Assignee: John Hopkins University

Location: Baltimore, MD
No. of patents: 34

Number	Title	Issue Date
8129353	Methods of gene therapy using nucleic acid sequences for ATP-binding cassette transporter The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combin...	03/06/2012
7988103	Solid state supersonic flow actuator and method of use A method and device are provided for manipulating high-speed flows without moving aerodynamic structures. More particularly, a flow control actuator device is provided that is capable of producing a pulsating synthetic jet with high exhaust velocities for manipulati...	08/02/2011
7725161	Active MRI intramyocardial injeciton catheter with a deflectable distal section A deflectable tip catheter that is safe and effective for use in a magnetic resonance imaging environment. The deflectable tip catheter is configured such that it includes a built-in antenna, such as a loopless antenna or a loop antenna. The built-in antenna permits...	05/25/2010
7678390	Carbon monoxide as a biomarker and therapeutic agent The present invention relates to the use of carbon monoxide (CO) as a biomarker and therapeutic agent of heart, lung, liver, spleen, brain, skin and kidney diseases and other conditions and disease states including, for example, asthma, emphysema, bronchitis, adult ...	03/16/2010
7645587	Cancer-associated antigens and methods of their identification and use The present invention provides novel, isolated, tumor-associated antigens, and methods for identifying such antigens in a biological sample, and of screening for the presence of such an antigen in a biological specimen, wherein the tumor antigen identified reacts wi...	01/12/2010
7495438	Three dimensional magnetic resonance motion estimation on a single image plane Three-dimensional MR motion estimation on a single image plane based on tagged MRI and HARP processing. Tagged magnetic resonance imaging technique encodes and automatically tracks displacement of spatially modulated object in three dimensions, encoding both in plan...	02/24/2009
7366148	Intrusion detection system for wireless networks A method and system (FIG. 2) for facilitating detection of intruders into a wireless network, through the use of physical layer anomalies. One or more monitoring stations (22, 24, 26) can be distributed across the potential intruder's signal transmissi...	04/29/2008
RE40246	Method for the suppression of viral growth A method for suppressing undesired viral growth in a host which comprises administering to the host an effective amount of a compound of the formula: wherein R1, R2, R3 and R4 are indep...	04/15/2008
7189511	Methods of screening and diagnostics using ATP-binding cassette transporter The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combin...	03/13/2007
7141420	Nucleic acid and amino acid sequences for ATP-binding cassette transporter and methods of screening for agents that modify ATP-binding cassette transporter The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combin...	11/28/2006
7137994	Injectable bag intraocular lens system, inserting device for use therewith, method for inserting an injectable bag intraocular lens within a human eye, methods for treating aphakia and system kits Featured is an injectable intraocular lens system including an insertion and injection device and an injectable intraocular lens. In its broadest aspects, the injectable intraocular lens is a deflated flexible bag that is disposed within the insertion and injection ...	11/21/2006
7077848	Sutureless occular surgical methods and instruments for use in such methods Featured are new methods for performing intra-ocular surgery that allow surgical personnel to access the intra-ocular volume to perform a surgical procedure or technique but which does not require the use of sutures to seal the sclera and/or conjunctiva following th...	07/18/2006
7037648	Somatic transfer of modified genes to predict drug effects The present invention relates to somatic cell gene transfer methods for mimicking one or more effects of a drug candidate compound. In one aspect, the methods mimic the effect of a drug candidate compound with potential to potentiate or suppress activity of a select...	05/02/2006
6900370	Method for generating hypermutable plants Blockade of mismatch repair in a plant can lead to hypermutation and a new genotype and/or phenotype. One approach used to generate hypermutable plants is through the expression of dominant negative alleles of mismatch repair genes in transgenic plants or derived ce...	05/31/2005
6777444	Method for regulation of gene expression in eukaryotic cells using nordihydroguaiaretic acid derivatives Use of nordihydroguaiaretic derivatives to suppress CDC-2 and survivin, stimulate apoptosis, and treat tumors. ...	08/17/2004
6756201	Diagnostic methods and gene therapy using reagents derived from the human metastasis suppressor gene KAI1 The isolation and characterization of a metastasis tumor suppressor gene KAI1 is disclosed and diagnostic methods and gene therapy approaches utilizing reagents derived from the nucleotide and deduced amino acid sequences of the KAI1 gene are provided. ...	06/29/2004
6687528	Analysis of cardic MR relaxation time images with application to quantifying myocardial perfusion reserve indexes The present invention is a method and apparatus for semi-automatically registering low signal to noise ratio relaxation-time images, with particular application to tracking motion in moving organs and quantifying myocardial perfusion reserve. For each ima...	02/03/2004
6600010	Biodegradable terephthalate polyester-poly (phosphate) polymers, compositions, articles, and methods for making and using the same Biodegradable terephthalate polymers are described comprising the recurring monomeric units shown in formula I: ##STR1## wherein R is a divalent organic moiety; R' is an aliphatic, aromatic or heterocyclic residue; x is ࣙ1; and n is 0-5,000, wherein the biod...	07/29/2003
6583445	Integrated electronic-optoelectronic devices and method of making the same An integrated electronic-optoelectronic module comprising: an ultrathin silicon-on-sapphire composite substrate; at least one electronic device fabricated in the ultrathin silicon; and at least one optoelectronic device bonded to the ultrathin silicon-on-...	06/24/2003
6283718	Bubble based micropump A micro-pump pumps either electrically conductive or non-conductive liquids through channels of the micro-pump and/or micro-devices. A conductive or non-conductive liquid, depending on the specific application of the present invention, is disposed within ...	09/04/2001
6242190	Method for high throughput thermodynamic screening of ligands The present invention provides a method of rapidly screening ligands on the basis of their binding affinity and binding enthalpy by carrying out binding assays at a minimum of two temperatures. This technique permits the selection for further optimization...	06/05/2001
6214874	Treatment of HPV induced cancer using in situ application of two nordihydroguiaretic acid derivatives, tetramethyl NDGA M4N and tetraglycinal NDGA G4N A method for using nordihydroguiaretic acid derivatives, in particular tetramethyl nordihydroguiaretic acid and tetraglycinal nordihydroguiaretic acid, for the localized treatment of tumors induced by human papillomavirus....	04/10/2001
6043386	Non-calcemic, antiproliferative, transcriptionally active 24-fluorinated hybrid analogs of 1଱,-25-dihydroxy vitamin D₃ Fluorinated analogs of 1଱,25-dihydroxyvitamin D3. These analogs are synthesized in a convergent manner by joining A-ring and C,D-ring fragments. Each hybrid analog, having a calcemia-lowering 1-hydroxymethyl group and a potentiating 16-en...	03/28/2000
6025128	Prediction of prostate cancer progression by analysis of selected predictive parameters A method for screening individuals at risk for prostate cancer progression is disclosed. The method is useful for evaluating cells from patients at risk for recurrence of prostate cancer following surgery for prostate cancer. Specifically, the method uses...	02/15/2000
5919687	Recombinant N-SMases and nucleic acids encoding same Isolated nucleic acids are provided that encode human neutral sphingomyelinase (N-SMase) and N-SMase fragments and derivatives capable of hybridizing to such N-SMase-encoding nucleic acids. The invention also includes isolated recombinant human neutral sp...	07/06/1999
5843772	Artificial transposons We have developed efficient methods of creating artificial transposons and inserting these transposons into DNA targets in vitro, primarily for the purpose of mapping and sequencing DNA. A target DNA has been engineered to convert virtually any DNA sequen...	12/01/1998
5759837	Chemotherapy for cancer by inhibiting the fatty acid biosynthetic pathway Fatty acid synthase (FAS) is overexpressed in carcinomas with poor prognosis, but little FAS expression is identified in normal tissues Inhibition of fatty acid synthesis is selectively toxic to carcinoma cells, while normal cells with low FAS activity ar...	06/02/1998
5665874	Cancer related antigen A method of determining the prognosis of a solid tumor is provided, in which a sample from a patient bearing a tumor is assayed for the presence of a protein which is immunologically cross-reactive with the hpr gene product, but not with haptoglobin 1 or ...	09/09/1997
5486191	Winged biliary stent A stent, for example for maintaining the patency of a duct such as a biliary duct, is provided that includes a plurality of radially extending wings. The wings project from a core which has a guide wire or wire stylet lumen. Each of the wings preferably i...	01/23/1996
5219751	Xylase isomerase purified from Thermotoga maritima and Thermotoga Neapolitana This invention is in the field of glucose isomerization enzymes. More specifically, the invention is directed to a novel xylose isomerase, a process for the preparation of this enzyme, the use of this enzyme in glucose isomerization processes, and glucose...	06/15/1993
5101105	Neutralization/chemical reionization tandem mass spectrometry method and apparatus therefor A mass spectrometer system including a device for supplying a protonated ion species; a single chamber having an entrance and an exit slit, the chamber receiving the supplied protonated ion and transmitting a reprotonated ion through the exit slit; a devi...	03/31/1992
4856528	Tumor volume determination A computer-implemented arrangement (apparatus and method) for semi-automatically determining from CT image data the volume of a tumor. A primary application is to determining a tumor volume for patients with hepatoma and primary hepatic cholangiocarcinoma...	08/15/1989
4797750	Method and apparatus for transmitting/recording computer-generated displays on an information channel having only audio bandwidth A method and apparatus for transmitting/recording a computer-generated display simultaneously with the transmission of audio and/or video signals. A computer generates a series of codes from which an image may be derived, the resolution of which is not de...	01/10/1989
4645872	Videophone network system A controlled access automated-switching conferencing system includes a special microprocessor-controlled control console disposed at each of a plurality of stations. Each station includes video and audio inputs and outputs. Central automatic video and aud...	02/24/1987

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Assignee: John Hopkins University