Assignee: John Wyeth and Brother Limited

Location: Maidenhead, GB2
No. of patents: 30

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Number	Title	Issue Date
5212179	Piperidine derivatives The invention concerns the preparation of compounds of formula ##STR1## and acid addition and quaternary ammonium salts thereof, wherein the dotted line represents an optional bond, Ar represents a ring system of formula ##STR2## in which Q...	05/18/1993
5082843	Pyrazinyl and pyridazinyl ethers Novel ethers of formula ##STR1## their heteroaromatic N-oxides, and the pharmaceutically acceptable acid additions of the compounds of formula (I) and their N-oxides possess 5-HT3 -antagonistic activity. In the formula ##STR2## r...	01/21/1992
5010196	Acylated hexahydropyrimidines N'-Acyl-N-alkyl-1,3-diaminopropanes of formula R1 CONH(CH2)3 NHR2 (where R1 is R- or RNH where R is a substituted or unsubstituted hydrocarbon group and R2 is alkyl) are prepared by selectively ...	04/23/1991
4983617	Stable crystal form of 1,4-dihydro-2-(imidazolyl-1-ylmethyl)-6-methyl-4-(3-nitrophenyl)pyridine -3,5-dicarboxylic acid 3-ethyl 5-methyl diester, hydrochloride The invention concerns a new stable crystal form of anhydrous, crystalline 1,4-dihydro-2-(imidazol-1-ylmethyl)-6-methyl-4-(3-nitrophenyl)pyridine)-3, 5-dicarboxylic acid 3-ethyl 5-methyl diester hydrochloride, "having a melting point greater than about 215...	01/08/1991
4929625	Ethers Novel ethers of formula ##STR1## their heteroaromatic N-oxides, and the pharmaceutically acceptable acid additions of the compounds of formula (I) and their N-oxides possess 5-HT3 -antagonistic activity. In the formula ##STR2## r...	05/29/1990
4927936	Quinoline derivatives The invention concerns a compound formula II ##STR1## or an acid addition salt thereof, wherein R1, R2, R3, R4, R5, R6, and R7 are the same or different and represent hydrog...	05/22/1990
4921860	Quinuclidyl- and tropanyl-pyridyl ethers as 5-HT₃ receptor antagonists Pyridyl ethers of formula ##STR1## [where R is hydrogen, or 1 to 4 hydroxy, alkyl, alkoxy, amino, alkylamino, dialkylamino, halogen, trifluoromethyl, phenyl, halophenyl, alkyphenyl, alkoxyphenyl, carboxy, carboxamide, nitro, thiol or alkylthio substi...	05/01/1990
4866075	Indole derivatives The invention concerns compounds of formula: ##STR1## wherein R1 is hydrogen, lower alkyl, halogen, lower alkoxy or hydroxy; R2 represents hydrogen or lower alkyl; A represents an alkylene, oxoalkylene or hydoxyalkylene chain ea...	09/12/1989
4789677	N-alkyl-[N-[N-alkyl-N-[4-(4-quinolinylamino)benzoyl]ami no]alkyl]benzenesulphonamides New compounds having the formula I ##STR1## where one of A and B is CH or N, the other of A and B is CH, Q is lower alkylene, R is lower alkyl, X1 is halogen or trifluoromethyl and X2 and X3 are independently selected...	12/06/1988
4783455	Substituted pyrimidoindoles and diazepinoindoles useful as hypoglycaemics Compounds of formula (I) ##STR1## and their pharmaceutically acceptable acid addition salts, wherein R represents lower alkyl or a mono- or bicyclic aryl or heteroaryl radical, R1 and R2 which may be the same or different each r...	11/08/1988
4722930	3-benzoyl-1-[(oxo or thioheteroaryl-ylalkyl)-piperid-4-yl]ureas and derivatives The invention concerns the preparation of compounds of formula ##STR1## and acid addition and quaternary ammonium salts thereof, wherein the dotted line represents an optional bond, Ar represents a ring system of formula ##STR2## in which Q...	02/02/1988
4701462	Method for prevention of hypertension This invention provides a method for preventing the development of hypertension in a non-hypertension animal, including a human, having an elevated natriuretic hormone level, which comprises administering to said animal an amount of indoramin or a pharmac...	10/20/1987
4470202	Process and apparatus for freezing a liquid medium Spherical frozen particles, which may be subsequently freeze dried are prepared by introducing a liquid medium in the form of droplets beneath the surface of a cooling liquid. The temperature and density of the cooling liquid is chosen so that liquid drop...	09/11/1984
4428954	Method for treatment of cerebrovascular disorders Treating cerebrovascular disorders characterized by poor oxygenation with 3-[2-C benzamide-1-piperidyl) ethyl] indole....	01/31/1984
4419362	Imidazalylalkylthioimidazoles The invention concerns novel compounds of formula I wherein X is a radical selected from imidazolyl, pyridyl, quinolyl, tetrahydropyridyl or piperidyl any of which may be substituted and Y is any of the above radicals or a pyridinum radical, A is alkylene of 1...	12/06/1983
4415579	Pyridine derivatives The invention relates to a pharmaceutical composition comprising an anti-ulcer effective amount of a compound of formula I ##STR1## wherein R represents hydrogen, lower alkyl, phenyl, halophenyl, loweralkylphenyl, loweralkoxyphenyl, or aralkyl of 7 t...	11/15/1983
4415582	Method of treating ulcers or hypersecretion The invention concerns novel compounds of formula I wherein X is a radical selected from imidazolyl, pyridyl, quinolyl, tetrahydropyridyl or piperidyl any of which may be substituted and Y is any of the above radicals or a pyridinium radical, A is alkylene of ...	11/15/1983
4409218	Analgesic method Morpholine derivatives of the formula ##STR1## and their acid addition salts, wherein n represents 1, 2 or 3, R3 is alkyl of 1 to 10 carbon atoms, R4 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl(lower)alkyl, 2-te...	10/11/1983
4406903	Xanthine derivatives useful as antidepressives Xanthine derivatives are provided which exhibit psychotropic activity in that they inhibit 5-hydroxytryptamine reuptake in vitro and are indicated for antidepressive use....	09/27/1983
4399129	Treating shock Meptazinol and its pharmaceutically acceptable acid addition salts can be used in treating shock in mammals....	08/16/1983
4399144	Pyridinium salts The invention concerns compounds of formula ##STR1## wherein the sulphur is bonded to the pyridinium ring at position 2 or 4, Y is --S--or --CH2 --, R represents hydrogen, or a lower alkyl group, or other carboxylic protecting group; R	08/16/1983
4394509	2-[(Phenylthio)methyl or ethyl]pyridine derivatives The invention provides a compound of formula I ##STR1## wherein R represents hydrogen, lower alkyl, phenyl, halophenyl, loweralkylphenyl, loweralkoxyphenyl or aralkyl of 7 to 12 carbon atoms, R1 represents hydrogen or fluorine, R2	07/19/1983
4391752	Process for preparing 5H-pyrrolo[2,1-c]-[1,4]thiazepine-1,5-diones The invention relates to the preparation of 1-bromo-2-D-alkylpropanoyl-L-proline derivatives and analogous compounds which are useful as chemical intermediates to angiotensin converting enzyme (ACE) inhibitors and to the stereospecific synthesis of such A...	07/05/1983
4387230	Process for preparing a dihydropyridine derivative Dihydropyridines of formula ##STR1## where R6 is lower alkyl and R5 is lower alkyl or aryl (lower)alkyl are prepared by a novel process from sodium or potassium salts of 1-substituted-1,6-dihydro-5-hydroxy-3[2H]-pyridones. The ...	06/07/1983
4387097	Morpholines Morpholine derivatives of the formula ##STR1## and their acid addition salts, wherein n represents 1, 2 or 3, R4 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl(lower)alkyl, 2-tetrahydrofurylmethyl or cyclo(lower)alkylmethyl, ...	06/07/1983
4385059	Thiazole compositions The invention concerns compounds of formula ##STR1## or salts thereof, wherein R represents hydrogen which possess anti-inflammatory activity and have low toxicity. Methods for preparing the compounds and pharmaceutical compositions are also disclose...	05/24/1983
4374992	Certain arylaliphaticthio-pyridine type compounds The invention concerns the treatment of ulcers and hypersecretion in a mammal using compounds of the formula I where Ar is phenyl, which may be substituted or cycloalkyl of 5 to 7 carbon atoms, A is saturated or unsaturated lower alkylene which may be sub...	02/22/1983
4370477	Certain 2-(arylaliphatic thio)-pyridinium compounds The invention concerns the treatment of ulcers and hypersecretion in a mammal using compounds of the formula I where Ar is phenyl, which may be substituted or cycloalkyl of 5 to 7 carbon atoms, A is saturated or unsaturated lower alkylene which may be sub...	01/25/1983
4325953	4-Aryl-4-aryloxypiperidines 4-Aryl-4-aryloxypiperidines of the general formula (I) ##STR1## and their pharmaceutically acceptable acid addition salts, wherein R1 and R2 are hydrogen or lower alkyl, R3 is hydrogen, lower alkyl or benzyl, Ar is ph...	04/20/1982
3973025	1,4-Dihydro-3,5-pyridine dicarbonitrile derivatives The invention relates to 3,5-dicyano-1,4-dihydro-2,6-di(lower)alkyl-4-methyl-4-phenylpyridines which have hypotensive activity....	08/03/1976

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Assignee: John Wyeth and Brother Limited