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| Number | Title | Issue Date |
| 8163719 | Regulators of the hedgehog pathway, compositions and uses related thereto The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway,... | 04/24/2012 |
| 8099151 | System and method for magnetic-resonance-guided electrophysiologic and ablation procedures A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures includes an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and ... | 01/17/2012 |
| 8097632 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto The present invention makes available assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other smal... | 01/17/2012 |
| 8071290 | Hypermethylation of GATA-4 and GATA-5 transcription factor genes in cancer Methods are provided for identifying the presence of cancer cells in a sample by detecting hypermethylation of the promoter region of a GATA-4 transcription factor gene, a GATA-5 transcription factor gene, or both. Methods for ameliorating a cancer by effecting expr... | 12/06/2011 |
| 8067240 | Methods for the diagnosis and treatment of lung cancer The present invention provides methods for aiding in the diagnoses of the neoplastic condition of a lung cell and methods of screening for a potential therapeutic agent for the reversal of the neoplastic condition. ... | 11/29/2011 |
| 8012469 | Universal GM-CSF expressing bystander human K562 cell line The present invention provides a universal immunomodulatory cytokine-expressing bystander cell line, a composition comprising such a cell line and a cancer antigen, a method of making such a cell line, and a method of using such a composition. ... | 09/06/2011 |
| 7998946 | Regulators of the hedgehog pathway, compositions and uses related thereto The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway,... | 08/16/2011 |
| 7989426 | Selective induction of apoptosis to treat ocular disease by expression of PEDF The invention is directed to a method of prophylactically or therapeutically treating choroidal neovascularization, wherein the method comprises directly administering to the eye a therapeutic factor or a nucleic acid sequence that encodes a therapeutic factor, whic... | 08/02/2011 |
| 7976839 | Growth differentiation factor-11 A transgenic non-human animal of the species selected from the group consisting of avian, bovine, ovine and porcine having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-11 (GDF-11) chromosomally integrated... | 07/12/2011 |
| 7858317 | Aberrantly methylated genes as markers of breast malignancy The invention is directed to a method of diagnosing a cell proliferative disorder of breast tissue by determining the methylation status of nucleic acids obtained from a subject. Aberrant methylation of several genes including TWIST, HOXA5, NES-1, retinoic acid rece... | 12/28/2010 |
| 7740871 | Cancer immunotherapy with a viral antigen-defined, immunomodulator-secreting cell vaccine A human cell line, which lacks major histocompatibility class I (MHC-I) antigens and major histocompatibility class II (MHC-II) antigens and which has been modified to comprise and express (i) a nucleotide sequence encoding an immunomodulator and (ii) a nucleotide s... | 06/22/2010 |
| 7462457 | Identification of activated receptors and ion channels The present invention related to methods and reagents for generating and using activating mutations of receptors and ion channels. ... | 12/09/2008 |
| 7412276 | Brain therapy A method of performing brain therapy may include placing a subject in a main magnetic field, introducing into the subject's brain a combination imaging and therapeutic probe, the probe including a magnetic resonance imaging antenna and an electrical energy applicati... | 08/12/2008 |
| 7390483 | Universal GM-CSF expressing bystander human K562 cell line The present invention provides a universal immunomodulatory cytokine-expressing bystander cell line, a composition comprising such a cell line and a cancer antigen, a method of making such a cell line, and a method of using such a composition. ... | 06/24/2008 |
| 7371527 | Hypermethylation of GATA-4 and GATA-5 transcription factor genes in cancer Methods are provided for identifying the presence of cancer cells in a sample by detecting hypermethylation of the promoter region of a GATA-4 transcription factor gene, a GATA-5 transcription factor gene, or both. Methods for ameliorating a cancer by effecting expr... | 05/13/2008 |
| 7196070 | Prophylactic and therapeutic treatment of the ductal epithelium of a mammary gland for cancer The present invention provides prophylactic and therapeutic methods of treating the ductal epithelium of an exocrine gland, in particular a mammary gland, for disease, in particular cancer. The methods comprise contacting the ductal epithelium of the exocrine gland ... | 03/27/2007 |
| 7163697 | Biodegradable polymer compositions, compositions and uses related thereto The present application is directed to biodegradable polymers, compositions, including microspheres and nanospheres, formed of such polymers, and methods of using such polymers and compositions. In certain embodiments, the subject polymer compositions include therap... | 01/16/2007 |
| 7155271 | System and method for magnetic-resonance-guided electrophysiologic and ablation procedures A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures is disclosed. The system in its preferred embodiment provides an invasive combined electrophysiology and imaging antenna catheter which includes an RF ... | 12/26/2006 |
| 7098196 | Regulators of the hedgehog pathway, compositions and uses related thereto The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway,... | 08/29/2006 |
| 6932777 | Prophylactic and therapeutic treatment of the ductal epithelium of a mammary gland for cancer The present invention provides prophylactic and therapeutic methods of treating the ductal epithelium of an exocrine gland, in particular a mammary gland, for disease, in particular cancer. The methods comprise contacting the ductal epithelium of the exocrine gland ... | 08/23/2005 |
| 6867216 | Inhibitors of hedgehog signal pathways, compositions and uses related thereto The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other sma... | 03/15/2005 |
| 6812248 | Prevention and treatment of degenerative diseases by glutathione and phase II detoxification enzymes The present invention generally relates to the field of treating degenerative disease by administering a pharmaceutically effective amount of a compound that elevates glutathione or at least one Phase II detoxification enzyme in diseased tissue. The present inventio... | 11/02/2004 |
| 6800672 | Biodegradable compositions comprising poly(cycloaliphatic phosphoester) compounds, articles, and methods for using the same Biodegradable, flowable or flexible polymer compositions are described comprising a polymer having the recurring monomeric units shown in formula I: wherein: each of R and R′ is independently straight or branche... | 10/05/2004 |
| 6780592 | Method for detecting cell proliferative disorders The present invention relates to the detection of a cell proliferative disorder associated with alterations of microsatellite DNA in a sample. The microsatellite DNA can be contained within any of a variety of samples, such as urine, sputum, bile, stool, cervical ti... | 08/24/2004 |
| 6701176 | Magnetic-resonance-guided imaging, electrophysiology, and ablation A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures is disclosed. The system in its preferred embodiment provides an invasive combined electrophysiology and imaging antenna catheter which incl... | 03/02/2004 |
| 6675033 | Magnetic resonance imaging guidewire probe The invention describes a system, method, and means for an MRI guidewire that can be visible on an MRI, can act as an antenna and receive MRI signals from surrounding subject matter, and can allow the use of multiple interventional tools without removal o... | 01/06/2004 |
| 6656918 | Prophylactic and therapeutic treatment of the ductal epithelium of a mammary gland for cancer The present invention provides prophylactic and therapeutic methods of treating the ductal epithelium of an exocrine gland, in particular a mammary gland, for disease, in particular cancer. The methods comprise contacting the ductal epithelium of the exoc... | 12/02/2003 |
| 6573271 | Method of preventing proliferation of retinal pigment epithelium by retinoic acid receptor agonists Proliferation of retinal pigment epithelium following surgery or trauma or resulting in ocular diseases associated with choroidal neovascularization, such as age related macular degeneration and histoplasmosis syndrome, is prevented by contacting retinal ... | 06/03/2003 |
| 6559130 | Destruction of the epithelium of an exocrine gland in the prophylactic and therapeutic treatment of cancer The present invention provides prophylactic and therapeutic methods of treating the ductal epithelium of an exocrine gland, in particular a mammary gland, for disease, in particular cancer. The methods comprise contacting the ductal epithelium of the exoc... | 05/06/2003 |
| 6549800 | Methods for in vivo magnetic resonance imaging The systems and methods of the present invention provide for MRI probes adapted for insertion into a plurality of body orifices, in order to evaluate the anatomy of proximate anatomic structures, to diagnose abnormalities thereof and to treat the diagnose... | 04/15/2003 |
| 6548302 | Polymers for delivery of nucleic acids The present invention relates to compositions and methods for delivery of nucleic acids. In particular, the invention provides a polymeric delivery formulation including a nucleic acid to be transfected into a host cell, formulated in a biodegradable poly... | 04/15/2003 |
| 6500843 | Inhibitors of rotamase enzyme activity This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptid... | 12/31/2002 |
| 6495144 | EBNA2 peptides and methods of using same The present invention provides peptides having substantial homology with the CBF1/RBPJk interaction domain of EBNA2. The peptides preferably comprise between about ten and twenty amino acids. The peptides are able to compete with the native EBV EBNA2 prot... | 12/17/2002 |
| 6444643 | Methods of using inhibitors of cyclophilin rotamase activity to affect neurological activity This invention relates to the method of using neurotrophic cyclophilin inhibitor compounds having an affinity for cyclophilin-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of pep... | 09/03/2002 |
| 6432970 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein comprising contacting a cell sensitive to the hedgehog protein with a steroidal alkaloid, or other small molecule, in a... | 08/13/2002 |
| 6420524 | Gain of function mutations in ATP-dependent transposition proteins The invention is specifically directed to efficient, random, simple insertion of a transposon or derivative transposable element into DNA in vivo or in vitro. The invention is particularly directed to mutations in ATP-utilizing regulatory transposition pr... | 07/16/2002 |
| 6419709 | Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same An essentially non-osteoconductive medical device is described comprising a biodegradable terephthalate copolymer comprising the recurring monomeric units shown in formula I: ##STR1## wherein R is a divalent organic moiety; x is ࣙ1; and n is 3-7,500, wh... | 07/16/2002 |
| 6376644 | Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same Biodegradable polymers are described comprising the recurring monomeric units shown in formula I or II: ##STR1## wherein X is --O-- or --NR'--, where R' is H or alkyl; L is a branched or straight chain aliphatic group having from 1-20 carbon atoms; M... | 04/23/2002 |
| 6350445 | Method of treating cancer with a tumor cell line having modified cytokine expression The present invention provides a method of treating cancer comprising (a) obtaining a tumor cell line, (b) modifying the tumor cell line to render it capable of producing an increased level of a cytokine relative to the unmodified tumor cell line, and (c)... | 02/26/2002 |
| 6330472 | Prophylactic and therapeutic treatment of the ductal epithelium for a mammary gland for cancer The present invention provides prophylactic and therapeutic methods of treating the ductal epithelium of an exocrine gland, in particular a mammary gland, for disease, in particular cancer. The methods comprise contacting the ductal epithelium of the exoc... | 12/11/2001 |
