examination unit An image acquisition unit provides true color high resolution digital images of the retina of the eye to a computer network (14, 16, 18) which interfaces with a central record library and displays the images at a remote work station (20A and 20B) for diag...	11/30/1999
5908627	Antigen associated with Type I diabetes mellitus A 69 kD protein, designated PM-1, is expressed in human pancreatic islet cells and a human insulinoma. The amino acid sequence of the protein has been determined. Autoantibodies to the PM-1 protein have been found in sera of prediabetic patients. Natural,...	06/01/1999
5891430	Diabetogene rad: a type II diabetes specific gene Purified DNA including a sequence encoding Diabetogene rad....	04/06/1999
5858701	DNA encoding an insulin receptor substrate A substantially pure nucleic acid comprising a sequence encoding an IRS-2 polypeptide, a substantially pure preparation of an IRS-2 polypeptide, and related methods....	01/12/1999
5849708	Promotion of eating behavior A method for promoting eating, the gain of weight or maintenance of weight in a subject. The method includes administering to the subject an effective amount of melanocyte concentrating hormone (MCH) or agonist thereof....	12/15/1998
5801149	Inhibition of signal transduction molecules A peptide capable of inhibiting the interaction of an SH2 domain containing protein with a second protein....	09/01/1998
5776685	Protein kinase C assay A method evaluating the tumor promoter agonist or antagonist activity or the PKC activator or inhibitor activity of a compound. The method includes supplying a yeast cell expressing a PKC , contacting the yeast cell with a compound to be evaluated; and de...	07/07/1998
5650293	Nucleic acid encoding pp60^PIK and the methods of making pp60^PIK A substantially pure nucleic acid comprising a sequence encoding a pp60PIK peptide and methods of using nucleic acid encoding pp60PIK to make pp60PIK polypeptide....	07/22/1997
5621075	Insulin receptor substrate A purified protein that is identified herein as insulin receptor substrate 1 (IRS-1) is disclosed, as well as a method of purifying IRS-1 and a recombinant nucleic acid encoding it....	04/15/1997
5589374	Diabetogene rad: a type II diabetes specific gene Purified DNA including a sequence encoding Diabetogene rad....	12/31/1996
5422339	Peptides having insulin autoantibody but not insulin receptor binding capacity A therapeutic agent that includes a purified peptide bound to a cytotoxic moiety, the peptide being specifically reactive with human insulin autoantibodies and non-reactive with human insulin cell surface receptor, is disclosed....	06/06/1995
5306729	Method for effecting vasodilation with monoglycerides The invention provides a novel method of effecting vasodilation in a warm-blooded animal in need of such treatment and involves administering to a warm-blooded animal an effective amount of a vasodilatory monoglyceride of the formula: ##STR1## w...	04/26/1994
5260200	Isolated DNA encoding an insulin receptor substrate A purified nucleic acid consisting essentially of nucleic acid encoding insulin receptor substrate 1....	11/09/1993
4855242	Method of detecting antibodies A method for determining the quantity of an antibody in a sample, the method having the steps of: (1) providing a labelled antigen to the antibody; (2) contacting the labelled antigen with the sample in solution to form a labelled antigen-antibody complex...	08/08/1989
4396464	Method for sensing the concentration of glucose in biological fluids Glucose sensing apparatus for use in biological fluids comprising an electrode and a voltage source connected to the electrode to cause a current to flow therethrough, in which the voltage applied to the electrode is varied in a sweep ranging from a first...	08/02/1983

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Assignee: Joslin Diabetes Center, Inc.