Assignee: John Wyeth & Brother Limited

Location: Maidenhead, GB2
No. of patents: 230

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Number	Title	Issue Date
6395902	Oxathiazolidinyl pyridines Compounds having the formula R5 O--A--NR4 --R2 (V) where R2 is a heteroaryl group linked to the remainder of the molecule via a carbon atom adjacent a nitrogen atom and R4 and R5 are both hydro...	05/28/2002
6175012	Processes and intermediates for the preparation of piperazine derivatives Compounds having the formula R5 O--A--NR4 --R2 (V) where R2 is a heteroaryl group linked to the remainder of the molecule via a carbon atom adjacent a nitrogen atom and R4 and R5 are both hydro...	01/16/2001
6133449	Processes and intermediates for the preparation of piperazine derivatives Compounds having the formula R5 O--A--NR4 --R2 (V) where R2 is a heteroaryl group linked to the remainder of the molecule via a carbon atom adjacent a nitrogen atom and R4 and R5	10/17/2000
6127357	N-((phenyl, benzodioxinyl or N-heteroarylpiperazinyl)alkyl)-N-(N-heteroaryl)substituted carboxamides Piperazine derivatives of formula I ##STR1## and their pharmaceutically acceptable acid addition salts are 5-HT1A binding agents, particularly 5-HT1A antagonists and may be used, for example, as anxiolytics. In the formula A is ...	10/03/2000
6056942	5-HT_1A ligands Selective 5-HT1A antagonists radiolabelled with 3 H or 11 C are radiolabelled ligands useful, for example, in pharmacological screening procedures and in positron emission tomography (PET) studies....	05/02/2000
5965696	Potassium channel modulators This invention concerns peptides (I) having intracellular potassium channel modulating activity comprising the amino acid sequence shown in SEQ ID No: 2: (N terminal function) (I) Met Ile Ser Ser Val Cys Val Ser Ser 1 5...	10/12/1999
5827847	Treatment of cognitive disorders with piperazine derivatives Piperazine derivatives of formula (I) are useful in the treatment of cognitive disorders. In formula (I), X is a group of (IIa): --(CH2)n CR2 R3 CONR4 R5 or (IIIb): --A--NR6 COR	10/27/1998
5710149	Piperazine derivatives as 5-ht antagonists This invention concerns compounds of formula (I) ##STR1## where A is a C1 or C2 alkylene chain optionally substituted by lower alkyl; Z is a bicyclic oxygen-containing aryl radical (e.g. 2,3-dihydro-1,4-benzodioxin-5-yl); R is h...	01/20/1998
5637701	Process for preparing optically active amide derivatives A novel asymmetric synthesis is provided for preparing optically active amides of formula (A) and their salts. ##STR1## In the formula, X represent --N-- or --CH--, R represents a mono or bicyclic aryl or heteroaryl group, R1 is an aryl or...	06/10/1997
5629432	Preparation of ଱-aryl γ-butyrolactones This appliciation discloses a process for preparing a lactone of general formula (I), where R is an optionally substituted phenyl group or an optionally substituted mono- or bicyclic heteroaryl radical which process comprises reacting an anion of a malona...	05/13/1997
5610154	Bicyclic carboxamides Bicyclic carboxamides of formula I ##STR1## and the pharmaceutically acceptable acid addition salts are 5-HT1A binding agents, particularly 5-HT1A antagonists and may be used, for example, as anxiolytics. In the formula X repres...	03/11/1997
5585374	Amide derivatives Amide derivatives of formula (I) and their pharmaceutically acceptable salts (where a and b each represent 0, 1, 2 or 3 such that a+b=0, 1, 2 or 3, the dotted line represents an optional double bond, A is an optionally substituted C1-2 -alkylen...	12/17/1996
5541326	Piperazine Derivatives Piperazine derivatives of formula: ##STR1## and their pharmaceutically acceptable acid addition salts are disclosed. In the formula, n is 1 or 2; R and R5 are hydrogen or lower alkyl, R1 is substituted or unsubstituted aryl or a...	07/30/1996
5538956	Amine derivatives containing a phosphonic acid moiety This invention concerns compounds of formula (I) wherein E represents hydrogen, C1 -C6 alkyl or a group Ar1 -A1 ; Ar and Ar1 when present each represent an aryl group of 6 to 10 carbon atoms or a hete...	07/23/1996
5527955	Method of treating depression and tri-substituted amines therefor The invention concerns a method for treating depression or senile dementia using a compound which acts selectively as an agonist of gamma aminobutyric acid (GABA) at GABA autoreceptors with the proviso that the compound is not fengabine and progabide....	06/18/1996
5436251	Treatment of anxiety and gastrointestinal disorders with azabicyclo carbonyl-2-(cyclopropylmethyloxy)benzamide (Endo)-N-[[[8-azabicyclo[3.2.1]octan-3-yl]amino]carbonyl]-2-(cyclopropylmet hyloxy)benzamide and pharmaceutically acceptable salts thereof possess 5-HT3 antagonistic activity and are useful in the treatment of neuro-psychiatric disorders (e.g. a...	07/25/1995
5430033	Piperazine derivatives Piperazine derivatives of formula I ##STR1## and their pharmaceutically acceptable acid addition salts are 5-HT1A binding agents, particularly 5-HT1A antagonists and may be used, for example, as anxiolytics. In the formula R is ...	07/04/1995
5422355	Composition for treating depression with (N-heteroaryl)alkylamines The invention concerns compounds having formula: ##STR1## or a salt thereof, wherein E represents hydrogen, lower alkyl or a group Ar1 --A1 --; Ar and Ar1 are the same or different aryl groups (including heteroaryl) w...	06/06/1995
5420278	ω-(4-aryl or heteroarylpiperazine-1-yl)-2-aryl or aralkyl-propanoic or butanoic acids Piperazine derivatives of formula ##STR1## and their pharmaceutically acceptable acid addition salts are disclosed. In the formula n is 1 or 2, R is hydrogen or lower alkyl, R1 is an aryl or nitrogen containing heteroaryl radical, R2	05/30/1995
5382583	Piperazine derivatives Piperazine derivatives of formula: ##STR1## and their pharmaceutically acceptable acid addition salts are disclosed. In the formula, n is 1 or 2; R and R5 are hydrogen or lower alkyl, R1 is substituted or unsubstituted aryl or a...	01/17/1995
5369103	Piperazine derivatives	11/29/1994
5364849	1-[3 or 4-[1-[4-piperazinyl]]-2 arylpropionyl or butryl]-heterocyclic derivatives Piperazine derivatives of formula ##STR1## and their pharmaceutically acceptable acid addition salts are disclosed. In the formula n is 1 or 2, R is hydrogen or lower alkyl, R1 is an aryl or nitrogen containing heteroaryl radical, R2	11/15/1994
5346896	1-(aryl or heteroaryl)-4[ω-(aryl or heteroaryl)ω-(aryl or heteroaryl)alkylene]piperazines Disclosed herein are piperazine derivatives of the formula ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein W is (CH2)m, CHOH or O, m is one of the integers 1 or 2, A is an alkylene chain of 1 to 3 carbon...	09/13/1994
5340812	Piperazine derivatives Piperazine derivatives of formula ##STR1## and their pharmaceutically acceptable acid addition salts are disclosed. In the formula n is 1 or 2, R is hydrogen or lower alkyl, R1 is an aryl or nitrogen containing heteroaryl radical, R2	08/23/1994
5321047	Method and amines used therein The invention concerns a method for treating depression or senile dementia using a compound which acts selectively as an agohist of gamma aminobutyric acid (GABA) at GABA autoreceptors with the proviso that the compound is not fengabine and progabide....	06/14/1994
5260331	Composition for treating depression with (S- or O-heteroaryl)alkyl amines The invention concerns compounds having formula: ##STR1## or a salt thereof, wherein E represents hydrogen, lower alkyl or a group Ar1 --A1 --; Ar and Ar1 are the same or different aryl groups (including heteroaryl) w...	11/09/1993
5225419	Certain 1,8-ethano or propano-1,4-dihydro-4-oxo-quinoline-3-carboxamides and derivatives thereof Compounds of formula ##STR1## wherein R1 is hydrogen or one or more specified substituents, X is --O--or --NR2 -- where R2 is lower alkyl, lower alkenyl, lower alkynyl, aryl or specified substituted lower alkyl or R2	07/06/1993
5210088	Method of treatment and heterocyclic compounds used therein The invention concerns a method for treating pain and/or CNS disorders characterized in that the method uses a compound which acts selectively as an antagonist of gamma aminobutyric acid (GABA) at GABA autoreceptors relative to GABAA receptors....	05/11/1993
5204470	Azabicyclic derivatives Azabicyclic compounds of formula ##STR1## and their pharmaceutically acceptable acid addition salts are disclosed. In the formula, ##STR2## is an optionally substituted heteroaryl group containing at least one hetero atom X; n is 2, 3 or 4;...	04/20/1993
5194439	N-(2,3-dihydro-1,4-benzodioxinyl)-N-substituted aminopyrido-fused cycloalkanes Pyridine derivatives of formula ##STR1## their heteroaromatic N-oxides and their pharmaceutically acceptable acid addition salts are disclosed. In the formula z is 0, 1 and 2; R is hydrogen, hydroxy, lower alkyl, lower alkoxy, halogen, trifluoromethy...	03/16/1993
5177078	Piperazine derivatives Compounds of formula ##STR1## where A is an alkylene chain of 1 or 2 carbon atoms optionally substituted by one or more lower alkyl groups, R is hydrogen or lower alkyl, R1 is an aryl or heteroaryl radical, R2 is a mono- or bicyclic ...	01/05/1993
5169845	Piperazine derivatives Piperazine derivative of formula ##STR1## and the pharmaceutically acceptable acid addition salts, where A is an alkylene chain of 1 or 2 carbon atoms optionally substituted by one or more lower alkyl groups, m is 0, 1 or 2, R is hydrogen or lower al...	12/08/1992
5164385	Azetidine derivatives and hypotensive compositions thereof Azetidine derivatives of formula ##STR1## and their pharmaceutically acceptable acid addition salts are disclosed. In the formula R is hydrogen or one or more specified substituents. The compounds have hypotensive activity. Some are also 5-HT1A	11/17/1992
5112832	Certain cyclopenta[b]pyridines and 5,6,7,8-tetrahydroquinolines having anti-inflammatory activity The invention concerns compounds of formula I ##STR1## or a salt thereof, wherein R1 and R2 each independently represent hydrogen, lower alkyl, lower alkoxy, carboxyloweralkyl, carboxy, hydroxyloweralkyl, halogen, haloloweralkyl...	05/12/1992
5096901	Pharmacologically active amides and esters containing an azabicycloalkane moiety Compounds of formula ##STR1## wherein R1 is hydrogen or one or more specified substituents, X is --O-- or --NR2 -- where R2 is lower alkyl, lower alkenyl, lower alkynyl, aryl or specified substituted lower alkyl or R2...	03/17/1992
5086073	Composition for treating depression with aralkyl amines The invention concerns compounds having formula: ##STR1## or a salt thereof, wherein E represents hydrogen, lower alkyl or a group Ar1 --A1 ; Ar and Ar1 are the same or different aryl groups (including heteroaryl) whi...	02/04/1992
5075303	Pyridine derivatives Pyridine derivatives of formula ##STR1## their heteroaromatic N-oxides and their pharmaceutically acceptable acid addition salts are disclosed. In the formula z is 0, 1 and 2 and R, R1, R2 and R2 have specified meanin...	12/24/1991
5068337	1,4-dihydropyridines and their ability to inhibit blood platelet aggregation, inhibit thromboxane synthetase and phospholipase The invention concerns compounds of formula ##STR1## or salts thereof; wherein Ar is an optionally substituted aryl radical; R represents hydrogen or an optionally substituted alkyl or aralkyl group; R1 and R2 are the same or different an...	11/26/1991
5064842	1,4-dihydropyridines The invention concerns compounds of formula ##STR1## or salts thereof; wherein: ଱ and ଲ together represent a bond and additionally when B is an electron withdrawing group ଱ can also represent OH and ଲ can represent hydrogen; A...	11/12/1991
5026854	Method for the production of 2-bromo-5,6,7,8-tetrahydroquinoline and the analogous 2-bromo-trimethylene and pentamethylene pyridines The invention concerns compounds of formula I ##STR1## or a salt thereof, wherein R1 and R2 each independently represent hydrogen, lower alkyl, lower alkoxy, carboxyloweralkyl, carboxy, hydroxyloweralkyl, halogen, haloloweralkyl...	06/25/1991

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Assignee: John Wyeth & Brother Limited