Assignee: Johns Hopkins University

Location: Baltimore, MD
No. of patents: 229

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Number	Title	Issue Date
8178512	Methods and compositions for treating diseases and disorders associated with siglec-8. The invention provides therapeutic methods and compositions for the prevention and treatment of Siglec-8 associated diseases and disorders such as asthma and allergic reactions. In particular, the invention provides methods and compositions for the prevention and tr...	05/15/2012
8147433	CPR chest compression monitor and method of use A chest compressions monitor for measuring the depth of chest compressions achieved during CPR. A displacement detector produces a displacement indicative signal indicative of the displacement of the CPR recipient's chest toward the recipient's spine. A signaling me...	04/03/2012
8130260	System and method for 3-dimensional display of image data Disclosed is a system for a 3-dimensional display that includes at least one eyepiece having first and second eyepiece sockets, having a first display contained in said first eyepiece socket associated with a first eye, two eye cameras mounted such that a first eye ...	03/06/2012
8128922	Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen Nucleic acids encoding a chimeric or fusion polypeptide which polypeptide comprises a first domain comprising a translocation polypeptide; and a second domain comprising at least one antigenic peptide are disclosed. The preferred translocation polypeptide is a bacte...	03/06/2012
8096972	Devices for intraocular drug delivery A therapeutic agent delivery device that is particularly suitable for delivery of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. Preferred devices of the invention are minimally invasive, refillable and may be ...	01/17/2012
8021833	Method for reducing HIV viral budding by administering a VPS28-specfic antibody that disrupts Gag-TSG101-VPS28 binding interactions The importance of interaction between TSG101 and Vps28 in the release of HIV-1 and other viruses is disclosed. Suppressing or interfering in this interaction may inhibit HIV-1 virion release from infected cells. Agents that modulate this interaction include antibodi...	09/20/2011
7973137	Cell compositions comprising molecular complexes that modify immune responses Compositions comprising a cell in which a molecular complex with high affinity for its cognate ligand is bound to the surface of the cell are provided. To form the molecular complexes, extracellular domains of transmembrane heterodimeric proteins, particularly T cel...	07/05/2011
7910300	Disease detection by protein truncation assays Genetic diseases can be diagnosed by detection of mutations in causative genes. Protein truncation assays can be used to detect gene products of truncation-type mutations. However, the sensitivity of the assays is often insufficient to detect mutations present in a ...	03/22/2011
7883717	Reservoir device for intraocular drug delivery A delivery device that allows for the sustained release of an agent, particularly useful for the sustained release of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. The delivery device is minimally invasive, re...	02/08/2011
7846667	Methods for the diagnosis and treatment of lung cancer The present invention provides methods for aiding in the diagnoses of the neoplastic condition of a lung cell and methods of screening for a potential therapeutic agent for the reversal of the neoplastic condition. ...	12/07/2010
7867167	Ultrasound calibration and real-time quality assurance based on closed form formulation Disclosed is a system and method for intra-operatively spatially calibrating an ultrasound probe. The method includes determining the relative changes in ultrasound images of a phantom, or high-contrast feature points within a target volume, for three different ultr...	01/11/2011
7863262	Nitroxyl progenitors in the treatment of heart failure Administration of an HNO/NO− donating compound, such as Angeli's salt, increases myocardial contractility while concomitantly lowering left ventricular preload in subjects experiencing heart failure. Moreover, administration of the HNO/NO− ...	01/04/2011
7829742	Boronic acid aryl analogs The present invention relates to novel boronic acid aryl derivatives which are useful as antitumor/anticancer agents. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good inhibitors of the growth of human breast cancer cells. The pre...	11/09/2010
7829078	Methods of treating anemia using recombinant adeno-associated virus virions The use of recombinant adeno-associated virus (AAV) virions for delivery of DNA molecules to muscle cells and tissue in the treatment of anemia is disclosed. The invention allows for the direct, in vivo injection of recombinant AAV virions into muscle tissue, e.g., ...	11/09/2010
7818049	ECG signal processor and method An ECG signal processing system which removes the CPR-induced artifact from measured ECG signals obtained during the administration of CPR. ...	10/19/2010
7800366	Three dimensional magnetic resonance motion estimation on a single image plane Three-dimensional MR motion estimation on a single image plane based on tagged MRI and HARP processing. Tagged magnetic resonance imaging technique encodes and automatically tracks displacement of spatially modulated object in three dimensions, encoding both in plan...	09/21/2010
7794998	Primate T-lymphotropic viruses Disclosed are compositions and methods related to the isolation and identification of the primate T-lymphotropic viruses, HTLV-3 and HTLV-4. The diversity of HTLVs was investigated among central Africans reporting contact with NHP blood and body fluids through hunti...	09/14/2010
7778682	Biopsy and sampling needle antennas for magnetic resonance imaging-guided biopsies Herein is disclosed a magnetic resonance imaging antenna, including an inner conductor, an outer shield slideably displaceable with respect to the inner conductor, and an insulator electrically insulating the inner conductor from the outer shield. Herein is disclose...	08/17/2010
7741845	Imaging tissue deformation using strain encoded MRI Disclosed is a system and method for imaging strain of tissue, such as the heart, in a quantitative manner. The present invention provides images of strain, which corresponds to heart function, by tagging a tissue region of interest, and acquiring multiple images by...	06/22/2010
7741357	Heterocyclic and carbonate derivatives of NDGA and their use as new anti-HIV and anti-cancer agents Reaction of nordihydroguaiaretic acid with various alkyl chlorides, 1-piperidinecarbonyl chloride, methyl chloroformate, or 1,1′-carbonyldiimidazole under alkaline conditions produced the corresponding phenol ethers, carbamates and carbonates, respectively, in 67-...	06/22/2010
7728036	Methods for delivery of catecholic butanes for treatment of tumors The present invention provides kits, methods and compositions for the treatment of tumor and other proliferative diseases such as tumors. The compositions herein contain a substantially pure preparation of at least one catecholic butane, including, for example, NDGA...	06/01/2010
7721742	Methods for diagnostic and therapeutic interventions in the peritoneal cavity A novel approach to diagnostic and therapeutic interventions in the peritoneal cavity is described. More specifically, a technique for accessing the peritoneal cavity via the wall of the digestive tract is provided so that examination of and/or a surgical procedure ...	05/25/2010
7683617	Non-invasive MRI measurement of tissue glycogen In a method for deriving information about a selected monosaccharide or polysaccharide such as glucose or glycogen, a selected modification such as saturation is made of magnetic resonance at a magnetic resonance frequency of protons of hydroxyl groups of the select...	03/23/2010
7649012	Compounds, pharmaceutical compositions containing same, and methods of use for same A pharmaceutical composition comprising a pharmaceutical diluent and a compound of formula IV wherein R21=H, C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, —CH2OR25, —C(O)R25, �...	01/19/2010
7638122	Stat3 antagonists and their use as vaccines against cancer The present invention relates to methods for treating and/or preventing cancer. In particular the present invention relates to ex vivo immunotherapeutic methods. The methods comprise decreasing Stat3 (signal transducer and activator of transcription3) expression and...	12/29/2009
7625907	Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof A reactive oxygen generating enzyme inhibitor with NO donor bioactivity, e.g., nitrated allopurinol, is useful to treat heart failure, stable angina, ischemic disorder, ischemic reperfusion injury, atherosclerosis, sickle cell disease, diabetes, Alzheimer's disease,...	12/01/2009
7604989	Inhibition of apoptosis process and improvement of cell performance The present invention relates to preventing or delaying programmed cell death by expressing one or more anti-apoptotic polypeptides in a cell such that programmed cell death in the cell is prevented or delayed. The present invention also relates to increasing produc...	10/20/2009
7576323	Point-of-care mass spectrometer system A point-of-care mass spectrometer system has a sampling system, an ionization component structured to receive a sample for analysis from the sampling system, a mass analyzer structured to receive a source of ions for analysis from the ionization component, and a det...	08/18/2009
7557200	Superior molecular vaccine based on self-replicating RNA, suicidal DNA or naked DNA vector, that links antigen with polypeptide that promotes antigen presentation Improved molecular vaccines comprise nucleic acid vectors that encode a fusion polypeptide that includes polypeptide or peptide physically linked to an antigen. The linked polypeptide is one that (a) promotes processing of the expressed fusion polypeptide via the MH...	07/07/2009
7517680	Production of clavulanic acid by genetic engineering of Genetically engineered Streptomyces clavuligerus strains with improved capabilities to produce clavulanic acid are provided. The strains are genetically engineered by disrupting newly identified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) genes. This res...	04/14/2009
7514579	Boronic chalcone derivatives and uses thereof The present invention relates to novel boronic chalcone derivatives which are useful as antitumor/anticancer agents. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good inhibitors of the growth of human breast cancer cells. The pres...	04/07/2009
7508999	Fiber optic sensor device for measuring chromophoric compounds in biological fluid A fiber optic sensor device for detecting the presence of a chromophoric compound in a biological fluid is disclosed. The fiber optic sensor device includes at least one fiber optic member having an unclad portion, the fiber optic member having a proximal end and a ...	03/24/2009
7494494	Controllable motorized device for percutaneous needle placement in soft tissue target and methods and systems related thereto Featured is an apparatus that places or locates a proximal end portion of a penetrating member in a target area of a body. Such an apparatus or needle driver is particularly suited for locating a percutaneous needle in a soft tissue target area of a body particularl...	02/24/2009
7485113	Method for drug delivery through the vitreous humor Devices and devices for the treatment of the eye are disclosed. Preferred devices of the invention include a piercing member that is inserted into the eye to create a pathway for a cannula. The cannula is slidably mounted to the piercing member and is adapted to rea...	02/03/2009
7417156	Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers In only two steps and in 65% overall yield, natural trioxane artemisinin (I) was converted on gram scale into C-10-carba trioxane dimer (3). This new, very stable dimer was then transformed easily in one additional step into four different dimers (4-7). Alcohol and ...	08/26/2008
7399830	Synaptic activation protein compositions and method Disclosed are nucleotide coding sequences and polypeptide sequences for synaptic activation binding proteins that are characterized by induction in the central nervous system following neuronal activity in rat hippocampus. Such proteins are identified by (i) substan...	07/15/2008
7375520	Method for spectrally selective B1 insensitive T2 preparation contrast enhancement for high field magnetic resonance imaging A T2 preparation sequence uses a segmented BIR-4 adiabatic pulse with two substantially equal delays and is insensitive to B1 field variations and can simultaneously suppress fat signals with low specific absorption rate (SAR). An adiabatic rev...	05/20/2008
7361412	Nanostructured soldered or brazed joints made with reactive multilayer foils Self-propagating formation reactions in nanostructured multilayer foils provide rapid bursts of heat at room temperature and therefore can act as local heat sources to melt solder or braze layers and join materials. This reactive joining method provides very localiz...	04/22/2008
7344887	Methods and products for delivering biological molecules to cells using multicomponent nanostructures This invention is predicated on the present applicants' discovery that nanostructures comprising discrete regions of different composition can be used to deliver to a biological cell a desired combination of molecules in close proximity. Different molecules can be s...	03/18/2008
7282476	Proaerolysin containing protease activation sequences and methods of use for treatment of prostate cancer Disclosed herein are modified proaerolysin (PA) peptide. In some examples, the proteins include a prostate-specific protease cleavage site and can further include a prostate-tissue-specific binding domain which functionally replaces the native PA binding domain. In ...	10/16/2007

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Assignee: Johns Hopkins University